β-Cyclodextrin-threaded biocleavable polyrotaxanes ameliorate impaired autophagic flux in Niemann-Pick type C disease

Journal of Biological Chemistry

Volumn 290, Issue 15, 2015, Pages 9442-9454

  Tamura, Atsushi ^a   Yui, Nobuhiko ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; CYCLODEXTRINS; FIBROBLASTS; GENE EXPRESSION; PATIENT TREATMENT;

AUTOPHAGOSOMES; BASAL CONDITIONS; BETA-CYCLODEXTRIN; CHOLESTEROL ACCUMULATION; CHOLESTEROL REDUCTION; NIEMANN-PICK TYPE C; PROTEIN DEGRADATION; REPORTER-GENE EXPRESSION;

CELL CULTURE;

BETA CYCLODEXTRIN; BETA CYCLODEXTRIN DERIVATIVE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MICROTUBULE ASSOCIATED PROTEIN 1; MICROTUBULE ASSOCIATED PROTEIN 1 LIGHT CHAIN 3; POLYROTAXANE; PROTEIN P62; ROTAXANE; UNCLASSIFIED DRUG; 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN; CARRIER PROTEIN; CHOLESTEROL; MEMBRANE PROTEIN; NPC1 PROTEIN, HUMAN;

ARTICLE; AUTOLYSOSOME; AUTOPHAGOSOME; AUTOPHAGY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; LYSOSOME; NIEMANN PICK DISEASE; PRIORITY JOURNAL; PROTEIN DEGRADATION; SKIN FIBROBLAST; CELL CULTURE; CONFOCAL MICROSCOPY; DRUG EFFECTS; FIBROBLAST; GENETICS; IMMUNOBLOTTING; METABOLISM; MUTATION; PATHOLOGY; PHAGOSOME; TRANSPORT AT THE CELLULAR LEVEL;

AUTOPHAGY; BETA-CYCLODEXTRINS; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CELLS, CULTURED; CHOLESTEROL; FIBROBLASTS; HUMANS; IMMUNOBLOTTING; LYSOSOMES; MEMBRANE GLYCOPROTEINS; MICROSCOPY, CONFOCAL; MUTATION; NIEMANN-PICK DISEASE, TYPE C; PHAGOSOMES; ROTAXANES;

EID: 84927144989     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.636803     Document Type: Article

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