TCR-mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells

EMBO Reports

Volumn 13, Issue 4, 2012, Pages 386-391

  Warnecke, Nicole ^a   Poltorak, Mateusz ^a   Kowtharapu, Bhavani S ^a   Arndt, Boerge ^a,d   Stone, James C ^b   Schraven, Burkhart ^a,c   Simeoni, Luca ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b UNIVERSITY OF ALBERTA   (Canada)

^c HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^d UNIVERSITY OF MUNICH   (Germany)

Author keywords

Erk; Grb2; RasGRP1; Sos; T cells

Indexed keywords

GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; RAS PROTEIN; SOS PROTEIN; T LYMPHOCYTE RECEPTOR;

ARTICLE; CONTROLLED STUDY; DOWNSTREAM PROCESSING; HUMAN; HUMAN CELL; INSULATOR ELEMENT; PRIORITY JOURNAL; RNA INTERFERENCE; T LYMPHOCYTE;

CELLS, CULTURED; DNA-BINDING PROTEINS; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE KNOCKDOWN TECHNIQUES; GRB2 ADAPTOR PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; PHOSPHORYLATION; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, INTERLEUKIN-2; RNA, SMALL INTERFERING; SON OF SEVENLESS PROTEIN, DROSOPHILA; T-LYMPHOCYTES;

EID: 84859434861     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/embor.2012.17     Document Type: Article

References (23)

1. Yasuda T, Kurosaki T (2008) Regulation of lymphocyte fate by Ras/ERK signals. Cell Cycle 7: 3634-3640
2. Roose J, Weiss A (2000) T cells: getting a GRP on Ras. Nat Immunol 1: 275-276
3. Roose JP, Mollenauer M, Ho M, Kurosaki T, Weiss A (2007) Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes. Mol Cell Biol 27: 2732-2745 (Pubitemid 46581361)
4. Das J, Ho M, Zikherman J, Govern C, Yang M, Weiss A, Chakraborty AK, Roose JP (2009) Digital signaling and hysteresis characterize ras activation in lymphoid cells. Cell 136: 337-351
5. Buday L, Downward J (1993) Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor. Cell 73: 611-620 (Pubitemid 23143358)
6. Buday L, Egan SE, Rodriguez Viciana P, Cantrell DA, Downward J (1994) A complex of Grb2 adaptor protein, Sos exchange factor, and a 36-kDa membrane-bound tyrosine phosphoprotein is implicated in ras activation in T cells. J Biol Chem 269: 9019-9023 (Pubitemid 24209221)
7. Zhang L, Lorenz U, Ravichandran KS (2003) Role of Shc in T-cell development and function. Immunol Rev 191: 183-195 (Pubitemid 36398857)
8. Brockmeyer C et al (2011) T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component. J Biol Chem 286: 7535-7547
9. Jang IK, Zhang J, Chiang YJ, Kole HK, Cronshaw DG, Zou Y, Gu H (2010) Grb2 functions at the top of the T-cell antigen receptor-induced tyrosine kinase cascade to control thymic selection. Proc Natl Acad Sci USA 107: 10620-10625
10. Gong Q, Cheng AM, Akk AM, Alberola-Ila J, Gong G, Pawson T, Chan AC (2001) Disruption of T cell signaling networks and development by Grb2 haploid insufficiency. Nat Immunol 2: 29-36 (Pubitemid 33704950)
11. Dower NA, Stang SL, Bottorff DA, Ebinu JO, Dickie P, Ostergaard HL, Stone JC (2000) RasGRP is essential for mouse thymocyte differentiation and TCR signaling. Nat Immunol 1: 317-321
12. Priatel JJ, Teh SJ, Dower NA, Stone JC, Teh HS (2002) RasGRP1 transduces low-grade TCR signals which are critical for T cell development, homeostasis, and differentiation. Immunity 17: 617-627 (Pubitemid 35351507)
13. Priatel JJ et al (2010) RasGRP1 regulates antigen-induced developmental programming by naive CD8 T cells. J Immunol 184: 666-676
14. Roose JP, Mollenauer M, Gupta VA, Stone J, Weiss A (2005) A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells. Mol Cell Biol 25: 4426-4441 (Pubitemid 40705750)
15. Ebisuya M, Kondoh K, Nishida E (2005) The duration, magnitude and compartmentalization of ERK MAP kinase activity: mechanisms for providing signaling specificity. J Cell Sci 118: 2997-3002 (Pubitemid 41149904)
16. Prasad A, Zikherman J, Das J, Roose JP, Weiss A, Chakraborty AK (2009) Origin of the sharp boundary that discriminates positive and negative selection of thymocytes. Proc Natl Acad Sci USA 106: 528-533
17. Kortum RL, Sommers CL, Alexander CP, Pinski JM, Li W, Grinberg A, Lee J, Love PE, Samelson LE (2011) Targeted Sos1 deletion reveals its critical role in early T-cell development. Proc Natl Acad Sci USA 108: 12407-12412
18. Ruiz S, Santos E, Bustelo XR (2007) RasGRF2, a guanosine nucleotide exchange factor for Ras GTPases, participates in T-cell signaling responses. Mol Cell Biol 27: 8127-8142 (Pubitemid 350234228)
19. Acuto O, Di Bartolo V, Micheli F (2008) Tailoring T-cell receptor signals by proximal negative feedback mechanisms. Nat Rev Immunol 8: 699-712
20. Ravichandran KS, Igras V, Shoelson SE, Fesik SW, Burakoff SJ (1996) Evidence for a role for the phosphotyrosine-binding domain of Shc in interleukin 2 signaling. Proc Natl Acad Sci USA 93: 5275-5280 (Pubitemid 26159439)
21. Beyer T et al (2011) Integrating signals from the T-cell receptor and the interleukin-2 receptor. PLoS Comput Biol 7: e1002121
22. Arndt B, Krieger T, Kalinski T, Thielitz A, Reinhold D, Roessner A, Schraven B, Simeoni L (2011) The transmembrane adaptor protein SIT inhibits TCR-mediated signaling. PLoS ONE 6: e23761
23. Ebinu JO et al (2000) RasGRP links T-cell receptor signaling to Ras. Blood 95: 3199-3203 (Pubitemid 30321173)