-
2
-
-
0035348292
-
Sphingosine 1-phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma
-
Ammit AJ, Hastie AT, Edsall LC, Hoffman RK, Amrani Y, Krymskaya VP, Kane SA, Peters SP, Penn RB, Spiegel S, et al. (2001) Sphingosine 1-phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma. FASEB J 15:1212-1214.
-
(2001)
FASEB J
, vol.15
, pp. 1212-1214
-
-
Ammit, A.J.1
Hastie, A.T.2
Edsall, L.C.3
Hoffman, R.K.4
Amrani, Y.5
Krymskaya, V.P.6
Kane, S.A.7
Peters, S.P.8
Penn, R.B.9
Spiegel, S.10
-
3
-
-
0347481389
-
Phosphorylation of the Immunomodulatory Drug FTY720 by Sphingosine Kinases
-
DOI 10.1074/jbc.M307687200
-
Billich A, Bornancin F, Deváy P, Mechtcheriakova D, Urtz N, and Baumruker T (2003) Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases. J Biol Chem 278:47408-47415. (Pubitemid 37523181)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.48
, pp. 47408-47415
-
-
Billich, A.1
Bornancin, F.2
Devay, P.3
Mechtcheriakova, D.4
Urtz, N.5
Baumruker, T.6
-
4
-
-
0037077308
-
The immune modulator FTY720 targets sphingosine 1-phosphate receptors
-
DOI 10.1074/jbc.C200176200
-
Brinkmann V, Davis MD, Heise CE, Albert R, Cottens S, Hof R, Bruns C, Prieschl E, Baumruker T, Hiestand P, et al. (2002) The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J Biol Chem 277:21453-21457. (Pubitemid 34952287)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.24
, pp. 21453-21457
-
-
Brinkmann, V.1
Davis, M.D.2
Heise, C.E.3
Albert, R.4
Cottens, S.5
Hof, R.6
Bruns, C.7
Prieschl, E.8
Baumruker, T.9
Hiestand, P.10
Foster, C.A.11
Zollinger, M.12
Lynch, K.R.13
-
5
-
-
0031728417
-
Airway hyperresponsiveness in asthma: Not just a matter of airway inflammation
-
Brusasco V, Crimi E, and Pellegrino R (1998) Airway hyperresponsiveness in asthma: not just a matter of airway inflammation. Thorax 53:992-998. (Pubitemid 28494343)
-
(1998)
Thorax
, vol.53
, Issue.11
, pp. 992-998
-
-
Brusasco, V.1
Crimi, E.2
Pellegrino, R.3
-
6
-
-
77955276223
-
Downregulation of sphingosine-1-phosphate receptors in bronchial smooth muscle of mouse experimental asthma
-
Chiba Y, Suzuki K, Uechi M, Kurihara E, Goto K, Sakai H, and Misawa M (2010a) Downregulation of sphingosine-1-phosphate receptors in bronchial smooth muscle of mouse experimental asthma. Pharmacol Res 62:357-363.
-
(2010)
Pharmacol Res
, vol.62
, pp. 357-363
-
-
Chiba, Y.1
Suzuki, K.2
Uechi, M.3
Kurihara, E.4
Goto, K.5
Sakai, H.6
Misawa, M.7
-
7
-
-
78649403525
-
SKI-II, an inhibitor of sphingosine kinase, ameliorates antigen-induced bronchial smooth muscle hyperresponsiveness, but not airway inflammation, in mice
-
Chiba Y, Takeuchi H, Sakai H, and Misawa M (2010b) SKI-II, an inhibitor of sphingosine kinase, ameliorates antigen-induced bronchial smooth muscle hyperresponsiveness, but not airway inflammation, in mice. J Pharmacol Sci 114:304-310.
-
(2010)
J Pharmacol Sci
, vol.114
, pp. 304-310
-
-
Chiba, Y.1
Takeuchi, H.2
Sakai, H.3
Misawa, M.4
-
8
-
-
1442276369
-
Airway hyperresponsiveness to bradykinin induced by allergen challenge in actively sensitised Brown Norway rats
-
DOI 10.1007/s00210-003-0857-6
-
Ellis KM, Cannet C, Mazzoni L, and Fozard JR (2004) Airway hyperresponsiveness to bradykinin induced by allergen challenge in actively sensitised Brown Norway rats. Naunyn Schmiedebergs Arch Pharmacol 369:166-178. (Pubitemid 38270772)
-
(2004)
Naunyn-Schmiedeberg's Archives of Pharmacology
, vol.369
, Issue.2
, pp. 166-178
-
-
Ellis, K.M.1
Cannet, C.2
Mazzoni, L.3
Fozard, J.R.4
-
9
-
-
71749101249
-
Role of sphingosine kinase 1 in allergen-induced pulmonary vascular remodeling and hyperresponsiveness
-
Haberberger RV, Tabeling C, Runciman S, Gutbier B, König P, Andratsch M, Schütte H, Suttorp N, Gibbins I, and Witzenrath M (2009) Role of sphingosine kinase 1 in allergen-induced pulmonary vascular remodeling and hyperresponsiveness. J Allergy Clin Immunol 124:933-941.e1-9.
-
(2009)
J Allergy Clin Immunol
, vol.124
-
-
Haberberger, R.V.1
Tabeling, C.2
Runciman, S.3
Gutbier, B.4
König, P.5
Andratsch, M.6
Schütte, H.7
Suttorp, N.8
Gibbins, I.9
Witzenrath, M.10
-
10
-
-
0035823477
-
Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LPB3/EDG-3
-
Ishii I, Friedman B, Ye X, Kawamura S, McGiffert C, Contos JJ, Kingsbury MA, Zhang G, Brown JH, and Chun J (2001) Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LPB3/EDG-3. J Biol Chem 276:33697-33704.
-
(2001)
J Biol Chem
, vol.276
, pp. 33697-33704
-
-
Ishii, I.1
Friedman, B.2
Ye, X.3
Kawamura, S.4
McGiffert, C.5
Contos, J.J.6
Kingsbury, M.A.7
Zhang, G.8
Brown, J.H.9
Chun, J.10
-
11
-
-
33749018836
-
3
-
DOI 10.1038/sj.bjp.0706872, PII 0706872
-
Jongsma M, Hendriks-Balk MC, Michel MC, Peters SL, and Alewijnse AE (2006) BML-241 fails to display selective antagonism at the sphingosine-1- phosphate receptor, S1P3. Br J Pharmacol 149:277-282. (Pubitemid 44453428)
-
(2006)
British Journal of Pharmacology
, vol.149
, Issue.3
, pp. 277-282
-
-
Jongsma, M.1
Hendriks-Balk, M.C.2
Michel, M.C.3
Peters, S.L.M.4
Alewijnse, A.E.5
-
12
-
-
33846405257
-
Sphingosine 1-phosphate causes airway hyper-reactivity by Rho-mediated myosin phosphatase inactivation
-
DOI 10.1124/jpet.106.110718
-
Kume H, Takeda N, Oguma T, Ito S, Kondo M, Ito Y, and Shimokata K (2007) Sphingosine 1-phosphate causes airway hyper-reactivity by rho-mediated myosin phosphatase inactivation. J Pharmacol Exp Ther 320:766-773. (Pubitemid 46147958)
-
(2007)
Journal of Pharmacology and Experimental Therapeutics
, vol.320
, Issue.2
, pp. 766-773
-
-
Kume, H.1
Takeda, N.2
Oguma, T.3
Ito, S.4
Kondo, M.5
Ito, Y.6
Shimokata, K.7
-
13
-
-
44849137343
-
The role of sphingosine kinase in a murine model of allergic asthma
-
Lai WQ, Goh HH, Bao Z, Wong WS, Melendez AJ, and Leung BP (2008) The role of sphingosine kinase in a murine model of allergic asthma. J Immunol 180:4323-4329.
-
(2008)
J Immunol
, vol.180
, pp. 4323-4329
-
-
Lai, W.Q.1
Goh, H.H.2
Bao, Z.3
Wong, W.S.4
Melendez, A.J.5
Leung, B.P.6
-
14
-
-
0024266311
-
Morphological studies of bronchial mucosal biopsies from asthmatics before and after ten years of treatment with inhaled steroids
-
Lundgren R, Söderberg M, Hörstedt P, and Stenling R (1988) Morphological studies of bronchial mucosal biopsies from asthmatics before and after ten years of treatment with inhaled steroids. Eur Respir J 1:883-889. (Pubitemid 19015298)
-
(1988)
European Respiratory Journal
, vol.1
, Issue.10
, pp. 883-889
-
-
Lundgren, R.1
Soderberg, M.2
Horstedt, P.3
Stenling, R.4
-
15
-
-
0036181314
-
The pathophysiology of asthma
-
DOI 10.1146/annurev.med.53.082901.103921
-
Maddox L and Schwartz DA (2002) The pathophysiology of asthma. Annu Rev Med 53:477-498. (Pubitemid 34177892)
-
(2002)
Annual Review of Medicine
, vol.53
, pp. 477-498
-
-
Maddox, L.1
Schwartz, D.A.2
-
16
-
-
33747837449
-
Physiologically based pharmacokinetic modeling of FTY720 (2-amino-2[2-(-4-octylphenyl)ethyl]propane-1,3-diol hydrochloride) in rats after oral and intravenous doses
-
DOI 10.1124/dmd.105.009001
-
Meno-Tetang GM, Li H, Mis S, Pyszczynski N, Heining P, Lowe P, and Jusko WJ (2006) Physiologically based pharmacokinetic modeling of FTY720 (2-amino-2[2- (-4-octylphenyl)ethyl]propane-1,3-diol hydrochloride) in rats after oral and intravenous doses. Drug Metab Dispos 34:1480-1487. (Pubitemid 44285388)
-
(2006)
Drug Metabolism and Disposition
, vol.34
, Issue.9
, pp. 1480-1487
-
-
Meno-Tetang, G.M.L.1
Li, H.2
Mis, S.3
Pyszczynski, N.4
Heining, P.5
Lowe, P.6
Jusko, W.J.7
-
17
-
-
48949119356
-
Inhalation of sphingosine kinase inhibitor attenuates airway inflammation in asthmatic mouse model
-
Nishiuma T, Nishimura Y, Okada T, Kuramoto E, Kotani Y, Jahangeer S, and Nakamura S (2008) Inhalation of sphingosine kinase inhibitor attenuates airway inflammation in asthmatic mouse model. Am J Physiol Lung Cell Mol Physiol 294:L1085-L1093.
-
(2008)
Am J Physiol Lung Cell Mol Physiol
, vol.294
-
-
Nishiuma, T.1
Nishimura, Y.2
Okada, T.3
Kuramoto, E.4
Kotani, Y.5
Jahangeer, S.6
Nakamura, S.7
-
18
-
-
70350133784
-
Sphingolipids in inflammation: Pathological implications and potential therapeutic targets
-
Nixon GF (2009) Sphingolipids in inflammation: pathological implications and potential therapeutic targets. Br J Pharmacol 158:982-993.
-
(2009)
Br J Pharmacol
, vol.158
, pp. 982-993
-
-
Nixon, G.F.1
-
19
-
-
33751093316
-
A Monoselective Sphingosine-1-Phosphate Receptor-1 Agonist Prevents Allograft Rejection in a Stringent Rat Heart Transplantation Model
-
DOI 10.1016/j.chembiol.2006.09.017, PII S1074552106003772
-
Pan S, Mi Y, Pally C, Beerli C, Chen A, Guerini D, Hinterding K, Nuesslein-Hildesheim B, Tuntland T, Lefebvre S, et al. (2006) A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model. Chem Biol 13:1227-1234. (Pubitemid 44762192)
-
(2006)
Chemistry and Biology
, vol.13
, Issue.11
, pp. 1227-1234
-
-
Pan, S.1
Mi, Y.2
Pally, C.3
Beerli, C.4
Chen, A.5
Guerini, D.6
Hinterding, K.7
Nuesslein-Hildesheim, B.8
Tuntland, T.9
Lefebvre, S.10
Liu, Y.11
Gao, W.12
Chu, A.13
Brinkmann, V.14
Bruns, C.15
Streiff, M.16
Cannet, C.17
Cooke, N.18
Gray, N.19
-
20
-
-
34247379074
-
Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate
-
DOI 10.1126/science.1139221
-
Pappu R, Schwab SR, Cornelissen I, Pereira JP, Regard JB, Xu Y, Camerer E, Zheng YW, Huang Y, Cyster JG, et al. (2007) Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Science 316:295-298. (Pubitemid 46633109)
-
(2007)
Science
, vol.316
, Issue.5822
, pp. 295-298
-
-
Pappu, R.1
Schwab, S.R.2
Cornelissen, I.3
Pereira, J.P.4
Regard, J.B.5
Xu, Y.6
Camerer, E.7
Zheng, Y.-W.8
Huang, Y.9
Cyster, J.G.10
Coughlin, S.R.11
-
21
-
-
0141780843
-
Sphingosine-1-phosphate stimulates contraction of human airway smooth muscle cells
-
DOI 10.1096/fj.02-0836com
-
Rosenfeldt HM, Amrani Y, Watterson KR, Murthy KS, Panettieri RA Jr, and Spiegel S (2003) Sphingosine-1-phosphate stimulates contraction of human airway smooth muscle cells. FASEB J 17:1789-1799. (Pubitemid 37214773)
-
(2003)
FASEB Journal
, vol.17
, Issue.13
, pp. 1789-1799
-
-
Rosenfeldt, H.M.1
Amrani, Y.2
Watterson, K.R.3
Murthy, K.S.4
Panettieri Jr., R.A.5
Spiegel, S.6
-
22
-
-
77951638132
-
Systemic administration of sphingosine-1-phosphate increases bronchial hyperresponsiveness in the mouse
-
Roviezzo F, D'Agostino B, Brancaleone V, De Gruttola L, Bucci M, De Dominicis G, Orlotti D, D'Aiuto E, De Palma R, Rossi F, et al. (2010) Systemic administration of sphingosine-1-phosphate increases bronchial hyperresponsiveness in the mouse. Am J Respir Cell Mol Biol 42:572-577.
-
(2010)
Am J Respir Cell Mol Biol
, vol.42
, pp. 572-577
-
-
Roviezzo, F.1
D'Agostino, B.2
Brancaleone, V.3
De Gruttola, L.4
Bucci, M.5
De Dominicis, G.6
Orlotti, D.7
D'Aiuto, E.8
De Palma, R.9
Rossi, F.10
-
23
-
-
34249898946
-
Sphingosine-1-phosphate/sphingosine kinase pathway is involved in mouse airway hyperresponsiveness
-
DOI 10.1165/rcmb.2006-0383OC
-
Roviezzo F, Di Lorenzo A, Bucci M, Brancaleone V, Vellecco V, De Nardo M, Orlotti D, De Palma R, Rossi F, D'Agostino B, et al. (2007) Sphingosine-1-phosphate/sphingosine kinase pathway is involved in mouse airway hyperresponsiveness. Am J Respir Cell Mol Biol 36:757-762. (Pubitemid 46871431)
-
(2007)
American Journal of Respiratory Cell and Molecular Biology
, vol.36
, Issue.6
, pp. 757-762
-
-
Roviezzo, F.1
Di, L.A.2
Bucci, M.3
Brancaleone, V.4
Vellecco, V.5
De Nardo, M.6
Orlotti, D.7
De Palma, R.8
Rossi, F.9
D'Agostino, B.10
Cirino, G.11
-
24
-
-
43049137359
-
The role of sphingosine-1-phosphate and its receptors in asthma
-
DOI 10.1358/dnp.2008.21.2.1188195
-
Ryan JJ and Spiegel S (2008) The role of sphingosine-1-phosphate and its receptors in asthma. Drug News Perspect 21:89-96. (Pubitemid 351628233)
-
(2008)
Drug News and Perspectives
, vol.21
, Issue.2
, pp. 89-96
-
-
Ryan, J.J.1
Spiegel, S.2
-
25
-
-
79959686782
-
Pharmacological relevance and potential of sphingosine 1-phosphate in the vascular system
-
Schuchardt M, Tölle M, Prüfer J, and van der Giet M (2011) Pharmacological relevance and potential of sphingosine 1-phosphate in the vascular system. Br J Pharmacol 163:1140-1162.
-
(2011)
Br J Pharmacol
, vol.163
, pp. 1140-1162
-
-
Schuchardt, M.1
Tölle, M.2
Prüfer, J.3
Van Der Giet, M.4
-
26
-
-
24644469502
-
Immunology: Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients
-
DOI 10.1126/science.1113640
-
Schwab SR, Pereira JP, Matloubian M, Xu Y, Huang Y, and Cyster JG (2005) Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Science 309:1735-1739. (Pubitemid 41285945)
-
(2005)
Science
, vol.309
, Issue.5741
, pp. 1735-1739
-
-
Schwab, S.R.1
Pereira, J.P.2
Matloubian, M.3
Xu, Y.4
Huang, Y.5
Cyster, J.G.6
|