Inflammation in metabolic syndrome and type 2 diabetes: Impact of dietary glucose

Annals of the New York Academy of Sciences

Volumn 1084, Issue , 2006, Pages 30-48

  Kempf, Kerstin ^a   Rose, Bettina ^a   Herder, Christian ^a   Kleophas, Ursula ^a   Martin, Stephan ^a   Kolb, Hubert ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Exercise; Glucose; Inflammation; Lifestyle; Nutrition; Obesity; Type 2 diabetes

Indexed keywords

ACETYLSALICYLIC ACID; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GLUCOSE; INSULIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 18; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE;

CARDIOVASCULAR DISEASE; CONFERENCE PAPER; CYTOKINE RELEASE; DRUG MEGADOSE; DYSLIPIDEMIA; EXERCISE; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; GLUCOSE INTAKE; HYPERGLYCEMIA; IMMUNOMODULATION; INFLAMMATION; INSULIN RELEASE; INSULIN RESISTANCE; LEUKOCYTE; LIFESTYLE; LYMPHOCYTE; MACROPHAGE; METABOLIC DISORDER; METABOLIC SYNDROME X; MOUSE STRAIN; NEUTROPHIL; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PATHOGENESIS; WEIGHT REDUCTION; CARBOHYDRATE DIET; DRUG EFFECT; GENETIC TRANSCRIPTION; GENETICS; HUMAN; METABOLISM; PATHOPHYSIOLOGY; REVIEW; SECRETION;

CYTOKINES; DIABETES MELLITUS, TYPE 2; DIETARY CARBOHYDRATES; GLUCOSE; HUMANS; INFLAMMATION; INSULIN; METABOLIC SYNDROME X; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 33947412809     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1372.012     Document Type: Conference Paper

References (72)

1. BHARGAVA, S.K., H.S. SACHDEV, C.H. FALL, et al. 2004. Relation of serial changes in childhood body-mass index to impaired glucose tolerance in young adulthood. N. Engl. J. Med. 350: 865-875.
2. GLUCKMAN, P.D. & M.A. HANSON. 2004. Living with the past: evolution, development, and patterns of disease. Science 305: 1733-1736.
3. GRUNNET, L., P. POULSEN, B.K. PEDERSEN, et al. 2004. Interleukin 6 (IL-6), tumor necrosis factor-α (TNF-α) and soluble TNF receptor 1 (sTNFR1) in healthy twins - aetiology and relation to in vivo insulin action. Diabetologia 47: (Suppl1): A226-A227.
4. GOLDSTEIN, B.J. 2003. Insulin resistance: from benign to type 2 diabetes mellitus. Rev. Cardiovasc. Med. 4(Suppl 6): S3-S10.
5. PETERSEN, K.F., S. DUFOUR, D. BEFROY, et al. 2004. Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N. Engl. J. Med. 350: 664-671.
6. PORKSEN, N. 2002. Early changes in beta-cell function and insulin pulsatility as predictors for type 2 diabetes. Diabetes Nutr. Metab. 15: 9-14.
7. ZETHELIUS, B., L. BYBERG, C.N. HALES, et al. 2003. Proinsulin and acute insulin response independently predict type 2 diabetes mellitus in men - report from 27 years of follow-up study. Diabetologia 46: 20-26.
8. SRINIVASAN, S.R., A. ELKASABANI, E.R. DALFERES JR., et al. 1998. Characteristics of young offspring of type 2 diabetic parents in a biracial (black-white) community-based sample: the Bogalusa Heart Study. Metabolism 47: 998-1004.
9. SRINIVASAN, S.R., L. MYERS & G.S. BERENSON. 2002. Predictability of childhood adiposity and insulin for developing insulin resistance syndrome (syndrome X) in young adulthood: the Bogalusa Heart Study. Diabetes 51: 204-209.
10. SRINIVASAN, S.R., M.G. FRONTINI & G.S. BERENSON. 2003. Longitudinal changes in risk variables of insulin resistance syndrome from childhood to young adulthood in offspring of parents with type 2 diabetes: the Bogalusa Heart Study. Metabolism 52: 443-450.
11. XU, H., G.T. BARNES, Q. YANG, et al. 2003. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J. Clin. Invest. 112: 1821-1830.
12. WEISBERG, S.P., D. MCCANN, M. DESAI, et al. 2003. Obesity is associated with macrophage accumulation in adipose tissue. J. Clin. Invest 112: 1796-1808.
13. ROSMOND, R., M. CHAGNON, C. BOUCHARD, et al. 2003. Increased abdominal obesity, insulin and glucose levels in nondiabetic subjects with a T29C polymorphism of the transforming growth factor-beta1 gene. Horm. Res. 59: 191-194.
14. BUTLER, A.E., J. JANSON, S. BONNER-W EIR, et al. 2003. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 52: 102-110.
15. GOLDSTEIN, B.J. 2002. Insulin resistance as the core defect in type 2 diabetes mellitus. Am. J. Cardiol. 90: 3G-10G.
16. LINGOHR, M.K., R. BUETTNER & C.J. RHODES. 2002. Pancreatic beta-cell growth and survival - a role in obesity-linked type 2 diabetes? Trends Mol. Med. 8: 375-384.
17. SESTI, G. 2002. Apoptosis in the beta cells: cause or consequence of insulin secretion defect in diabetes? Ann. Med. 34: 444-450.
18. GODSLAND, I.F., J.A. JEFFS & D.G. JOHNSTON. 2004. Loss of beta cell function as fasting glucose increases in the non-diabetic range. Diabetologia 47: 1157-1166.
19. WINZLER, R.J. 1960. Glycoproteins. In The Plasma Proteins. F.W. Putnam, Ed.: 309. London Academic Press, New York.
20. COGAN, D.G., L. MEROLA & P.R. LAIBSON. 1961. Blood viscosity, serum hexosamine and diabetic retinopathy. Diabetes 10: 393-395.
21. BERGSTRAND, C.G., P. FURST, Y. LARSSON, et al. 1962. Serum haptoglobin in juvenile diabetes. Scand. J. Clin. Lab. Invest 14: 629-632.
22. GANROT, P.O., K. GYDELL & H. EKELUND. 1967. Serum concentration of alpha-2-macroglobulin, haptoglobin and alpha-1-antitrypsin in diabetes mellitus. Acta Endocrinol. (Copenh.) 55: 537-544.
23. CLEVE, H., K. ALEXANDER, H.J. MITZKAT, et al. 1968. Serum glycoproteins in diabetes mellitus; quantitative immunological determination of acid alpha 1-glycoprotein, Gc, alpha 2-macroglobulin and hemopexin in diabetics with and without angiopathy. Diabetologia 4: 48-55.
24. MCMILLAN, D.E. 1970. Changes in serum proteins and protein-bound carbohydrates in diabetes mellitus. Diabetologia 6: 597-604.
25. PICKUP, J.C. 2004. Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care 27: 813-823.
26. HERDER, C., B. HAASTERT, S. MULLER- SCHOLZE, et al. 2005. Association of systemic chemokine concentrations with impaired glucose tolerance and type 2 diabetes: results from the Cooperative Health Research in the region of Augsburg Survey S4 (KORA S4). Diabetes 54: S11-S17.
27. HERDER, C., H. KOLB, W. KOENIG, et al. 2006. Association of systemic concentrations of macrophage migration inhibitory factor with impaired glucose tolerance and type 2 diabetes: results from the Cooperative Health Research in the region of Augsburg, Survey 4 (KORA S4). Diabetes Care 29: 368-371.
28. KOLB, H. & T. MANDRUP-POULSEN. 2005. An immune origin of type 2 diabetes? Diabetologia 48: 1038-1050.
29. THORAND, B., H. KOLB, J. BAUMERT, et al. 2005. Elevated levels of interleukin-18 predict the development of type 2 diabetes: results from the MONICA/KORA Augsburg Study, 1984-2002. Diabetes 54: 2932-2938.
30. THORAND, B., J. BAUMERT, L. CHAMBLESS, et al. 2006. Elevated markers of endothelial dysfunction predict type 2 diabetes mellitus in middle-aged men and women from the general population. Arterioscler. Thromb.Vasc. Biol. 26: 398-405.
31. HERDER, C., J. BAUMERT, B. THORAND, et al. 2006. Chemokines as risk factors for type 2 diabetes - results from the MONIKA/KORA Augsburg Study, 1984-2002. Diabetologia 29: 1626-1631.
32. FERNANDEZ-REAL, J.M. 2006. Genetic predispositions to low-grade inflammation and type 2 diabetes. Diabetes Technol. Ther. 8: 55-66.
33. SIMEONI, E., M.M. HOFFMANN, B.R. WINKELMANN, et al. 2004. Association between the A-2518G polymorphism in the monocyte chemoattractant protein-1 gene and insulin resistance and type 2 diabetes mellitus. Diabetologia 47: 1574-1580.
34. HAMID, Y.H., S.A. URHAMMER, C. GLUMER, et al. 2005. The common T60N polymorphism of the lymphotoxin-alpha gene is associated with type 2 diabetes and other phenotypes of the metabolic syndrome. Diabetologia 48: 445-451.
35. SHIN, H.D., K.S. PARK, B.L. PARK, et al. 2006. Common promoter polymorphism in monocyte differentiation antigen CD14 is associated with serum triglyceride levels and body mass index in non-diabetic individuals. Diabet. Med. 23: 72-76.
36. GUBERN, C., A. LOPEZ-BERMEJO, J. BIARNES, et al. 2006. Natural antibiotics and insulin sensitivity: the role of bactericidal/permeability-increasing protein. Diabetes 55: 216-224.
37. UYSAL, K.T., S.M. WIESBROCK, M.W. MARINO, et al. 1997. Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 389: 610-614.
38. DONG, Z.M., J.C. GUTIERREZ-RAMOS, A. COXON, et al. 1997. A new class of obesity genes encodes leukocyte adhesion receptors. Proc. Natl. Acad. Sci. USA 94: 7526-7530.
39. WALLENIUS, V., K. WALLENIUS, B. AHREN, et al. 2002. Interleukin-6-deficient mice develop mature-onset obesity. Nat. Med. 8: 75-79.
40. SCHAFER, K., K. FUJISAWA, S. KONSTANTINIDES, et al. 2001. Disruption of the plasminogen activator inhibitor 1 gene reduces the adiposity and improves the metabolic profile of genetically obese and diabetic ob/ob mice. FASEB J. 15: 1840-1842.
41. MA, L.J., S.L. MAO, K.L. TAYLOR, et al. 2004. Prevention of obesity and insulin resistance in mice lacking plasminogen activator inhibitor 1. Diabetes 53: 336-346.
42. LIJNEN, H.R., E. MAQUOI, P. MORANGE, et al. 2003. Nutritionally induced obesity is attenuated in transgenic mice overexpressing plasminogen activator inhibitor-1. Arterioscler. Thromb. Vasc. Biol. 23: 78-84.
43. PERREAULT, M. & A. MARETTE. 2001.Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle. Nat. Med. 7: 1138-1143.
44. LANG, C.H., C. DOBRESCU & G.J. BAGBY. 1992. Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output. Endocrinology 130: 43-52.
45. LING, P.R., B.R. BISTRIAN, B. MENDEZ, et al. 1994. Effects of systemic infusions of endotoxin, tumor necrosis factor, and interleukin-1 on glucose metabolism in the rat: relationship to endogenous glucose production and peripheral tissue glucose uptake. Metabolism 43: 279-284.
46. SENN, J.J., P.J. KLOVER, I.A. NOWAK, et al. 2003. Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes. J. Biol. Chem. 278: 13740-13746.
47. KLOVER, P.J., T.A. ZIMMERS, L.G. KONIARIS, et al. 2003. Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice. Diabetes 52: 2784-2789.
48. KIM, H.J., T. HIGASHIMORI, S.Y. PARK, et al. 2004. Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo. Diabetes 53: 1060-1067.
49. KROGH-MADSEN, R., P. PLOMGAARD, K. MOLLER, et al. 2006. Influence of TNF-alpha and IL-6 infusions on insulin sensitivity and expression of IL-18 in human. Am. J. Physiol. Endocrinol. Metab 291: E108-E114.
50. HOTAMISLIGIL, G.S., N.S. SHARGILL & B.M. SPIEGELMAN. 1993. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259: 87-91.
51. PAQUOT, N., M.J. CASTILLO, P.J. LEFEBVRE, et al. 2000. No increased insulin sensitivity after a single intravenous administration of a recombinant human tumor necrosis factor receptor: Fc fusion protein in obese insulin-resistant patients. J. Clin. Endocrinol. Metab 85: 1316-1319.
52. DI ROCCO, P., M. MANCO, G. ROSA, et al. 2004. Lowered tumor necrosis factor receptors, but not increased insulin sensitivity, with infliximab. Obes. Res. 12: 734-739.
53. OFEI, F., S. HUREL, J. NEWKIRK, et al. 1996. Effects of an engineered human anti-TNF-alpha antibody (CDP571) on insulin sensitivity and glycemic control in patients with NIDDM. Diabetes 45: 881-885.
54. SHOELSON, S.E., J. LEE & M. YUAN. 2003. Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity and diet-induced insulin resistance. Int. J. Obes. Relat. Metab. Disord. 27(Suppl 3): S49-S52.
55. TUOMILEHTO, J., J. LINDSTROM, J.G. ERIKSSON, et al. 2001. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N. Engl. J. Med. 344: 1343-1350.
56. KNOWLER, W.C., E. BARRETT-CONNOR, S.E. FOWLER, et al. 2002. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N. Engl. J. Med. 346: 393-403.
57. PAN, X.R., G.W. LI, Y.H. HU, et al. 1997. Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care 20: 537-544.
58. RAMACHANDRAN, A., C. SNEHALATHA, S. MARY, et al. 2006. The Indian Diabetes Prevention Programme shows that lifestyle modification and metformin prevent type 2 diabetes in Asian Indian subjects with impaired glucose tolerance (IDPP-1). Diabetologia 49: 289-297.
59. YAMAOKA, K. & T. TANGO. 2005. Efficacy of lifestyle education to prevent type 2 diabetes: a meta-analysis of randomized controlled trials. Diabetes Care 28: 2780-2786.
60. LAAKSONEN, D.E., J. LINDSTROM, T.A. LAKKA, et al. 2005. Physical activity in the prevention of type 2 diabetes: the Finnish Diabetes Prevention Study. Diabetes 54: 158-165.
61. PLOMGAARD, P., M. PENKOWA & B.K. PEDERSEN. 2005. Fiber type specific expression of TNF-alpha, IL-6 and IL-18 in human skeletal muscles. Exerc. Immunol. Rev. 11: 53-63.
62. PETERSEN, A.M. & B.K. PEDERSEN. 2005. The anti-inflammatory effect of exercise. J. Appl. Physiol. 98: 1154-1162.
63. PEDERSEN, B.K. & M. FEBBRAIO. 2005. Muscle-derived interleukin-6 - a possible link between skeletal muscle, adipose tissue, liver, and brain. Brain Behav. Immun. 19: 371-376.
64. HAFFNER, S., M. TEMPROSA, J. CRANDALL, et al. 2005. Intensive lifestyle intervention or metformin on inflammation and coagulation in participants with impaired glucose tolerance. Diabetes 54: 1566-1572.
65. VALLE, T., S. MULLER, J. LINDSTROEM, et al. 2003. Changes in C-reactive protein and interleukin-6 correlate with a change in glucose in women but not in men with impaired glucose tolerance in the Finnish Diabetes Prevention Study. Diabetes 52:(Suppl 1): A231.
66. NICKLAS, B.J., T. YOU & M. PAHOR. 2005. Behavioural treatments for chronic systemic inflammation: effects of dietary weight loss and exercise training. CMAJ 172: 1199-1209.
67. PEDERSEN, M., A. STEENSBERG, C. KELLER, et al. 2004. Does the aging skeletal muscle maintain its endocrine function? Exerc. Immunol. Rev. 10: 42-55.
68. CURAT, C.A., A. MIRANVILLE, C. SENGENES, et al. 2004. From blood monocytes to adipose tissue-resident macrophages: induction of diapedesis by human mature adipocytes. Diabetes 53: 1285-1292.
69. HOWARD, B.V., L. VAN HORN, J. HSIA, et al. 2006. Low-fat dietary pattern and risk of cardiovascular disease: the Women's Health Initiative Randomized Controlled Dietary Modification Trial. JAMA 295: 655-666.
70. HE, F.J., C.A. NOWSON & G.A. MACGREGOR. 2006. Fruit and vegetable consumption and stroke: meta-analysis of cohort studies. Lancet 367: 320-326.
71. NORDMANN, A.J., A. NORDMANN, M. BRIEL, et al. 2006. Effects of low-carbohydrate vs low-fat diets on weight loss and cardiovascular risk factors: a meta-analysis of randomized controlled trials. Arch. Intern. Med. 166: 285-293.
72. ARORA, S.K. & S.I. MCFARLANE. 2005. The case for low carbohydrate diets in diabetes management. Nutr. Metab. (Lond.) 2: 16