Short-term heating reduces the anti-inflammatory effects of fresh raw garlic extracts on the LPS-induced production of NO and pro-inflammatory cytokines by downregulating allicin activity in RAW 264.7 macrophages

Food and Chemical Toxicology

Volumn 58, Issue , 2013, Pages 545-551

  Shin, Jung Hye ^b   Ryu, Ji Hyeon ^a   Kang, Min Jung ^b   Hwang, Cho Rong ^b   Han, Jaehee ^a   Kang, Dawon ^a  

^a Gyeongsang National University School of Medicine   (South Korea)

^b Garlic Research Institute   (South Korea)

Author keywords

Allicin; Cytokines; Garlic; Heme oxygenase 1; Nitric oxide

Indexed keywords

ALLICIN; CYTOKINE; FRESH RAW GARLIC EXTRACT; GARLIC EXTRACT; HEATED RAW GARLIC EXTRACT; HEME OXYGENASE 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; NITRIC OXIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL STRAIN RAW 264.7; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; DRUG ISOLATION; ENZYME ACTIVITY; HEATING; MACROPHAGE; NONHUMAN; PROTEIN INDUCTION; TEMPERATURE; UPREGULATION; WESTERN BLOTTING;

ALLICIN; CYTOKINES; FRESH RAW GARLIC EXTRACT; FRGE; GARLIC; HEATED RAW GARLIC EXTRACT; HEME OXYGENASE-1; HO-1; HRGE; INDUCIBLE NITRIC OXIDE SYNTHASE; INOS; NITRIC OXIDE; NO; TNF-Α; TUMOR NECROSIS FACTOR-Α;

ANIMALS; CELL LINE; CYTOKINES; DOWN-REGULATION; GARLIC; HOT TEMPERATURE; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NITRIC OXIDE; PLANT EXTRACTS; SULFINIC ACIDS;

ALLIUM SATIVUM;

EID: 84879841829     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.04.002     Document Type: Article

References (34)

1. Akgul B., Lin K.W., Ou Yang H.M., Chen Y.H., Lu T.H., Chen C.H., Kikuchi T., Chen Y.T., Tu C.P. Garlic accelerates red blood cell turnover and splenic erythropoietic gene expression in mice: evidence for erythropoietin-independent erythropoiesis. PLoS One 2010, 5:e15358.
2. Ankri S., Miron T., Rabinkov A., Wilchek M., Mirelman D. Allicin from garlic strongly inhibits cysteine proteinases and cytopathic effects of Entamoeba histolytica. Antimicrob. Agents Chemother. 1997, 41:2286-2288.
3. Block E. The chemistry of garlic and onions. Sci. Am. 1985, 252:114-119.
4. Dirsch V.M., Kiemer A.K., Wagner H., Vollmar A.M. Effect of allicin and ajoene, two compounds of garlic, on inducible nitric oxide synthase. Atherosclerosis 1998, 139:333-339.
5. Dwyer-Nield L.D., Srebernak M.C., Barrett B.S., Ahn J., Cosper P., Meyer A.M., Kisley L.R., Bauer A.K., Thompson D.C., Malkinson A.M. Cytokines differentially regulate the synthesis of prostanoid and nitric oxide mediators in tumorigenic versus non-tumorigenic mouse lung epithelial cell lines. Carcinogenesis 2005, 26:1196-1206.
6. Farombi E.O., Surh Y.J. Heme oxygenase-1 as a potential therapeutic target for hepatoprotection. J. Biochem. Mol. Biol. 2006, 39:479-491.
7. Hald A., Rono B., Lund L.R., Egerod K.L. LPS counter regulates RNA expression of extracellular proteases and their inhibitors in murine macrophages. Mediators Inflamm. 2012, 2012:157894.
8. Imai J., Ide N., Nagae S., Moriguchi T., Matsuura H., Itakura Y. Antioxidant and radical scavenging effects of aged garlic extract and its constituents. Planta Med. 1994, 60:417-420.
9. Kitasato A., Tajima Y., Kuroki T., Tsutsumi R., Adachi T., Mishima T., Kanematsu T. Inflammatory cytokines promote inducible nitric oxide synthase-mediated DNA damage in hamster gallbladder epithelial cells. World J. Gastroenterol. 2007, 13:6379-6384.
10. Kobayashi Y. The regulatory role of nitric oxide in proinflammatory cytokine expression during the induction and resolution of inflammation. J. Leukoc. Biol. 2010, 88:1157-1162.
11. Lang A., Lahav M., Sakhnini E., Barshack I., Fidder H.H., Avidan B., Bardan E., Hershkoviz R., Bar-Meir S., Chowers Y. Allicin inhibits spontaneous and TNF-alpha induced secretion of proinflammatory cytokines and chemokines from intestinal epithelial cells. Clin. Nutr. 2004, 23:1199-1208.
12. Lee Y.J., Eun J.R. Cilostazol decreases ethanol-mediated TNFalpha expression in RAW264.7 murine macrophage and in liver from binge drinking mice. Korean J. Physiol. Pharmacol. 2012, 16:131-138.
13. Lee Y.M., Gweon O.C., Seo Y.J., Im J., Kang M.J., Kim M.J., Kim J.I. Antioxidant effect of garlic and aged black garlic in animal model of type 2 diabetes mellitus. Nutr. Res. Pract. 2009, 3:156-161.
14. Lee S.J., Shin J.H., Kang M.J., Jung W.J., Ryu J.H., Kim R.J., Sung N.J. Antioxidants activity of aged red garlic. J. Life Sci. 2010, 20:775-781.
15. Lee J.W., Bae C.J., Choi Y.J., Kim S.I., Kim N.H., Lee H.J., Kim S.S., Kwon Y.S., Chun W. 3,4,5-Trihydroxycinnamic acid inhibits LPS-induced iNOS expression by suppressing NF-kappaB activation in BV2 microglial cells. Korean J. Physiol. Pharmacol. 2012, 16:107-112.
16. Li X.H., Li C.Y., Xiang Z.G., Hu J.J., Lu J.M., Tian R.B., Jia W. Allicin ameliorates cardiac hypertrophy and fibrosis through enhancing of Nrf2 antioxidant signaling pathways. Cardiovasc. Drugs Ther. 2012, 26:457-465.
17. Li Volti G., Sacerdoti D., Di Giacomo C., Barcellona M.L., Scacco A., Murabito P., Biondi A., Basile F., Gazzolo D., Abella R., Frigiola A., Galvano F. Natural heme oxygenase-1 inducers in hepatobiliary function. World J. Gastroenterol. 2008, 14:6122-6132.
18. Luz Sanz M., Corzo-Martinez M., Rastall R.A., Olano A., Moreno F.J. Characterization and in vitro digestibility of bovine beta-lactoglobulin glycated with galactooligosaccharides. J. Agric. Food Chem. 2007, 55:7916-7925.
19. Miron T., Shin I., Feigenblat G., Weiner L., Mirelman D., Wilchek M., Rabinkov A. A spectrophotometric assay for allicin, alliin, and alliinase (alliin lyase) with a chromogenic thiol: reaction of 4-mercaptopyridine with thiosulfinates. Anal. Biochem. 2002, 307:76-83.
20. Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB J. 1992, 6:3051-3064.
21. Nguyen M.T., Chen A., Lu W.J., Fan W., Li P.P., Oh da Y., Patsouris D. Regulation of chemokine and chemokine receptor expression by PPARgamma in adipocytes and macrophages. PLoS One 2012, 7:e34976.
22. Otterbein L.E., Soares M.P., Yamashita K., Bach F.H. Heme oxygenase-1: unleashing the protective properties of heme. Trends Immunol. 2003, 24:449-455.
23. Pae H.O., Chung H.T. Heme oxygenase-1: its therapeutic roles in inflammatory diseases. Immune Netw. 2009, 9:12-19.
24. Paine A., Eiz-Vesper B., Blasczyk R., Immenschuh S. Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential. Biochem. Pharmacol. 2010, 80:1895-1903.
25. Pan C.H., Kim E.S., Jung S.H., Nho C.W., Lee J.K. Tectorigenin inhibits IFN-gamma/LPS-induced inflammatory responses in murine macrophage RAW 264.7 cells. Arch. Pharm. Res. 2008, 31:1447-1456.
26. Park H.J., Jeon B.T., Kim H.C., Roh G.S., Shin J.H., Sung N.J., Han J., Kang D. Aged red garlic extract reduces lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages and acute pulmonary inflammation through haeme oxygenase-1 induction. Acta Physiol. (Oxf.) 2012, 205:61-70.
27. Petrovska B.B., Cekovska S. Extracts from the history and medical properties of garlic. Pharmacogn. Rev. 2010, 4:106-110.
28. Sigala I., Zacharatos P., Boulia S., Toumpanakis D., Michailidou T., Parthenis D., Roussos C., Papapetropoulos A., Hussain S.N., Vassilakopoulos T. Nitric oxide regulates cytokine induction in the diaphragm in response to inspiratory resistive breathing. J. Appl. Physiol. 2012, 113:1594-1603.
29. Tian B., Liu J., Bitterman P.B., Bache R.J. Mechanisms of cytokine induced NO-mediated cardiac fibroblast apoptosis. Am. J. Physiol. Heart Circ. Physiol. 2002, 283:H1958-H1967.
30. Tsoyi K., Kim H.J., Shin J.S., Kim D.H., Cho H.J., Lee S.S., Ahn S.K., Yun-Choi H.S., Lee J.H., Seo H.G., Chang K.C. HO-1 and JAK-2/STAT-1 signals are involved in preferential inhibition of iNOS over COX-2 gene expression by newly synthesized tetrahydroisoquinoline alkaloid, CKD712, in cells activated with lipopolysacchride. Cell. Signal. 2008, 20:1839-1847.
31. van Rooijen N., Sanders A. Elimination, blocking, and activation of macrophages: three of a kind?. J. Leukoc. Biol. 1997, 62:702-709.
32. Velmurugan K., Alam J., McCord J.M., Pugazhenthi S. Synergistic induction of heme oxygenase-1 by the components of the antioxidant supplement Protandim. Free Radic. Biol. Med. 2009, 46:430-440.
33. Wu M.L., Ho Y.C., Lin C.Y., Yet S.F. Heme oxygenase-1 in inflammation and cardiovascular disease. Am. J. Cardiovasc. Dis. 2011, 1:150-158.
34. Yu T., Wu C. Stability of allicin in garlic juice. J. Food Sci. 1989, 54:977-981.