Aged red garlic extract suppresses nitric oxide production in lipopolysaccharide-treated RAW 264.7 macrophages through inhibition of NF-κB

Journal of Medicinal Food

Volumn 18, Issue 4, 2015, Pages 439-445

  Ryu, Ji Hyeon ^a   Park, Hye Jin ^a   Jeong, Yi Yeong ^a   Han, Sunkyu ^b   Shin, Jung Hye ^c   Lee, Soo Jung ^d   Kang, Min Jung ^c   Sung, Nak Ju ^d   Kang, Dawon ^a  

^a Gyeongsang National University School of Medicine   (South Korea)

^b Pusan National University   (South Korea)

^c Garlic Research Institute   (South Korea)

^d Gyeongsang National University   (South Korea)

Author keywords

Anti inflammatory; garlic; NF jB; nitric oxide

Indexed keywords

3 (4 TERT BUTYLPHENYLSULFONYL) 2 PROPENENITRILE; AGED RED GARLIC EXTRACT; GARLIC EXTRACT; HEME OXYGENASE 1; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; NITRIC OXIDE; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PLANT EXTRACT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; GARLIC; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TREATMENT OUTCOME; UPREGULATION; ANIMAL; CELL LINE RAW 264.7; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; GENETICS; HUMAN; IMMUNOLOGY;

ALLIUM SATIVUM;

ANIMALS; ANTI-INFLAMMATORY AGENTS; DOWN-REGULATION; GARLIC; HEME OXYGENASE-1; HUMANS; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PLANT EXTRACTS; RAW 264.7 CELLS;

EID: 84926482823     PISSN: 1096620X     EISSN: 15577600     Source Type: Journal    
DOI: 10.1089/jmf.2014.3214     Document Type: Article

References (37)

1. Pan CH, Kim ES, Jung SH, Nho CW, Lee JK: Tectorigenin inhibits IFN-gamma/LPS-induced inflammatory responses in murine macrophage RAW 264.7 cells. Arch Pharm Res 2008;31: 1447-1456.
2. Hald A, Rono B, Lund LR, Egerod KL: LPS counter regulates RNA expression of extracellular proteases and their inhibitors in murine macrophages. Mediators Inflamm 2012;2012:157894.
3. Nguyen MT, Chen A, Lu WJ, et al.: Regulation of chemokine and chemokine receptor expression by PPARgamma in adipo-cytes and macrophages. PLoS One 2012;7:e34976.
4. Lee JW, Bae CJ, Choi YJ, et al.: 3, 4, 5-Trihydroxycinnamic acid inhibits LPS-induced iNOS expression by suppressing NF-kap-paB activation in BV2 microglial cells. Korean J Physiol Pharmacol 2012;16:107-112.
5. Lee YJ, Eun JR: Cilostazol decreases ethanol-mediated TNFalpha expression in RAW264.7 murine macrophage and in liver from binge drinking mice. Korean J Physiol Pharmacol 2012;16:131-138.
6. Sharif O, Bolshakov VN, Raines S, Newham P, Perkins ND: Transcriptional profiling of the LPS induced NF-kappaB re sponse in macrophages. BMC Immunol 2007;8:1.
7. Jones E, Adcock IM, Ahmed BY, Punchard NA: Modulation of LPS stimulated NF-kappaB mediated nitric oxide production by PKCep-silon and JAK2 in RAW macrophages. J Inflamm (Lond) 2007;4:23.
8. Covert MW, Leung TH, Gaston JE, Baltimore D: Achieving stability of lipopolysaccharide-induced NF-kappaB activation. Science 2005;309:1854-1857.
9. Ghosh S, May MJ, Kopp EB: NF-kappa B and Rel proteins: Evolutionarily conserved mediators of immune responses. Annu Rev Immunol 1998;16:225-260.
10. Nathan C, Xie QW: Nitric oxide synthases: Roles, tolls, and controls. Cell 1994;78:915-918.
11. Aggarwal BB, Shishodia S: Suppression of the nuclear factor-kappaB activation pathway by spice-derived phytochemicals: Reasoning for seasoning. Ann NY Acad Sci 2004;1030:434-441.
12. Das I, Acharya A, Berry DL, et al.: Antioxidative effects of the spice cardamom against non-melanoma skin cancer by modu lating nuclear factor erythroid-2-related factor 2 and NF-kappaB signalling pathways. Br J Nutr 2012;108:984-997.
13. Olivera A, Moore TW, Hu F, et al.: Inhibition of the NF-kappaB signaling pathway by the curcumin analog, 3, 5-bis(2-pyridinyl-methylidene)-4-piperidone (EF31): Anti-inflammatory and anti-cancer properties. Int Immunopharmacol 2012;12:368-377.
14. Butt MS, Sultan MT, Butt MS, Iqbal J: Garlic: Nature's pro tection against physiological threats. Crit Rev Food Sci Nutr 2009;49:538-551.
15. Liu KL, Chen HW, Wang RY, et al.: DATS reduces LPS-induced iNOS expression, NO production, oxidative stress, and NF-kappaB activation in RAW 264.7 macrophages. J Agric Food Chem 2006;54:3472-3478.
16. Keiss HP, Dirsch VM, Hartung T, et al.: Garlic (Allium sativum L.) modulates cytokine expression in lipopolysaccharide-activated hu man blood thereby inhibiting NF-kappaB activity. J Nutr 2003;133: 2171-2175.
17. Ban JO, Oh JH, Kim TM, et al.: Anti-inflammatory and arthritic effects of thiacremonone, a novel sulfur compound isolated from garlic via inhibition of NF-kappaB. Arthritis Res Ther 2009;11:R145.
18. Bruck R, Aeed H, Brazovsky E, Noor T, Hershkoviz R: Allicin, the active component of garlic, prevents immune-mediated, concanavalin A-induced hepatic injury in mice. Liver Int 2005;25:613-621.
19. Dirsch VM, Kiemer AK, Wagner H, Vollmar AM: Effect of allicin and ajoene, two compounds of garlic, on inducible nitric oxide synthase. Atherosclerosis 1998;139:333-339.
20. Lee EN, Choi YW, Kim HK, et al.: Chloroform extract of aged black garlic attenuates TNF-alpha-induced ROS generation, VCAM-1 expression, NF-kappaB activation and adhesiveness for monocytes in human umbilical vein endothelial cells. Phytother Res 2011;25:92-100.
21. Park HJ, Jeon BT, Kim HC, et al.: Aged red garlic extract reduces lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages and acute pulmonary inflammation through haeme oxygenase-1 induction. Acta Physiol (Oxf) 2012;205:61-70.
22. Ryter SW, Alam J, Choi AM: Heme oxygenase-1/carbon mon oxide: From basic science to therapeutic applications. Physiol Rev 2006;86:583-650.
23. Paine A, Eiz-Vesper B, Blasczyk R, Immenschuh S: Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic poten tial. Biochem Pharmacol 2010;80:1895-1903.
24. Wu ML, Ho YC, Lin CY, Yet SF: Heme oxygenase-1 in in flammation and cardiovascular disease. Am J Cardiovasc Dis 2011;1:150-158.
25. Sawle P, Foresti R, Mann BE, et al.: Carbon monoxide-releasing molecules (CO-RMs) attenuate the inflammatory response eli cited by lipopolysaccharide in RAW264.7 murine macrophages. Br J Pharmacol 2005;145:800-810.
26. Wijayanti N, Huber S, Samoylenko A, Kietzmann T, Im-menschuh S: Role of NF-kappaB and p38 MAP kinase signaling pathways in the lipopolysaccharide-dependent activation of heme oxygenase-1 gene expression. Antioxid Redox Signal 2004;6: 802-810.
27. Tran K, Merika M, Thanos D: Distinct functional properties of IkappaB alpha and IkappaB beta. Mol Cell Biol 1997;17:5386-5399.
28. Thompson JE, Phillips RJ, Erdjument-Bromage H, Tempst P, Ghosh S: I kappa B-beta regulates the persistent response in a biphasic activation of NF-kappa B. Cell 1995;80:573-582.
29. Wilson EA, Demmig-Adams B: Antioxidant, anti-inflammatory, and antimicrobial properties of garlic and onions. Nutr Food Sci 2007;37:178-183.
30. Geng Z, Rong Y, Lau BH: S-allyl cysteine inhibits activation of nuclear factor kappa B in human T cells. Free Radic Biol Med 1997;23:345-350.
31. Ide N, Lau BH: Garlic compounds minimize intracellular oxi-dative stress and inhibit nuclear factor-kappa b activation. J Nutr 2001;131:1020S-1026S.
32. Lee SJ, Shin JH, Kang MJ, et al.: Antioxidants activity of aged red garlic. J Life Sci 2010;20:775-781.
33. Shin JH, Ryu JH, Kang MJ, et al.: Short-term heating reduces the anti-inflammatory effects of fresh raw garlic extracts on the LPS-induced production of NO and pro-inflammatory cytokines by downregulating allicin activity in RAW 264.7 macrophages. Food Chem Toxicol 2013;58:545-551.
34. Kang MJ, Yoon HS, Jeong SH, Sung NJ, Shin JH: Physico-chemical characteristics of red garlic during processing. Korean J Food Preserv 2011;18:898-906.
35. Shin JH, Kang MJ, Kim RJ, et al.: Biological activity of browning compounds from processed garlics separated by dialysis membrane. J Korean Soc Food Sci Nutr 2011;40:357-365.
36. Lee SJ, Hwang CR, Kang JR, et al.: Anti-obesity effect of red garlic composites in rats efd a hig fat-cholesterol diet. J Life Sci 2012;22:671-680.
37. Lee SJ, Kwon MH, Kwon HJ, et al.: Effect of red garlic-composites on the fecal lipid level and hepatic antioxidant en zyme activity in rats fed a high fat-cholesterol diet. J Korean Soc Food Sci Nutr 2013;42:17-25.