A Thr94Ala mutation in human liver fatty acid-binding protein contributes to reduced hepatic glycogenolysis and blunted elevation of plasma glucose levels in lipid-exposed subjects

American Journal of Physiology - Endocrinology and Metabolism

Volumn 293, Issue 4, 2007, Pages

  Weickert, Martin O ^a,b   Loeffelholz, Christian V ^a,b   Roden, Michael ^c   Chandramouli, Visvanathan ^d   Brehm, Attila ^c   Nowotny, Peter ^e   Osterhoff, Martin A ^a,b   Isken, Frank ^a,b   Spranger, Jochen ^a,b   Landau, Bernard R ^d   Pfeiffer, Andreas F H ^a,b   Möhlig, Matthias ^a,b  

^a GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c HANUSCH HOSPITAL   (Austria)

^d CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Endogenous glucose production; Free fatty acids; Gluconeogenesis; Insulin resistance; Nutrigenomics; Randomized controlled study

Indexed keywords

ALANINE; FATTY ACID; FATTY ACID BINDING PROTEIN; GLUCAGON; GLUCOSE; HEPARIN; INSULIN; LIPID; NEUTRAL INSULIN; RECOMBINANT GLUCAGON; RECOMBINANT HUMAN INSULIN; SOMATOSTATIN; THREONINE;

ADULT; AMINO ACID SUBSTITUTION; ARTICLE; BLOOD SAMPLING; BODY MASS; BODY WEIGHT; CLINICAL ARTICLE; CLINICAL TRIAL; COHORT ANALYSIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; GENE MUTATION; GENOTYPE; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLYCOGENOLYSIS; HETEROZYGOTE; HUMAN; HYPERGLYCEMIA; INFUSION; INSULIN RESISTANCE; LIVER METABOLISM; NUTRIGENOMICS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROVOCATION TEST; RANDOMIZED CONTROLLED TRIAL; TREATMENT RESPONSE; WEIGHT REDUCTION; COMPARATIVE STUDY; DRUG EFFECT; FEMALE; GENETICS; GLUCOSE CLAMP TECHNIQUE; LIVER; MALE; METABOLISM; MIDDLE AGED; MUTATION; PHYSIOLOGY;

ALANINE; BLOOD GLUCOSE; BODY WEIGHT; COHORT STUDIES; FATTY ACID-BINDING PROTEINS; FEMALE; GENOTYPE; GLUCOSE CLAMP TECHNIQUE; GLYCOGENOLYSIS; HUMANS; LIPIDS; LIVER; MALE; MIDDLE AGED; MUTATION; THREONINE;

EID: 35148853628     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00337.2007     Document Type: Article

References (33)

1. Atshaves BP, McIntosh AM, Lyuksyutova OI, Zipfel W, Webb WW, Schroeder F. Liver fatty acid-binding protein gene ablation inhibits branched-chain fatty acid metabolism in cultured primary hepatocytes. J Biol Chem 279: 30954-30965, 2004.
2. Baron AD, Kolterman OG, Bell J, Mandarino LJ, Olefsky JM. Rates of noninsulin-mediated glucose uptake are elevated in type II diabetic subjects. J Clin Invest 76: 1782-1788, 1985.
3. Bass NM, Manning JA. Tissue expression of three structurally different fatty acid binding proteins from rat heart muscle, liver, and intestine. Biochem Biophys Res Commun 137: 929-935, 1986.
4. Boden G. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 46: 3-10, 1997.
5. Boden G, Chen X, Capulong E, Mozzoli M. Effects of free fatty acids on gluconeogenesis and autoregulation of glucose production in type 2 diabetes. Diabetes 50: 810-816, 2001.
6. Boden G, Jadali F. Effects of lipid on basal carbohydrate metabolism in normal men. Diabetes 40: 686-692, 1991.
7. Brouillette C, Bosse Y, Perusse L, Gaudet D, Vohl MC. Effect of liver fatty acid binding protein (FABP) T94A missense mutation on plasma lipoprotein responsiveness to treatment with fenofibrate. J Hum Genet 49: 424-432, 2004.
8. Bugianesi E, McCullough AJ, Marchesini G. Insulin resistance: a metabolic pathway to chronic liver disease. Hepatology 42: 987-1000, 2005.
9. Chandramouli V, Ekberg K, Schumann WC, Kalhan SC, Wahren J, Landau BR. Quantifying gluconeogenesis during fasting. Am J Physiol Endocrinol Metab 273: E1209-E1215, 1997.
10. Cherrington AD, Edgerton D, Sindelar DK. The direct and indirect effects of insulin on hepatic glucose production in vivo. Diabetologia 41: 987-996, 1998.
11. Chu CA, Sherck SM, Igawa K, Sindelar DK, Neal DW, Emshwiller M, Cherrington AD. Effects of free fatty acids on hepatic glycogenolysis and gluconeogenesis in conscious dogs. Am J Physiol Endocrinol Metab 282: E402-E411, 2002.
12. Clore JN, Glickman PS, Nestler JE, Blackard WG. In vivo evidence for hepatic autoregulation during FFA-stimulated gluconeogenesis in normal humans. Am J Physiol Endocrinol Metab 261: E425-E429, 1991.
13. Couillard C, Bergeron N, Prud'homme D, Bergeron J, Tremblay A, Bouchard C, Mauriege P, Despres JP. Postprandial triglyceride response in visceral obesity in men. Diabetes 47: 953-960, 1998.
14. DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol Endocrinol Metab Gastrointest Physiol 237: E214-E223, 1979.
15. Edgerton DS, Cardin S, Emshwiller M, Neal D, Chandramouli V, Schumann WC, Landau BR, Rossetti L, Cherrington AD. Small increases in insulin inhibit hepatic glucose production solely caused by an effect on glycogen metabolism. Diabetes 50: 1872-1882, 2001.
16. Ferrannini E, Barrett EJ, Bevilacqua S, DeFronzo RA. Effect of fatty acids on glucose production and utilization in man. J Clin Invest 72: 1737-1747, 1983.
17. Hother-Nielsen O, Beck-Nielsen H. On the determination of basal glucose production rate in patients with type 2 (non-insulin-dependent) diabetes mellitus using primed-continuous 3-3H-glucose infusion. Diabetologia 33: 603-610, 1990.
18. Landau BR, Wahren J, Chandramouli V, Schumann WC, Ekberg K, Kalhan SC. Contributions of gluconeogenesis to glucose production in the fasted state. J Clin Invest 98: 378-385, 1996.
19. Liljenquist JE, Mueller GL, Cherrington AD, Keller U, Chiasson JL, Perry JM, Lacy WW, Rabinowitz D. Evidence for an important role of glucagon in the regulation of hepatic glucose production in normal man. J Clin Invest 59: 369-374, 1977.
20. Makowski L, Hotamisligil GS. The role of fatty acid binding proteins in metabolic syndrome and atherosclerosis. Curr Opin Lipidol 16: 543-548, 2005.
21. Newberry EP, Xie Y, Kennedy S, Han X, Buhman KK, Luo J, Gross RW, Davidson NO. Decreased hepatic triglyceride accumulation and altered fatty acid uptake in mice with deletion of the liver fatty acid-binding protein gene. J Biol Chem 278: 51664-51672, 2003.
22. Newberry EP, Xie Y, Kennedy SM, Luo J, Davidson NO. Protection against Western diet-induced obesity and hepatic steatosis in liver fatty acid-binding protein knockout mice. Hepatology 44: 1191-1205, 2006.
23. Radziuk J, Lickley HL. The metabolic clearance of glucose: measurement and meaning. Diabetologia 28: 315-322, 1985.
24. Robitaille J, Brouillette C, Lemieux S, Perusse L, Gaudet D, Vohl MC. Plasma concentrations of apolipoprotein B are modulated by a gene - diet interaction effect between the LFABP T94A polymorphism and dietary fat intake in French-Canadian men. Mol Genet Metab 82: 296-303, 2004.
25. Roden M, Price TB, Perseghin G, Petersen KF, Rothman DL, Cline GW, Shulman GI. Mechanism of free fatty acid-induced insulin resistance in humans. J Clin Invest 97: 2859-2865, 1996.
26. Roden M, Stingl H, Chandramouli V, Schumann WC, Hofer A, Landau BR, Nowotny P, Waldhausl W, Shulman GI. Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in humans. Diabetes 49: 701-707, 2000.
27. Schumann WC, Gastaldelli A, Chandramouli V, Previs SF, Pettiti M, Ferrannini E, Landau BR. Determination of the enrichment of the hydrogen bound to carbon 5 of glucose on 2H2O administration. Anal Biochem 297: 195-197, 2001.
28. Sidossis LS, Mittendorfer B, Chinkes D, Walser E, Wolfe RR. Effect of hyperglycemia-hyperinsulinemia on whole body and regional fatty acid metabolism. Am J Physiol Endocrinol Metab 276: E427-E434, 1999.
29. Staehr P, Hother-Nielsen O, Landau BR, Chandramouli V, Holst JJ, Beck-Nielsen H. Effects of free fatty acids per se on glucose production, gluconeogenesis, and glycogenolysis. Diabetes 52: 260-267, 2003.
30. Weickert MO, Mohlig M, Schofl C, Arafat AM, Otto B, Viehoff H, Koebnick C, Kohl A, Spranger J, Pfeiffer AF. Cereal fiber improves whole-body insulin sensitivity in overweight and obese women. Diabetes Care 29: 775-780, 2006.
31. Weickert MO, Pfeiffer AF. Signalling mechanisms linking hepatic glucose and lipid metabolism. Diabetologia 49: 1732-1741, 2006.
32. Williamson JR, Browning ET, Scholz R, Kreisberg RA, Fritz IB. Inhibition of fatty acid stimulation of gluconeogenesis by (+-)- decanoylcarnitine in perfused rat liver. Diabetes 17: 194-208, 1968.
33. Yang D, Diraison F, Beylot M, Brunengraber DZ, Samols MA, Anderson VE, Brunengraber H. Assay of low deuterium enrichment of water by isotopic exchange with [U-13C3]acetone and gas chromatography-mass spectrometry. Anal Biochem 258: 315-321, 1998.