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Volumn 6, Issue MAR, 2015, Pages

GRB2 nucleates T cell receptor-mediated LAT clusters that control PLC-γ1 activation and cytokine production

Author keywords

Clustering; Cytokines; GRB2; PLC 1; TCR

Indexed keywords

GAMMA INTERFERON; GLYCOSYLPHOSPHATIDYLINOSITOL DIACYLGLYCEROL LYASE; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; INTERLEUKIN 2; LAT PROTEIN; MICRORNA; SHORT HAIRPIN RNA;

EID: 84926681840     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2015.00141     Document Type: Article
Times cited : (23)

References (53)
  • 1
    • 0035475428 scopus 로고    scopus 로고
    • The role of Gads in hematopoietic cell signalling
    • Liu SK, Berry DM, Mcglade CJ. The role of Gads in hematopoietic cell signalling. Oncogene (2001) 20:6284-90. doi:10.1038/sj.onc.1204771.
    • (2001) Oncogene , vol.20 , pp. 6284-6290
    • Liu, S.K.1    Berry, D.M.2    Mcglade, C.J.3
  • 2
    • 0036221481 scopus 로고    scopus 로고
    • Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins
    • Samelson LE. Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins. Annu Rev Immunol (2002) 20:371-94. doi:10.1146/annurev.immunol.20.092601.111357.
    • (2002) Annu Rev Immunol , vol.20 , pp. 371-394
    • Samelson, L.E.1
  • 3
    • 33646104191 scopus 로고    scopus 로고
    • Molecular targeting of growth factor receptor-bound 2 (Grb2) as an anti-cancer strategy
    • Dharmawardana PG, Peruzzi B, Giubellino A, Burke TR Jr, Bottaro DP. Molecular targeting of growth factor receptor-bound 2 (Grb2) as an anti-cancer strategy. Anticancer Drugs (2006) 17:13-20. doi:10.1097/01.cad.0000185180.72604.ac.
    • (2006) Anticancer Drugs , vol.17 , pp. 13-20
    • Dharmawardana, P.G.1    Peruzzi, B.2    Giubellino, A.3    Burke, T.R.4    Bottaro, D.P.5
  • 4
    • 33748366578 scopus 로고    scopus 로고
    • Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1
    • Houtman JC, Yamaguchi H, Barda-Saad M, Braiman A, Bowden B, Appella E, et al. Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1. Nat Struct Mol Biol (2006) 13:798-805. doi:10.1038/nsmb1133.
    • (2006) Nat Struct Mol Biol , vol.13 , pp. 798-805
    • Houtman, J.C.1    Yamaguchi, H.2    Barda-Saad, M.3    Braiman, A.4    Bowden, B.5    Appella, E.6
  • 5
    • 25844457433 scopus 로고    scopus 로고
    • The epidermal growth factor receptor family
    • Bazley LA, Gullick WJ. The epidermal growth factor receptor family. Endocr Relat Cancer (2005) 12(Suppl 1):S17-27. doi:10.1677/erc.1.01032.
    • (2005) Endocr Relat Cancer , vol.12 , pp. S17-S27
    • Bazley, L.A.1    Gullick, W.J.2
  • 6
    • 84862669198 scopus 로고    scopus 로고
    • Inhibition of basal FGF receptor signaling by dimeric Grb2
    • Lin CC, Melo FA, Ghosh R, Suen KM, Stagg LJ, Kirkpatrick J, et al. Inhibition of basal FGF receptor signaling by dimeric Grb2. Cell (2012) 149:1514-24. doi:10.1016/j.cell.2012.04.033.
    • (2012) Cell , vol.149 , pp. 1514-1524
    • Lin, C.C.1    Melo, F.A.2    Ghosh, R.3    Suen, K.M.4    Stagg, L.J.5    Kirkpatrick, J.6
  • 7
    • 33644925547 scopus 로고    scopus 로고
    • Potential disease targets for drugs that disrupt protein-protein interactions of Grb2 and Crk family adaptors
    • Feller SM, Lewitzky M. Potential disease targets for drugs that disrupt protein-protein interactions of Grb2 and Crk family adaptors. Curr Pharm Des (2006) 12:529-48. doi:10.2174/138161206775474369.
    • (2006) Curr Pharm Des , vol.12 , pp. 529-548
    • Feller, S.M.1    Lewitzky, M.2
  • 8
  • 9
    • 0036247432 scopus 로고    scopus 로고
    • T-cell activation through the antigen recepto. Part 1: signaling components, signaling pathways, and signal integration at the T-cell antigen receptor synapse
    • Nel AE. T-cell activation through the antigen receptor. Part 1: signaling components, signaling pathways, and signal integration at the T-cell antigen receptor synapse. J Allergy Clin Immunol (2002) 109:758-70. doi:10.1067/mai.2002.124259.
    • (2002) J Allergy Clin Immunol , vol.109 , pp. 758-770
    • Nel, A.E.1
  • 11
    • 68649083044 scopus 로고    scopus 로고
    • LAT polices T cell activation
    • Brownlie R, Zamoyska R. LAT polices T cell activation. Immunity (2009) 31:174-6. doi:10.1016/j.immuni.2009.08.002.
    • (2009) Immunity , vol.31 , pp. 174-176
    • Brownlie, R.1    Zamoyska, R.2
  • 13
    • 84871390477 scopus 로고    scopus 로고
    • The adaptor protein LAT serves as an integration node for signaling pathways that drive T cell activation
    • Bartelt RR, Houtman JC. The adaptor protein LAT serves as an integration node for signaling pathways that drive T cell activation. Wiley Interdiscip Rev Syst Biol Med (2013) 5:101-10. doi:10.1002/wsbm.1194.
    • (2013) Wiley Interdiscip Rev Syst Biol Med , vol.5 , pp. 101-110
    • Bartelt, R.R.1    Houtman, J.C.2
  • 14
    • 79952772660 scopus 로고    scopus 로고
    • Role of two adaptor molecules SLP-76 and LAT in the PI3K signaling pathway in activated T cells
    • Shim EK, Jung SH, Lee JR. Role of two adaptor molecules SLP-76 and LAT in the PI3K signaling pathway in activated T cells. J Immunol (2011) 186:2926-35. doi:10.4049/jimmunol.1001785.
    • (2011) J Immunol , vol.186 , pp. 2926-2935
    • Shim, E.K.1    Jung, S.H.2    Lee, J.R.3
  • 15
    • 0034725625 scopus 로고    scopus 로고
    • Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling
    • Zhang W, Trible RP, Zhu M, Liu SK, Mcglade CJ, Samelson LE. Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling. J Biol Chem (2000) 275:23355-61. doi:10.1074/jbc. M000404200.
    • (2000) J Biol Chem , vol.275 , pp. 23355-23361
    • Zhang, W.1    Trible, R.P.2    Zhu, M.3    Liu, S.K.4    Mcglade, C.J.5    Samelson, L.E.6
  • 16
    • 84888093616 scopus 로고    scopus 로고
    • The ability of Sos1 to oligomerize the adaptor protein LAT is separable from its guanine nucleotide exchange activity in vivo
    • Kortum RL, Balagopalan L, Alexander CP, Garcia J, Pinski JM, Merrill RK, et al. The ability of Sos1 to oligomerize the adaptor protein LAT is separable from its guanine nucleotide exchange activity in vivo. Sci Signal (2013) 6:ra99. doi:10.1126/scisignal.2004494.
    • (2013) Sci Signal , vol.6
    • Kortum, R.L.1    Balagopalan, L.2    Alexander, C.P.3    Garcia, J.4    Pinski, J.M.5    Merrill, R.K.6
  • 17
    • 0035229933 scopus 로고    scopus 로고
    • Disruption of T cell signaling networks and development by Grb2 haploid insufficiency
    • Gong Q, Cheng AM, Akk AM, Alberola-Ila J, Gong G, Pawson T, et al. Disruption of T cell signaling networks and development by Grb2 haploid insufficiency. Nat Immunol (2001) 2:29-36. doi:10.1038/83134.
    • (2001) Nat Immunol , vol.2 , pp. 29-36
    • Gong, Q.1    Cheng, A.M.2    Akk, A.M.3    Alberola-Ila, J.4    Gong, G.5    Pawson, T.6
  • 18
    • 77953800164 scopus 로고    scopus 로고
    • Grb2 functions at the top of the T-cell antigen receptor-induced tyrosine kinase cascade to control thymic selection
    • Jang IK, Zhang J, Chiang YJ, Kole HK, Cronshaw DG, Zou Y, et al. Grb2 functions at the top of the T-cell antigen receptor-induced tyrosine kinase cascade to control thymic selection. Proc Natl Acad Sci U S A (2010) 107:10620-5. doi:10.1073/pnas.0905039107.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 10620-10625
    • Jang, I.K.1    Zhang, J.2    Chiang, Y.J.3    Kole, H.K.4    Cronshaw, D.G.5    Zou, Y.6
  • 19
    • 84859434861 scopus 로고    scopus 로고
    • TCR-mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells
    • Warnecke N, Poltorak M, Kowtharapu BS, Arndt B, Stone JC, Schraven B, et al. TCR-mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells. EMBO Rep (2012) 13:386-91. doi:10.1038/embor.2012.17.
    • (2012) EMBO Rep , vol.13 , pp. 386-391
    • Warnecke, N.1    Poltorak, M.2    Kowtharapu, B.S.3    Arndt, B.4    Stone, J.C.5    Schraven, B.6
  • 20
    • 84890333698 scopus 로고    scopus 로고
    • Focal adhesion kinase negatively regulates Lck function downstream of the T cell antigen receptor
    • Chapman NM, Connolly SF, Reinl EL, Houtman JC. Focal adhesion kinase negatively regulates Lck function downstream of the T cell antigen receptor. J Immunol (2013) 191:6208-21. doi:10.4049/jimmunol.1301587.
    • (2013) J Immunol , vol.191 , pp. 6208-6221
    • Chapman, N.M.1    Connolly, S.F.2    Reinl, E.L.3    Houtman, J.C.4
  • 21
    • 0344375083 scopus 로고    scopus 로고
    • Lentivirus-delivered stable gene silencing by RNAi in primary cells
    • Stewart SA, Dykxhoorn DM, Palliser D, Mizuno H, Yu EY, An DS, et al. Lentivirus-delivered stable gene silencing by RNAi in primary cells. RNA (2003) 9:493-501. doi:10.1261/rna.2192803.
    • (2003) RNA , vol.9 , pp. 493-501
    • Stewart, S.A.1    Dykxhoorn, D.M.2    Palliser, D.3    Mizuno, H.4    Yu, E.Y.5    An, D.S.6
  • 22
    • 23444457121 scopus 로고    scopus 로고
    • Early phosphorylation kinetics of proteins involved in proximal TCR-mediated signaling pathways
    • Houtman JC, Houghtling RA, Barda-Saad M, Toda Y, Samelson LE. Early phosphorylation kinetics of proteins involved in proximal TCR-mediated signaling pathways. J Immunol (2005) 175:2449-58. doi:10.4049/jimmunol.175.4.2449.
    • (2005) J Immunol , vol.175 , pp. 2449-2458
    • Houtman, J.C.1    Houghtling, R.A.2    Barda-Saad, M.3    Toda, Y.4    Samelson, L.E.5
  • 23
    • 84892894307 scopus 로고    scopus 로고
    • Activated PLC-gamma1 is catalytically induced at LAT but activated PLC-gamma1 is localized at both LAT-and TCR-containing complexes
    • Cruz-Orcutt N, Vacaflores A, Connolly SF, Bunnell SC, Houtman JC. Activated PLC-gamma1 is catalytically induced at LAT but activated PLC-gamma1 is localized at both LAT-and TCR-containing complexes. Cell Signal (2014) 26:797-805. doi:10.1016/j.cellsig.2013.12.022.
    • (2014) Cell Signal , vol.26 , pp. 797-805
    • Cruz-Orcutt, N.1    Vacaflores, A.2    Connolly, S.F.3    Bunnell, S.C.4    Houtman, J.C.5
  • 25
    • 11144358282 scopus 로고    scopus 로고
    • Binding specificity of multiprotein signaling complexes is determined by both cooperative interactions and affinity preferences
    • Houtman JC, Higashimoto Y, Dimasi N, Cho S, Yamaguchi H, Bowden B, et al. Binding specificity of multiprotein signaling complexes is determined by both cooperative interactions and affinity preferences. Biochemistry (2004) 43:4170-8. doi:10.1021/bi0357311.
    • (2004) Biochemistry , vol.43 , pp. 4170-4178
    • Houtman, J.C.1    Higashimoto, Y.2    Dimasi, N.3    Cho, S.4    Yamaguchi, H.5    Bowden, B.6
  • 26
    • 58249092059 scopus 로고    scopus 로고
    • Digital signaling and hysteresis characterize ras activation in lymphoid cells
    • Das J, Ho M, Zikherman J, Govern C, Yang M, Weiss A, et al. Digital signaling and hysteresis characterize ras activation in lymphoid cells. Cell (2009) 136:337-51. doi:10.1016/j.cell.2008.11.051.
    • (2009) Cell , vol.136 , pp. 337-351
    • Das, J.1    Ho, M.2    Zikherman, J.3    Govern, C.4    Yang, M.5    Weiss, A.6
  • 27
    • 0033565295 scopus 로고    scopus 로고
    • TCR and CD28 are coupled via ZAP-70 to the activation of the Vav/Rac-1-/PAK-1/p38 MAPK signaling pathway
    • Salojin KV, Zhang J, Delovitch TL. TCR and CD28 are coupled via ZAP-70 to the activation of the Vav/Rac-1-/PAK-1/p38 MAPK signaling pathway. J Immunol (1999) 163:844-53.
    • (1999) J Immunol , vol.163 , pp. 844-853
    • Salojin, K.V.1    Zhang, J.2    Delovitch, T.L.3
  • 28
    • 0035366079 scopus 로고    scopus 로고
    • MAP-kinase signaling pathways in T cells
    • Rincon M. MAP-kinase signaling pathways in T cells. Curr Opin Immunol (2001) 13:339-45. doi:10.1016/S0952-7915(00)00224-7.
    • (2001) Curr Opin Immunol , vol.13 , pp. 339-345
    • Rincon, M.1
  • 30
    • 0031030988 scopus 로고    scopus 로고
    • The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling
    • Trub T, Frantz JD, Miyazaki M, Band H, Shoelson SE. The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling. J Biol Chem (1997) 272:894-902. doi:10.1074/jbc.272.2.894.
    • (1997) J Biol Chem , vol.272 , pp. 894-902
    • Trub, T.1    Frantz, J.D.2    Miyazaki, M.3    Band, H.4    Shoelson, S.E.5
  • 32
    • 0029072239 scopus 로고
    • A comparison of the interaction of Shc and the tyrosine kinase ZAP-70 with the T cell antigen receptor zeta chain tyrosine-based activation motif
    • Osman N, Lucas SC, Turner H, Cantrell D. A comparison of the interaction of Shc and the tyrosine kinase ZAP-70 with the T cell antigen receptor zeta chain tyrosine-based activation motif. J Biol Chem (1995) 270:13981-6. doi:10.1074/jbc.270.23.13981.
    • (1995) J Biol Chem , vol.270 , pp. 13981-13986
    • Osman, N.1    Lucas, S.C.2    Turner, H.3    Cantrell, D.4
  • 33
    • 0032493626 scopus 로고    scopus 로고
    • Tyrosine 474 of ZAP-70 is required for association with the Shc adaptor and for T-cell antigen receptor-dependent gene activation
    • Pacini S, Ulivieri C, Di Somma MM, Isacchi A, Lanfrancone L, Pelicci PG, et al. Tyrosine 474 of ZAP-70 is required for association with the Shc adaptor and for T-cell antigen receptor-dependent gene activation. J Biol Chem (1998) 273:20487-93. doi:10.1074/jbc.273.32.20487.
    • (1998) J Biol Chem , vol.273 , pp. 20487-20493
    • Pacini, S.1    Ulivieri, C.2    Di Somma, M.M.3    Isacchi, A.4    Lanfrancone, L.5    Pelicci, P.G.6
  • 34
    • 84903643106 scopus 로고    scopus 로고
    • TCR microclusters pre-exist and contain molecules necessary for TCR signal transduction
    • Crites TJ, Padhan K, Muller J, Krogsgaard M, Gudla PR, Lockett SJ, et al. TCR microclusters pre-exist and contain molecules necessary for TCR signal transduction. J Immunol (2014) 193:56-67. doi:10.4049/jimmunol.1400315.
    • (2014) J Immunol , vol.193 , pp. 56-67
    • Crites, T.J.1    Padhan, K.2    Muller, J.3    Krogsgaard, M.4    Gudla, P.R.5    Lockett, S.J.6
  • 35
    • 0027724634 scopus 로고
    • Interaction of Shc with the zeta chain of the T cell receptor upon T cell activation
    • Ravichandran KS, Lee KK, Songyang Z, Cantley LC, Burn P, Burakoff SJ. Interaction of Shc with the zeta chain of the T cell receptor upon T cell activation. Science (1993) 262:902-5. doi:10.1126/science.8235613.
    • (1993) Science , vol.262 , pp. 902-905
    • Ravichandran, K.S.1    Lee, K.K.2    Songyang, Z.3    Cantley, L.C.4    Burn, P.5    Burakoff, S.J.6
  • 37
    • 0035525572 scopus 로고    scopus 로고
    • Positive and negative regulation of T-cell activation by adaptor proteins
    • Koretzky GA, Myung PS. Positive and negative regulation of T-cell activation by adaptor proteins. Nat Rev Immunol (2001) 1:95-107. doi:10.1038/35100523.
    • (2001) Nat Rev Immunol , vol.1 , pp. 95-107
    • Koretzky, G.A.1    Myung, P.S.2
  • 38
    • 0036186527 scopus 로고    scopus 로고
    • The lymphoid protein tyrosine phosphatase Lyp interacts with the adaptor molecule Grb2 and functions as a negative regulator of T-cell activation
    • Hill RJ, Zozulya S, Lu YL, Ward K, Gishizky M, Jallal B. The lymphoid protein tyrosine phosphatase Lyp interacts with the adaptor molecule Grb2 and functions as a negative regulator of T-cell activation. Exp Hematol (2002) 30:237-44. doi:10.1016/S0301-472X(01)00794-9.
    • (2002) Exp Hematol , vol.30 , pp. 237-244
    • Hill, R.J.1    Zozulya, S.2    Lu, Y.L.3    Ward, K.4    Gishizky, M.5    Jallal, B.6
  • 39
    • 1342303482 scopus 로고    scopus 로고
    • Of mice and not men: differences between mouse and human immunology
    • Mestas J, Hughes CC. Of mice and not men: differences between mouse and human immunology. J Immunol (2004) 172:2731-8. doi:10.4049/jimmunol.172.5.2731.
    • (2004) J Immunol , vol.172 , pp. 2731-2738
    • Mestas, J.1    Hughes, C.C.2
  • 40
    • 79954986185 scopus 로고    scopus 로고
    • Grb2 regulates B-cell maturation, B-cell memory responses and inhibits B-cell Ca2+ signalling
    • Ackermann JA, Radtke D, Maurberger A, Winkler TH, Nitschke L. Grb2 regulates B-cell maturation, B-cell memory responses and inhibits B-cell Ca2+ signalling. EMBO J (2011) 30:1621-33. doi:10.1038/emboj.2011.74.
    • (2011) EMBO J , vol.30 , pp. 1621-1633
    • Ackermann, J.A.1    Radtke, D.2    Maurberger, A.3    Winkler, T.H.4    Nitschke, L.5
  • 41
    • 79956348707 scopus 로고    scopus 로고
    • Growth-factor receptor-bound protein-2 (Grb2) signaling in B cells controls lymphoid follicle organization and germinal center reaction
    • Jang IK, Cronshaw DG, Xie LK, Fang G, Zhang J, Oh H, et al. Growth-factor receptor-bound protein-2 (Grb2) signaling in B cells controls lymphoid follicle organization and germinal center reaction. Proc Natl Acad Sci U S A (2011) 108:7926-31. doi:10.1073/pnas.1016451108.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 7926-7931
    • Jang, I.K.1    Cronshaw, D.G.2    Xie, L.K.3    Fang, G.4    Zhang, J.5    Oh, H.6
  • 44
    • 84886910386 scopus 로고    scopus 로고
    • Multipoint binding of the SLP-76 SH2 domain to ADAP is critical for oligomerization of SLP-76 signaling complexes in stimulated T cells
    • Coussens NP, Hayashi R, Brown PH, Balagopalan L, Balbo A, Akpan I, et al. Multipoint binding of the SLP-76 SH2 domain to ADAP is critical for oligomerization of SLP-76 signaling complexes in stimulated T cells. Mol Cell Biol (2013) 33:4140-51. doi:10.1128/MCB.00410-13.
    • (2013) Mol Cell Biol , vol.33 , pp. 4140-4151
    • Coussens, N.P.1    Hayashi, R.2    Brown, P.H.3    Balagopalan, L.4    Balbo, A.5    Akpan, I.6
  • 45
    • 0037221580 scopus 로고    scopus 로고
    • Minimal requirement of tyrosine residues of linker for activation of T cells in TCR signaling and thymocyte development
    • Zhu M, Janssen E, Zhang W. Minimal requirement of tyrosine residues of linker for activation of T cells in TCR signaling and thymocyte development. J Immunol (2003) 170:325-33. doi:10.4049/jimmunol.170.1.325.
    • (2003) J Immunol , vol.170 , pp. 325-333
    • Zhu, M.1    Janssen, E.2    Zhang, W.3
  • 46
  • 47
    • 0034116561 scopus 로고    scopus 로고
    • Prolonged activation of the mitogen-activated protein kinase pathway is required for macrophage-like differentiation of a human myeloid leukemic cell line
    • Hu X, Moscinski LC, Valkov NI, Fisher AB, Hill BJ, Zuckerman KS. Prolonged activation of the mitogen-activated protein kinase pathway is required for macrophage-like differentiation of a human myeloid leukemic cell line. Cell Growth Differ (2000) 11:191-200.
    • (2000) Cell Growth Differ , vol.11 , pp. 191-200
    • Hu, X.1    Moscinski, L.C.2    Valkov, N.I.3    Fisher, A.B.4    Hill, B.J.5    Zuckerman, K.S.6
  • 48
    • 0035848665 scopus 로고    scopus 로고
    • Differential requirements for ERK1/2 and P38 MAPK activation by thrombin in T cells. Role of P59 Fyn and PKCepsilon
    • Maulon L, Mari B, Bertolotto C, Ricci JE, Luciano F, Belhacene N, et al. Differential requirements for ERK1/2 and P38 MAPK activation by thrombin in T cells. Role of P59 Fyn and PKCepsilon. Oncogene (2001) 20:1964-72. doi:10.1038/sj.onc.1204266.
    • (2001) Oncogene , vol.20 , pp. 1964-1972
    • Maulon, L.1    Mari, B.2    Bertolotto, C.3    Ricci, J.E.4    Luciano, F.5    Belhacene, N.6
  • 49
    • 61949299950 scopus 로고    scopus 로고
    • Biochemical signaling pathways for memory T cell recall
    • Farber DL. Biochemical signaling pathways for memory T cell recall. Semin Immunol (2009) 21:84-91. doi:10.1016/j.smim.2009.02.003.
    • (2009) Semin Immunol , vol.21 , pp. 84-91
    • Farber, D.L.1
  • 50
    • 58849158737 scopus 로고    scopus 로고
    • Different T cell receptor signals determine CD8+ memory versus effector development
    • Teixeiro E, Daniels MA, Hamilton SE, Schrum AG, Bragado R, Jameson SC, et al. Different T cell receptor signals determine CD8+ memory versus effector development. Science (2009) 323:502-5. doi:10.1126/science.1163612.
    • (2009) Science , vol.323 , pp. 502-505
    • Teixeiro, E.1    Daniels, M.A.2    Hamilton, S.E.3    Schrum, A.G.4    Bragado, R.5    Jameson, S.C.6
  • 51
    • 79952180387 scopus 로고    scopus 로고
    • T-cell receptor ligation induces distinct signaling pathways in naive vs. antigen-experienced T cells
    • Adachi K, Davis MM. T-cell receptor ligation induces distinct signaling pathways in naive vs. antigen-experienced T cells. Proc Natl Acad Sci U S A (2011) 108:1549-54. doi:10.1073/pnas.1017340108.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 1549-1554
    • Adachi, K.1    Davis, M.M.2
  • 52
    • 84875444226 scopus 로고    scopus 로고
    • GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development
    • Paster W, Brockmeyer C, Fu G, Simister PC, De Wet B, Martinez-Riano A, et al. GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development. J Immunol (2013) 190:3749-56. doi:10.4049/jimmunol.1203389.
    • (2013) J Immunol , vol.190 , pp. 3749-3756
    • Paster, W.1    Brockmeyer, C.2    Fu, G.3    Simister, P.C.4    De Wet, B.5    Martinez-Riano, A.6
  • 53
    • 84878097076 scopus 로고    scopus 로고
    • Manipulating the lateral diffusion of surface-anchored EGF demonstrates that receptor clustering modulates phosphorylation levels
    • Stabley D, Retterer S, Marshall S, Salaita K. Manipulating the lateral diffusion of surface-anchored EGF demonstrates that receptor clustering modulates phosphorylation levels. Integr Biol (Camb) (2013) 5:659-68. doi:10.1039/c3ib20239a.
    • (2013) Integr Biol (Camb) , vol.5 , pp. 659-668
    • Stabley, D.1    Retterer, S.2    Marshall, S.3    Salaita, K.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.