Involvement of autophagy in antitumor activity of folate-appended methyl-β-cyclodextrin

Scientific Reports

Volumn 4, Issue , 2014, Pages

  Onodera, Risako ^a   Motoyama, Keiichi ^a   Tanaka, Nao ^a   Ohyama, Ayumu ^a   Okamatsu, Ayaka ^a   Higashi, Taishi ^a   Kariya, Ryusho ^a   Okada, Seiji ^a   Arima, Hidetoshi ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BETA CYCLODEXTRIN DERIVATIVE; FOLATE RECEPTOR 1; FOLIC ACID; LIGAND; METHYL-BETA-CYCLODEXTRIN; PROTEIN BINDING;

AUTOPHAGY; CHEMISTRY; DRUG EFFECTS; GENE EXPRESSION; GENETICS; HUMAN; KB CELL LINE; METABOLISM; SYNTHESIS;

ANTINEOPLASTIC AGENTS; AUTOPHAGY; BETA-CYCLODEXTRINS; FOLATE RECEPTOR 1; FOLIC ACID; GENE EXPRESSION; HUMANS; KB CELLS; LIGANDS; PROTEIN BINDING;

EID: 84898885491     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep04417     Document Type: Article

References (36)

1. Chen, H., Ahn, R., Van den Bossche, J., Thompson, D. H. & O'Halloran, T. V. Folate-mediated intracellular drug delivery increases the anticancer efficacy of nanoparticulate formulation of arsenic trioxide. Mol. Cancer Ther. 8, 1955-1963 (2009).
2. Gabizon, A. et al. Improved therapeutic activity of folate-targeted liposomal doxorubicin in folate receptor-expressing tumor models. Cancer Chemother. Pharmacol. 66, 43-52 (2010).
3. Lu, Y. & Low, P. S. Folate-mediated delivery of macromolecular anticancer therapeutic agents. Adv. Drug Deliv. Rev. 54, 675-693 (2002).
4. Mi, Y., Liu, Y.&Feng, S. S. Formulation of Docetaxel by folic acid-conjugated d-atocopheryl polyethylene glycol succinate 2000 (Vitamin E TPGS(2k)) micelles for targeted and synergistic chemotherapy. Biomaterials 32, 4058-4066 (2011).
5. Nukolova, N. V., Oberoi, H. S., Cohen, S. M., Kabanov, A. V. & Bronich, T. K. Folate-decorated nanogels for targeted therapy of ovarian cancer. Biomaterials 32, 5417-5426 (2011).
6. Antony, A. C. The biological chemistry of folate receptors. Blood 79, 2807-2820 (1992).
7. Low, P. S. & Kularatne, S. A. Folate-targeted therapeutic and imaging agents for cancer. Curr. Opin. Chem. Biol. 13, 256-262 (2009).
8. Limmon, G. V. et al. Scavenger receptor class-A is a novel cell surface receptor for double-stranded RNA. FASEB J. 22, 159-167 (2008).
9. Parker, N. et al. Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay. Anal. Biochem. 338, 284-293 (2005).
10. Szente, L. & Szejtli, J. Highly soluble cyclodextrin derivatives: chemistry, properties, and trends in development. Adv. Drug Deliv. Rev. 36, 17-28 (1999).
11. Uekama, K. & Otagiri, M. Cyclodextrins in drug carrier systems. Crit. Rev. Ther. Drug Carrier Syst. 3, 1-40 (1987).
12. Motoyama, K. et al. Effect of 2,6-di-O-methyl-α-cyclodextrin on hemolysis and morphological change in rabbit's red blood cells. Eur. J. Pharm. Sci. 29, 111-119 (2006).
13. Motoyama, K. et al. Involvement of lipid rafts of rabbit red blood cells in morphological changes induced by methylated β-cyclodextrins. Biol. Pharm. Bull. 32, 700-705 (2009).
14. Ohtani, Y., Irie, T., Uekama, K., Fukunaga, K. & Pitha, J. Differential effects of α-, β-and γ-cyclodextrins on human erythrocytes. Eur. J. Biochem. 186, 17-22 (1989).
15. Galbiati, F., Razani, B.&Lisanti, M. P. Emerging themes in lipid rafts and caveolae. Cell 106, 403-411 (2001).
16. Grosse, P. Y., Bressolle, F. & Pinguet, F. Antiproliferative effect of methyl-βcyclodextrin in vitro and in human tumour xenografted athymic nude mice. Br. J. Cancer 78, 1165-1169 (1998).
17. Onodera, R., Motoyama, K. & Arima, H. Design and evaluation of folateappended methyl-β-cyclodextrin as a new antitumor agent. J. Incl. Phenom. Macrocycl. Chem. 70, 321-326 (2011).
18. Onodera, R., Motoyama, K., Okamatsu, A., Higashi, T. & Arima, H. Potential use of folate-appended methyl-b-cyclodextrin as an anticancer agent. Sci. Rep. 3(1109), 1-9 (2013).
19. Liang, C. et al. Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nat. Cell Biol. 8, 688-699 (2006).
20. Liu, E. Y.&Ryan, K. M. Autophagy and cancer-issues we need to digest. J. Cell Sci. 125, 2349-2358 (2012).
21. Qu, X. et al. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J. Clin. Invest. 112, 1809-1820 (2003).
22. Takahashi, Y. et al. Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis. Nat. Cell Biol. 9, 1142-1151 (2007).
23. White, E. Deconvoluting the context-dependent role for autophagy in cancer. Nat. Rev. Cancer 12, 401-410 (2012).
24. Motoyama, K. et al. Involvement of PI3K-Akt-Bad pathway in apoptosis induced by 2,6-di-O-methyl-β-cyclodextrin, not 2,6-di-O-methyl-α- cyclodextrin, through cholesterol depletion from lipid rafts on plasmamembranes in cells. Eur. J. Pharm. Sci. 38, 249-261 (2009).
25. Kondo, Y., Kanzawa, T., Sawaya, R. & Kondo, S. The role of autophagy in cancer development and response to therapy. Nat. Rev. Cancer. 5, 726-734 (2005).
26. Geetha, T. &Wooten, M. W. Structure and functional properties of the ubiquitin binding protein p62. FEBS Lett. 512, 19-24 (2002).
27. Pankiv, S. et al. p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J. Biol. Chem. 282, 24131-24145 (2007).
28. Kim, I., Rodriguez-Enriquez, S. & Lemasters, J. J. Selective degradation of mitochondria by mitophagy. Arch. Biochem. Biophys. 462, 245-253 (2007).
29. Rodriguez-Hernandez, A. et al. Coenzyme Q deficiency triggers mitochondria degradation by mitophagy. Autophagy 5, 19-32 (2009).
30. Doherty, G. J. & McMahon, H. T. Mechanisms of endocytosis. Annu. Rev. Biochem. 78, 857-902 (2009).
31. Long, J. S. & Ryan, K. M. New frontiers in promoting tumour cell death: targeting apoptosis, necroptosis and autophagy. Oncogene 31, 5045-5060 (2012).
32. Simons, K. & Ehehalt, R. Cholesterol, lipid rafts, and disease. J. Clin. Invest. 110, 597-603 (2002).
33. Park, E. K. et al. Cholesterol depletion induces anoikis-like apoptosis via FAK down-regulation and caveolae internalization. J. Pathol. 218, 337-349 (2009).
34. Onodera, R. et al. Involvement of cholesterol depletion from lipid rafts in apoptosis induced by methyl-β-cyclodextrin. Int. J. Pharm. 452, 116-123 (2013).
35. Bernardi, P., Scorrano, L., Colonna, R., Petronilli, V. & Di Lisa, F. Mitochondria and cell death. Mechanistic aspects and methodological issues. Eur. J. Biochem. 264, 687-701 (1999).
36. Ziolkowski, W. et al. Methyl-β-cyclodextrin induces mitochondrial cholesterol depletion and alters the mitochondrial structure and bioenergetics. FEBS Lett. 584, 4606-4610 (2010).