Acid hydrolysis of wheat gluten induces formation of new epitopes but does not enhance sensitizing capacity by the oral route: A study in ''Gluten Free'' brown Norway rats

PLoS ONE

Volumn 9, Issue 9, 2014, Pages

  Kroghsbo, Stine ^a,b   Andersen, Nanna B ^a   Rasmussen, Tina F ^a   Jacobsenf, Susanne ^a   Madsen, Charlotte B ^a  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^b Unisensor A/S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; GLUTEN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; ACID; ALLERGEN; VEGETABLE PROTEIN;

ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; ASSAY; BROWN NORWAY RAT; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GLUTEN FREE DIET; HYDROLYSIS; IMMUNIZATION; NONHUMAN; PROTEIN BINDING; RAT; RAT BASOPHILIC LEUKEMIA ASSAY; SENSITIZATION; ANIMAL; BLOOD; CHEMISTRY; DOSE RESPONSE; IMMUNOLOGY; INTRAPERITONEAL DRUG ADMINISTRATION; ORAL DRUG ADMINISTRATION; PATHOPHYSIOLOGY; WHEAT ALLERGY;

ACIDS; ADMINISTRATION, ORAL; ALLERGENS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; EPITOPES; FEMALE; GLUTENS; HYDROLYSIS; IMMUNIZATION; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; INJECTIONS, INTRAPERITONEAL; PLANT PROTEINS; RATS; RATS, INBRED BN; WHEAT HYPERSENSITIVITY;

EID: 84926508547     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0107137     Document Type: Article

References (39)

1. Belitz H-D, Grosch W, Schieberle P (2004) Food Chemistry, 3rd revised Edn, Berlin: Springer.
2. Shils ME, Shike M, Ross AC, Caballero B, Cousins RJ (2006) Modern nutrition in health and disease, 10th Edition, 50th anniversary Edition. Philadelphia: Lippincott Williams and Wilkins, Wolters Kluwer.
3. Wieser H (2007) Chemistry of gluten proteins. Food Microbiol 24: 115-119.
4. Tatham AS, Shewry PR (2008) Allergens in wheat and related cereals. Clin Exp Allergy 38: 1712-1726.
5. Mills ENC, Sancho AI, Rigby NM, Jenkins JA, Mackie AR (2009) Impact of food processing on the structural and allergenic properties of food allergens. Mol Nutr Food Res 53: 963-969.
6. Gourbeyre P, Denery-Papini S, Larré C, Gaudin JC, Brossard C, et al. (2012) Wheat gliadins modified by deamidation are more efficient than native gliadins in inducing a Th2 response in Balb/c mice experimentally sensitized to wheat allergens. Mol Nutr Food Res 56: 336-344.
7. Varjonen E, Petman L, Mäkinen-Kiljunen S (2000) Immediate contact allergy from hydrolyzed wheat in a cosmetic cream. Allergy 55: 294-296.
8. Finley JW, Hopkins DT (1985) Digestibility and amino acid availability in cereals and oilseeds. Minnesota, St. Paul: American Association of Cereal Chemists.
9. Mittag D, Niggemann B, Sander I, Reese I, Fiedler E-M, et al. (2004) Immunoglobulin E-reactivity of wheat-allergic subjects (baker's asthma, food allergy, wheat-dependent, exercise-induced anaphylaxis) to wheat protein fractions with different solubility and digestibility. Mol Nutr Food Res 48: 380-389.
10. Kumagai H, Suda A, Sakurai H, Kumagai H, Arai S, et al. (2007) Improvement of digestibility, reduction in allergenicity, and induction of oral tolerance of wheat gliadin by deamidation. Biosci Biotechnol Biochem 71: 977-985.
11. Lauriére M, Pecquet C, Boulenc E, Bouchez-Mahiout I, Snégaroff J, et al. (2007) Genetic differences in omega-gliadins involved in two different immediate food hypersensitivities to wheat. Allergy 62: 890-896.
12. Palosuo K (2003) Update on wheat hypersensitivity. Curr Opin Allergy Clin Immunol 3: 205-209.
13. Leduc V, Moneret-Vautrin D-A, Guerin L, Morisset M, Kanny G (2003) Anaphylaxis to wheat isolates: immunochemical study of a case proved by means of double-blind, placebo-controlled food challenge. J Allergy Clin Immunol 111: 897-899.
14. Lauriére M, Pecquet C, Bouchez-Mahiout I, Snégaroff J, Bayrou O, et al. (2006) Hydrolysed wheat proteins present in cosmetics can induce immediate hypersensitivities. Contact Dermatitis 54: 283-289.
15. Bouchez-Mahiout I, Pecquet C, Kerre S, Snégaroff J, Raison-Peyron N, et al. (2010) High molecular weight entities in industrial wheat protein hydrolysates are immunoreactive with IgE from allergic patients. J Agric Food Chem 58: 4207-4215.
16. Pelkonen AS, Mäkinen-Kiljunen S, Hilvo S, Siltanen M, Mäkelä MJ (2011) Severe allergic reaction to gluten hydrolysate without reaction to wheat. Ann Allergy Asthma Immunol 106: 343-344.
17. Shinoda J, Inomata N, Chinuki Y, Morita E, Ikezawa Z (2012) Case of allergy due to hydrolyzed wheat proteins in commercial boiled pork. J Dermatol 39: 724-726.
18. Pecquet C, Bayrou O, Vigan M, Raison N, Lauriére M (2004) Hydrolysed wheat protein: a new allergen in cosmetics and food. Contact Dermatitis 50: 182-183.
19. Chinuki Y, Murata S, Morita E (2011) A case of wheat-dependent exercise-induced anaphylaxis sensitized with hydrolysed wheat protein in a soap. Contact Dermatitis 65: 55-57.
20. Fukutomi Y, Itagaki Y, Taniguchi M, Saito A, Yasueda H, et al. (2011) Rhinoconjunctival sensitization to hydrolysed wheat protein in facial soap can induce wheat-dependent excersise-induced anaphylaxis. J Allergy Clin Immunol 127: 531-533.
21. Nakamura R, Nakamura R, Sakai S, Adachi R, Hachisuka A, et al. (2013) Tissue transglutaminase generates deamidated epitopes on gluten, increasing reactivity with hydrolysed wheat protein-sensitized IgE. Allergy Clin Immunol 132: 1436-1438.
22. Battais F, Mothes T, Moneret-Vautrin DA, Pineau F, Kanny G, et al. (2005) Identification of IgE-binding epitopes on gliadins for patients with food allergy to wheat. Allergy 60: 815-821.
23. Pastorello EA, Farioli L, Conti A, Pravettoni V, Bonomi S, et al. (2007) Wheat IgE-mediated food allergy in European patients: a-amylase inhibitors, lipid transfer proteins and low-molecular-weight glutenins. Int Arch Allergy Immunol 144: 10-22.
24. Denery-Papini S, Bodinier M, Pineau F, Triballeau S, Tranquet O, et al. (2011) Immunoglobulin-E-binding epitopes of wheat allergens in patients with food allergy to wheat and in mice experimentally sensitized to wheat proteins. Clin Exp Allergy 41: 1478-1492.
25. Bohle B (2004) T lymphocytes and food allergy. Mol Nutr Food Res 48: 424-433.
26. Berin MC, Sicherer S (2011) Food allergy: mechanisms and therapeutics. Curr Opin Immunol 23: 794-800.
27. Cianferoni A, Spergel JM (2009) Food allergy: review, classification and diagnosis. Allergol Int 58: 457-66.
28. Barkholt V, Jensen AL (1989) Amino acid analysis: determination of cysteine plus half-cysteine in proteins after hydrochloric acid hydrolysis with a disulfide compound as additive. Anal Biochem 177: 318-322.
29. Kroghsbo S, Bøgh KL, Rigby NM, Mills EN, Rogers A, et al. (2011) Sensitization with 7S globulins from peanut, hazelnut, soy or pea induces IgE with different biological activities which are modified by soy tolerance. Int Arch Allergy Immunol 155: 212-224.
30. Pilegaard K, Madsen C (2004) An oral Brown Norway rat model for food allergy: comparison of age, sex, dosing volume, and allergen preparation. Toxicology 196: 247-257.
31. Kroghsbo S, Madsen C, Poulsen M, Schrøder M, Kvist PH, et al. (2008) Immunotoxicological studies of genetically modified rice expressing PHA-E lectin or Bt toxin in Wistar rats. Toxicology 245: 24-34.
32. Shreffler WG, Beyer K, Chu TH, Burks AW, Sampson HA (2004) Microarray immunoassay: association of clinical history, in vitro IgE function, and heterogeneity of allergenic peanut epitopes. J Allergy Clin Immunol 13: 776-782.
33. Denery-Papini S, Bodinier M, Larré C, Brossard C, Pineau F, et al. (2012) Allergy to deamidated gluten in patients tolerant to wheat: specific epitopes linked to deamidation. Allergy 67: 1023-32.
34. Christensen HR, Brix S, Frøkiaer H (2004) Immune response in mice to ingested soya protein: antibody production, oral tolerance and maternal transfer. Br J Nutr 91: 725-732.
35. Brix S, Christensen HR, Barkholt V, Frøkiaer H (2005) Effect of maternal dietary cow's milk on the immune response to beta-lactoglobulin in the offspring: a four-generation study in mice. Int Arch Allergy Immunol 136: 250-257.
36. De Jonge JD, Knippels LM, Ezendam J, Odink J, Penninks AH, et al. (2007) The importance of dietary control in the development of a peanut allergy model in Brown Norway rats. Methods 41: 99-111.
37. Adachi R, Nakamura R, Sakai S, Fukutomi Y, Teshima R (2012) Sensitization to acid-hydrolyzed wheat protein by transdermal administration to BALB/c mice, and comparison with gluten. Allergy 67: 1392-1399.
38. Fukutomi Y, Kishikawa R, Sugiyama A, Minami T, Taniguchi M, et al. (2014) Akiyama K. Risk factors for the development of wheat allergy among individuals who have used a facial soap containing hydrolysed wheat protein: case-control study. EAACI Copenhagen Abstract 1617.
39. Strid J, Hourihane J, Kimber I, Callard R, Strobel S (2005) Epicutaneous exposure to peanut protein prevents oral tolerance and enhances allergic sensitization. Clin Exp Allergy 35: 757-766.