The sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 axis regulates early airway T-cell infiltration in murine mast cell-dependent acute allergic responses

Journal of Allergy and Clinical Immunology

Volumn 135, Issue 4, 2015, Pages 1008-1018.e1

  Oskeritzian, Carole A ^a,b   Hait, Nitai C ^b   Wedman, Piper ^a   Chumanevich, Alena ^a   Kolawole, Elizabeth M ^c   Price, Megan M ^b   Falanga, Yves T ^c   Harikumar, Kuzhuvelil B ^b   Ryan, John J ^c   Milstien, Sheldon ^b   Sabbadini, Roger ^d   Spiegel, Sarah ^b  

^a UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^d Lpath Inc   (United States)

Author keywords

Airway inflammation; allergy, mast cells; recruitment; signal transducer and activator of transcription 3; sphingosine 1 phosphate; sphingosine 1 phosphate receptor 2; T cells

Indexed keywords

4 (2,6 DICHLORO 4 PYRIDINYL) 1 (1,3 DIMETHYL 4 ISOPROPYL 1H PYRAZOLO[3,4 B]PYRIDIN 6 YL)SEMICARBAZIDE; BETA N ACETYLHEXOSAMINIDASE; CD14 ANTIGEN; CHEMOKINE; CHEMOKINE RECEPTOR CCR2; CYTOKINE; HISTAMINE; IMMUNOGLOBULIN E; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCLONAL ANTIBODY; RANTES; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR 2; STAT3 PROTEIN; UNCLASSIFIED DRUG; ANTIGEN; LYSOPHOSPHOLIPID; PYRAZOLE DERIVATIVE; PYRIDINE DERIVATIVE; SPHINGOSINE; SPHINGOSINE 1-PHOSPHATE; SPHINGOSINE-1-PHOSPHATE RECEPTOR-2, MOUSE;

ALLERGIC REACTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CD3+ T LYMPHOCYTE; CELL ACTIVATION; CELL COUNT; CELL INFILTRATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORE TEMPERATURE; ENZYME INHIBITION; ENZYME REGULATION; FEMALE; HISTAMINE BLOOD LEVEL; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; LUNG INFILTRATE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; RESPIRATORY TRACT INFLAMMATION; T LYMPHOCYTE; ADOPTIVE TRANSFER; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; DEGRANULATION; DISEASE MODEL; DRUG EFFECTS; HYPERSENSITIVITY; IMMUNOLOGY; LUNG; MACROPHAGE; MACROPHAGE ACTIVATION; MAST CELL; METABOLISM; PATHOLOGY; TRANSGENIC MOUSE;

ADOPTIVE TRANSFER; ANIMALS; ANTIGENS; CELL DEGRANULATION; CHEMOKINES; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; HYPERSENSITIVITY; LUNG; LYSOPHOSPHOLIPIDS; MACROPHAGE ACTIVATION; MACROPHAGES; MAST CELLS; MICE; MICE, TRANSGENIC; PYRAZOLES; PYRIDINES; RECEPTORS, LYSOSPHINGOLIPID; SPHINGOSINE; STAT3 TRANSCRIPTION FACTOR; T-LYMPHOCYTES;

EID: 84926245199     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2014.10.044     Document Type: Article

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