3,4,5-Trihydroxycinnamic acid inhibits LPS-induced iNOS expression by suppressing NF-κB activation in BV2 microglial cells

Korean Journal of Physiology and Pharmacology

Volumn 16, Issue 2, 2012, Pages 107-112

  Lee, Jae Won ^a   Bae, Chang Jun ^b,c   Choi, Yong Jun ^a   Kim, Song In ^a   Kim, Nam Ho ^a   Lee, Hee Jae ^a   Kim, Sung Soo ^a   Kwon, Yong Soo ^a   Chun, Wanjoo ^a  

^a Kangwon National University   (South Korea)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^c Seoul National University   (South Korea)

Author keywords

3,4,5 Trihydroxycinnamic acid (THC); BV2 microglial cells; iNOS; Lipopolysaccharide; NF B

Indexed keywords

3,4,5 TRIHYDROXYCINNAMIC ACID; CINNAMIC ACID DERIVATIVE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; NITRIC OXIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; MICROGLIA; PROTEIN EXPRESSION;

EID: 84861016739     PISSN: 12264512     EISSN: None     Source Type: Journal    
DOI: 10.4196/kjpp.2012.16.2.107     Document Type: Article

References (28)

1. Sugama S. Stress-induced microglial activation may facilitate the progression of neurodegenerative disorders. Med Hypotheses. 2009;73:1031-1034.
2. Perry VH, Gordon S. Macrophages and microglia in the nervous system. Trends Neurosci. 1988;11:273-277.
3. Hailer NP. Immunosuppression after traumatic or ischemic CNS damage: it is neuroprotective and illuminates the role of microglial cells. Prog Neurobiol. 2008;84:211-233.
4. Itagaki S, McGeer PL, Akiyama H, Zhu S, Selkoe D. Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease. J Neuroimmunol. 1989;24:173-182. (Pubitemid 19271472)
5. Matsumoto H. Some markers reflecting the pathology and disease activity of multiple sclerosis. No To Shinkei. 1992;44:95-102.
6. McGeer PL, McGeer EG. Glial cell reactions in neurodegenerative diseases: pathophysiology and therapeutic interventions. Alzheimer Dis Assoc Disord. 1998;12 Suppl 2:S1-6.
7. Tuttolomondo A, Di Raimondo D, di Sciacca R, Pinto A, Licata G. Inflammatory cytokines in acute ischemic stroke. Curr Pharm Des. 2008;14:3574-3589.
8. Merrill JE, Benveniste EN. Cytokines in inflammatory brain lesions: helpful and harmful. Trends Neurosci. 1996;19:331-338. (Pubitemid 26349062)
9. Chao CC, Hu S, Close K, Choi CS, Molitor TW, Novick WJ, Peterson PK. Cytokine release from microglia: differential inhibition by pentoxifylline and dexamethasone. J Infect Dis. 1992;166:847-853.
10. Lee IS, Lim J, Gal J, Kang JC, Kim HJ, Kang BY, Choi HJ. Anti-inflammatory activity of xanthohumol involves heme oxygenase-1 induction via NRF2-ARE signaling in microglial BV2 cells. Neurochem Int. 2011;58:153-160.
11. Steinbrecher T, Hrenn A, Dormann KL, Merfort I, Labahn A. Bornyl (3,4,5-trihydroxy)-cinnamate-an optimized human neutrophil elastase inhibitor designed by free energy calculations. Bioorg Med Chem. 2008;16:2385-2390. (Pubitemid 351380947)
12. Nagasaka R, Chotimarkorn C, Shafiqul IM, Hori M, Ozaki H, Ushio H. Anti-inflammatory effects of hydroxycinnamic acid derivatives. Biochem Biophys Res Commun. 2007;358:615-619. (Pubitemid 46755749)
13. Kim YC. Neuroprotective phenolics in medicinal plants. Arch Pharm Res. 2010;33:1611-1632.
14. Lee JW, Cheong IY, Kim HS, Lee JJ, Lee YS, Kwon YS, Kim MJ, Lee HJ, Kim SS, Chun W. Anti-inflammatory activity of 1-docosanoyl cafferate isolated from rhus verniciflua in LPS-stimulated BV2 microglial cells. Korean J Physiol Pharmacol. 2011;15:9-15.
15. Lee Y, Shin DH, Kim JH, Hong S, Choi D, Kim YJ, Kwak MK, Jung Y. Caffeic acid phenethyl ester-mediated Nrf2 activation and IkappaB kinase inhibition are involved in NFkappaB inhibitory effect: structural analysis for NFkappaB inhibition. Eur J Pharmacol. 2010;643:21-28.
16. Rabe C, Steenkamp JA, Joubert E, Burger JF, Ferreira D. Phenolic metabolites from rooibos tea (Aspalathus linearis). Phytochem. 1994;35:1559-1565. (Pubitemid 2067932)
17. Ock J, Kim S, Suk K. Anti-inflammatory effects of a fluorovinyloxyacetamide compound KT-15087 in microglia cells. Pharmacol Res. 2009;59:414-422.
18. Zheng LT, Ryu GM, Kwon BM, Lee WH, Suk K. Anti-inflammatory effects of catechols in lipopolysaccharide- stimulated microglia cells: inhibition of microglial neurotoxicity. Eur J Pharmacol. 2008;588:106-113.
19. Kreutzberg GW. Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 1996;19:312-318. (Pubitemid 26349059)
20. Graeber MB, Streit WJ. Microglia: biology and pathology. Acta Neuropathol. 2010;119:89-105.
21. Aquilano K, Baldelli S, Rotilio G, Ciriolo MR. Role of nitric oxide synthases in Parkinson's disease: a review on the antioxidant and anti-inflammatory activity of polyphenols. Neurochem Res. 2008;33:2416-2426.
22. Ray B, Lahiri DK. Neuroinflammation in Alzheimer's disease: different molecular targets and potential therapeutic agents including curcumin. Curr Opin Pharmacol. 2009;9:434-444.
23. Kuprash DV, Udalova IA, Turetskaya RL, Rice NR, Nedospasov SA. Conserved kappa B element located downstream of the tumor necrosis factor alpha gene: distinct NF-kappa B binding pattern and enhancer activity in LPS activated murine macrophages. Oncogene. 1995;11:97-106.
24. Siebenlist U, Franzoso G, Brown K. Structure, regulation and function of NF-kappa B. Annu Rev Cell Biol. 1994;10:405-455.
25. Li Q, Verma IM. NF-kappaB regulation in the immune system. Nat Rev Immunol. 2002;2:725-734.
26. Karin M, Takahashi T, Kapahi P, Delhase M, Chen Y, Makris C, Rothwarf D, Baud V, Natoli G, Guido F, Li N. Oxidative stress and gene expression: the AP-1 and NF-kappaB connections. Biofactors. 2001;15:87-89. (Pubitemid 34455067)
27. Moon DO, Park SY, Lee KJ, Heo MS, Kim KC, Kim MO, Lee JD, Choi YH, Kim GY. Bee venom and melittin reduce proinflammatory mediators in lipopolysaccharide-stimulated BV2 microglia. Int Immunopharmacol. 2007;7:1092-1101. (Pubitemid 46900911)
28. Zheng LT, Ock J, Kwon BM, Suk K. Suppressive effects of flavonoid fisetin on lipopolysaccharide-induced microglial activation and neurotoxicity. Int Immunopharmacol. 2008;8:484-494.