HIF-1α and paradoxical phenomena in cardioprotection

Cardiovascular Research

Volumn 96, Issue 2, 2012, Pages 214-215

  Heusch, Gerd ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CONNEXIN 43; GLYCOGEN SYNTHASE KINASE 3BETA; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN KINASE C; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; CELL DEATH; CELL SURVIVAL; EDITORIAL; HEART INFARCTION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HUMAN; ISCHEMIC PRECONDITIONING; MITOCHONDRIAL RESPIRATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; ISCHEMIC PRECONDITIONING, MYOCARDIAL; MALE; MYOCARDIAL INFARCTION;

EID: 84867717542     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvs145     Document Type: Editorial

References (20)

1. Murry CE, Jennings RB, Reimer KA. Preconditioning with ischaemia: a delay of lethal cell injury in ischaemic myocardium. Circulation 1986;74:1124-1136.
2. Yellon DM, Downey JM. Preconditioning the myocardium: from cellular physiology to clinical cardiology. Physiol Rev 2003;83:1113-1151.
3. Heusch G, Boengler K, Schulz R. Cardioprotection: nitric oxide, protein kinases, and mitochondria. Circulation 2008;118:1915-1919.
4. Heusch G. Nitroglycerin and delayed preconditioning in humans. Yet another new mechanism for an old drug? Circulation 2001;103:2876-2878.
5. Heusch G, Boengler K, Schulz R. Inhibition of mitochondrial permeability transition pore opening: the holy grail of cardioprotection. Basic Res Cardiol 2010;105:151-154.
6. Hausenloy D, Wynne A, Duchen M, Yellon D. Transient mitochondrial permeability transition pore opening mediates preconditioning-induced protection. Circulation 2004;109:1714-1717.
7. Hausenloy DJ, Maddock HL, Baxter GF, Yellon DM. Inhibiting mitochondrial permeability transition pore opening: a new paradigm for myocardial preconditioning? Cardiovasc Res 2002;55:534-543.
8. Pain T, Yang X-M, Critz SD, Yue Y, Nakano A, Liu GS et al. Opening of mitochondrial KATP channels triggers the preconditioned state by generating free radicals. Circ Res 2000;87:460-466.
9. Heinzel FR, Luo Y, Li X, Boengler K, Buechert A, García-Dorado D et al. Impairment of diazoxide-induced formation of reactive oxygen species and loss of cardioprotection in connexin 43 deficient mice. Circ Res 2005;97:583-586.
10. Rottlaender D, Boengler K, Wolny M, Michels G, Endres-Becker J, Motloch LJ et al. Connexin 43 acts as a cytoprotective mediator of signal transduction by stimulating mitochondrial KATP channels in mouse cardiomyocytes. J Clin Invest 2010;120: 1441-1453.
11. Rottlaender D, Boengler K, Wolny M, Schwaiger A, Motloch LJ, Ovize M et al. Glycogen synthase kinase 3beta transfers cytoprotective signaling through connexin 43 onto mitochondrial ATP-sensitive K+ channels. Proc Natl Acad Sci USA 2012;109: E242-E251.
12. Cai Z, Zhong H, Bosch-Marce M, Fox-Talbot K, Wang L, Wei C et al. Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1a. Cardiovasc Res 2008;77:463-470.
13. Semenza GL. Hypoxia-inducible factors in physiology and medicine. Cell 2012;148: 399-408.
14. Cohen MV, Yang X-M, Liu GS, Heusch G, Downey JM. Acetylcholine, bradykinin, opioids, and phenylephrine, but not adenosine, trigger preconditioning by generating free radicals and opening mitochondrial KATP channels. Circ Res 2001;89: 273-278.
15. Fukuda R, Zhang H, Kim JW, Shimoda L, Dang CV, Semenza GL. HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells. Cell 2007;129:111-122.
16. Schwanke U, Konietzka I, Duschin A, Li X, Schulz R, Heusch G. No ischaemic preconditioning in heterozygous connexin43-deficient mice. Am J Physiol Heart Circ Physiol 2002;283:H1740-H1742.
17. Schulz R, Rose J, Post H, Heusch G. Involvement of endogenous adenosine in ischaemic preconditioning in swine. Pflugers Arch 1995;430:273-282.
18. Eckle T, Kohler D, Lehmann R, El KK, Eltzschig HK. Hypoxia-inducible factor-1 is central to cardioprotection: a new paradigm for ischaemic preconditioning. Circulation 2008;118:166-175.
19. Hausenloy DJ, Baxter G, Bell R, Botker HE, Davidson SM, Downey J et al. Translating novel strategies for cardioprotection: the Hatter Workshop Recommendations. Basic Res Cardiol 2010;105:677-686.
20. Schwartz Longacre L, Kloner RA, Arai AE, Baines CP, Bolli R, Braunwald E et al. New horizons in cardioprotection: recommendations from the 2010 National Heart, Lung, and Blood Institute Workshop. Circulation 2011;124:1172-1179.