The liberation of CD44

Journal of Cell Biology

Volumn 161, Issue 5, 2003, Pages 839-843

  Cichy, Joanna ^a   Puré, Ellen ^b,c  

^a JAGIELLONIAN UNIVERSITY   (Poland)

^b WISTAR INSTITUTE   (United States)

^c LUDWIG INSTITUTE FOR CANCER RESEARCH   (Australia)

Author keywords

CD44; Cell adhesion; Extracellular matrix; Presenilin; Proteolytic processing

Indexed keywords

CELL ADHESION MOLECULE; HERMES ANTIGEN; HYALURONIC ACID; LIGAND; MEMBRANE RECEPTOR; PROTEIN;

ANTIGEN FUNCTION; ANTIGEN STRUCTURE; BODY FLUID; CELL FUNCTION; CELL SURFACE; CYTOPLASM; ENZYME MODIFICATION; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; INFLAMMATION; LIGAND BINDING; METASTASIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MODIFICATION; RECEPTOR AFFINITY; REGULATORY MECHANISM; SHORT SURVEY; STRUCTURE ACTIVITY RELATION; TUMOR GROWTH;

ANIMALS; ANTIGENS, CD44; CELL MEMBRANE; EUKARYOTIC CELLS; EXTRACELLULAR MATRIX; HUMANS; PROTEIN BIOSYNTHESIS; RECEPTORS, CELL SURFACE;

EID: 0037780985     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200302098     Document Type: Short Survey

References (35)

1. Blass, S.L., E. Puré, and C.A. Hunter. 2001. A role for CD44 in the production of IFN-γ and immunopathology during infection with Toxoplasma gondii. J. Immunol 166:5726-5732.
2. Brown, K.L., A. Maiti, and P. Johnson. 2001. Role of sulfation in CD44-mediated hyaluronan binding induced by inflammatory mediators in human CD14(+) peripheral blood monocytes. J. Immunol. 167:5367-5374.
3. Brown, M.S., J. Ye, R.B. Rawson, and J.L. Goldstein. 2000. Regulated intramembrahe proteolysis: a control mechanism conserved from bacteria to humans. Cell. 100:391-398.
4. Camp, R.L., A. Scheynius, C. Johansson, and E. Puré. 1993. CD44 is necessary for optimal contact allergic responses but is not required for normal leukocyte extravasation. J. Exp. Med. 178:497-508.
5. Cichy, J., and E. Puré. 2000. Oncostatin M and transforming growth factor-β1 induce post-translational modification and hyaluronan binding to CD44 in lung-derived epithelial tumor cells. J. Biol. Chem. 275:18061-18069.
6. Cichy, J., R. Bals, J. Potempa, A. Mani, and E. Puré. 2002. Proteinase-mediated release of epithelial cell-associated CD44. Extracellular CD44 complexes with components of cellular matrices. J. Biol. Chem. 277:44440-44447.
7. Cuff, C.A., D. Kothapalli, I. Azonobi, S. Chun, Y. Zhang, R. Belkin, C. Yeh, A. Secreto, R.K. Assoian, D.J. Rader, and E. Puré. 2001. The adhesion receptor CD44 promotes atherosclerosis by mediating inflammatory cell recruitment and vascular cell activation. J. Clin. Invest. 108:1031-1040.
8. DeGrendele, H.C., P. Estess, and M.H. Siegelman. 1997. Requirement for CD44 in activated T cell extravasation into an inflammatory site. Science. 278:672-675.
9. Estess, P., H.C. DeGrendele, V. Pascual, and M.H. Siegelman. 1998. Functional activation of lymphocyte CD44 in peripheral blood is a marker of autoimmune disease activity. J. Clin. Invest. 102:1173-1182.
10. Kajita, M., Y. Itoh, T. Chiba, H. Mori, A. Okada, H. Kinoh, and M. Seiki. 2001. Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migration. J. Cell Biol. 153:893-904.
11. Katoh, S., J.B. McCarthy, and P.W. Kincade. 1994. Charactetization of soluble CD44 in the circulation of mice. Levels are affected by immune activity and tumor growth. J. Immunol. 153:3440-3449.
12. Katoh, S., H. Taniguchi, Y. Matsubara, N. Matsumoto, K. Fukushima, J. Kadota, S. Matsukura, and S. Kohno. 1999. Overexpression of CD44 on alveolar eosinophils with high concentrations of soluble CD44 in broncholaveolar lavage fluid in patients with eosinophilic pneumonia. Allergy, 54:1286-1292.
13. Kaya, G., I. Rodriguez, J.L. Jorcano, P. Vassali, and I. Stamenkovic. 1997. Selective suppression of CD44 in keratinocytes of mice bearing an antisense CD44 transgene driven by a tissue-specific promotor disrupts hyaluronate metabolism in the skin and impaires keratinocyte proliferation. Genes Dev. 11:996-1007.
14. Kawano, Y., I. Okamoto, D. Murakami, H. Itoh, M. Yoshida, S. Ueda, and H. Saya. 2000. Ras oncoprotein induces CD44 cleavage through phosphoinositide 3-OH kinase and the Rho family of small G proteins. J. Biol. Chem. 275:29628-29635.
15. Knudson, W., D.J. Aguiar, Q. Hua, and C.B. Knudson. 1996. CD44-anchored hyaluronan-rich pericellular matrices: an ultrastructural and biochemical analysis. Exp. Cell Res. 228:216-228.
16. Lammich, S., M. Okochi, M. Takeda, C. Kaether, A. Capell, A.-K. Zimmer, D. Edbauer, J. Walter, H. Steiner, and C. Haass. 2002. Presenilin dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Aβ-like peptide. J. Biol. Chem. 277:44754-44759.
17. Lazaar, A.L., M.I. Plotnik, U. Kuciech, I. Crichton, S. Lofti, S.K. Das, S. Kane, J. Rosenbloom, R.A. Panettieri, Jr., and E. Puré. 2002. Mast cell chymase modifies cell-matrix interactions and inhibits mitogen-induced proliferation of human airway smooth muscle cells. J. Immunol. 169:1014-1020.
18. Levesque, M.C., B.F. Haynes, and W.T. Lewis. 1997. Cytokine induction of the ability of human monocyte CD44 to bind hyaluronan is mediated primarily by TNF-α and is inhibited by IL-4 and IL-13. J. Immunol. 159:6184-6194.
19. Mikecz, K., F.R. Brennan, J.H. Kim, and T.T. Glant. 1995. Anti-CD44 treatment abrogates tissue oedema and leukocyte infiltration in murine arthritis. Nat. Med. 1:558-563.
20. Naor, D., R.V. Sionov, and D. Ish-Shalom. 1997. CD44: structure, function, and association with the malignant process. Adv. Cancer Res. 71:241-319.
21. Okamoto, I., Y. Kawano, H. Tsuiki, J. Sasaki, M. Nakao, M. Matsumoto, M. Suga, M. Ando, M. Nakajima, and H. Saya. 1999. CD44 cleavage induced by a membrane-associated metalloprotease plays a critical role in tumor cell migration. Oncogene. 18:1435-1446.
22. Okamoto, I., Y. Kawano, D. Murakami, T. Sasayama, N. Araki, T. Miki, A.J. Wong, and H. Saya. 2001. Proteolytic release of CD44 intracellular domain and its role in the CD44 signaling pathway. J. Cell Biol. 155:755-762.
23. Okamoto, I., H. Tsuiki, L.C. Kenyon, A.K. Godwin, D.R. Emlet, M. Holgado-Madruga, I.S. Lanham, C.J. Joynes, K.T. Vo, A. Guha, et al. 2002. Proteolytic cleavage of the CD44 adhesion molecule in multiple human tumors. Am. J. Pathol. 160:441-447.
24. Peterson, R.M., Q. Yu, I. Stamenkovic, and B.P. Toole. 2000. Perturbation of hyaluronan interactions by soluble CD44 inhibits growth of murine mammary carcinoma cells in ascites. Am. J. Pathol. 156:2159-2167.
25. Ponta, H., L. Sherman, and P.A. Herrlich. 2003. CD44: from adhesion molecules to signaling regulators. Nat. Rev. Mol. Cell Biol. 4:33-45.
26. Ristamaki, R., H. Joensuu, K. Gron-Virta, M. Salmi, and M. Jalkanen. 1997. Origin and function of circulating CD44 in non-Hodgkin's lymphoma. J. Immunol. 158:3000-3008.
27. Schmits, R., J. Filmus, N. Gerwin, G. Senaldi, F. Kiefer, T. Kundig, A. Wakeham, A. Shahinian, C. Catzavelos, S. Rak, et al. 1997. CD44 regulates hematopoietic progenitor distribution, granuloma formation and tumorigenicity. Blood. 90:2217-2233.
28. Shi, M., K. Dennis, J.J. Peschon, R. Chandrasekaran, and K. Mikecz. 2001. Antibody-induced shedding of CD44 from adherent cells is linked to the assembly of the cytoskeleton. J. Immunol. 167:123-131.
29. Teder, P., R.W. Vandivier, D. Jiang, J. Liang, L. Cohn, E. Puré, P.M. Henson, and P.W. Noble. 2002. Resolution of lung inflammation by CD44. Science. 296:155-158.
30. Weber, G.F., R.T. Bronson, J. Ilagan, H. Cantor, R. Schmits, and T.W. Mak. 2002. Absence of the CD44 gene prevents sarcoma metastasis. Cancer Res. 62:2281-2286.
31. Wittig, B.M., B. Johansson, M. Zoller, C. Schwarzler, and U. Gunthert. 2000. Abrogation of experimental colitis correlates with increased apotosis in mice deficient for CD44 variant exon 7 (CD44v7). J. Exp. Med. 191:2053-2064.
32. Yu, Q., and I. Stamenkovic. 1999. Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasion. Genes Dev. 13:35-48.
33. Yu, Q., and I. Stamenkovic. 2000. Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-β and promotes tumor invasion and angiogenesis. Genes Dev. 14:163-176.
34. Yu, Q., and B.P. Toole. 1996. A new alternatively spliced exon between v9 and v10 provides molecular basis for synthesis of soluble CD44. J. Biol. Chem. 271:20603-20607.
35. Yu, Q., B.P. Toole, and I. Stamenkovic. 1997. Induction of apoptosis of metastatic mammary carcinoma cells in vivo by disruption of tumor cell surface CD44 function. J. Exp. Med. 186:1985-1996.