Cancer microenviroment and inflammation: Role of hyaluronan

Frontiers in Immunology

Volumn 6, Issue MAR, 2015, Pages

  Nikitovic, Dragana ^a   Tzardi, Maria ^a   Berdiaki, Aikaterini ^a   Tsatsakis, Aristidis ^a   Tzanakakis, George N ^a  

^a UNIVERSITY OF CRETE   (Greece)

Author keywords

Cancer microenvironment; CD44; Hyaluronan; Inflammation; Rhamm

Indexed keywords

COLLAGENASE 3; GELATINASE A; HERMES ANTIGEN; HYALURONAN SYNTHASE; HYALURONIC ACID; HYALURONIC ACID BINDING PROTEIN; HYALURONIDASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; INTERLEUKIN 8; INTERSTITIAL COLLAGENASE; MITOGEN ACTIVATED PROTEIN KINASE; MYELOID DIFFERENTIATION FACTOR 88; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; RECEPTOR FOR HYALURONAN MEDIATED MOTILITY; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANTINEOPLASTIC ACTIVITY; BIOACCUMULATION; CANCER CELL; CANCER IMMUNOLOGY; CANCER TISSUE; CELL DAMAGE; CELL INVASION; CELL PROLIFERATION; ENZYME DEGRADATION; EXTRACELLULAR MATRIX; FIBROSIS; GENE OVEREXPRESSION; HUMAN; IMMUNE RESPONSE; INFLAMMATION; INFLAMMATORY CELL; METASTASIS; PROTEIN EXPRESSION; SHORT SURVEY; SIGNAL TRANSDUCTION; TUMOR GROWTH; TUMOR MICROENVIRONMENT; TURNOVER TIME; UPREGULATION;

EID: 84926672853     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2015.00169     Document Type: Short Survey

References (101)

1. Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow? The Lancet (2001) 357:539-545.
2. Hussain SP, Harris C. Inflammation and cancer: an ancient link with novel potentials. International Journal of Cancer (2007) 121:2373-2380.
3. Mantovani A, Allavena P, Sic A, Balkwill F. Cancer-Related Inflammation. Nature (2008) 454:436-444.
4. Hanahan D, Weinberg RA. Hallmarks of Cancer: The Next Generation. Cell (2011) 144:646-74.
5. Chaffer CI, Weinberg RA. A perspective on cancer cell metastasis. Science (2011) 331:1559-1564.
6. Hynes RO. The extracellular matrix: not just pretty fibrils. Science (2009) 326:1216-1219.
7. Sorokin L. The Impact of the Extracellular Matrix on Inflammation. Nat Rev Immunol (2010) 10:712-23.
8. Corsini E, Galbiati V, Nikitovic D, Tsatsakis AM. Role of oxidative stress in chemical allergens induced skin cells activation. Food Chem. Toxicol. (2013) 61:74-81.
9. Afratis N, Gialeli C, Nikitovic D, Tsegenidis T, Karousou E, Theocharis AD, et al. Glycosaminoglycans key players in cancer cell biology and treatment. FEBS Journal (2013) 279:1177-1197.
10. Nikitovic D, Chatzinikolaou G, Tsiaoussis J, Tsatsakis A, Karamanos NK, Tzanakakis GN. Insights into targeting colon cancer cell fate at the level of proteoglycans/glycosaminoglycans. Cur. Med. Chem. (2012) 19:4247-4258.
11. Lu P, Weaver VM, Werb Z. The extracellular matrix: A dynamic niche in cancer progression The Journal of Cell Biology (2012) 196:395-406.
12. Nikitovic D, Corsini E, Kouretas D, Tsatsakis A, Tzanakakis G. ROS-major mediators of extracellular matrix remodeling during tumor progression. Food Chem. Toxicol. (2013) 61:178-186.
13. Nikitovic D, Berdiaki A, Banos A, Tsatsakis A, Karamanos NK, Tzanakakis GN. Could growth factor-mediated extracellular matrix deposition and degradation offer the ground for directed pharmacological targeting in fibrosarcoma? Curr Med Chem. (2013) 20:2868-80.
14. Kouvidi K, Berdiaki A, Tzanakakis GN. Hyaluronan/RHAMM interactions in mesenchymal tumor pathogenesis: role of growth factors. Adv Cancer Res. (2014) 123:319-49.
15. Petrey AC, de la Motte CA. Hyaluronan, a crucial regulator of inflammation. Front Immunol. (2014) 5:101.
16. Weigel PH, Hascall VC, Tammi M. Hyaluronan Synthases. J Biol Chem. (1997) 272:3997-4000.
17. Tammi RH, Kultti A, Kosma VM, Pirinen R, Auvinen P, Tammi MI. Hyaluronan in human tumors: pathobiological and prognostic messages from cell-associated and stromal hyaluronan. Semin Cancer Biol. (2008) 18:288-95.
18. Schulz T, Schumacher U, Prehm P. Hyaluronan Export by the Abc Transporter Mrp5 and Its Modulation by Intracellular Cgmp. J Biol Chem (2007) 282:20999-1004.
19. Itano N, Kimata K. Mammalian Hyaluronan Synthases. IUBMB Life (2002) 54:195-9.
20. Jiang D, Liang J, Noble PW. Hyaluronan as an Immune Regulator in Human Diseases. Physiol Rev. (2011): 221-64.
21. Klagas IS, Goulet G, Karakiulaki, J, Zhong M, Baraket JL, et al. Decreased Hyaluronan in Airway Smooth Muscle Cells from Patients with Asthma and Copd. Eur Respir J (2009) 34:616-28.
22. McKee CM, Lowenstein CJ, Horton MR, Wu J, Bao C, Chin BY, et al. Hyaluronan fragments induce nitric-oxide synthase in murine macrophages through a nuclear factor kappaB-dependent mechanism. The Journal of biological chemistry (1997) 272:8013-8.
23. West DC, Hampson IN, Arnold F, Kumar S. Angiogenesis induced by degradation products of hyaluronic acid. Science (1985) 228:1324-6.
24. Karousou E, Kouvidi K, Vigetti D, Viola M, Nikitovic D, De Luca G, Passi A. Collagen VI and hyaluronan: the common role in breast cancer. Biomed Res Int. (2014): 606458.
25. Lokeshwar VB, Rubinowicz D, Schroeder GL, Forgacs E, Minna JD, Block NL, et al. Stromal and epithelial expression of tumor markers hyaluronic acid and HYAL1 hyaluronidase in prostate cancer. The Journal of biological chemistry (2001) 276:11922-32.
26. Pirinen R, Tammi R, Tammi M, Hirvikoski P, Parkkinen JJ, Johansson R, et al. Prognostic value of hyaluronan expression in non-small-cell lung cancer: Increased stromal expression indicates unfavorable outcome in patients with adenocarcinoma. International journal of cancer Journal international du cancer (2001) 95:12-7.
27. Toole BP, Wight TN, Tammi MI. Hyaluronan-cell interactions in cancer and vascular disease. The Journal of biological chemistry (2002) 277:4593-6.
28. Nikitovic D, Tsatsakis AM, Karamanos NK, Tzanakakis GN. The effects of genistein on the synthesis and distribution of glycosaminoglycans/proteoglycans by two osteosarcoma cell lines depends on tyrosine kinase and the estrogen receptor density. Anticancer research (2003) 23:459-64.
29. Karvinen S, Pasonen-Seppanen S, Hyttinen JM, Pienimaki JP, Torronen K, Jokela TA, et al. Keratinocyte growth factor stimulates migration and hyaluronan synthesis in the epidermis by activation of keratinocyte hyaluronan synthases 2 and 3. The Journal of biological chemistry (2003) 278:49495-504.
30. Pasonen-Seppanen S, Karvinen S, Torronen K, Hyttinen JM, Jokela T, Lammi MJ, et al. EGF upregulates, whereas TGF-beta downregulates, the hyaluronan synthases Has2 and Has3 in organotypic keratinocyte cultures: correlations with epidermal proliferation and differentiation. The Journal of investigative dermatology (2003) 120:1038-44.
31. Bohrer LR, Chuntova P, Bade LK, Beadnell TC, Leon RP, Brady NJ, et al. Activation of the Fgfr-Stat3 Pathway in Breast Cancer Cells Induces a Hyaluronan-Rich Microenvironment That Licenses Tumor Formation. Cancer Res. (2014) 74: 374-86.
32. Berdiaki A, Zafiropoulos A, Fthenou E, Katonis P, Tsatsakis A, Karamanos NK Tzanakakis GN. Regulation of Hyaluronan and Versican Deposition by Growth Factors in Fibrosarcoma Cell Lines. Biochim Biophys Acta (2008) 1780:194-202.
33. Adamia S, Pilarski PM, Belch AR, Pilarski LM. Aberrant Splicing, Hyaluronan Synthases and Intracellular Hyaluronan as Drivers of Oncogenesis and Potential Drug Targets. Curr Cancer Drug Targets (2013) 13:347-61.
34. Simpson MA, Lokeshwar VB. Hyaluronan and hyaluronidase in genitourinary tumors. Frontiers in bioscience: a journal and virtual library (2008) 13:5664- 80.
35. Poola I, Abraham J, Marshalleck Q, Yue VB, Lokeshwar G, Bonney RL, Dewitty. Molecular Risk Assessment for Breast Cancer Development in Patients with Ductal Hyperplasias. Clin Cancer Res (2008) 14: 1274-80.
36. Storz P. Reactive Oxygen Species in Tumor Progression. Front. Biosci. (2005) 10:1881-1896.
37. Hrabarova E, Juranek I, Soltes L. Pro-oxidative effect of peroxynitrite regarding biological systems: a special focus on high-molar-mass hyaluronan degradation. General physiology and biophysics (2011) 30:223-38.
38. Darley-Usmar V, Wiseman H, Halliwell B. Nitric oxide and oxygen radicals: a question of balance. FEBS letters (1995) 369:131-5.
39. Vilar RE, Ghael D, Li M, Bhagat DD, Arrigo LM, Cowman MK, et al. Nitric oxide degradation of heparin and heparan sulphate. The Biochemical journal (1997) 324:473-9.
40. McAtee CO, Barycki JJ, Simpson MA. Emerging roles for hyaluronidase in cancer metastasis and therapy. Advances in cancer research (2014) 123:1-34.
41. Kouvidi K, Berdiaki A, Nikitovic D, Katonis P, Afratis N, Hascall VC, et al. Role of receptor for hyaluronic acid-mediated motility (RHAMM) in low molecular weight hyaluronan (LMWHA)-mediated fibrosarcoma cell adhesion. The Journal of biological chemistry (2011) 286:38509-20.
42. Alaniz L, Rizzo M, Malvicini M, Jaunarena J, Avella D, Atorrasagasti C, et al. Low Molecular Weight Hyaluronan Inhibits Colorectal Carcinoma Growth by Decreasing Tumor Cell Proliferation and Stimulating Immune Response. Cancer Letters (2009) 278:9-16.
43. Sugahara HT, Hayasaka H, Stern R, Murai T, Miyasaka M. Tumor cells enhance their own CD44 cleavage and motility by generating hyaluronan fragments. J Biol Chem. (2006) 281:5861-8.
44. Singleton PA. Hyaluronan regulation of endothelial barrier function in cancer. Advances in cancer research (2014) 123:191-209.
45. Yu M, He P, Liu Y, He Y, Du Y, Wu M, Zhang G, Yang C, Gao F. Hyaluroan-regulated lymphatic permeability through S1P receptors is crucial for cancer metastasis. Medical oncology (2015) 32:381.
46. Bharadwaj AG, Rector K, Simpson MA. Inducible hyaluronan production reveals differential effects on prostate tumor cell growth and tumor angiogenesis. The Journal of biological chemistry (2007) 282:20561-72.
47. Simpson MA. Concurrent expression of hyaluronan biosynthetic and processing enzymes promotes growth and vascularization of prostate tumors in mice. The American journal of pathology (2006) 169:247-57.
48. Bharadwaj AG, Kovar JL, Loughman E, Elowsky C, Oakley GG, Simpson MA. Spontaneous metastasis of prostate cancer is promoted by excess hyaluronan synthesis and processing. The American journal of pathology (2009) 174:1027-36.
49. Kouvidi K, Nikitovic D, Berdiaki A, Tzanakakis GN. Hyaluronan/RHAMM interactions in mesenchymal tumor pathogenesis: role of growth factors. Advances in cancer research (2014) 123:319-49.
50. Fuchs K, Hippe A, Schmaus A, Homey B, Sleeman JP, Orian-Rousseau V. Opposing effects of high-and low-molecular weight hyaluronan on CXCL12-induced CXCR4 signaling depend on CD44. Cell death & disease (2013) 4:819.
51. Bharadwaj AG, Goodrich NP, McAtee CO, Haferbier K, Oakley GG, Wahl JK, 3rd, et al. Hyaluronan suppresses prostate tumor cell proliferation through diminished expression of N-cadherin and aberrant growth factor receptor signaling. Experimental cell research (2011) 317:1214-25.
52. Zhang C, Toole BP, Xu Y. Cancer may be a pathway to cell survival under persistent hypoxia and elevated ROS: A model for solid-cancer initiation and early development. Int J Cancer (2014) doi: 10.1002/ijc.28975.
53. Termeer C, Benedix F, Sleeman J, Fieber C, Voith U, Ahrens T, et al. Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4. J. Exp. Med. (2002) 195:99-111.
54. Jiang D, Liang J, Fan J, Yu S, Chen S, Luo Y, et. al Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat. Med. (2005) 11:1173-1179.
55. Scheibner KA, Lutz MA, Boodoo S, Fenton MJ, Powell JD, Horton MR Hyaluronan fragments act as an endogenous danger signal by engaging TLR2. J. Immunol. (2006) 177:1272-1281.
56. Vigetti GA, Karousou E, Viola M, Moretto P, Clerici M, Deleonibus S, et al. Proinflammatory cytokines induce hyaluronan synthesis and monocyte adhesion in human endothelial cells through hyaluronan synthase 2 (HAS2) and the nuclear factor-kappaB (NF-kappaB) pathway. J Biol Chem. (2010) 285:24639-45.
57. Voelcker GC, Averbeck M, Saalbach A, Wolf V, Weih F, Sleeman J, Anderegg U, Simon J. Hyaluronan fragments induce cytokine and metalloprotease upregulation in human melanoma cells in part by signalling via TLR4. Exp Dermatol. (2008) 2:100-7.
58. Bourguignon WG, Earle CA, Xia W. Interaction of low molecular weight hyaluronan with CD44 and toll-like receptors promotes the actin filamentassociated protein 110-actin binding and MyD88-NFκB signaling leading to proinflammatory cytokine/chemokine production and breast tumor invasion. Cytoskeleton (Hoboken) (2011) 68:671-93.
59. Chang CC, Hsieh MS, Liao ST, Chen YH, Cheng CW, Huang PT, et al. Hyaluronan regulates PPARgamma and inflammatory responses in IL-1betastimulated human chondrosarcoma cells, a model for osteoarthritis. Carbohydrate polymers (2012) 90:1168-75.
60. Inman KS, Francis AA, Murray NR. Complex role for the immune system in initiation and progression of pancreatic cancer. World J Gastroenterol (2014) 20:11160-81.
61. Trinchieri G. Cancer and inflammation: an old intuition with rapidly evolving new concepts. Annual Review of Immunology (2012) 30:677-706.
62. Leu SL, Xu C, Zhao Y, Liu B, Li Y, Shiedlin A, et al. TLR4 through IFN-β promotes low molecular mass hyaluronan-induced neutrophil apoptosis. J. Immunol. (2011) 186:556-62.
63. Wu ZQ, Peng C, Sun L, Li XF, Kuang DM. Neutrophils promote motility of cancer cells via a hyaluronan-mediated TLR4/PI3K activation loop. J Pathol. (2011) 225:438-47.
64. Rilla K, Siiskonen H2, Tammi M3, Tammi R3. Hyaluronan-Coated Extracellular Vesicles-a Novel Link between Hyaluronan and Cancer. Adv Cancer Res. (2014) 123:121-48.
65. Day AJ, Prestwich GD. Hyaluronan-binding proteins: tying up the giant. J. Biol. Chem. (2002) 277:4585-8.
66. Toole BP. Hyaluronan: from extracellular glue to pericellular cue. Nature reviews Cancer (2004) 4:528-39.
67. Turley EA, Noble PW, Bourguignon LY. Signaling properties of hyaluronan receptors. The Journal of biological chemistry (2002) 277:4589-92.
68. McCourt PA EB, Forsberg N, Gustafson S Intercellular adhesion molecule-1 is a cell surface receptor for hyaluronan. The Journal of biological chemistry (1994) 269:30081-4.
69. Tolg C, Hamilton SR, Zalinska E, McCulloch L, Amin R, Akentieva N, et al. A RHAMM mimetic peptide blocks hyaluronan signaling and reduces inflammation and fibrogenesis in excisional skin wounds. Am J Pathol. (2012) 181:1250-1270.
70. Underhill C. CD44: the hyaluronan receptor. Journal of cell science (1992) 103:293-8.
71. Ponta H, Sherman L, Herrlich PA. CD44: from adhesion molecules to signalling regulators. Nat. Rev. Mol. Cell Biol. (2003) 4:33-45.
72. Li Z, Chen K, Jiang P, Zhang X, Li X1, Li Z. CD44v/CD44s expression patterns are associated with the survival of pancreatic carcinoma patients. Diagn Pathol. (2014) 9:79.
73. Hoshimoto K, Yamauchi N, Takazawa Y, Onda T, Taketani Y, Fukayama M. CD44 variant 6 in endometrioid carcinoma of the uterus: its expression in the adenocarcinoma component is an independent prognostic marker. Pathol Res Pract. (2003) 199:71-7.
74. Fox SB, Fawcett J, Jackson DG, Collins I, Gatter KC, Harris AL, et al. Normal human tissues, in addition to some tumors, express multiple different CD44 isoforms. Cancer Res. (1994) 54:4539-4546.
75. Cichy J. PE. The liberation of CD44. J Cell Biol. (2003) 161:839-43.
76. Nagano O, Saya H. Mechanism and Biological Significance of Cd44 Cleavage. Cancer Sci. (2004) 95:930-935.
77. Mahoney DJ, Blundell CD, Day AJ. Mapping the Hyaluronan-Binding Site on the Link Module from Human Tumor Necrosis Factor-Stimulated Gene-6 by Site-Directed Mutagenesis. J Biol Chem. (2001) 22:22764-71.
78. Pure E, Cuff CA. A Crucial Role for Cd44 in Inflammation. TRENDS Mol. Med (2001) 7:213-221.
79. Zhuo L, Kanamori A, Kannagi R, Itano N, Wu J, Hamaguchi M, et al. Shap Potentiates the Cd44-Mediated Leukocyte Adhesion to the Hyaluronan Substratum. J Biol Chem (2006) 201:20303-1.
80. Siiskonen H, Kärnä R, Hyttinen JM, Tammi RH, Tammi MI, Rilla K. Hyaluronan Synthase 1 (Has1) Produces a Cytokine-and Glucose-Inducible, Cd44-Dependent Cell Surface Coat. Exp Cell Res. (2014) 320:153-63.
81. Termeer C, Sleeman JP, Simon JC. Hyaluronan-magic glue for the regulation of the immune response? Trends Immunol. (2003) 3:24112-24114.
82. Lesley J, Hyman R, English N, Catterall JB, Turner GA. CD44 in inflammation and metastasis. Glycoconj. J. (1997) 14:611-622.
83. Yasuda M, Tanaka Y, Fujii K, Yasumoto K. Cd44 Stimulation Down-Regulates Fas Expression and Fas-Mediated Apoptosis of Lung Cancer Cells. Int Immunol (2001) 13:309-19.
84. Nakano K, Saito K, Mine S, Matsushita S, Tanaka Y. Engagement of CD44 up-regulates Fas ligand expression on T cells leading to activation-induced cell death. Apoptosis: an international journal on programmed cell death (2007) 12:45-54.
85. Bourguignon LY, Singleton PA, Zhu H, Diedrich F. Hyaluronan-Mediated Cd44 Interaction with Rhogef and Rho Kinase Promotes Grb2-Associated Binder-1 Phosphorylation and Phosphatidylinositol 3-Kinase Signaling Leading to Cytokine (Macrophage-Colony Stimulating Factor) Production and Breast Tumor Progression. J Biol Chem. (2003) 278:29420-34.
86. Muthukumaran N, Miletti-González KE, Ravindranath AK, Rodríguez-Rodríguez L. Tumor Necrosis Factor-Alpha Differentially Modulates Cd44 Expression in Ovarian Cancer Cells. Mol Cancer Res. (2006) 4:511-20.
87. Kawana H, Karaki H, Higashi M, Miyazaki M, Hilberg F, Kitagawa M, Harigaya K. Cd44 Suppresses Tlr-Mediated Inflammation. J Immunol. (2008) 180:4235-45.
88. Tolg C, McCarthy JB, Yazdani A, Turley EA. Hyaluronan and RHAMM in wound repair and the "cancerization" of stromal tissues. BioMed research international (2014) 2014:103923.
89. Tolg C, Hamilton SR, Zalinska E, McCulloch L, Amin R, Akentieva N, et al. A RHAMM mimetic peptide blocks hyaluronan signaling and reduces inflammation and fibrogenesis in excisional skin wounds. The American journal of pathology (2012) 181:1250-70.
90. Jiang J, Casalegno-Garduno R, Chen H, Schmitt A, Schmitt M, Maxwell CA. Multifunctional Proteins Bridge Mitosis with Motility and Cancer with Inflammation and Arthritis. ScientificWorldJournal (2010) 10:1244-5.
91. Garcia-Posadas L, Contreras-Ruiz L, Arranz-Valsero I, Lopez-Garcia A, Calonge M, Diebold Y. CD44 and RHAMM hyaluronan receptors in human ocular surface inflammation. Graefe's archive for clinical and experimental ophthalmology. Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (2014) 252:1289-95.
92. Foley JP, Lam D, Jiang H, Liao J, Cheong N, McDevitt T.M, Zaman A, Wright JR, Savani RC. Toll-like receptor 2 (TLR2), transforming growth factor-beta, hyaluronan (HA), and receptor for HA-mediated motility (RHAMM) are required for surfactant protein A-stimulated macrophage chemotaxis. The Journal of biological chemistry (2012) 287:37406-19.
93. Tolg C, Hamilton SR, Zalinska E, McCulloch L, Amin R, Akentieva N, Winnik, F, Savani R, Bagli DJ, Luyt LG, Cowman MK, McCarthy JB, Turley EA. A RHAMM mimetic peptide blocks hyaluronan signaling and reduces inflammation and fibrogenesis in excisional skin wounds. The American journal of pathology (2012) 181:1250-70.
94. Greiner J, Ringhoffer M, Taniguchi M, et al. Receptor for hyaluronan acidmediated motility (RHAMM) is a new immunogenic leukemia associatedantigen in acute and chronic myeloid leukemia. Exp Hematol. (2002) 30:1029-1035.
95. Greiner J, Schmitt A, Giannopoulos K, et. al High-dose RHAMM-R3 peptide vaccination for patients with acute myeloid leukemia, myelodysplastic syndrome and multiple myeloma. Haematologica (2010) 95:1191-1197.
96. Casalegno-Garduño R, Meier C, Schmitt A, Spitschak A, Hilgendorf I, Rohde S, et. al Immune responses to RHAMM in patients with acute myeloid leukemia after chemotherapy and allogeneic stem cell transplantation. Clin Dev Immunol. (2012):146463.
97. Schmitt A, Li L, Giannopoulos K, Greiner J, Reinhardt P, Wiesneth M, Schmitt M. Quantitative expression of Toll-like receptor-2,-4, and-9 in dendritic cells generated from blasts of patients with acute myeloid leukemia. Transfusion (2008) 48:861-70.
98. Giannopoulos K, Dmoszynska A, Kowal M, Rolinski J, Gostick E, Price DA, Greiner J, Rojewski M, Stilgenbauer S, Dohner H, Schmitt M. Peptide vaccination elicits leukemia-associated antigen-specific cytotoxic CD8+ T-cell responses in patients with chronic lymphocytic leukemia. Leukemia (2010) 24:798-805.
99. Gustafson S, Bjorkman T, Forsberg N, Lind T, Wikstrom T, Lidholt K. Accessible Hyaluronan Receptors Identical to Icam-1 in Mouse Mast-Cell Tumors. Glycoconj J (1995) 12:350-355.
100. Shao Y, Lu GL, Shen ZJ, He HC. Reduction of intercellular adhesion molecule 1 may play a role in anti-inflammatory effect of hyaluronic acid in a rat model of severe non-bacterial cystitis. World journal of urology (2013) 31:535-40.
101. Hirabara S, Kojima T, Takahashi N, Hanabayashi M, Ishiguro N. Hyaluronan inhibits TLR-4 dependent cathepsin K and matrix metalloproteinase 1 expression in human fibroblasts. Biochemical and biophysical research communications (2013) 430:519-22.