-
2
-
-
84901594345
-
Hypoxia and the extracellular matrix: Drivers of tumour metastasis
-
Gilkes DM, Semenza GL, Wirtz D. Hypoxia and the extracellular matrix: drivers of tumour metastasis. Nat Rev Cancer 2014.
-
(2014)
Nat Rev Cancer
-
-
Gilkes, D.M.1
Semenza, G.L.2
Wirtz, D.3
-
3
-
-
78649364332
-
Hypoxia-inducible factors and the response to hypoxic stress
-
Majmundar AJ, Wong WJ, Simon MC. Hypoxia-inducible factors and the response to hypoxic stress. Mol Cell 2010; 40(2): 294-309.
-
(2010)
Mol Cell
, vol.40
, Issue.2
, pp. 294-309
-
-
Majmundar, A.J.1
Wong, W.J.2
Simon, M.C.3
-
4
-
-
84856739946
-
Hypoxia-inducible factors in physiology and medicine
-
Semenza GL. Hypoxia-inducible factors in physiology and medicine. Cell 2012; 148(3): 399-408.
-
(2012)
Cell
, vol.148
, Issue.3
, pp. 399-408
-
-
Semenza, G.L.1
-
5
-
-
84873160542
-
Hypoxia-inducing factors as master regulators of stemness properties and altered metabolism of cancer-and metastasis-initiating cells
-
Mimeault M, Batra SK. Hypoxia-inducing factors as master regulators of stemness properties and altered metabolism of cancer-and metastasis-initiating cells. J Cellular Mole Med 2013; 17(1): 30-54.
-
(2013)
J Cellular Mole Med
, vol.17
, Issue.1
, pp. 30-54
-
-
Mimeault, M.1
Batra, S.K.2
-
6
-
-
0029051439
-
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
-
Wang GL, Jiang BH, Rue EA, Semenza GL. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA 1995; 92(12): 5510-4.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, Issue.12
, pp. 5510-5514
-
-
Wang, G.L.1
Jiang, B.H.2
Rue, E.A.3
Semenza, G.L.4
-
7
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003; 3(10): 721-32.
-
(2003)
Nat Rev Cancer
, vol.3
, Issue.10
, pp. 721-732
-
-
Semenza, G.L.1
-
8
-
-
0032493368
-
Regulation of hypoxiainducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway
-
Huang LE, Gu J, Schau M, Bunn HF. Regulation of hypoxiainducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc Natl Acad Sci USA 1998; 95(14): 7987-92.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, Issue.14
, pp. 7987-7992
-
-
Huang, L.E.1
Gu, J.2
Schau, M.3
Bunn, H.F.4
-
9
-
-
0242298321
-
Tatbinding protein-1, a component of the 26S proteasome, contributes to the E3 ubiquitin ligase function of the von Hippel-Lindau protein
-
Corn PG, McDonald ER, 3rd, Herman JG, El-Deiry WS. Tatbinding protein-1, a component of the 26S proteasome, contributes to the E3 ubiquitin ligase function of the von Hippel-Lindau protein. Nat Genetics 2003; 35(3): 229-37.
-
(2003)
Nat Genetics
, vol.35
, Issue.3
, pp. 229-237
-
-
Corn, P.G.1
McDonald, E.R.2
Herman, J.G.3
El-Deiry, W.S.4
-
10
-
-
0033776536
-
Ubiquitination of hypoxiainducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein
-
Ohh M, Park CW, Ivan M, et al. Ubiquitination of hypoxiainducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat Cell Biol 2000; 2(7): 423-7.
-
(2000)
Nat Cell Biol
, vol.2
, Issue.7
, pp. 423-427
-
-
Ohh, M.1
Park, C.W.2
Ivan, M.3
-
11
-
-
84873050284
-
Regulatory networks defining EMT during cancer initiation and progression
-
De Craene B, Berx G. Regulatory networks defining EMT during cancer initiation and progression. Nat Rev Cancer 2013; 13(2): 97-110.
-
(2013)
Nat Rev Cancer
, vol.13
, Issue.2
, pp. 97-110
-
-
De Craene, B.1
Berx, G.2
-
12
-
-
44449144396
-
Epithelial-mesenchymal transition: At the crossroads of development and tumor metastasis
-
Yang J, Weinberg RA. Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Developmental Cell 2008; 14(6): 818-29.
-
(2008)
Developmental Cell
, vol.14
, Issue.6
, pp. 818-829
-
-
Yang, J.1
Weinberg, R.A.2
-
13
-
-
70450198396
-
Epithelialmesenchymal transitions in development and disease
-
Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelialmesenchymal transitions in development and disease. Cell 2009; 139(5): 871-90.
-
(2009)
Cell
, vol.139
, Issue.5
, pp. 871-890
-
-
Thiery, J.P.1
Acloque, H.2
Huang, R.Y.3
Nieto, M.A.4
-
14
-
-
84876668732
-
Novel evidence demonstrates that epithelial-mesenchymal transition contributes to nephrolithiasisinduced renal fibrosis
-
Liu M, Liu YZ, Feng Y, et al. Novel evidence demonstrates that epithelial-mesenchymal transition contributes to nephrolithiasisinduced renal fibrosis. J Surgical Res 2013; 182(1): 146-52.
-
(2013)
J Surgical Res
, vol.182
, Issue.1
, pp. 146-152
-
-
Liu, M.1
Liu, Y.Z.2
Feng, Y.3
-
15
-
-
84894593599
-
Molecular mechanisms of epithelial-mesenchymal transition
-
Lamouille S, Xu J, Derynck R. Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mole Cell Biol 2014; 15(3): 178-96.
-
(2014)
Nat Rev Mole Cell Biol
, vol.15
, Issue.3
, pp. 178-196
-
-
Lamouille, S.1
Xu, J.2
Derynck, R.3
-
16
-
-
47749131186
-
TWIST activation by hypoxia inducible factor-1 (HIF-1): Implications in metastasis and development
-
Yang MH, Wu KJ. TWIST activation by hypoxia inducible factor-1 (HIF-1): implications in metastasis and development. Cell Cycle 2008; 7(14): 2090-6.
-
(2008)
Cell Cycle
, vol.7
, Issue.14
, pp. 2090-2096
-
-
Yang, M.H.1
Wu, K.J.2
-
17
-
-
70449527638
-
Hypoxia, Snail and incomplete epithelial-mesenchymal transition in breast cancer
-
Lundgren K, Nordenskjold B, Landberg G. Hypoxia, Snail and incomplete epithelial-mesenchymal transition in breast cancer. Br J Cancer 2009; 101(10): 1769-81.
-
(2009)
Br J Cancer
, vol.101
, Issue.10
, pp. 1769-1781
-
-
Lundgren, K.1
Nordenskjold, B.2
Landberg, G.3
-
18
-
-
84865169224
-
Epigenetic reprogramming and post-transcriptional regulation during the epithelialmesenchymal transition
-
Wu CY, Tsai YP, Wu MZ, Teng SC, Wu KJ. Epigenetic reprogramming and post-transcriptional regulation during the epithelialmesenchymal transition. Trends in genetics : TIG 2012; 28: 454-63.
-
(2012)
Trends in Genetics : TIG
, vol.28
, pp. 454-463
-
-
Wu, C.Y.1
Tsai, Y.P.2
Wu, M.Z.3
Teng, S.C.4
Wu, K.J.5
-
19
-
-
84877157115
-
Wnt/beta-catenin signaling enhances hypoxia-induced epithelial-mesenchymal transition in hepatocellular carcinoma via crosstalk with hif-1alpha signaling
-
Zhang Q, Bai X, Chen W, et al. Wnt/beta-catenin signaling enhances hypoxia-induced epithelial-mesenchymal transition in hepatocellular carcinoma via crosstalk with hif-1alpha signaling. Carcinogenesis 2013; 34(5): 962-73.
-
(2013)
Carcinogenesis
, vol.34
, Issue.5
, pp. 962-973
-
-
Zhang, Q.1
Bai, X.2
Chen, W.3
-
20
-
-
84876515764
-
Epigenetic control of epithelial-mesenchymal-transition in human cancer
-
Kiesslich T, Pichler M, Neureiter D. Epigenetic control of epithelial-mesenchymal-transition in human cancer. Mol Clin Oncol 2013; 1(1): 3-11.
-
(2013)
Mol Clin Oncol
, vol.1
, Issue.1
, pp. 3-11
-
-
Kiesslich, T.1
Pichler, M.2
Neureiter, D.3
-
21
-
-
80054788317
-
Histone modifiers in cancer: Friends or foes?
-
Cohen I, Poreba E, Kamieniarz K, Schneider R. Histone modifiers in cancer: friends or foes? Genes Cancer 2011; 2(6): 631-47.
-
(2011)
Genes Cancer
, vol.2
, Issue.6
, pp. 631-647
-
-
Cohen, I.1
Poreba, E.2
Kamieniarz, K.3
Schneider, R.4
-
22
-
-
84901311713
-
Uncoupling transcription from covalent histone modification
-
Zhang H, Gao L, Anandhakumar J, Gross DS. Uncoupling transcription from covalent histone modification. PLoS Genet 2014; 10(4): e1004202.
-
(2014)
Plos Genet
, vol.10
, Issue.4
-
-
Zhang, H.1
Gao, L.2
Anandhakumar, J.3
Gross, D.S.4
-
23
-
-
84887440904
-
SUMOylation negatively modulates target gene occupancy of the KDM5B, a histone lysine demethylase
-
Bueno MT, Richard S. SUMOylation negatively modulates target gene occupancy of the KDM5B, a histone lysine demethylase. Epigenetics : official J DNA Methylation Soc 2013; 8(11): 1162-75.
-
(2013)
Epigenetics : Official J DNA Methylation Soc
, vol.8
, Issue.11
, pp. 1162-1175
-
-
Bueno, M.T.1
Richard, S.2
-
24
-
-
34547890019
-
Functions of site-specific histone acetylation and deacetylation
-
Shahbazian MD, Grunstein M. Functions of site-specific histone acetylation and deacetylation. Ann Rev Biochem 2007; 76: 75-100.
-
(2007)
Ann Rev Biochem
, vol.76
, pp. 75-100
-
-
Shahbazian, M.D.1
Grunstein, M.2
-
25
-
-
0035467951
-
Histone acetylation/deacetylation and cancer: An "open" and "shut" case?
-
Gray SG, Teh BT. Histone acetylation/deacetylation and cancer: an "open" and "shut" case? Curr Mol Med 2001; 1(4): 401-29.
-
(2001)
Curr Mol Med
, vol.1
, Issue.4
, pp. 401-429
-
-
Gray, S.G.1
Teh, B.T.2
-
26
-
-
84895925247
-
Context-specific regulation of cancer epigenomes by histone and transcription factor methylation
-
Sarris M, Nikolaou K, Talianidis I. Context-specific regulation of cancer epigenomes by histone and transcription factor methylation. Oncogene 2014; 33(10): 1207-17.
-
(2014)
Oncogene
, vol.33
, Issue.10
, pp. 1207-1217
-
-
Sarris, M.1
Nikolaou, K.2
Talianidis, I.3
-
27
-
-
33847070442
-
The role of chromatin during transcription
-
Li B, Carey M, Workman JL. The role of chromatin during transcription. Cell 2007; 128(4): 707-19.
-
(2007)
Cell
, vol.128
, Issue.4
, pp. 707-719
-
-
Li, B.1
Carey, M.2
Workman, J.L.3
-
28
-
-
79961023271
-
Genomescale epigenetic reprogramming during epithelial-to-mesenchymal transition
-
McDonald OG, Wu H, Timp W, Doi A, Feinberg AP. Genomescale epigenetic reprogramming during epithelial-to-mesenchymal transition. Nat Structural Mol Biol 2011; 18(8): 867-74.
-
(2011)
Nat Structural Mol Biol
, vol.18
, Issue.8
, pp. 867-874
-
-
McDonald, O.G.1
Wu, H.2
Timp, W.3
Doi, A.4
Feinberg, A.P.5
-
29
-
-
80052221592
-
Interplay between HDAC3 and WDR5 is essential for hypoxia-induced epithelial-mesenchymal transition
-
Wu MZ, Tsai YP, Yang MH, et al. Interplay between HDAC3 and WDR5 is essential for hypoxia-induced epithelial-mesenchymal transition. Mol Cell 2011; 43(5): 811-22.
-
(2011)
Mol Cell
, vol.43
, Issue.5
, pp. 811-822
-
-
Wu, M.Z.1
Tsai, Y.P.2
Yang, M.H.3
-
30
-
-
77950473704
-
A chromodomain switch mediated by histone H3 Lys 4 acetylation regulates heterochromatin assembly
-
Xhemalce B, Kouzarides T. A chromodomain switch mediated by histone H3 Lys 4 acetylation regulates heterochromatin assembly. Genes Development 2010; 24(7): 647-52.
-
(2010)
Genes Development
, vol.24
, Issue.7
, pp. 647-652
-
-
Xhemalce, B.1
Kouzarides, T.2
-
31
-
-
34547909260
-
HDAC3: Taking the SMRT-N-CoRrect road to repression
-
Karagianni P, Wong J. HDAC3: taking the SMRT-N-CoRrect road to repression. Oncogene 2007; 26(37): 5439-49.
-
(2007)
Oncogene
, vol.26
, Issue.37
, pp. 5439-5449
-
-
Karagianni, P.1
Wong, J.2
-
32
-
-
20444417108
-
WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development
-
Wysocka J, Swigut T, Milne TA, et al. WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development. Cell 2005; 121(6): 859-72.
-
(2005)
Cell
, vol.121
, Issue.6
, pp. 859-872
-
-
Wysocka, J.1
Swigut, T.2
Milne, T.A.3
-
33
-
-
76249122462
-
WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kappaB activation
-
Wang YY, Liu LJ, Zhong B, et al. WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kappaB activation. Proc Natl Acad Sci USA 2010; 107(2): 815-20.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, Issue.2
, pp. 815-820
-
-
Wang, Y.Y.1
Liu, L.J.2
Zhong, B.3
-
34
-
-
79954414897
-
Wdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network
-
Ang YS, Tsai SY, Lee DF, et al. Wdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network. Cell 2011; 145(2): 183-97.
-
(2011)
Cell
, vol.145
, Issue.2
, pp. 183-197
-
-
Ang, Y.S.1
Tsai, S.Y.2
Lee, D.F.3
-
35
-
-
69449102464
-
Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes
-
Wang Z, Zang C, Cui K, et al. Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes. Cell 2009; 138(5): 1019-31.
-
(2009)
Cell
, vol.138
, Issue.5
, pp. 1019-1031
-
-
Wang, Z.1
Zang, C.2
Cui, K.3
-
36
-
-
64249111489
-
Dimethylation of H3K4 by Set1 recruits the Set3 histone deacetylase complex to 5' transcribed regions
-
Kim T, Buratowski S. Dimethylation of H3K4 by Set1 recruits the Set3 histone deacetylase complex to 5' transcribed regions. Cell 2009; 137(2): 259-72.
-
(2009)
Cell
, vol.137
, Issue.2
, pp. 259-272
-
-
Kim, T.1
Buratowski, S.2
-
37
-
-
33646070846
-
A bivalent chromatin structure marks key developmental genes in embryonic stem cells
-
Bernstein BE, Mikkelsen TS, Xie X, et al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 2006; 125(2): 315-26.
-
(2006)
Cell
, vol.125
, Issue.2
, pp. 315-326
-
-
Bernstein, B.E.1
Mikkelsen, T.S.2
Xie, X.3
-
38
-
-
84879983245
-
Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity
-
Chaffer CL, Marjanovic ND, Lee T, et al. Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity. Cell 2013; 154(1): 61-74.
-
(2013)
Cell
, vol.154
, Issue.1
, pp. 61-74
-
-
Chaffer, C.L.1
Marjanovic, N.D.2
Lee, T.3
-
39
-
-
79951711112
-
Role for Dpy-30 in ES cell-fate specification by regulation of H3K4 methylation within bivalent domains
-
Jiang H, Shukla A, Wang X, Chen WY, Bernstein BE, Roeder RG. Role for Dpy-30 in ES cell-fate specification by regulation of H3K4 methylation within bivalent domains. Cell 2011; 144(4): 513-25.
-
(2011)
Cell
, vol.144
, Issue.4
, pp. 513-525
-
-
Jiang, H.1
Shukla, A.2
Wang, X.3
Chen, W.Y.4
Bernstein, B.E.5
Roeder, R.G.6
-
40
-
-
84887463065
-
Epigenetic regulation of hypoxia-responsive gene expression: Focusing on chromatin and DNA modifications
-
Tsai Y-P, Wu K-J. Epigenetic regulation of hypoxia-responsive gene expression: focusing on chromatin and DNA modifications. Int J Cancer 2014; 134: 249-56.
-
(2014)
Int J Cancer
, vol.134
, pp. 249-256
-
-
Tsai, Y.-P.1
Wu, K.-J.2
-
41
-
-
84856528807
-
Epigenetic repression of E-cadherin expression by hepatitis B virus x antigen in liver cancer
-
Arzumanyan A, Friedman T, Kotei E, Ng IO, Lian Z, Feitelson MA. Epigenetic repression of E-cadherin expression by hepatitis B virus x antigen in liver cancer. Oncogene 2012; 31(5): 563-72.
-
(2012)
Oncogene
, vol.31
, Issue.5
, pp. 563-572
-
-
Arzumanyan, A.1
Friedman, T.2
Kotei, E.3
Ng, I.O.4
Lian, Z.5
Feitelson, M.A.6
-
42
-
-
33846019277
-
Methylation of lysine 4 on histone H3: Intricacy of writing and reading a single epigenetic mark
-
Ruthenburg AJ, Allis CD, Wysocka J. Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark. Mol Cell 2007; 25(1): 15-30.
-
(2007)
Mol Cell
, vol.25
, Issue.1
, pp. 15-30
-
-
Ruthenburg, A.J.1
Allis, C.D.2
Wysocka, J.3
-
43
-
-
79953760389
-
H3 lysine 4 is acetylated at active gene promoters and is regulated by H3 lysine 4 methylation
-
Guillemette B, Drogaris P, Lin HH, et al. H3 lysine 4 is acetylated at active gene promoters and is regulated by H3 lysine 4 methylation. PLoS Genet 2011; 7(3): e1001354.
-
(2011)
Plos Genet
, vol.7
, Issue.3
-
-
Guillemette, B.1
Drogaris, P.2
Lin, H.H.3
-
44
-
-
0030606239
-
The transcriptional coactivators p300 and CBP are histone acetyltransferases
-
Ogryzko VV, Schiltz RL, Russanova V, Howard BH, Nakatani Y. The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell 1996; 87(5): 953-9.
-
(1996)
Cell
, vol.87
, Issue.5
, pp. 953-959
-
-
Ogryzko, V.V.1
Schiltz, R.L.2
Russanova, V.3
Howard, B.H.4
Nakatani, Y.5
-
45
-
-
14044257943
-
Role of CBP in regulating HIF-1-mediated activation of transcription
-
Ruas JL, Poellinger L, Pereira T. Role of CBP in regulating HIF-1-mediated activation of transcription. J Cell Sci 2005; 118(Pt 2): 301-11.
-
(2005)
J Cell Sci
, vol.118
, pp. 301-311
-
-
Ruas, J.L.1
Poellinger, L.2
Pereira, T.3
-
46
-
-
79956370722
-
Coactivators necessary for transcriptional output of the hypoxia inducible factor, HIF, are directly recruited by ARNT PAS-B
-
Partch CL, Gardner KH. Coactivators necessary for transcriptional output of the hypoxia inducible factor, HIF, are directly recruited by ARNT PAS-B. Proc Natl Acad Sci USA 2011; 108(19): 7739-44.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, Issue.19
, pp. 7739-7744
-
-
Partch, C.L.1
Gardner, K.H.2
-
48
-
-
34547635236
-
CAMP-responsive elementbinding protein regulates vascular endothelial growth factor expression: Implication in human prostate cancer bone metastasis
-
Wu D, Zhau HE, Huang WC, et al. cAMP-responsive elementbinding protein regulates vascular endothelial growth factor expression: implication in human prostate cancer bone metastasis. Oncogene 2007; 26(35): 5070-7.
-
(2007)
Oncogene
, vol.26
, Issue.35
, pp. 5070-5077
-
-
Wu, D.1
Zhau, H.E.2
Huang, W.C.3
-
49
-
-
33750466563
-
Prostate cancer metastasis: Role of the host microenvironment in promoting epithelial to mesenchymal transition and increased bone and adrenal gland metastasis
-
Xu J, Wang R, Xie ZH, et al. Prostate cancer metastasis: role of the host microenvironment in promoting epithelial to mesenchymal transition and increased bone and adrenal gland metastasis. The Prostate 2006; 66(15): 1664-73.
-
(2006)
The Prostate
, vol.66
, Issue.15
, pp. 1664-1673
-
-
Xu, J.1
Wang, R.2
Xie, Z.H.3
-
50
-
-
53249088036
-
PCAF is an HIF-1alpha cofactor that regulates p53 transcriptional activity in hypoxia
-
Xenaki G, Ontikatze T, Rajendran R, et al. PCAF is an HIF-1alpha cofactor that regulates p53 transcriptional activity in hypoxia. Oncogene 2008; 27(44): 5785-96.
-
(2008)
Oncogene
, vol.27
, Issue.44
, pp. 5785-5796
-
-
Xenaki, G.1
Ontikatze, T.2
Rajendran, R.3
-
51
-
-
25444515680
-
Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes
-
Jung SY, Malovannaya A, Wei J, O'Malley BW, Qin J. Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes. Mol Endocrinol 2005; 19(10): 2451-65.
-
(2005)
Mol Endocrinol
, vol.19
, Issue.10
, pp. 2451-2465
-
-
Jung, S.Y.1
Malovannaya, A.2
Wei, J.3
O'malley, B.W.4
Qin, J.5
-
52
-
-
67749140014
-
The p160 coactivator PAS-B motif stabilizes nuclear receptor binding and contributes to isoform-specific regulation by thyroid hormone receptors
-
Privalsky ML, Lee S, Hahm JB, Young BM, Fong RN, Chan IH. The p160 coactivator PAS-B motif stabilizes nuclear receptor binding and contributes to isoform-specific regulation by thyroid hormone receptors. J Biological Chem 2009; 284(29): 19554-63.
-
(2009)
J Biological Chem
, vol.284
, Issue.29
, pp. 19554-19563
-
-
Privalsky, M.L.1
Lee, S.2
Hahm, J.B.3
Young, B.M.4
Fong, R.N.5
Chan, I.H.6
-
53
-
-
0035846953
-
Synergistic enhancement of nuclear receptor function by p160 coactivators and two coactivators with protein methyltransferase activities
-
Koh SS, Chen D, Lee YH, Stallcup MR. Synergistic enhancement of nuclear receptor function by p160 coactivators and two coactivators with protein methyltransferase activities. J Biological Chem 2001; 276(2): 1089-98.
-
(2001)
J Biological Chem
, vol.276
, Issue.2
, pp. 1089-1098
-
-
Koh, S.S.1
Chen, D.2
Lee, Y.H.3
Stallcup, M.R.4
-
54
-
-
27844514169
-
Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression
-
Kasper LH, Boussouar F, Boyd K, et al. Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression. EMBO J 2005; 24(22): 3846-58.
-
(2005)
EMBO J
, vol.24
, Issue.22
, pp. 3846-3858
-
-
Kasper, L.H.1
Boussouar, F.2
Boyd, K.3
-
55
-
-
33749494456
-
Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells
-
Chen H, Yan Y, Davidson TL, Shinkai Y, Costa M. Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells. Cancer Res 2006; 66(18): 9009-16.
-
(2006)
Cancer Res
, vol.66
, Issue.18
, pp. 9009-9016
-
-
Chen, H.1
Yan, Y.2
Davidson, T.L.3
Shinkai, Y.4
Costa, M.5
-
56
-
-
77954265666
-
Negative regulation of hypoxic responses via induced Reptin methylation
-
Lee JS, Kim Y, Kim IS, et al. Negative regulation of hypoxic responses via induced Reptin methylation. Mol Cell 2010; 39(1): 71-85.
-
(2010)
Mol Cell
, vol.39
, Issue.1
, pp. 71-85
-
-
Lee, J.S.1
Kim, Y.2
Kim, I.S.3
-
57
-
-
80051978418
-
Hypoxia-induced methylation of a pontin chromatin remodeling factor
-
Lee JS, Kim Y, Bhin J, et al. Hypoxia-induced methylation of a pontin chromatin remodeling factor. Proc Natl Acad Sci USA 2011; 108(33): 13510-5.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, Issue.33
, pp. 13510-13515
-
-
Lee, J.S.1
Kim, Y.2
Bhin, J.3
-
58
-
-
84857042390
-
Hypoxia-induced mixedlineage leukemia 1 regulates glioma stem cell tumorigenic potential
-
Heddleston JM, Wu Q, Rivera M, et al. Hypoxia-induced mixedlineage leukemia 1 regulates glioma stem cell tumorigenic potential. Cell Death Differentiation 2012; 19(3): 428-39.
-
(2012)
Cell Death Differentiation
, vol.19
, Issue.3
, pp. 428-439
-
-
Heddleston, J.M.1
Wu, Q.2
Rivera, M.3
-
59
-
-
77956338683
-
Requirement of the histone demethylase LSD1 in Snai1-mediated transcriptional repression during epithelial-mesenchymal transition
-
Lin T, Ponn A, Hu X, Law BK, Lu J. Requirement of the histone demethylase LSD1 in Snai1-mediated transcriptional repression during epithelial-mesenchymal transition. Oncogene 2010; 29(35): 4896-904.
-
(2010)
Oncogene
, vol.29
, Issue.35
, pp. 4896-4904
-
-
Lin, T.1
Ponn, A.2
Hu, X.3
Law, B.K.4
Lu, J.5
-
60
-
-
11144332565
-
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
-
Shi Y, Lan F, Matson C, et al. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell 2004; 119(7): 941-53.
-
(2004)
Cell
, vol.119
, Issue.7
, pp. 941-953
-
-
Shi, Y.1
Lan, F.2
Matson, C.3
-
61
-
-
73549088729
-
Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth
-
Krieg AJ, Rankin EB, Chan D, Razorenova O, Fernandez S, Giaccia AJ. Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth. Molecular and cellular biology 2010; 30(1): 344-53.
-
(2010)
Molecular and Cellular Biology
, vol.30
, Issue.1
, pp. 344-353
-
-
Krieg, A.J.1
Rankin, E.B.2
Chan, D.3
Razorenova, O.4
Fernandez, S.5
Giaccia, A.J.6
-
62
-
-
84865536482
-
HIF-1alpha-induced histone demethylase JMJD2B contributes to the malignant phenotype of colorectal cancer cells via an epigenetic mechanism
-
Fu L, Chen L, Yang J, Ye T, Chen Y, Fang J. HIF-1alpha-induced histone demethylase JMJD2B contributes to the malignant phenotype of colorectal cancer cells via an epigenetic mechanism. Carcinogenesis 2012; 33(9): 1664-73.
-
(2012)
Carcinogenesis
, vol.33
, Issue.9
, pp. 1664-1673
-
-
Fu, L.1
Chen, L.2
Yang, J.3
Ye, T.4
Chen, Y.5
Fang, J.6
-
63
-
-
84870608916
-
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
-
Luo W, Chang R, Zhong J, Pandey A, Semenza GL. Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression. Proc Natl Acad Sci USA 2012; 109(49): E3367-76.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, Issue.49
, pp. 3367-3376
-
-
Luo, W.1
Chang, R.2
Zhong, J.3
Pandey, A.4
Semenza, G.L.5
-
64
-
-
84889573275
-
Histone lysine demethylases as targets for anticancer therapy
-
Hojfeldt JW, Agger K, Helin K. Histone lysine demethylases as targets for anticancer therapy. Nature reviews Drug discovery 2013; 12(12): 917-30.
-
(2013)
Nature Reviews Drug Discovery
, vol.12
, Issue.12
, pp. 917-930
-
-
Hojfeldt, J.W.1
Agger, K.2
Helin, K.3
-
65
-
-
84867747419
-
Histone demethylase JMJD2Bmediated cell proliferation regulated by hypoxia and radiation in gastric cancer cell
-
Kim JG, Yi JM, Park SJ, et al. Histone demethylase JMJD2Bmediated cell proliferation regulated by hypoxia and radiation in gastric cancer cell. Biochimica et Biophysica acta 2012; 1819(11-12): 1200-7.
-
(2012)
Biochimica Et Biophysica Acta
, vol.1819
, Issue.11-12
, pp. 1200-1207
-
-
Kim, J.G.1
Yi, J.M.2
Park, S.J.3
-
66
-
-
84855340668
-
SET8 promotes epithelial-mesenchymal transition and confers TWIST dual transcriptional activities
-
Yang F, Sun L, Li Q, et al. SET8 promotes epithelial-mesenchymal transition and confers TWIST dual transcriptional activities. EMBO J 2012; 31(1): 110-23.
-
(2012)
EMBO J
, vol.31
, Issue.1
, pp. 110-123
-
-
Yang, F.1
Sun, L.2
Li, Q.3
-
67
-
-
38949086502
-
Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy
-
Weichert W, Roske A, Gekeler V, et al. Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy. Br J Cancer 2008; 98(3): 604-10.
-
(2008)
Br J Cancer
, vol.98
, Issue.3
, pp. 604-610
-
-
Weichert, W.1
Roske, A.2
Gekeler, V.3
-
68
-
-
59349103985
-
-
Fritzsche FR, Weichert W, Roske A, et al. Class I histone deacetylases 1, 2 and 3 are highly expressed in renal cell cancer. BMC cancer 2008; 8: 381.
-
(2008)
Class I Histone Deacetylases 1, 2 and 3 are Highly Expressed in Renal Cell Cancer. BMC Cancer
, vol.8
, pp. 381
-
-
Fritzsche, F.R.1
Weichert, W.2
Roske, A.3
-
69
-
-
16844385708
-
Histone deacetylase-1 and-3 protein expression in human breast cancer: A tissue microarray analysis
-
Krusche CA, Wulfing P, Kersting C, et al. Histone deacetylase-1 and-3 protein expression in human breast cancer: a tissue microarray analysis. Breast Cancer Res Treatment 2005; 90(1): 15-23.
-
(2005)
Breast Cancer Res Treatment
, vol.90
, Issue.1
, pp. 15-23
-
-
Krusche, C.A.1
Wulfing, P.2
Kersting, C.3
-
71
-
-
77349115530
-
Current and emerging treatment strategies for cutaneous T-cell lymphoma
-
Lansigan F, Foss FM. Current and emerging treatment strategies for cutaneous T-cell lymphoma. Drugs 2010; 70(3): 273-86.
-
(2010)
Drugs
, vol.70
, Issue.3
, pp. 273-286
-
-
Lansigan, F.1
Foss, F.M.2
-
72
-
-
77953373245
-
The pandeacetylase inhibitor panobinostat inhibits growth of hepatocellular carcinoma models by alternative pathways of apoptosis
-
Di Fazio P, Schneider-Stock R, Neureiter D, et al. The pandeacetylase inhibitor panobinostat inhibits growth of hepatocellular carcinoma models by alternative pathways of apoptosis. Cellular oncology : the official J Int Soc Cellular Oncol 2010; 32(4): 285-300.
-
(2010)
Cellular Oncology : The Official J Int Soc Cellular Oncol
, vol.32
, Issue.4
, pp. 285-300
-
-
Di Fazio, P.1
Schneider-Stock, R.2
Neureiter, D.3
-
73
-
-
84867542415
-
Targeting schistosome histone modifying enzymes for drug development
-
Pierce RJ, Dubois-Abdesselem F, Lancelot J, Andrade L, Oliveira G. Targeting schistosome histone modifying enzymes for drug development. Curr Pharm Des 2012; 18(24): 3567-78.
-
(2012)
Curr Pharm Des
, vol.18
, Issue.24
, pp. 3567-3578
-
-
Pierce, R.J.1
Dubois-Abdesselem, F.2
Lancelot, J.3
Rade, L.4
Oliveira, G.5
-
74
-
-
84896470334
-
Small-molecule inhibitors of histone deacetylase for the treatment of cancer and non-cancer diseases: A patent review (2011-2013)
-
Valente S, Mai A. Small-molecule inhibitors of histone deacetylase for the treatment of cancer and non-cancer diseases: a patent review (2011-2013). Expert Opinion Therapeutic Patents 2014; 24(4): 401-15.
-
(2014)
Expert Opinion Therapeutic Patents
, vol.24
, Issue.4
, pp. 401-415
-
-
Valente, S.1
Mai, A.2
-
75
-
-
84891911184
-
Superior antimitogenic and chemosensitization activities of the combination treatment of the histone deacetylase inhibitor apicidin and proteasome inhibitors on human colorectal cancer cells
-
Abaza MS, Bahman AM, Al-Attiyah R. Superior antimitogenic and chemosensitization activities of the combination treatment of the histone deacetylase inhibitor apicidin and proteasome inhibitors on human colorectal cancer cells. Int J Oncol 2014; 44(1): 105-28.
-
(2014)
Int J Oncol
, vol.44
, Issue.1
, pp. 105-128
-
-
Abaza, M.S.1
Bahman, A.M.2
Al-Attiyah, R.3
-
76
-
-
84876401638
-
Silibinin synergizes with histone deacetylase and DNA methyltransferase inhibitors in upregulating E-cadherin expression together with inhibition of migration and invasion of human non-small cell lung cancer cells
-
Mateen S, Raina K, Agarwal C, Chan D, Agarwal R. Silibinin synergizes with histone deacetylase and DNA methyltransferase inhibitors in upregulating E-cadherin expression together with inhibition of migration and invasion of human non-small cell lung cancer cells. J Pharmacol Exp Therapeutics 2013; 345(2): 206-14.
-
(2013)
J Pharmacol Exp Therapeutics
, vol.345
, Issue.2
, pp. 206-214
-
-
Mateen, S.1
Raina, K.2
Agarwal, C.3
Chan, D.4
Agarwal, R.5
-
77
-
-
70349311616
-
Histone acetyl transferases as emerging drug targets
-
Dekker FJ, Haisma HJ. Histone acetyl transferases as emerging drug targets. Drug Discov Today 2009; 14(19-20): 942-8.
-
(2009)
Drug Discov Today
, vol.14
, Issue.19-20
, pp. 942-948
-
-
Dekker, F.J.1
Haisma, H.J.2
-
78
-
-
77954204335
-
Virtual ligand screening of the p300/CBP histone acetyltransferase: Identification of a selective small molecule inhibitor
-
Bowers EM, Yan G, Mukherjee C, et al. Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor. Chem Biol 2010; 17(5): 471-82.
-
(2010)
Chem Biol
, vol.17
, Issue.5
, pp. 471-482
-
-
Bowers, E.M.1
Yan, G.2
Mukherjee, C.3
-
79
-
-
84877642396
-
Small-molecule inhibitors of acetyltransferase p300 identified by high-throughput screening are potent anticancer agents
-
Yang H, Pinello CE, Luo J, et al. Small-molecule inhibitors of acetyltransferase p300 identified by high-throughput screening are potent anticancer agents. Mol Cancer Therapeutics 2013; 12(5): 610-20.
-
(2013)
Mol Cancer Therapeutics
, vol.12
, Issue.5
, pp. 610-620
-
-
Yang, H.1
Pinello, C.E.2
Luo, J.3
-
80
-
-
80052375547
-
Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines
-
Liu F, Barsyte-Lovejoy D, Allali-Hassani A, et al. Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines. J Med Chem 2011; 54(17): 6139-50.
-
(2011)
J Med Chem
, vol.54
, Issue.17
, pp. 6139-6150
-
-
Liu, F.1
Barsyte-Lovejoy, D.2
Allali-Hassani, A.3
-
81
-
-
84899819989
-
The Discovery of Novel Histone Lysine Methyltransferase G9a Inhibitors (Part 1): Molecular Design Based on a Series of Substituted 2, 4-Diamino-7-aminoalkoxyquinazoline by Molecular-Docking-Guided 3D Quantitative Structure-Activity Relationship Studies
-
Feng T, Wang H, Zhang X, Sun H, You Q. The Discovery of Novel Histone Lysine Methyltransferase G9a Inhibitors (Part 1): Molecular Design Based on a Series of Substituted 2, 4-Diamino-7-aminoalkoxyquinazoline by Molecular-Docking-Guided 3D Quantitative Structure-Activity Relationship Studies. Med Chem 2014; 10(4): 426-40.
-
(2014)
Med Chem
, vol.10
, Issue.4
, pp. 426-440
-
-
Feng, T.1
Wang, H.2
Zhang, X.3
Sun, H.4
You, Q.5
-
82
-
-
84882700612
-
Effects of the monoamine oxidase inhibitors pargyline and tranylcypromine on cellular proliferation in human prostate cancer cells
-
Lee HT, Choi MR, Doh MS, Jung KH, Chai YG. Effects of the monoamine oxidase inhibitors pargyline and tranylcypromine on cellular proliferation in human prostate cancer cells. Oncol Reports 2013; 30(4): 1587-92.
-
(2013)
Oncol Reports
, vol.30
, Issue.4
, pp. 1587-1592
-
-
Lee, H.T.1
Choi, M.R.2
Doh, M.S.3
Jung, K.H.4
Chai, Y.G.5
-
83
-
-
77955025931
-
Structurally designed trans-2-phenylcyclopropylamine derivatives potently inhibit histone demethylase LSD1/KDM1
-
Mimasu S, Umezawa N, Sato S, Higuchi T, Umehara T, Yokoyama S. Structurally designed trans-2-phenylcyclopropylamine derivatives potently inhibit histone demethylase LSD1/KDM1. Biochemistry 2010; 49(30): 6494-503.
-
(2010)
Biochemistry
, vol.49
, Issue.30
, pp. 6494-6503
-
-
Mimasu, S.1
Umezawa, N.2
Sato, S.3
Higuchi, T.4
Umehara, T.5
Yokoyama, S.6
-
84
-
-
77955345001
-
Design, synthesis, enzymeinhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors
-
Hamada S, Suzuki T, Mino K, et al. Design, synthesis, enzymeinhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors. J Med Chem 2010; 53(15): 5629-38.
-
(2010)
J Med Chem
, vol.53
, Issue.15
, pp. 5629-5638
-
-
Hamada, S.1
Suzuki, T.2
Mino, K.3
-
85
-
-
78649528262
-
Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors
-
King ON, Li XS, Sakurai M, et al. Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors. PloS one 2010; 5(11): e15535.
-
(2010)
Plos One
, vol.5
, Issue.11
, pp. e15535
-
-
King, O.N.1
Li, X.S.2
Sakurai, M.3
-
86
-
-
84889595831
-
A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth
-
Wang L, Chang J, Varghese D, et al. A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth. Nat Communications 2013; 4: 2035.
-
(2013)
Nat Communications
, vol.4
-
-
Wang, L.1
Chang, J.2
Varghese, D.3
-
87
-
-
84877324084
-
Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2
-
Knutson SK, Warholic NM, Wigle TJ, et al. Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2. Proc Natl Acad Sci USA 2013; 110(19): 7922-7.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, Issue.19
, pp. 7922-7927
-
-
Knutson, S.K.1
Warholic, N.M.2
Wigle, T.J.3
-
88
-
-
84921318899
-
Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma
-
Knutson SK, Kawano S, Minoshima Y, et al. Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma. Mol Cancer Therapeutics 2014; 13(4): 842-54.
-
(2014)
Mol Cancer Therapeutics
, vol.13
, Issue.4
, pp. 842-854
-
-
Knutson, S.K.1
Kawano, S.2
Minoshima, Y.3
|