Hyaluronan inhibits TLR-4 dependent cathepsin K and matrix metalloproteinase 1 expression in human fibroblasts

Biochemical and Biophysical Research Communications

Volumn 430, Issue 2, 2013, Pages 519-522

  Hirabara, Shinya ^a   Kojima, Toshihisa ^a   Takahashi, Nobunori ^a   Hanabayashi, Masahiro ^a   Ishiguro, Naoki ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Cathepsin K; Fibroblasts; Hyaluronan; MMP 1; Rheumatoid arthritis; Toll like receptor 4

Indexed keywords

CATHEPSIN K; CD44V ANTIGEN; HYALURONIC ACID; INTERCELLULAR ADHESION MOLECULE 1; INTERSTITIAL COLLAGENASE; LIPOPOLYSACCHARIDE; TOLL LIKE RECEPTOR 4;

ARTICLE; FIBROBLAST; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CATHEPSIN K; CELL LINE; FIBROBLASTS; HUMANS; HYALURONIC ACID; LIPOPOLYSACCHARIDES; MATRIX METALLOPROTEINASE 1; TOLL-LIKE RECEPTOR 4;

EID: 84872341237     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.12.003     Document Type: Article

References (22)

1. Kim K.-W., Cho M.-L., Lee S.-H., et al. Human rheumatoid synovial fibroblasts promote osteoclastogenic activity by activating RANKL via TLR-2 and TLR-4 activation. Immunol. Lett. 2007, 110:54-64.
2. Brentano F., Kyburz D., Schorr O., et al. The role of toll-like receptor signalling in the pathogenesis of arthritis. Cell. Immunol. 2005, 233:90-96.
3. Firestein G.S. Evolving concepts of rheumatoid arthritis. Nature 2003, 423:356-361.
4. Konttinen Y.T., Ainola M., Valleala H., et al. Analysis of 16 different matrix metalloproteinases (MMP-1 to MMP-20) in the synovial membrane: different profiles in trauma and rheumatoid arthritis. Ann. Rheum. Dis. 1999, 58:691-697.
5. Chen Y., Nixon N.B., Dawes P.T., et al. Influence of variations across the MMP-1 and -3 genes on the serum levels of MMP-1 and -3 and disease activity in rheumatoid arthritis. Genes Immun. 2012, 13:29-37.
6. Cunnane G., Fitzgerald O., Beeton C., et al. Early joint erosions and serum levels of matrix metalloproteinase 1, matrix metalloproteinase 3, and tissue inhibitor of metalloproteinases 1 in rheumatoid arthritis. Arthritis Rheum. 2001, 44:2263-2274.
7. Hou W.-S., Li W., Keyszer G., et al. Comparison of cathepsins K and S expression within the rheumatoid and osteoarthritic synovium. Arthritis Rheum. 2002, 46:663-674.
8. Hou W.S., Li Z., Gordon R.E., et al. Cathepsin K is a critical protease in synovial fibroblast-mediated collagen degradation. Am. J. Pathol. 2001, 159:2167-2177.
9. Pelletier J.-P., Boileau C., Boily M., et al. The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases. Arthritis Res. Ther. 2005, 7:R1091-R1102.
10. Hiramitsu T., Yasuda T., Ito H., et al. Intercellular adhesion molecule-1 mediates the inhibitory effects of hyaluronan on interleukin-1beta-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts via down-regulation of NF-kappaB and p38. Rheumatology (Oxford, England) 2006, 45:824-832.
11. Saito S., Momohara S., Taniguchi A., et al. The intra-articular efficacy of hyaluronate injections in the treatment of rheumatoid arthritis. Mod. Rheumatol. Jpn. Rheum. Assoc. 2009, 19:643-651.
12. Ohashi M., Aizawa S., Ooka H., et al. A new human diploid cell strain, TIG-1, for the research on cellular aging. Exp. Gerontol. 1980, 15:121-133.
13. Ohno S., Im H.-J., Knudson C.B., et al. Hyaluronan oligosaccharides induce matrix metalloproteinase 13 via transcriptional activation of NFkappaB and p38 MAP kinase in articular chondrocytes. J. Biol. Chem. 2006, 281:17952-17960.
14. Dahl L.B., Dahl I.M.S., Engstrom-laurent A., et al. Concentration and molecular weight of sodium hyaluronate in synovial fluid from patients with rheumatoid arthritis and other arthropathies. Ann. Rheum. Dis. 1985, 44:817-822.
15. Julovi S.M., Yasuda T., Shimizu M., et al. Inhibition of interleukin-1beta-stimulated production of matrix metalloproteinases by hyaluronan via CD44 in human articular cartilage. Arthritis Rheum. 2004, 50:516-525.
16. Shimizu M., Yasuda T., Nakagawa T., et al. Hyaluronan inhibits matrix metalloproteinase-1 production by rheumatoid synovial fibroblasts stimulated by proinflammatory cytokines. J. Rheumatol. 2003, 30:1164-1172.
17. McCourt P., Ek B., Forsberg N., et al. Intercellular adhesion molecule-1 is a cell surface receptor for hyaluronan. J. Biol. Chem. 1994, 269:30081-30084.
18. Hashizume M., Mihara M. High molecular weight hyaluronic acid inhibits IL-6-induced MMP production from human chondrocytes by up-regulating the ERK inhibitor, MKP-1. Biochem. Biophys. Res. Commun. 2010, 403:184-189.
19. Asagiri M., Hirai T., Kunigami T., et al. Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis. Science (New York, N.Y.) 2008, 319:624-627.
20. Ospelt C., Brentano F., Rengel Y., et al. Overexpression of toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis toll-like receptor expression in early and longstanding arthritis. Arthritis Rheum. 2008, 58:3684-3692.
21. Abdollahi-Roodsaz S., Joosten L.B., Helsen M.M., et al. Shift from toll-like receptor 2 (TLR-2) toward TLR-4 dependency in the erosive stage of chronic streptococcal cell wall arthritis coincident with TLR-4-mediated interleukin-17 production. Arthritis Rheum. 2008, 58:3753-3764.
22. Abdollahi-Roodsaz S., Joosten L.B., Roelofs M.F. Inhibition of toll-like receptor 4 breaks the inflammatory loop in autoimmune destructive arthritis. Arthritis Rheum. 2007, 56:2957-2967.