A chromodomain switch mediated by histone H3 Lys 4 acetylation regulates heterochromatin assembly

Genes and Development

Volumn 24, Issue 7, 2010, Pages 647-652

  Xhemalce, Blerta ^a   Kouzarides, Tony ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Chromodomain switch; H3K4ac; Heterochromatin; HPI; RITS complex

Indexed keywords

ARGININE; CHROMODOMAIN PROTEIN 1; CHROMODOMAIN PROTEIN 2; HISTONE H3; LYSINE; PROTEIN CLR4; PROTEIN DERIVATIVE; PROTEIN SWI6; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; CHP1 PROTEIN, S POMBE; HISTONE; SCHIZOSACCHAROMYCES POMBE PROTEIN;

ACETYLATION; ARTICLE; CENTROMERE; CHROMATIN ASSEMBLY AND DISASSEMBLY; HETEROCHROMATIN; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; STRUCTURE ANALYSIS; TRANSCRIPTION INITIATION; YEAST; CELL CYCLE; CENTROSOME; GENETICS; METABOLISM; NUCLEOTIDE REPEAT; SCHIZOSACCHAROMYCES;

SCHIZOSACCHAROMYCETACEAE;

ACETYLATION; CELL CYCLE; CELL CYCLE PROTEINS; CENTROMERE; CENTROSOME; HETEROCHROMATIN; HISTONES; LYSINE; MUTATION; REPETITIVE SEQUENCES, NUCLEIC ACID; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS;

EID: 77950473704     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.1881710     Document Type: Article

References (26)

1. Bannister AJ, Zegerman P, Partridge JF, Miska EA, Thomas JO, Allshire RC, Kouzarides T. 2001. Selective recognition of methylated lysine 9 on histone H3 by the HPl chromo domain. Nature 410: 120-124, (Pubitemid 32225848)
2. Bernard P, Maure JF, Partridge JF, Genier S, Javerzat JP, Allshire RC. 2001. Requirement of heterochromatin for cohesion at centromeres. Science 294: 2539-2542.
3. Buhler M, Verdel A, Moazed D. 2006. Tethering RITS to a nascent transcript initiates RNAi- and heterochromatin-dependent gene silencing. Cell 125: 873-886. (Pubitemid 43795192)
4. Chen ES, Zhang K, Nicolas E, Cam HP, Zofall M, Grewal SI. 2008. Cell cycle control of centromeric repeat transcription and heterochromatin assembly. Nature 451: 734-737. (Pubitemid 351220568)
5. ClarkeL,BaumMP.1990.Functionalanalysisofacentromerefromfissionyeast: Aroleforcentromere-specificrepeatedDNAsequences.MolCellBiol10:1863-1872. (Pubitemid20138805)
6. Fischer T, Cui B, Dhakshnamoorthy J, Zhou M, Rubin C, Zofall M, Veenstra TD, Grewal SI. 2009. Diverse roles of HPl proteins in heterochromatin assembly and functions in fission yeast. Proc Natl Acad Sd 106: 8998-9003.
7. Garcia BA, Hake SB, Diaz RL, Kauer M, Morris SA, Recht J, Shabanowitz J, Mishra N, Strahl BD, Alls CD, et al. 2007. Organismal differences in post-translational modifications in histones H3 and H4. J Biol Chem 282: 7641-7655. (Pubitemid 47093632)
8. Gomez EB, Nugent RL, Laria S, Forsburg SL. 2008. Schizosaccharomyces pombe hietone acetyltransferase Msti (KAT5) is an essential protein required for damage response and chromosome segregation. Genetics 179: 757-771.
9. Grewal SI, Jia S. 2007. Heterochromatin revisited. Nat Rev Genet 8: 35-46.
10. Jacobs SA, Khorasanizadeh S. 2002. Structure of HPl chromodomain bound to a lysine 9-methylated histone H3 tail. Science 295: 2080-2083. (Pubitemid 34229471)
11. Kanon J, Francesconi S, Collura A, Schramke V, Ishikawa F, Baldacci G, Geli V. 2003. The fission yeast spSetlp is a histone H3-K4 methyltransferase that functions in telomere maintenance and DNA repair in an ATM kinase Rad3-dependent pathway. }Mol Biol 326:1081-1094. (Pubitemid 36263384)
12. Kloc A, Zaratiegui M, Nora E, Martienssen R. 2008. RNA interference guides histone modification during the S phase of chromosomal replication. Curr Biol 18: 490-495.
13. Li F, Huarte M, Zaratiegui M, Vaughn MW, Shi Y, Martienssen R, Cande WZ. 2008. Lid2 is required for coordinating H3K4 and H3K9 methylation of heterochromatin and euchromatin. Cell 135: 272-283.
14. Motamedi MR, Verdel A, Colmenares SU, Gerber SA, Gygi SP, Moazed D. 2004. Two RNAi complexes, RITS and RDRC, physically interact and localize to noncoding centromeric RNAs. Cell 119: 789-802. (Pubitemid 40017686)
15. Motamedi MR, Hong EJ, Li X, Gerber S, Denison C, Gygi S, Moazed D. 2008. HPl proteins form distinct complexes and mediate heterochromatic gene silencing by nonoverlapping mechanisms. Mol Cell 32: 778-790.
16. Nakayama J, Rice JC, Strahl BD, Allis CD, Grewal SI. 2001. Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly. Science 292: 110-113. (Pubitemid 32289138)
17. Noma K, Grewal SI. 2002. Histone H3 lysine 4 methylation is mediated by Setl and promotes maintenance of active chromatin states in fission yeast. Proc Natl Acad Sci 99: 16438-16445. (Pubitemid 35470991)
18. Nonaka N, Kitajima T, Yokobayashi S, Xiao G, Yamamoto M, Grewal SI, Watanabe Y. 2002. Recruitment of cohesin to heterochromatic regions by SWi6/HP1 in fission yeast. Nat Cell Biol 4: 89-93. (Pubitemid 34071986)
19. Partridge JF, Scott KS, Bannister AJ, Kouzarides T, Allshire RC. 2002. exacting DNA from fission yeast centromeres mediates histone H3 methylation and recruitment of silencing factors and cohesin to an ectopic site. Curr Biol 12:1652-1660. (Pubitemid 35161918)
20. Reinhart BJ, Bartel DP. 2002. Small RNAs correspond to centromere heterochromatic repeats. Science 297: 1831.
21. Sadaie M, Kawaguchi R, Ohtani Y, Arisaka F, Tanaka K, Shirahige K, Nakayama J. 2008. Balance between distinct HPl family proteins controls heterochromatin assembly in fission yeast. Mol Cell Biol 28: 6973-6988.
22. Schalch T, Job G, Noffsinger VJ, Shanker S, Kuscu C, Joshua-Tor L, Partridge JF. 2009. High-affinity binding of Chpl chromodomain to K9 methylated histone H3 is required to establish centromeric heterochromatin. Mol Cell 34:36-46.
23. Verdel A, Jia S, Gerber S, Sugiyama T, Gygi S, Grewal SI, Moazed D. 2004. RNAi-mediated targeting of heterochromatin by the RITS complex. Science 303: 672-676. (Pubitemid 38141633)
24. Volpe TA, Kidner C, Hall IM, Teng G, Grewal SI, Martienssen RA. 2002. Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi. Science 297: 1833-1837. (Pubitemid 35024336)
25. Xhemalce B, Miller KM, Driscoll R, Masumoto H, Jackson SP, Kouzarides T, Verreault A, Arcangioli B. 2007. Regulation of histone H3 lysine 56 acetylation in Schizosaccharomyces pombe. J Biol Cham 282:1504015047.
26. Zhang K, Mosch K, Fischle W, Grewal SI. 2008. Roles of the Clr4 methyltransferase complex in nucleation, spreading and maintenance of heterochromatin. Nat Struct Mol Biol 15: 381-388. (Pubitemid 351483395)