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Volumn 4, Issue , 2014, Pages

Lysosomal-specific cholesterol reduction by biocleavable polyrotaxanes for ameliorating niemann-pick type C disease

Author keywords

[No Author keywords available]

Indexed keywords

BETA CYCLODEXTRIN DERIVATIVE; BIOLOGICAL MARKER; CHOLESTEROL; PLURONIC BLOCK COPOLYMER P123; POLOXAMER; ROTAXANE;

EID: 84896272633     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep04356     Document Type: Article
Times cited : (67)

References (50)
  • 1
    • 2942687937 scopus 로고    scopus 로고
    • The cell biology of lysosomal storage disorders
    • DOI 10.1038/nrm1423
    • Futerman, A. H. & van Meer G. The cell biology of lysosomal storage disorders. Nat. Rev. Mol. Cell Biol. 5, 554-565 (2004). (Pubitemid 38868584)
    • (2004) Nature Reviews Molecular Cell Biology , vol.5 , Issue.7 , pp. 554-565
    • Futerman, A.H.1    Van Meer, G.2
  • 3
    • 0141886877 scopus 로고    scopus 로고
    • Niemann-Pick disease type C
    • DOI 10.1034/j.1399-0004.2003.00147.x
    • Vanier, M. T. & Millat, G. Niemann-Pick disease type C. Clin. Genet. 64, 269-281 (2003). (Pubitemid 37236127)
    • (2003) Clinical Genetics , vol.64 , Issue.4 , pp. 269-281
    • Vanier, M.T.1    Millat, G.2
  • 5
    • 3142774112 scopus 로고    scopus 로고
    • Niemann-Pick type C disease involves disrupted neurosteroidogenesis and responds to allopregnanolone
    • DOI 10.1038/nm1073
    • Griffin, L. D., Gong, W., Verot, L. & Mellon, S. H. Niemann-Pick type C disease involves disrupted neurosteroidogenesis and responds to allopregnanolone. Nat. Med. 10, 704-711 (2004). (Pubitemid 38937635)
    • (2004) Nature Medicine , vol.10 , Issue.7 , pp. 704-711
    • Griffin, L.D.1    Gong, W.2    Verot, L.3    Mellon, S.H.4
  • 6
    • 55549134611 scopus 로고    scopus 로고
    • Emann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium
    • Lloyd-Evans, E. et al. Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium. Nat. Med. 14, 1247-1255 (2008).
    • (2008) Nat. Med. , vol.14 , pp. 1247-1255
    • Lloyd-Evans, E.1
  • 7
    • 84869223163 scopus 로고    scopus 로고
    • D-Tocopherol reduces lipid accumulation in Niemann-Pick type C1 and Wolman cholesterol storage disorders
    • Xu, M. et al. d-Tocopherol reduces lipid accumulation in Niemann-Pick type C1 and Wolman cholesterol storage disorders. J. Biol. Chem. 287, 39349-39360 (2012).
    • (2012) J. Biol. Chem. , vol.287 , pp. 39349-39360
    • Xu, M.1
  • 8
    • 10444279209 scopus 로고    scopus 로고
    • Cyclodextrin-based pharmaceutics: Past, present and future
    • DOI 10.1038/nrd1576
    • Davis, M. E. & Brewster, M. E. Cyclodextrin-based pharmaceutics: past, present and future. Nat. Rev. Drug Discov. 3, 1023-1035 (2004). (Pubitemid 39642365)
    • (2004) Nature Reviews Drug Discovery , vol.3 , Issue.12 , pp. 1023-1035
    • Davis, M.E.1    Brewster, M.E.2
  • 9
    • 0033105151 scopus 로고    scopus 로고
    • Cyclodextrins in peptide and protein delivery
    • DOI 10.1016/S0169-409X(98)00057-X, PII S0169409X9800057X
    • Irie, T. & Uekama, K. Cyclodextrins in peptide and protein delivery. Adv. Drug Deliv. Rev. 36, 101-123 (1999). (Pubitemid 29074479)
    • (1999) Advanced Drug Delivery Reviews , vol.36 , Issue.1 , pp. 101-123
    • Irie, T.1    Uekama, K.2
  • 10
    • 84863816998 scopus 로고    scopus 로고
    • Therapeutic potential of cyclodextrins in the treatment of Niemann-Pick type C disease
    • Liu, B. Therapeutic potential of cyclodextrins in the treatment of Niemann-Pick type C disease. Clin. Lipidol. 7, 289-301 (2012).
    • (2012) Clin. Lipidol. , vol.7 , pp. 289-301
    • Liu, B.1
  • 11
    • 77950402392 scopus 로고    scopus 로고
    • Endocytosis of betacyclodextrins is responsible for cholesterol reduction in Niemann-Pick type C mutant cells
    • Rosenbaum, A. I., Zhang, G.,Warren, J. D. &;Maxfield, F. R. Endocytosis of betacyclodextrins is responsible for cholesterol reduction in Niemann-Pick type C mutant cells. Proc. Natl. Acad. Sci. USA 107, 5477-5482 (2010).
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 5477-5482
    • Rosenbaum, A.I.1    Zhang, G.2    Warren, J.D.3    Maxfield, F.R.4
  • 12
    • 84858612964 scopus 로고    scopus 로고
    • Normalization of cholesterol homeostasis by 2-hydroxypropyl-b- cyclodextrin in neurons and glia from Niemann-Pick C1 (NPC1)-deficient mice
    • Peake, K. B. & Vance, J. E. Normalization of cholesterol homeostasis by 2-hydroxypropyl-b-cyclodextrin in neurons and glia from Niemann-Pick C1 (NPC1)-deficient mice. J. Biol. Chem. 287, 9290-9298 (2012).
    • (2012) J. Biol. Chem. , vol.287 , pp. 9290-9298
    • Peake, K.B.1    Vance, J.E.2
  • 14
    • 60549084168 scopus 로고    scopus 로고
    • Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc12/2 mouse
    • Liu, B. et al. Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc12/2 mouse. Proc. Natl. Acad. Sci. USA 106, 2377-2382 (2009).
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 2377-2382
    • Liu, B.1
  • 15
    • 70349190528 scopus 로고    scopus 로고
    • Chronic cyclodextrin treatment of murine Niemann-Pick C disease ameliorates neuronal cholesterol and glycosphingolipid storage and disease progression
    • Davidson, C. D. et al. Chronic cyclodextrin treatment of murine Niemann-Pick C disease ameliorates neuronal cholesterol and glycosphingolipid storage and disease progression. PLoS One 4, e6951 (2009).
    • (2009) PLoS One , vol.4
    • Davidson, C.D.1
  • 16
    • 84871717628 scopus 로고    scopus 로고
    • Effects of cyclodextrin in two patients with Niemann-Pick type C disease
    • Matsuo, M. et al. Effects of cyclodextrin in two patients with Niemann-Pick type C disease. Mol. Genet. Metab. 108, 76-81 (2013).
    • (2013) Mol. Genet. Metab. , vol.108 , pp. 76-81
    • Matsuo, M.1
  • 17
    • 0025608105 scopus 로고
    • The pharmacokinetics of b-cyclodextrin and hydroxypropylb-cyclodextrin in the rat
    • Frijlink, H. W. et al. The pharmacokinetics of b-cyclodextrin and hydroxypropylb-cyclodextrin in the rat. Pharm. Res. 7, 1248-1252 (1990).
    • (1990) Pharm. Res. , vol.7 , pp. 1248-1252
    • Frijlink, H.W.1
  • 18
    • 21844459973 scopus 로고    scopus 로고
    • 2-Hydroxypropyl-b-cyclodextrin (HP-b-CD): A toxicology review
    • Gould, S. & Scott, R. C. 2-Hydroxypropyl-b-cyclodextrin (HP-b-CD): a toxicology review. Food. Chem. Toxicol. 43, 1451-1459 (2005).
    • (2005) Food. Chem. Toxicol. , vol.43 , pp. 1451-1459
    • Gould, S.1    Scott, R.C.2
  • 19
    • 84884207111 scopus 로고    scopus 로고
    • Involvement of cholesterol depletion from lipid rafts in apoptosis induced by methyl-b-cyclodextrin
    • Onodera, R. et al. Involvement of cholesterol depletion from lipid rafts in apoptosis induced by methyl-b-cyclodextrin. Int. J. Pharm. 452, 116-123 (2013).
    • (2013) Int. J. Pharm. , vol.452 , pp. 116-123
    • Onodera, R.1
  • 20
    • 0029120852 scopus 로고
    • Cellular cholesterol efflux mediated by cyclodextrins
    • Kilsdonk, E. P. et al. Cellular cholesterol efflux mediated by cyclodextrins. J. Biol. Chem. 270, 17250-17256 (1995).
    • (1995) J. Biol. Chem. , vol.270 , pp. 17250-17256
    • Kilsdonk, E.P.1
  • 21
    • 0031054513 scopus 로고    scopus 로고
    • Pharmaceutical applications of cyclodextrins. III. Toxicological issues and safety evaluation
    • DOI 10.1021/js960213f
    • Irie, T. & Uekama, K. Pharmaceutical applications of cyclodextrins. III. toxicological issues and safety evaluation. J. Pharm. Sci. 86, 147-162 (1997). (Pubitemid 27078377)
    • (1997) Journal of Pharmaceutical Sciences , vol.86 , Issue.2 , pp. 147-162
    • Irie, T.1    Uekama, K.2
  • 23
    • 70349124557 scopus 로고    scopus 로고
    • Involvement of PI3K-Akt-Bad pathway in apoptosis induced by 2,6-di-O-methyl-b-cyclodextrin, not 2,6-di-O-methyl-A-cyclodextrin, through cholesterol depletion from lipid rafts on plasmamembranes in cells
    • Motoyama, K. et al. Involvement of PI3K-Akt-Bad pathway in apoptosis induced by 2,6-di-O-methyl-b-cyclodextrin, not 2,6-di-O-methyl-a-cyclodextrin, through cholesterol depletion from lipid rafts on plasmamembranes in cells. Eur. J. Pharm. Sci. 38, 249-261 (2009).
    • (2009) Eur. J. Pharm. Sci. , vol.38 , pp. 249-261
    • Motoyama, K.1
  • 24
    • 84873133493 scopus 로고    scopus 로고
    • Potential use of folate-appended methyl-b-cyclodextrin as an anticancer agent
    • DOI:10.1038/srep01104
    • Onodera, R.,Motoyama, K., Okamatsu, A., Higashi, T. & Arima, H. Potential use of folate-appended methyl-b-cyclodextrin as an anticancer agent. Sci. Rep. 3, 1104; DOI:10.1038/srep01104 (2013).
    • (2013) Sci. Rep. , vol.3 , pp. 1104
    • Onodera, R.1    Motoyama, K.2    Okamatsu, A.3    Higashi, T.4    Arima, H.5
  • 25
    • 0000827460 scopus 로고
    • The molecular necklace: A rotaxane containing many threaded a-cyclodextrins
    • Harada, A., Li, J. & Kamachi, M. The molecular necklace: a rotaxane containing many threaded a-cyclodextrins. Nature 356, 325-327 (1992).
    • (1992) Nature , vol.356 , pp. 325-327
    • Harada, A.1    Li, J.2    Kamachi, M.3
  • 26
    • 33645331847 scopus 로고    scopus 로고
    • Cyclodextrin rotaxanes and polyrotaxanes
    • Wenz, G., Han, B. H. & Müller, A. Cyclodextrin rotaxanes and polyrotaxanes. Chem. Rev. 106, 782-817 (2006).
    • (2006) Chem. Rev. , vol.106 , pp. 782-817
    • Wenz, G.1    Han, B.H.2    Müller, A.3
  • 27
    • 43449102775 scopus 로고    scopus 로고
    • Cyclodextrin-based supramolecular architectures: Syntheses, structures, and applications for drug and gene delivery
    • Li, J. & Loh, X. J. Cyclodextrin-based supramolecular architectures: syntheses, structures, and applications for drug and gene delivery. Adv. Drug Deliv. Rev. 60, 1000-1017 (2008).
    • (2008) Adv. Drug Deliv. Rev. , vol.60 , pp. 1000-1017
    • Li, J.1    Loh, X.J.2
  • 28
    • 33645460372 scopus 로고    scopus 로고
    • Biocleavable polyrotaxane-plasmid DNA polyplex for enhanced gene delivery
    • Ooya, T. et al. Biocleavable polyrotaxane-plasmid DNA polyplex for enhanced gene delivery. J. Am. Chem. Soc. 128, 3852-3853 (2006).
    • (2006) J. Am. Chem. Soc. , vol.128 , pp. 3852-3853
    • Ooya, T.1
  • 29
    • 34548848796 scopus 로고    scopus 로고
    • Synthesis of a biocleavable polyrotaxane-plasmid DNA (pDNA) polyplex and its use for the rapid nonviral delivery of pDNA to cell nuclei
    • Yamashita, A. et al. Synthesis of a biocleavable polyrotaxane-plasmid DNA (pDNA) polyplex and its use for the rapid nonviral delivery of pDNA to cell nuclei. Nat. Protoc. 1, 2861-2869 (2006).
    • (2006) Nat. Protoc. , vol.1 , pp. 2861-2869
    • Yamashita, A.1
  • 30
    • 84880866088 scopus 로고    scopus 로고
    • Molecular logistics using cytocleavable polyrotaxanes for the reactivation of enzymes delivered in living cells
    • DOI:10.1038/ srep02252
    • Tamura, A. et al. Molecular logistics using cytocleavable polyrotaxanes for the reactivation of enzymes delivered in living cells. Sci. Rep. 3, 2252; DOI:10.1038/ srep02252 (2013).
    • (2013) Sci. Rep. , vol.3 , pp. 2252
    • Tamura, A.1
  • 31
    • 84872679923 scopus 로고    scopus 로고
    • Cellular internalization and gene silencing of siRNA polyplexes by cytocleavable cationic polyrotaxanes with tailored rigid backbones
    • Tamura, A. & Yui, N. Cellular internalization and gene silencing of siRNA polyplexes by cytocleavable cationic polyrotaxanes with tailored rigid backbones. Biomaterials 34, 2480-2491 (2013).
    • (2013) Biomaterials , vol.34 , pp. 2480-2491
    • Tamura, A.1    Yui, N.2
  • 32
    • 60849122214 scopus 로고    scopus 로고
    • Reduction-sensitive polymers and bioconjugates for biomedical applications
    • Meng, F., Hennink, W. E. & Zhong, Z. Reduction-sensitive polymers and bioconjugates for biomedical applications. Biomaterials 30, 2180-2198 (2009).
    • (2009) Biomaterials , vol.30 , pp. 2180-2198
    • Meng, F.1    Hennink, W.E.2    Zhong, Z.3
  • 33
    • 84877779469 scopus 로고    scopus 로고
    • Synthesis, characterization, and evaluation of pluronic-based bcyclodextrin polyrotaxanes for mobilization of accumulated cholesterol from Niemann-Pick type C fibroblasts
    • Collins, C. J. et al. Synthesis, characterization, and evaluation of pluronic-based bcyclodextrin polyrotaxanes for mobilization of accumulated cholesterol from Niemann-Pick type C fibroblasts. Biochemistry 52, 3242-3253 (2013).
    • (2013) Biochemistry , vol.52 , pp. 3242-3253
    • Collins, C.J.1
  • 34
    • 84890404443 scopus 로고    scopus 로고
    • Synthesis of 2-hydroxypropyl-b-cyclodextrin/pluronicbased polyrotaxanes via heterogeneous reaction as potential Niemann-Pick type C therapeutics
    • Mondjinou, Y. A. et al. Synthesis of 2-hydroxypropyl-b-cyclodextrin/ pluronicbased polyrotaxanes via heterogeneous reaction as potential Niemann-Pick type C therapeutics. Biomacromolecules 14, 4189-4197 (2013).
    • (2013) Biomacromolecules , vol.14 , pp. 4189-4197
    • Mondjinou, Y.A.1
  • 35
    • 0001635653 scopus 로고    scopus 로고
    • Thermally Induced Localization of Cyclodextrins in a Polyrotaxane Consisting of β-Cyclodextrins and Poly(ethylene glycol)-Poly(propylene glycol) Triblock Copolymer
    • Fujita, H. Ooya, T. & Yui, N. Thermally induced localization of cyclodextrins in a polyrotaxane consisting of b-cyclodextrins and poly(ethylene glycol)-poly(propylene glycol) triblock copolymer. Macromolecules 32, 2534-2541 (1999). (Pubitemid 129587199)
    • (1999) Macromolecules , vol.32 , Issue.8 , pp. 2534-2541
    • Fujita, H.1    Ooya, T.2    Yui, N.3
  • 36
    • 0036000152 scopus 로고    scopus 로고
    • Inhibitory effect of supramolecular polyrotaxane-dipeptide conjugates on digested peptide uptake via intestinal human peptide transporter
    • DOI 10.1021/bc015567z
    • Yui, N. et al. Inhibitory effect of supramolecular polyrotaxane-dipeptide conjugates on digested peptide uptake via intestinal human peptide transporter. Bioconjug. Chem. 13, 582-587 (2002). (Pubitemid 34527520)
    • (2002) Bioconjugate Chemistry , vol.13 , Issue.3 , pp. 582-587
    • Yui, N.1    Ooya, T.2    Kawashima, T.3    Saito, Y.4    Tamai, I.5    Sai, Y.6    Tsuji, A.7
  • 37
    • 84880139326 scopus 로고    scopus 로고
    • One-pot synthesis of an acid-labile amphiphilic triblock copolymer and its pH-responsive vesicular assembly
    • Dan, K. & Ghosh, S. One-pot synthesis of an acid-labile amphiphilic triblock copolymer and its pH-responsive vesicular assembly. Angew. Chem. Int. Ed. 52, 7300-7305 (2013).
    • (2013) Angew. Chem. Int. Ed. , vol.52 , pp. 7300-7305
    • Dan, K.1    Ghosh, S.2
  • 38
    • 84880125215 scopus 로고    scopus 로고
    • A supramolecular endosomal escape approach for enhancing gene silencing of siRNA using acid-degradable cationic polyrotaxanes
    • Tamura, A. & Yui, N. A supramolecular endosomal escape approach for enhancing gene silencing of siRNA using acid-degradable cationic polyrotaxanes. J. Mater. Chem. B 1, 3535-3544 (2013).
    • (2013) J. Mater. Chem. B , vol.1 , pp. 3535-3544
    • Tamura, A.1    Yui, N.2
  • 39
    • 76149084184 scopus 로고    scopus 로고
    • PH-Responsive nanogated ensemble based on gold-capped mesoporous silica through an acid-labile acetal linker
    • Liu, R. et al. pH-Responsive nanogated ensemble based on gold-capped mesoporous silica through an acid-labile acetal linker. J. Am. Chem. Soc. 132, 1500-1501 (2010).
    • (2010) J. Am. Chem. Soc. , vol.132 , pp. 1500-1501
    • Liu, R.1
  • 40
    • 0033384957 scopus 로고    scopus 로고
    • Regulation of endoplasmic reticulum cholesterol by plasma membrane cholesterol
    • Lange, Y., Ye, J., Rigney, M. & Steck, T. L. Regulation of endoplasmic reticulum cholesterol by plasma membrane cholesterol. J. Lipid Res. 40, 2264-2270 (1999). (Pubitemid 30017528)
    • (1999) Journal of Lipid Research , vol.40 , Issue.12 , pp. 2264-2270
    • Lange, Y.1    Ye, J.2    Rigney, M.3    Steck, T.L.4
  • 41
    • 0036186426 scopus 로고    scopus 로고
    • Dynamics of lysosomal cholesterol in Niemann-Pick type C and normal human fibroblasts
    • Lange, Y., Ye, J., Rigney, M. & Steck, T. L. Dynamics of lysosomal cholesterol in Niemann-Pick type C and normal human fibroblasts. J. Lipid Res. 43, 198-204 (2002). (Pubitemid 34184006)
    • (2002) Journal of Lipid Research , vol.43 , Issue.2 , pp. 198-204
    • Lange, Y.1    Ye, J.2    Rigney, M.3    Steck, T.L.4
  • 42
    • 0034625354 scopus 로고    scopus 로고
    • Cholesterol movement in Niemann-Pick type C cells and in cells treated with amphiphiles
    • DOI 10.1074/jbc.M000875200
    • Lange, Y., Ye, J., Rigney, M.&Steck, T. L. Cholesterol movement inNiemann-Pick type C cells and in cells treated with amphiphiles. J. Biol. Chem. 275, 17468-17475 (2000). (Pubitemid 30430786)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.23 , pp. 17468-17475
    • Lange, Y.1    Ye, J.2    Rigney, M.3    Steck, T.4
  • 44
    • 0030941803 scopus 로고    scopus 로고
    • The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
    • DOI 10.1016/S0092-8674(00)80213-5
    • Brown, M. S. & Goldstein, J. L. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 89, 331-340 (1997). (Pubitemid 27220877)
    • (1997) Cell , vol.89 , Issue.3 , pp. 331-340
    • Brown, M.S.1    Goldstein, J.L.2
  • 45
    • 84879322602 scopus 로고    scopus 로고
    • Abnormal accumulation and recycling of glycoproteins visualized in Niemann-Pick typeCcells using the chemical reporter strategy
    • Mbua, N. E. et al. Abnormal accumulation and recycling of glycoproteins visualized in Niemann-Pick typeCcells using the chemical reporter strategy. Proc. Natl. Acad. Sci. USA 110, 10207-10212 (2013).
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 10207-10212
    • Mbua, N.E.1
  • 46
    • 84896323657 scopus 로고    scopus 로고
    • Tailoring the supramolecular structure of aminated polyrotaxanes toward enhanced cellular internalization
    • in press; DOI:10.1002/mabi.201300198.
    • Yokoyama, N., Seo, J.-H., Tamura, A., Sasaki, Y. & Yui, N. Tailoring the supramolecular structure of aminated polyrotaxanes toward enhanced cellular internalization. Macromol. Biosci. in press; DOI:10.1002/mabi.201300198.
    • Macromol. Biosci.
    • Yokoyama, N.1    Seo, J.-H.2    Tamura, A.3    Sasaki, Y.4    Yui, N.5
  • 47
    • 0022555867 scopus 로고
    • Acidification of the endocytic and exocytic pathways
    • Mellman, I., Fuchs, R. & Helenius, A. Acidification of the endocytic and exocytic pathways. Annu. Rev. Biochem. 55, 663-700 (1986). (Pubitemid 16070784)
    • (1986) Annual Review of Biochemistry , vol.VOL. 55 , pp. 663-700
    • Mallman, I.1    Fuchs, R.2    Helenius, A.3
  • 49
    • 73349138621 scopus 로고    scopus 로고
    • Cyclodextrin overcomes deficient lysosome-to-endoplasmic reticulum transport of cholesterol in Niemann-Pick type C cells
    • Abi-Mosleh, L., Infante, R. E., Radhakrishnan, A., Goldstein, J. L. & Brown, M. S. Cyclodextrin overcomes deficient lysosome-to-endoplasmic reticulum transport of cholesterol in Niemann-Pick type C cells. Proc. Natl. Acad. Sci. USA 106, 19316-19321 (2009).
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 19316-19321
    • Abi-Mosleh, L.1    Infante, R.E.2    Radhakrishnan, A.3    Goldstein, J.L.4    Brown, M.S.5
  • 50
    • 67649429268 scopus 로고    scopus 로고
    • Impact of cholesterol metabolism and the LXRa-SREBP-1c pathway on nonalcoholic fatty liver disease
    • Nakamuta, M. et al. Impact of cholesterol metabolism and the LXRa-SREBP-1c pathway on nonalcoholic fatty liver disease. Int. J. Mol. Med. 23, 603-608 (2009).
    • (2009) Int. J. Mol. Med. , vol.23 , pp. 603-608
    • Nakamuta, M.1


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