Cellular repressor of E1A-stimulated gene overexpression in bone mesenchymal stem cells protects against rat myocardial infarction

International Journal of Cardiology

Volumn 183, Issue , 2015, Pages 232-241

  Peng, Chengfei ^a,b   Pei, Haifeng ^c   Wei, Feipeng ^d   Tian, Xiaoxiang ^b   Deng, Jie ^b   Yan, Chenghui ^b   Li, Yang ^b   Sun, Mingyu ^b   Zhang, Jian ^b   Liu, Dan ^e   Rong, Jingjing ^e   Wang, Jie ^d   Gao, Erhe ^f   Li, Shaohua ^g   Han, Yaling ^b  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b GENERAL HOSPITAL OF NORTHERN THEATER COMMAND   (China)

^c CHENGDU MILITARY GENERAL HOSPITAL   (China)

^d FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^e THIRD MILITARY MEDICAL UNIVERSITY   (China)

^f TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

BMSCs; CREG; HIF 1 ; Myocardial infarction; VHL

Indexed keywords

CELLULAR REPRESSOR OF E1A STIMULATED GENE PROTEIN; GLYCOPROTEIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 1BETA; MATRIGEL; MESSENGER RNA; PHOSPHATE BUFFERED SALINE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VASCULOTROPIN; VON HIPPEL LINDAU PROTEIN; CREG PROTEIN, RAT; HIF1A PROTEIN, RAT; REPRESSOR PROTEIN; VASCULOTROPIN A;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BONE MARROW DERIVED MESENCHYMAL STEM CELL; CONTROLLED STUDY; ECHOCARDIOGRAPHY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE OVEREXPRESSION; GENE SILENCING; HEART FUNCTION; HEART INFARCTION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART MUSCLE FIBROSIS; HEART PROTECTION; IMMUNOFLUORESCENCE TEST; IN VITRO STUDY; IN VIVO STUDY; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESSENGER RNA SYNTHESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SECRETION; RAT; STEM CELL GENE THERAPY; SUPERNATANT; WESTERN BLOTTING; ANIMAL; BONE; BONE MARROW CELL; CYTOLOGY; GENE EXPRESSION; GENETICS; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HUMAN; MESENCHYMAL STROMA CELL; METABOLISM; MYOCARDIAL INFARCTION; PHYSIOLOGY; PROCEDURES; SPRAGUE DAWLEY RAT; UMBILICAL VEIN ENDOTHELIAL CELL;

ANIMALS; APOPTOSIS; BONE AND BONES; BONE MARROW CELLS; GENE EXPRESSION; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; MODELS, ANIMAL; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; MYOCYTES, CARDIAC; NEOVASCULARIZATION, PHYSIOLOGIC; RATS; RATS, SPRAGUE-DAWLEY; REPRESSOR PROTEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 84926673649     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2015.01.059     Document Type: Article

References (54)

1. M.A. Pfeffer, and E. Braunwald Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications Circulation 81 1990 1161 1172
2. Y. Han, J. Deng, L. Guo, C. Yan, M. Liang, and J. Kang et al. CREG promotes a mature smooth muscle cell phenotype and reduces neointimal formation in balloon-injured rat carotid artery Cardiovasc. Res. 78 2008 597 604
3. L.B. Balsam, A.J. Wagers, J.L. Christensen, T. Kofidis, I.L. Weissman, and R.C. Robbins Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium Nature 428 2004 668 673
4. B.C. Lee, H.C. Hsu, W.Y. Tseng, C.Y. Chen, H.J. Lin, and Y.L. Ho et al. Cell therapy generates a favourable chemokine gradient for stem cell recruitment into the infarcted heart in rabbits Eur. J. Heart Fail. 11 2009 238 245
5. Z. Zhang, D. Liang, X. Gao, C. Zhao, X. Qin, and Y. Xu et al. Selective inhibition of inositol hexakisphosphate kinases (IP6Ks) enhances mesenchymal stem cell engraftment and improves therapeutic efficacy for myocardial infarction Basic Res. Cardiol. 109 2014 417
6. M.B. Britten, N.D. Abolmaali, B. Assmus, R. Lehmann, J. Honold, and J. Schmitt et al. Infarct remodeling after intracoronary progenitor cell treatment in patients with acute myocardial infarction (TOPCARE-AMI): mechanistic insights from serial contrast-enhanced magnetic resonance imaging Circulation 108 2003 2212 2218
7. S.J. Brunskill, C.J. Hyde, C.J. Doree, S.M. Watt, and E. Martin-Rendon Route of delivery and baseline left ventricular ejection fraction, key factors of bone-marrow-derived cell therapy for ischaemic heart disease Eur. J. Heart Fail. 11 2009 887 896
8. Y. Jiang, L. Chen, Y. Tang, G. Ma, C. Shen, and C. Qi et al. HO-1 gene overexpression enhances the beneficial effects of superparamagnetic iron oxide labeled bone marrow stromal cells transplantation in swine hearts underwent ischemia/reperfusion: an MRI study Basic Res. Cardiol. 105 2010 431 442
9. E. Veal, M. Eisenstein, Z.H. Tseng, and G. Gill A cellular repressor of E1A-stimulated genes that inhibits activation by E2F Mol. Cell. Biol. 18 1998 5032 5041
10. Z. Bian, J. Cai, D.F. Shen, L. Chen, L. Yan, and Q. Tang et al. Cellular repressor of E1A-stimulated genes attenuates cardiac hypertrophy and fibrosis J. Cell. Mol. Med. 13 2009 1302 1313
11. J. Deng, Y. Han, C. Yan, X. Tian, J. Tao, and J. Kang et al. Overexpressing cellular repressor of E1A-stimulated genes protects mesenchymal stem cells against hypoxia- and serum deprivation-induced apoptosis by activation of PI3K/Akt Apoptosis 15 2010 463 473
12. C.F. Peng, Y.L. Han, D. Jie, C.H. Yan, K. Jian, and L. Bo et al. Overexpression of cellular repressor of E1A-stimulated genes inhibits TNF-alpha-induced apoptosis via NF-kappaB in mesenchymal stem cells Biochem. Biophys. Res. Commun. 406 2011 601 607
13. K. Albrecht-Schgoer, W. Schgoer, J. Holfeld, M. Theurl, D. Wiedemann, and C. Steger et al. The angiogenic factor secretoneurin induces coronary angiogenesis in a model of myocardial infarction by stimulation of vascular endothelial growth factor signaling in endothelial cells Circulation 126 2012 2491 2501
14. G. Rengo, A. Cannavo, D. Liccardo, C. Zincarelli, C. de Lucia, and G. Pagano et al. Vascular endothelial growth factor blockade prevents the beneficial effects of beta-blocker therapy on cardiac function, angiogenesis, and remodeling in heart failure Circ. Heart Fail. 6 2013 1259 1267
15. Y. Dai, M. Xu, Y. Wang, Z. Pasha, T. Li, and M. Ashraf HIF-1alpha induced-VEGF overexpression in bone marrow stem cells protects cardiomyocytes against ischemia J. Mol. Cell. Cardiol. 42 2007 1036 1044
16. L. Zhou, W. Ma, Z. Yang, F. Zhang, L. Lu, and Z. Ding et al. VEGF165 and angiopoietin-1 decreased myocardium infarct size through phosphatidylinositol-3 kinase and Bcl-2 pathways Gene Ther. 12 2005 196 202
17. Z. Arany, L.E. Huang, R. Eckner, S. Bhattacharya, C. Jiang, and M.A. Goldberg et al. An essential role for p300/CBP in the cellular response to hypoxia Proc. Natl. Acad. Sci. U. S. A. 93 1996 12969 12973
18. C. Shen, and W.G. Kaelin Jr. The VHL/HIF axis in clear cell renal carcinoma Semin. Cancer Biol. 23 2013 18 25
19. E. Llurba, O. Sanchez, Q. Ferrer, K.H. Nicolaides, A. Ruiz, and C. Dominguez et al. Maternal and foetal angiogenic imbalance in congenital heart defects Eur. Heart J. 35 2014 701 707
20. M. Albrecht, K. Zitta, B. Bein, G. Wennemuth, O. Broch, and J. Renner et al. Remote ischemic preconditioning regulates HIF-1alpha levels, apoptosis and inflammation in heart tissue of cardiosurgical patients: a pilot experimental study Basic Res. Cardiol. 108 2013 314
21. C.A. Makarewich, R.N. Correll, H. Gao, H. Zhang, B. Yang, and R.M. Berretta et al. A caveolae-targeted L-type Ca(2)+ channel antagonist inhibits hypertrophic signaling without reducing cardiac contractility Circ. Res. 110 2012 669 674
22. D.K. Chang, C.Y. Chiu, S.Y. Kuo, W.C. Lin, A. Lo, and Y.P. Wang et al. Antiangiogenic targeting liposomes increase therapeutic efficacy for solid tumors J. Biol. Chem. 284 2009 12905 12916
23. X. Wang, M.N. Jameel, Q. Li, A. Mansoor, X. Qiang, and C. Swingen et al. Stem cells for myocardial repair with use of a transarterial catheter Circulation 120 2009 S238 S246
24. Y. Han, L. Guo, C. Yan, P. Guo, J. Deng, and X. Mai et al. Adenovirus-mediated intra-arterial delivery of cellular repressor of E1A-stimulated genes inhibits neointima formation in rabbits after balloon injury J. Vasc. Surg. 48 2008 201 209
25. T. Kinnaird, E. Stabile, M.S. Burnett, M. Shou, C.W. Lee, and S. Barr et al. Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms Circulation 109 2004 1543 1549
26. M. Gnecchi, H. He, O.D. Liang, L.G. Melo, F. Morello, and H. Mu et al. Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells Nat. Med. 11 2005 367 368
27. R. Uemura, M. Xu, N. Ahmad, and M. Ashraf Bone marrow stem cells prevent left ventricular remodeling of ischemic heart through paracrine signaling Circ. Res. 98 2006 1414 1421
28. I. Arnaoutova, J. George, H.K. Kleinman, and G. Benton The endothelial cell tube formation assay on basement membrane turns 20: state of the science and the art Angiogenesis 12 2009 267 274
29. V. Christoffels Regenerative medicine: muscle for a damaged heart Nature 474 2011 585 586
30. W.E. Wang, D. Yang, L. Li, W. Wang, Y. Peng, and C. Chen et al. Prolyl hydroxylase domain protein 2 silencing enhances the survival and paracrine function of transplanted adipose-derived stem cells in infarcted myocardium Circ. Res. 113 2013 288 300
31. A. Kawamoto, H.C. Gwon, H. Iwaguro, J.I. Yamaguchi, S. Uchida, and H. Masuda et al. Therapeutic potential of ex vivo expanded endothelial progenitor cells for myocardial ischemia Circulation 103 2001 634 637
32. A.A. Kocher, M.D. Schuster, M.J. Szabolcs, S. Takuma, D. Burkhoff, and J. Wang et al. Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function Nat. Med. 7 2001 430 436
33. L. Ye, P. Zhang, S. Duval, L. Su, Q. Xiong, and J. Zhang Thymosin beta4 increases the potency of transplanted mesenchymal stem cells for myocardial repair Circulation 128 2013 S32 S41
34. C. Toma, M.F. Pittenger, K.S. Cahill, B.J. Byrne, and P.D. Kessler Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart Circulation 105 2002 93 98
35. M.A. Sussman, and C.E. Murry Bones of contention: marrow-derived cells in myocardial regeneration J. Mol. Cell. Cardiol. 44 2008 950 953
36. A. Di Bacco, and G. Gill The secreted glycoprotein CREG inhibits cell growth dependent on the mannose-6-phosphate/insulin-like growth factor II receptor Oncogene 22 2003 5436 5445
37. E. Veal, R. Groisman, M. Eisenstein, and G. Gill The secreted glycoprotein CREG enhances differentiation of NTERA-2 human embryonal carcinoma cells Oncogene 19 2000 2120 2128
38. J. Wang, C.H. Yan, Y. Li, K. Xu, X.X. Tian, and C.F. Peng et al. MicroRNA-31 controls phenotypic modulation of human vascular smooth muscle cells by regulating its target gene cellular repressor of E1A-stimulated genes Exp. Cell Res. 319 2013 1165 1175
39. S. Ohnishi, B. Yanagawa, K. Tanaka, Y. Miyahara, H. Obata, and M. Kataoka et al. Transplantation of mesenchymal stem cells attenuates myocardial injury and dysfunction in a rat model of acute myocarditis J. Mol. Cell. Cardiol. 42 2007 88 97
40. N. Nagaya, K. Kangawa, T. Itoh, T. Iwase, S. Murakami, and Y. Miyahara et al. Transplantation of mesenchymal stem cells improves cardiac function in a rat model of dilated cardiomyopathy Circulation 112 2005 1128 1135
41. F.J. Giordano, H.P. Gerber, S.P. Williams, N. VanBruggen, S. Bunting, and P. Ruiz-Lozano et al. A cardiac myocyte vascular endothelial growth factor paracrine pathway is required to maintain cardiac function Proc. Natl. Acad. Sci. U. S. A. 98 2001 5780 5785
42. J.E. Nor, J. Christensen, D.J. Mooney, and P.J. Polverini Vascular endothelial growth factor (VEGF)-mediated angiogenesis is associated with enhanced endothelial cell survival and induction of Bcl-2 expression Am. J. Pathol. 154 1999 375 384
43. A. Plein, A. Fantin, and C. Ruhrberg Neuropilin regulation of angiogenesis, arteriogenesis and vascular permeability Microcirculation 21 2014 315 323
44. G. Heusch HIF-1alpha and paradoxical phenomena in cardioprotection Cardiovasc. Res. 96 2012 214 215
45. G.L. Semenza Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics Oncogene 29 2010 625 634
46. M. Heinis, M.T. Simon, K. Ilc, N.M. Mazure, J. Pouyssegur, and R. Scharfmann et al. Oxygen tension regulates pancreatic beta-cell differentiation through hypoxia-inducible factor 1alpha Diabetes 59 2010 662 669
47. H. Zhang, H. Li, H.S. Xi, and S. Li HIF1alpha is required for survival maintenance of chronic myeloid leukemia stem cells Blood 119 2012 2595 2607
48. S.H. Hsu, C.T. Chen, and Y.H. Wei Inhibitory effects of hypoxia on metabolic switch and osteogenic differentiation of human mesenchymal stem cells Stem Cells 31 2013 2779 2788
49. S.N. Heyman, S. Rosen, and C. Rosenberger Hypoxia-inducible factors and the prevention of acute organ injury Crit. Care. 15 2011 209
50. L. Gunaratnam, and J.V. Bonventre HIF in kidney disease and development J. Am. Soc. Nephrol. 20 2009 1877 1887
51. C. Loinard, A. Ginouves, J. Vilar, C. Cochain, Y. Zouggari, and A. Recalde et al. Inhibition of prolyl hydroxylase domain proteins promotes therapeutic revascularization Circulation 120 2009 50 59
52. W. Li, N. Ma, L.L. Ong, C. Nesselmann, C. Klopsch, and Y. Ladilov et al. Bcl-2 engineered MSCs inhibited apoptosis and improved heart function Stem Cells 25 2007 2118 2127
53. H. Haider, S. Jiang, N.M. Idris, and M. Ashraf IGF-1-overexpressing mesenchymal stem cells accelerate bone marrow stem cell mobilization via paracrine activation of SDF-1alpha/CXCR4 signaling to promote myocardial repair Circ. Res. 103 2008 1300 1308
54. M. Taljaard, M.R. Ward, M.J. Kutryk, D.W. Courtman, N.J. Camack, and S.G. Goodman et al. Rationale and design of Enhanced Angiogenic Cell Therapy in Acute Myocardial Infarction (ENACT-AMI): the first randomized placebo-controlled trial of enhanced progenitor cell therapy for acute myocardial infarction Am. Heart J. 159 2010 354 360