-
1
-
-
0032742992
-
The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus
-
Weyer C, Bogardus C, Mott DM, Pratley RE (1999) The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest 104:787–794
-
(1999)
J Clin Invest
, vol.104
, pp. 787-794
-
-
Weyer, C.1
Bogardus, C.2
Mott, D.M.3
Pratley, R.E.4
-
2
-
-
0018520840
-
Glucose clamp technique: A method for quantifying insulin secretion and resistance
-
Defronzo RA, Tobin JD, Andres R (1979) Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 237:E214–E223
-
(1979)
Am J Physiol
, vol.237
, pp. E214-E223
-
-
Defronzo, R.A.1
Tobin, J.D.2
Res, R.3
-
4
-
-
0031027502
-
Characterization of the MODY3 phenotype. Early-onset diabetes caused by an insulin secretion defect
-
Lehto M, Tuomi T, Mahtani MM et al (1997) Characterization of the MODY3 phenotype. Early-onset diabetes caused by an insulin secretion defect. J Clin Invest 99:582–591
-
(1997)
J Clin Invest
, vol.99
, pp. 582-591
-
-
Lehto, M.1
Tuomi, T.2
Mahtani, M.M.3
-
5
-
-
43249095915
-
Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance
-
Stancakova A, Pihlajamaki J, Kuusisto J et al (2008) Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance. J Clin Endocrinol Metab 93:1924–1930
-
(2008)
J Clin Endocrinol Metab
, vol.93
, pp. 1924-1930
-
-
Stancakova, A.1
Pihlajamaki, J.2
Kuusisto, J.3
-
6
-
-
0042168834
-
Importance of obtaining independent measures of insulin secretion and insulin sensitivity during the same test: Results with the Botnia clamp
-
Tripathy D, Wessman Y, Gullstrom M, Tuomi T, Groop L (2003) Importance of obtaining independent measures of insulin secretion and insulin sensitivity during the same test: results with the Botnia clamp. Diabetes Care 26:1395–1401
-
(2003)
Diabetes Care
, vol.26
, pp. 1395-1401
-
-
Tripathy, D.1
Wessman, Y.2
Gullstrom, M.3
Tuomi, T.4
Groop, L.5
-
7
-
-
0030941820
-
Metabolic defects in lean nondiabetic offspring of NIDDM parents: A cross-sectional study
-
Perseghin G, Ghosh S, Gerow K, Shulman GI (1997) Metabolic defects in lean nondiabetic offspring of NIDDM parents: a cross-sectional study. Diabetes 46:1001–1009
-
(1997)
Diabetes
, vol.46
, pp. 1001-1009
-
-
Perseghin, G.1
Ghosh, S.2
Gerow, K.3
Shulman, G.I.4
-
8
-
-
82255181866
-
Influence of hyperinsulinemia and insulin resistance on in vivo beta-cell function: Their role in human beta-cell dysfunction
-
Mari A, Tura A, Natali A et al (2011) Influence of hyperinsulinemia and insulin resistance on in vivo beta-cell function: their role in human beta-cell dysfunction. Diabetes 60:3141–3147
-
(2011)
Diabetes
, vol.60
, pp. 3141-3147
-
-
Mari, A.1
Tura, A.2
Natali, A.3
-
9
-
-
4143151942
-
Pathogenesis of type 2 diabetes mellitus
-
Defronzo RA (2004) Pathogenesis of type 2 diabetes mellitus. Med Clin N Am 88:787–835
-
(2004)
Med Clin N Am
, vol.88
, pp. 787-835
-
-
Defronzo, R.A.1
-
10
-
-
0029948212
-
Mechanism of free fatty acid-induced insulin resistance in humans
-
Roden M, Price TB, Perseghin G et al (1996) Mechanism of free fatty acid-induced insulin resistance in humans. J Clin Invest 97:2859–2865
-
(1996)
J Clin Invest
, vol.97
, pp. 2859-2865
-
-
Roden, M.1
Price, T.B.2
Perseghin, G.3
-
11
-
-
0037840422
-
Elevated plasma nonesterified fatty acids are associated with deterioration of acute insulin response in IGT but not NGT
-
Stefan N, Stumvoll M, Bogardus C, Tataranni PA (2003) Elevated plasma nonesterified fatty acids are associated with deterioration of acute insulin response in IGT but not NGT. Am J Physiol Endocrinol Metab 284:E1156–E1161
-
(2003)
Am J Physiol Endocrinol Metab
, vol.284
, pp. E1156-E1161
-
-
Stefan, N.1
Stumvoll, M.2
Bogardus, C.3
Tataranni, P.A.4
-
12
-
-
4143088340
-
Non-esterified fatty acids impair insulin-mediated glucose uptake and disposition in the liver
-
Iozzo P, Lautamaki R, Geisler F et al (2004) Non-esterified fatty acids impair insulin-mediated glucose uptake and disposition in the liver. Diabetologia 47:1149–1156
-
(2004)
Diabetologia
, vol.47
, pp. 1149-1156
-
-
Iozzo, P.1
Lautamaki, R.2
Geisler, F.3
-
13
-
-
0037340352
-
Increased insulin sensitivity is associated with reduced insulin and glucagon secretion and increased insulin clearance in man
-
Ahren B, Thorsson O (2003) Increased insulin sensitivity is associated with reduced insulin and glucagon secretion and increased insulin clearance in man. J Clin Endocrinol Metab 88:1264–1270
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 1264-1270
-
-
Ahren, B.1
Thorsson, O.2
-
14
-
-
85003195436
-
Cortisol-induced insulin resistance in man: Impaired suppression of glucose production and stimulation of glucose utilization due to a postreceptor detect of insulin action
-
Rizza RA, Mandarino LJ, Gerich JE (1982) Cortisol-induced insulin resistance in man: impaired suppression of glucose production and stimulation of glucose utilization due to a postreceptor detect of insulin action. J Clin Endocrinol Metab 54:131–138
-
(1982)
J Clin Endocrinol Metab
, vol.54
, pp. 131-138
-
-
Rizza, R.A.1
Mandarino, L.J.2
Gerich, J.E.3
-
15
-
-
0034072554
-
Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in humans
-
Roden M, Stingl H, Chandramouli Vet al (2000) Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in humans. Diabetes 49:701–707
-
(2000)
Diabetes
, vol.49
, pp. 701-707
-
-
Roden, M.1
Stingl, H.2
Al, C.V.3
-
16
-
-
0035091266
-
Recent advances in our understanding of insulin action and insulin resistance
-
Le RD, Zick Y (2001) Recent advances in our understanding of insulin action and insulin resistance. Diabetes Care 24:588–597
-
(2001)
Diabetes Care
, vol.24
, pp. 588-597
-
-
Le, R.D.1
Zick, Y.2
-
17
-
-
56049086867
-
Insulin as a physiological modulator of glucagon secretion
-
Bansal P, Wang Q (2008) Insulin as a physiological modulator of glucagon secretion. Am J Physiol Endocrinol Metab 295:E751–E761
-
(2008)
Am J Physiol Endocrinol Metab
, vol.295
, pp. E751-E761
-
-
Bansal, P.1
Wang, Q.2
-
18
-
-
80052538623
-
Glucose ingestion selectively amplifies ACTH and cortisol secretory-burst mass and enhances their joint synchrony in healthy men
-
Iranmanesh A, Lawson D, Dunn B, Veldhuis JD (2011) Glucose ingestion selectively amplifies ACTH and cortisol secretory-burst mass and enhances their joint synchrony in healthy men. J Clin Endocrinol Metab 96:2882–2888
-
(2011)
J Clin Endocrinol Metab
, vol.96
, pp. 2882-2888
-
-
Iranmanesh, A.1
Lawson, D.2
Dunn, B.3
Veldhuis, J.D.4
-
19
-
-
0037109184
-
Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: Role of oxidative stress
-
Esposito K, Nappo F, Marfella R et al (2002) Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress. Circulation 106:2067–2072
-
(2002)
Circulation
, vol.106
, pp. 2067-2072
-
-
Esposito, K.1
Nappo, F.2
Marfella, R.3
-
20
-
-
18844442889
-
Effect of atorvastatin and irbesartan, alone and in combination, on postprandial endothelial dysfunction, oxidative stress, and inflammation in type 2 diabetic patients
-
Ceriello A, Assaloni R, Da RR et al (2005) Effect of atorvastatin and irbesartan, alone and in combination, on postprandial endothelial dysfunction, oxidative stress, and inflammation in type 2 diabetic patients. Circulation 111:2518–2524
-
(2005)
Circulation
, vol.111
, pp. 2518-2524
-
-
Ceriello, A.1
Assaloni, R.2
Da, R.R.3
-
21
-
-
33947412809
-
Inflammation in metabolic syndrome and type 2 diabetes: Impact of dietary glucose
-
Kempf K, Rose B, Herder C, Kleophas U, Martin S, Kolb H (2006) Inflammation in metabolic syndrome and type 2 diabetes: impact of dietary glucose. Ann N Y Acad Sci 1084:30–48
-
(2006)
Ann N Y Acad Sci
, vol.1084
, pp. 30-48
-
-
Kempf, K.1
Rose, B.2
Herder, C.3
Kleophas, U.4
Martin, S.5
Kolb, H.6
-
22
-
-
0032587240
-
The role of TNFalpha and TNF receptors in obesity and insulin resistance
-
Hotamisligil GS (1999) The role of TNFalpha and TNF receptors in obesity and insulin resistance. J Intern Med 245:621–625
-
(1999)
J Intern Med
, vol.245
, pp. 621-625
-
-
Hotamisligil, G.S.1
-
23
-
-
64749095071
-
Elevated levels of the anti-inflammatory interleukin-1 receptor antagonist precede the onset of type 2 diabetes: The Whitehall II study
-
Herder C, Brunner EJ, Rathmann W et al (2009) Elevated levels of the anti-inflammatory interleukin-1 receptor antagonist precede the onset of type 2 diabetes: the Whitehall II study. Diabetes Care 32: 421–423
-
(2009)
Diabetes Care
, vol.32
, pp. 421-423
-
-
Herder, C.1
Brunner, E.J.2
Rathmann, W.3
-
24
-
-
0038809142
-
Monocyte chemoattractant protein 1 in obesity and insulin resistance
-
Sartipy P, Loskutoff DJ (2003) Monocyte chemoattractant protein 1 in obesity and insulin resistance. Proc Natl Acad Sci U S A 100: 7265–7270
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 7265-7270
-
-
Sartipy, P.1
Loskutoff, D.J.2
-
25
-
-
34247857663
-
Obesity, inflammation, and insulin resistance
-
Shoelson SE, Herrero L, Naaz A (2007) Obesity, inflammation, and insulin resistance. Gastroenterology 132:2169–2180
-
(2007)
Gastroenterology
, vol.132
, pp. 2169-2180
-
-
Shoelson, S.E.1
Herrero, L.2
Naaz, A.3
-
26
-
-
84855185039
-
Standards of medical care in diabetes–2012
-
Anonymous
-
Anonymous (2012) Standards of medical care in diabetes–2012. Diabetes Care 35(Suppl 1):S11–S63
-
(2012)
Diabetes Care
, vol.35
, pp. S11-S63
-
-
-
27
-
-
79951697487
-
Liver ATP synthesis is lower and relates to insulin sensitivity in patients with type 2 diabetes
-
Schmid AI, Szendroedi J, Chmelik M, Krssak M, Moser E, Roden M (2011) Liver ATP synthesis is lower and relates to insulin sensitivity in patients with type 2 diabetes. Diabetes Care 34:448–453
-
(2011)
Diabetes Care
, vol.34
, pp. 448-453
-
-
Schmid, A.I.1
Szendroedi, J.2
Chmelik, M.3
Krssak, M.4
Moser, E.5
Roden, M.6
-
28
-
-
0023881187
-
Lean body mass estimation by bioelectrical impedance analysis: A four-site cross-validation study
-
Segal KR, Van LM, Fitzgerald PI, Hodgdon JA, Van Itallie TB (1988) Lean body mass estimation by bioelectrical impedance analysis: a four-site cross-validation study. Am J Clin Nutr 47:7–14
-
(1988)
Am J Clin Nutr
, vol.47
, pp. 7-14
-
-
Segal, K.R.1
Van, L.M.2
Fitzgerald, P.I.3
Hodgdon, J.A.4
Van Itallie, T.B.5
-
29
-
-
61849172978
-
Effects of high-dose simvastatin therapy on glucose metabolism and ectopic lipid deposition in nonobese type 2 diabetic patients
-
Szendroedi J, Anderwald C, Krssak M et al (2009) Effects of high-dose simvastatin therapy on glucose metabolism and ectopic lipid deposition in nonobese type 2 diabetic patients. Diabetes Care 32: 209–214
-
(2009)
Diabetes Care
, vol.32
, pp. 209-214
-
-
Szendroedi, J.1
Erwald, C.2
Krssak, M.3
-
30
-
-
35148853628
-
A Thr94Ala mutation in human liver fatty acid-binding protein contributes to reduced hepatic glycogenolysis and blunted elevation of plasma glucose levels in lipid-exposed subjects
-
Weickert MO, Loeffelholz CV, Roden M et al (2007) A Thr94Ala mutation in human liver fatty acid-binding protein contributes to reduced hepatic glycogenolysis and blunted elevation of plasma glucose levels in lipid-exposed subjects. Am J Physiol Endocrinol Metab 293:E1078–E1084
-
(2007)
Am J Physiol Endocrinol Metab
, vol.293
, pp. E1078-E1084
-
-
Weickert, M.O.1
Loeffelholz, C.V.2
Roden, M.3
-
31
-
-
84875853698
-
Indirect calorimetry in humans: A postcalorimetric evaluation procedure for correction of metabolic monitor variability
-
Schadewaldt P, Nowotny B, Strassburger K, Kotzka J, Roden M (2013) Indirect calorimetry in humans: a postcalorimetric evaluation procedure for correction of metabolic monitor variability. Am J Clin Nutr 97:763–773
-
(2013)
Am J Clin Nutr
, vol.97
, pp. 763-773
-
-
Schadewaldt, P.1
Nowotny, B.2
Strassburger, K.3
Kotzka, J.4
Roden, M.5
-
32
-
-
0020576146
-
Calculation of substrate oxidation rates in vivo from gaseous exchange
-
Frayn KN (1983) Calculation of substrate oxidation rates in vivo from gaseous exchange. J Appl Physiol 55:628–634
-
(1983)
J Appl Physiol
, vol.55
, pp. 628-634
-
-
Frayn, K.N.1
-
33
-
-
84855793818
-
Precision and accuracy of blood glucose measurements using three different instruments
-
Nowotny B, Nowotny PJ, Strassburger K, Roden M (2012) Precision and accuracy of blood glucose measurements using three different instruments. Diabet Med 29:260–265
-
(2012)
Diabet Med
, vol.29
, pp. 260-265
-
-
Nowotny, B.1
Nowotny, P.J.2
Strassburger, K.3
Roden, M.4
-
34
-
-
36849013098
-
Low-grade inflammation, obesity, and insulin resistance in adolescents
-
Herder C, Schneitler S, Rathmann W et al (2007) Low-grade inflammation, obesity, and insulin resistance in adolescents. J Clin Endocrinol Metab 92:4569–4574
-
(2007)
J Clin Endocrinol Metab
, vol.92
, pp. 4569-4574
-
-
Herder, C.1
Schneitler, S.2
Rathmann, W.3
-
35
-
-
17744383753
-
Free fatty acids inhibit the glucose-stimulated increase of intramuscular glucose-6-phosphate concentration in humans
-
Krebs M, Krssak M, Nowotny P et al (2001) Free fatty acids inhibit the glucose-stimulated increase of intramuscular glucose-6-phosphate concentration in humans. J Clin Endocrinol Metab 86: 2153–2160
-
(2001)
J Clin Endocrinol Metab
, vol.86
, pp. 2153-2160
-
-
Krebs, M.1
Krssak, M.2
Nowotny, P.3
-
36
-
-
72449142600
-
An empirical index of insulin sensitivity from short IVGTT: Validation against the minimal model and glucose clamp indices in patients with different clinical characteristics
-
Tura A, Sbrignadello S, Succurro E, Groop L, Sesti G, Pacini G (2010) An empirical index of insulin sensitivity from short IVGTT: validation against the minimal model and glucose clamp indices in patients with different clinical characteristics. Diabetologia 53:144–152
-
(2010)
Diabetologia
, vol.53
, pp. 144-152
-
-
Tura, A.1
Sbrignadello, S.2
Succurro, E.3
Groop, L.4
Sesti, G.5
Pacini, G.6
-
37
-
-
84883684931
-
Mechanisms underlying the onset of oral lipid-induced skeletal muscle insulin resistance in humans
-
Nowotny B, Zahiragic L, Krog D et al (2013) Mechanisms underlying the onset of oral lipid-induced skeletal muscle insulin resistance in humans. Diabetes 62:2240–2248
-
(2013)
Diabetes
, vol.62
, pp. 2240-2248
-
-
Nowotny, B.1
Zahiragic, L.2
Krog, D.3
-
38
-
-
0037866804
-
A circulatory model for calculating non-steady-state glucose fluxes. Validation and comparison with compartmental models
-
Mari A, Stojanovska L, Proietto J, Thorburn AW (2003) A circulatory model for calculating non-steady-state glucose fluxes. Validation and comparison with compartmental models. Comput Methods Prog Biomed 71:269–281
-
(2003)
Comput Methods Prog Biomed
, vol.71
, pp. 269-281
-
-
Mari, A.1
Stojanovska, L.2
Proietto, J.3
Thorburn, A.W.4
-
39
-
-
79951768140
-
Identification of a model of non-esterified fatty acids dynam ics through genetic algorithms: The case of women with a history of gestational diabetes
-
Morbiducci U, Di BG, Kautzky-Willer A, Deriu MA, Pacini G, Tura A (2011) Identification of a model of non-esterified fatty acids dynam ics through genetic algorithms: the case of women with a history of gestational diabetes. Comput Biol Med 41:146–153
-
(2011)
Comput Biol Med
, vol.41
, pp. 146-153
-
-
Morbiducci, U.1
Di, B.G.2
Kautzky-Willer, A.3
Deriu, M.A.4
Pacini, G.5
Tura, A.6
-
40
-
-
84862857458
-
Defining insulin resistance from hyperinsulinemic-euglycemic clamps
-
Tam CS, Xie W, Johnson WD, Cefalu WT, Redman LM, Ravussin E (2012) Defining insulin resistance from hyperinsulinemic-euglycemic clamps. Diabetes Care 35:1605–1610
-
(2012)
Diabetes Care
, vol.35
, pp. 1605-1610
-
-
Tam, C.S.1
Xie, W.2
Johnson, W.D.3
Cefalu, W.T.4
Redman, L.M.5
Ravussin, E.6
-
41
-
-
84868616910
-
Insulin-mediated FFA suppression is associated with triglyceridemia and insulin sensitivity independent of adiposity
-
Bush NC, Basu R, Rizza RA, Nair KS, Khosla S, Jensen MD (2012) Insulin-mediated FFA suppression is associated with triglyceridemia and insulin sensitivity independent of adiposity. J Clin Endocrinol Metab 97:4130–4138
-
(2012)
J Clin Endocrinol Metab
, vol.97
, pp. 4130-4138
-
-
Bush, N.C.1
Basu, R.2
Rizza, R.A.3
Nair, K.S.4
Khosla, S.5
Jensen, M.D.6
-
42
-
-
34249681435
-
Muscle mitochon-drial ATP synthesis and glucose transport/phosphorylation in type 2 diabetes
-
Szendroedi J, Schmid AI, Chmelik M et al (2007) Muscle mitochon-drial ATP synthesis and glucose transport/phosphorylation in type 2 diabetes. PLoS Med 4:e154
-
(2007)
Plos Med
, vol.4
-
-
Szendroedi, J.1
Schmid, A.I.2
Chmelik, M.3
-
43
-
-
77953868236
-
Lipid-induced insulin resistance: Unravelling the mechanism
-
Samuel VT, Petersen KF, Shulman GI (2010) Lipid-induced insulin resistance: unravelling the mechanism. Lancet 375:2267–2277
-
(2010)
Lancet
, vol.375
, pp. 2267-2277
-
-
Samuel, V.T.1
Petersen, K.F.2
Shulman, G.I.3
-
44
-
-
84860497397
-
Diacylglycerol activation of protein kinase Cepsilon and hepatic insulin resistance
-
Jornayvaz FR, Shulman GI (2012) Diacylglycerol activation of protein kinase Cepsilon and hepatic insulin resistance. Cell Metab 15: 574–584
-
(2012)
Cell Metab
, vol.15
, pp. 574-584
-
-
Jornayvaz, F.R.1
Shulman, G.I.2
-
45
-
-
80555124939
-
Ceramides as modulators of cellular and whole-body metabolism
-
Bikman BT, Summers SA (2011) Ceramides as modulators of cellular and whole-body metabolism. J Clin Invest 121:4222–4230
-
(2011)
J Clin Invest
, vol.121
, pp. 4222-4230
-
-
Bikman, B.T.1
Summers, S.A.2
-
46
-
-
0032829745
-
Overnight lowering of free fatty acids with Acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects
-
Santomauro AT, Boden G, Silva ME et al (1999) Overnight lowering of free fatty acids with Acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects. Diabetes 48:1836–1841
-
(1999)
Diabetes
, vol.48
, pp. 1836-1841
-
-
Santomauro, A.T.1
Boden, G.2
Silva, M.E.3
-
48
-
-
0030023775
-
The roles of insulin and glucagon in the regulation of hepatic glycogen synthesis and turnover in humans
-
Roden M, Perseghin G, Petersen KF et al (1996) The roles of insulin and glucagon in the regulation of hepatic glycogen synthesis and turnover in humans. J Clin Invest 97:642–648
-
(1996)
J Clin Invest
, vol.97
, pp. 642-648
-
-
Roden, M.1
Perseghin, G.2
Petersen, K.F.3
-
49
-
-
0036084417
-
Effect of hepatic denervation on peripheral insulin sensitivity in conscious dogs
-
Moore MC, Satake S, Baranowski B, Hsieh PS, Neal DW, Cherrington AD (2002) Effect of hepatic denervation on peripheral insulin sensitivity in conscious dogs. Am J Physiol Endocrinol Metab 282:E286–E296
-
(2002)
Am J Physiol Endocrinol Metab
, vol.282
, pp. E286-E296
-
-
Moore, M.C.1
Satake, S.2
Baranowski, B.3
Hsieh, P.S.4
Neal, D.W.5
Cherrington, A.D.6
|