Sensing Cytosolic RpsL by Macrophages Induces Lysosomal Cell Death and Termination of Bacterial Infection

PLoS Pathogens

Volumn 11, Issue 3, 2015, Pages 1-23

  Zhu, Wenhan ^a   Tao, Lili ^a,b   Quick, Marsha L ^c   Joyce, Johanna A ^c   Qu, Jie Ming ^b   Luo, Zhao Qing ^a  

^a PURDUE UNIVERSITY   (United States)

^b FUDAN UNIVERSITY   (China)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 11; CASPASE 3; CASPASE 7; CATHEPSIN B; INTERLEUKIN 1BETA CONVERTING ENZYME; LACTATE DEHYDROGENASE; PROTEIN BID; RIBOSOME PROTEIN; RIBOSOME PROTEIN RPSL; STREPTOMYCIN; UNCLASSIFIED DRUG; BACTERIAL PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; BACTERIAL CLEARANCE; BACTERIAL GROWTH; CELL DEATH; CONTROLLED STUDY; FEMALE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; LEGIONELLA PNEUMOPHILA; LEGIONNAIRE DISEASE; LYSOSOME; MACROPHAGE; MEMBRANE PERMEABILITY; MINIMUM INHIBITORY CONCENTRATION; MOUSE; MUTATION; NICK END LABELING; NONHUMAN; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; CYTOSOL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; MICROBIOLOGY; TUNEL ASSAY;

BACTERIA (MICROORGANISMS); LEGIONELLA PNEUMOPHILA;

ANIMALS; BACTERIAL PROTEINS; CELL DEATH; CYTOSOL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; LEGIONELLA PNEUMOPHILA; LEGIONNAIRES' DISEASE; LYSOSOMES; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RIBOSOMAL PROTEINS;

EID: 84926461892     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1004704     Document Type: Article

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