Chloroform extract of aged black garlic attenuates TNF-α-induced ROS generation, VCAM-1 expression, NF-κB activation and adhesiveness for monocytes in human umbilical vein endothelial cells

Phytotherapy Research

Volumn 25, Issue 1, 2011, Pages 92-100

  Lee, Eun Na ^a   Choi, Young Whan ^b   Kim, Hye Kyung ^a   Park, Jin Kyeong ^a   Kim, Hyo Jin ^a   Kim, Myoung June ^a   Lee, Hee Woo ^c   Kim, Ki Hyung ^a   Bae, Sun Sik ^a   Kim, Bong Seon ^a   Yoon, Sik ^a  

^a Pusan National University School of Medicine   (South Korea)

^b Pusan National University   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

aged black garlic; cell adhesion molecules; human umbilical vein endothelial cells; NF B transcription factor; reactive oxygen species

Indexed keywords

CHLOROFORM; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GARLIC EXTRACT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

ARTICLE; CELL ADHESION; CELL LINE; CELL SURFACE; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; GENE ACTIVATION; HUMAN; HUMAN CELL; MONOCYTE; PROTEIN EXPRESSION; UMBILICAL VEIN ENDOTHELIAL CELL;

ANTI-INFLAMMATORY AGENTS; CELL ADHESION; CELLS, CULTURED; E-SELECTIN; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; GARLIC; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; MONOCYTES; NF-KAPPA B; PLANT EXTRACTS; PROTEIN TRANSPORT; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA; UMBILICAL VEINS; VASCULAR CELL ADHESION MOLECULE-1;

ALLIUM NIGRUM; ALLIUM SATIVUM;

EID: 78650638894     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3230     Document Type: Article

References (23)

1. Alpers DH., 2009. Garlic and its potential for prevention of colorectal cancer and other conditions. Curr Opin Gastroenterol 25: 116-121.
2. Bordia T, Mohammed N, Thomson M., 1996. An evaluation of garlic and onion as antithrombotic agents. Protaglandins Leukot Essent Fatty Acids 54: 183-186.
3. Cellini L, Campli ED, Masulli M., 1996. Inhibition of Helicobacter pylori by garlic extracts (Allium sativum). FEMS Immunol Med Microbiol 13: 273-277.
4. Chen JW, Chen YH, Lin FY, Chen YL, Lin SJ., 2003. Ginkgo biloba extract inhibits tumor necrosis factor-α-induced reactive oxygen species generation, transcription factor activation, and cell adhesion molecule expression in human aortic endothelial cells. Arterioscler Thromb Vasc Biol 23: 1559-1566.
5. Chen JW, Lin FY, Chen YH, Wu TC, Chen YL, Lin SJ., 2004. Carvedilol inhibits tumor necrosis factor-alpha-induced endothelial transcription factor activation, adhesion molecule expression, and adhesiveness to human mononuclear cells. Arterioscler Thromb Vasc Biol 24: 2075-2081.
6. Collins T., 1993. Endothelial nuclear factor-kappa B and the initiation of the atherosclerotic lesion. Lab Invest 68: 499-508.
7. Collins T, Cybulsky MI., 2001. NF-κB: pivotal mediator or innocent bystander in atherogenesis? J Clin Invest 107: 255-264.
8. Cybulsky MI, Gimbrone MA Jr,. 1991. Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. Science 251: 788-791.
9. Hodge G, Hodge S, Han P., 2002. Allium sativum (garlic) suppresses leukocyte inflammatory cytokine production in vitro: potential therapeutic use in the treatment of inflammatory bowel disease. Cytometry 48: 209-215.
10. Iiyama K, Hajra L, Iiyama M, et al,. 1999. Patterns of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 expression in rabbit and mouse atherosclerotic lesions and at sites predisposed to lesion formation. Circ Res 85: 199-207.
11. Libby P, Ridker PM, Maseri A., 2002. Inflammation and atherosclerosis. Circulation 105: 1135-1143.
12. Lusis AJ., 2000. Atherosclerosis. Nature 407: 233-241.
13. Marui N, Offermann MK, Swerlick R, et al,. 1993. Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant sensitive mechanism in human vascular endothelial cells. J Clin Invest 92: 1866-1874.
14. Mcmahon FG, Vargas R., 1993. Can garlic lower blood pressure? A pilot study. Pharmacotherapy 13: 406-407.
15. Meier B, Radeke HH, Selle S, et al,. 1989. Human fibroblasts release reactive oxygen species in response to interleukin-1 or tumour necrosis factor-alpha. Biochem J 263: 539-545.
16. Patya M, Zahalka MA, Vanichkin A, et al,. 2004. Allicin stimulates lymphocytes and elicits an antitumor effect: a possible role of p21ras. Int Immunol 16: 275-281.
17. Paoletti R, Gotto AM Jr, /SNM>, Hajjar DP., 2004. Inflammation in atherosclerosis and implications for therapy. Circulation 109 (23 Suppl 1): III 20-26.
18. Ross R., 1999. Atherosclerosis: an inflammatory disease. N Engl J Med 340: 115-126.
19. Springer TA., 1994. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76: 301-314.
20. Thomson M, Ali M., 2003. Garlic [Allium sativum]: a review of its potential use as an anti-cancer agent. Curr Cancer Drug Targets 3: 67-81.
21. Weber C, Erl W, Pietsch A, Strobel M, Ziegler-Heitbrock HW, Weber PC., 1994. Antioxidants inhibit monocyte adhesion by suppressing nuclear factor-kappa B mobilization and induction of vascular cell adhesion molecule-1 in endothelial cells stimulated to generate radicals. Arterioscler Thromb 14: 1665-1673.
22. Wolle J, Hill RR, Ferguson E, et al,. 1996. Selective inhibition of tumor necrosis factor-induced vascular cell adhesion molecule-1 gene expression by a novel flavonoid. Lack of effect on transcription factor NF-kappa B. Arteriosclerosis Arterioscler Thromb Vasc Biol 16: 1501-1508.
23. Yeh YY, Yeh SM., 1994. Garlic reduces plasma lipids by inhibiting hepatic cholesterol and triacylglycerol synthesis. Lipids 29: 189-193.