Prospects and perspectives on IgA nephropathy from animal models

Contributions to Nephrology

Volumn 169, Issue , 2011, Pages 126-152

  Emancipator, Steven N ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN A;

ANIMAL; ARTICLE; DISEASE MODEL; GLOMERULUS; GLYCOSYLATION; IMMUNOGLOBULIN A NEPHROPATHY; METABOLISM; MOUSE; PATHOLOGY; PATHOPHYSIOLOGY;

ANIMALS; DISEASE MODELS, ANIMAL; GLOMERULONEPHRITIS, IGA; GLYCOSYLATION; IMMUNOGLOBULIN A; KIDNEY GLOMERULUS; MICE;

EID: 84925941248     PISSN: 03025144     EISSN: None     Source Type: Book Series    
DOI: 10.1159/000319124     Document Type: Article

References (179)

1. Rifai A, Small PA Jr, Teague PO, Ayoub EM: Experimental IgA nephropathy. J Exp Med 1979;150:1161-1173.
2. Isaacs KL, Miller F: Antigen size and charge in immune complex glomerulonephritis. II. Passive induction of immune deposits with dextran- antidextran immune complexes. Am J Pathol 1983;111:298-306.
3. Isaacs K, Miller F, Lane B: Experimental model for IgA nephropathy. Clin Immunol Immunopathol 1981;20:419-426.
4. Isaacs KL, Miller F: Role of antigen size and charge in immune complex glomerulonephritis. Lab Invest 1982;47:198-205.
5. Emancipator SN, Gallo GR, Lamm ME: Experimental IgA nephropathy induced by oral immunization. J Exp Med 1983;157:572-582.
6. Gormly AA, Smith PS, Seymour AE, Clarkson AR, Woodroffe AJ: IgA glomerular deposits in experimental cirrhosis. Am J Pathol 1981;104:50-54.
7. Iida H, Izumino K, Matsumoto M, Takata M, Mizumura Y, Sugimoto T: Glomerular deposition of IgA in experimental hepatic cirrhosis. Acta Pathol Jpn 1985;35:561-567.
8. Emancipator SN, Gallo GR, Razaboni R, Lamm ME: Experimental cholestasis promotes the deposition of glomerular IgA immune complexes. Am J Pathol 1983;113: 19-26.
9. Melvin T, Burke B, Michael AF, Kim Y: Experimental IgA nephropathy in bile duct ligated rats. Clin Immunol Immunopathol 1983;27:369-377.
10. Smith SM, Tokuda S, Tsukamoto H: Mucosal immune dysfunction associated with alcoholic IgA nephropathy. Clin Immunol Immunopathol 1992;64:205-209.
11. Emancipator SN: Animal models of IgA nephropathy. Curr Protoc Immunol 2001;Chapter 15: Unit 15.11.
12. Pestka JJ, Dong W, Warner RL, Rasooly L, Bondy GS: Effect of dietary administration of the trichothecene vomitoxin (deoxynivalenol) on IgA and IgG secretion by Peyers patch and splenic lymphocytes. Food Chem Toxicol 1990;28:693-699.
13. Dong W, Sell JE, Pestka JJ: Quantitative assessment of mesangial immunoglobulin A (IgA) accumulation, elevated circulating IgA immune complexes, and hematuria during vomitoxin- induced IgA nephropathy. Fundam Appl Toxicol 1991;17:197-207.
14. Imai H, Nakamoto Y, Asakura K, Miki K, Yasuda T, Miura AB: Spontaneous glomerular IgA deposition in ddY mice: an animal model of IgA nephritis. Kidney Int 1985;27: 756-761.
15. Miyawaki S, Muso E, Takeuchi E, Matsushima H, Shibata Y, Sasayama S, Yoshida H: Selective breeding for high serum IgA levels from noninbred ddY mice: isolation of a strain with an early onset of glomerular IgA deposition. Nephron 1997;76: 201-207.
16. Muso E, Yoshida H, Takeuchi E, Yashiro M, Matsushima H, Oyama A, Suyama K, Kawamura T, Kamata T, Miyawaki S, Izui S, Sasayama S: Enhanced production of glomerular extracellular matrix in a new mouse strain of high serum IgA ddY mice. Kidney Int 1996;50:1946-1957.
17. Hiki Y, Takahashi K, Shimozato S, Odani H, Yamamoto K, Tomita M, Hasegawa M, Murakami K, Nabeshima K, Nakai S, Fujita Y, Ishida I, Iwase H, Sugiyama S: Protective role of anti- synthetic hinge peptide antibody for glomerular deposition of hypoglycosylated IgA1. Clin Exp Nephrol 2008;12: 20-27.
18. Nishie T, Miyaishi O, Azuma H, Kameyama A, Naruse C, Hashimoto N, Yokoyama H, Narimatsu H, Wada T, Asano M: Development of immunoglobulin A nephropathy- like disease in beta- 1,4- galactosyltransferase- I- deficient mice. Am J Pathol 2007;170:447-456.
19. Alexander WS, Viney EM, Zhang JG, Metcalf D, Kauppi M, Hyland CD, Carpinelli MR, Stevenson W, Croker BA, Hilton AA, Ellis S, Selan C, Nandurkar HH, Goodnow CC, Kile BT, Nicola NA, Roberts AW, Hilton DJ: Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene. Proc Natl Acad Sci USA 2006;103:16442-16447.
20. Strober W, McGhee JR: Inductive and effector tissues and cells of the mucosal immune system: an overview; in Mestecky J, Lamm ME, Strober W, Bienenstock J, McGhee JR and Mayer L (eds): Mucosal Immunology, ed 3. Amsterdam, Elsevier Academic Press, 2005, pp 371- 374.
21. Emancipator SN, Mestecky J, Lamm ME: IgA nephropathy and related diseases; in Mestecky J, Lamm ME, Strober W, Bienenstock J, McGhee JR and Mayer L (eds): Mucosal Immunology, ed 3. Amsterdam, Elsevier Academic Press, 2005, pp 1579-1600, ISBN: 0- 12- 491543-4.
22. Sato M, Ideura T, Koshikawa S: Experimental IgA nephropathy in mice. Lab Invest 1986;54: 377-384.
23. Genin C, Laurent B, Sabatier JC, Colon S, Berthoux FC: IgA mesangial deposits in C3H/HeJ mice after oral immunization with ferritin or bovine serum albumin. Clin Exp Immunol 1986;63:385-394.
24. Genin C, Sabatier JC, Berthoux FC: IgA mesangial deposits in C3H/HeJ mice after oral immunisation. Proc Eur Dial Transplant Assoc Eur Ren Assoc 1985;21:703-708.
25. Emancipator SN, Ovary Z, Lamm ME: The role of mesangial complement in the hematuria of experimental IgA nephropathy. Lab Invest 1987;57:269-276.
26. Biewenga J, Noordhoek GT, Donker AJ, Beukhof JR: IgA nephropathy is not induced in mice by oral administration of TNP- conjugated ovalbumin. Nephron 1987;47: 295-298.
27. Emancipator SN, Lamm ME: The role of IgG, IgM, and C3 in experimental murine IgA nephropathy. Semin Nephrol 1987;7:286-288.
28. Coppo R, Mazzucco G, Martina G, Roccatello D, Amore A, Novara R, Bargoni A, Piccoli G, Sena LM: Gluten- induced experimental IgA glomerulopathy. Lab Invest 1989;60:499-506.
29. Jin SY, Choi IJ: The effect of sodium cromoglycate on the induction of experimental IgA nephropathy. Yonsei Med J 1990;31:33-48.
30. Gesualdo L, Lamm ME, Emancipator SN: Defective oral tolerance promotes nephritogenesis in experimental IgA nephropathy induced by oral immunization. J Immunol 1990;145:3684-3691.
31. Jessen RH, Emancipator SN, Jacobs GH, Nedrud JG: Experimental IgAIgG nephropathy induced by a viral respiratory pathogen. Dependence on antigen form and immune status. Lab Invest 1992;67:379-386.
32. Endo Y, Kanbayashi H, Hara M: Experimental immunoglobulin A nephropathy induced by Gram- negative bacteria. Nephron 1993;65:196-205.
33. Chintalacharuvu SR, Nagy NU, Sigmund N, Nedrud JG, Amm ME, Emancipator SN: T cell cytokines determine the severity of experimental IgA nephropathy by regulating IgA glycosylation. Clin Exp Immunol 2001; 126:326-333.
34. Yamamoto C, Suzuki S, Kimura H, Yoshida H, Gejyo F: Experimental nephropathy induced by Haemophilus parainfluenzae antigens. Nephron 2002;90:320-327.
35. Amore A, Coppo R, Nedrud JG, Sigmund N, Lamm ME, Emancipator SN: The role of nasal tolerance in a model of IgA nephropathy induced in mice by Sendai virus. Clin Immunol 2004;113:101-108.
36. Jia L, Wang C, Kong H, Yang J, Li F, Lv S, Xu G: Effect of PA- MSHA vaccine on plasma phospholipids metabolic profiling and the ratio of Th2/Th1 cells within immune organ of mouse IgA nephropathy. J Pharm Biomed Anal 2007;43:646-654.
37. Soylu A, Berktaş S, Sarioǧlu S, Erbil G, Yilmaz O, Demir BK, Tufan Y, Yeşüilirmak D, Türkmen M, Kavukçu S. Saccharomyces boulardii prevents oral- poliovirus vaccine- induced IgA nephropathy in mice. Pediatr Nephrol 2008;23:1287-1291.
38. Chintalacharuvu SR, Yamashita M, Bagheri N, Blanchard TG, Nedrud JG, Lamm ME, Tomino Y, Emancipator SN: T cell cytokine polarity as a determinant of immunoglobulin A (IgA) glycosylation and the severity of experimental IgA nephropathy. Clin Exp Immunol 2008;153:456-462.
39. Gesualdo L, Emancipator SN, Kesselheim C, Lamm ME: Glomerular hemodynamics and eicosanoid synthesis in a rat model of IgA nephropathy. Kidney Int 1992;42:106-114.
40. Yi ZW, Rodriguez GE, Krieg RJ Jr, Tokieda K, Chan JC: Rat macrophages in experimental IgA nephropathy. Biochem Mol Med 1996; 57:152-155.
41. Trachtman H, Chan JC, Chan W, Valderrama E, Brandt R, Wakely P, Futterweit S, Maesaka J, Ma C: Vitamin E ameliorates renal injury in an experimental model of immunoglobulin A nephropathy. Pediatr Res 1996;40:620-626.
42. Chan W, Krieg RJ Jr, Norkus EP, Chan JC: alpha- Tocopherol reduces proteinuria, oxidative stress, and expression of transforming growth factor beta 1 in IgA nephropathy in the rat. Mol Genet Metab 1998;63:224-229.
43. Kuemmerle NB, Chan W, Krieg RJ Jr, Norkus EP, Trachtman H, Chan JC: Effects of fish oil and alphatocopherol in immunoglobulin A nephropathy in the rat. Pediatr Res 1998;43: 791-797.
44. Zhong Q, Leung JC, Chan LY, Tsang AW, Chen X, Lai KN: The study of Chinese medicinal herbal formula Shen San Fang in the treatment of experimental IgA nephropathy. Am J Chin Med 2005;33:613-626.
45. Zhang GZ, Wu XC, Peng XJ, Yi ZW, Mo SH, Tan H: Effects of astragalus on renal tubulointerestitial lesions and expression of NF- kappaB and MCP- 1 in renal tissues in rat experimental IgA nephropathy (in Chinese). Zhongguo Dang Dai Er Ke Za Zhi 2008;10: 173-178.
46. Tang Y, Lou TQ, Wang C, Peng H, Liu X, Tang H: Study on protective effects and its mechanism of leflunomide on renal tissue in rat IgA nephropathy model (in Chinese). Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2008;20:283-285.
47. Peng W, Liu ZR: Comparison of two rat models of IgA nephropathy (in Chinese). Nan Fang Yi Ke Da Xue Xue Bao 2008;28: 1842-1845.
48. Gómez- Guerrero C, López- Franco O, Suzuki Y, Sanjuán G, Hernández- Vargas P, Blanco J, Egido J: Nitric oxide production in renal cells by immune complexes: role of kinases and nuclear factor- kappaB. Kidney Int 2002;62: 2022-2034.
49. Sharmin S, Shimizu Y, Hagiwara M, Hirayama K, Koyama A: Staphylococcus aureus antigens induce IgA- type glomerulonephritis in Balb/c mice. J Nephrol 2004;17: 504-511.
50. Kurihara RS, Yokoo M, Domingues WV, Cabrera WH, Ribeiro OG, Ibanez OM, Malheiros DA, Barros RT, de Almeida Prado EB: Genetic potential for an acute inflammatory response in IgA glomerulonephritis in mice. Braz J Med Biol Res 2005;38:1807-1815.
51. Quigg RJ, Lim A, Haas M, Alexander JJ, He C, Carroll MC: Immune complex glomerulonephritis in C4- and C3- deficient mice. Kidney Int 1998;53:320-330.
52. Wang J, Anders RA, Wu Q, Peng D, Cho JH, Sun Y, Karaliukas R, Kang HS, Turner JR, Fu YX: Dysregulated LIGHT expression on T cells mediates intestinal inflammation and contributes to IgA nephropathy. J Clin Invest 2004;113:826-835.
53. Pestka JJ: Deoxynivalenol- induced IgA production and IgA nephropathyaberrant mucosal immune response with systemic repercussions. Toxicol Lett 2003;140- 141: 287-295.
54. Rasooly L, Pestka JJ: Vomitoxininduced dysregulation of serum IgA, IgM and IgG reactive with gut bacterial and self antigens. Food Chem Toxicol 1992;30:499-504.
55. Schroeder C, Osman AA, Roggenbuck D, Mothes T: IgA- gliadin antibodies, IgA- containing circulating immune complexes, and IgA glomerular deposits in wasting marmoset syndrome. Nephrol Dial Transplant 1999;14:1875-1880.
56. Brack M, Schroeder C, Fooke M, Schlumberger W: IgM/IgA nephropathy in callitrichids: antigen studies. Nephron 1999; 82:221-231.
57. Yan D, Rumbeiha WK, Pestka JJ: Experimental murine IgA nephropathy following passive administration of vomitoxin- induced IgA monoclonal antibodies. Food Chem Toxicol 1998;36:1095-1106.
58. Akadegawa K, Ishikawa S, Sato T, Suzuki J, Yurino H, Kitabatake M, Ito T, Kuriyama T, Matsushima K: Breakdown of mucosal immunity in the gut and resultant systemic sensitization by oral antigens in a murine model for systemic lupus erythematosus. J Immunol 2005;174:5499-5506.
59. Kamata T, Nogaki F, Fagarasan S, Sakiyama T, Kobayashi I, Miyawaki S, Ikuta K, Muso E, Yoshida H, Sasayama S, Honjo T: Increased frequency of surface IgA- positive plasma cells in the intestinal lamina propria and decreased IgA excretion in hyper IgA (HIGA) mice, a murine model of IgA nephropathy with hyperserum IgA. J Immunol 2000;165:1387-1394.
60. Makino T, Ono T, Matsuyama K, Nogaki F, Miyawaki S, Honda G, Muso E: Suppressive effects of Perilla frutescens on IgA nephropathy in HIGA mice. Nephrol Dial Transplant 2003;18:484-490.
61. Lopez MC, Watzl B, Hebert AR, Murphy L, Huang DS, Watson RR: Ethanol- induced changes in the intestinal mucosa- associated immune system of young and mature mice. Alcohol 1993;10:555-557.
62. González- Cabrero J, Egido J, Barat A, González E: Detection and characterization of circulating and glomerular immune complexes in experimental IgA nephropathy. Immunology 1990;70:296-302.
63. Gesualdo L, Ricanati S, Hassan MO, Emancipator SN, Lamm ME: Enzymolysis of glomerular immune deposits in vivo with dextranase/protease ameliorates proteinuria, hematuria, and mesangial proliferation in murine experimental IgA nephropathy. J Clin Invest 1990;86:715-722.
64. González E, González- Cabrero J, Egido J: Defective hepatic handling of IgA immune aggregates by mice with experimental IgA nephropathy. Immunology 1989;67:308-313.
65. Burg M, Grne HJ, Koch KM, Floege J: Cationic dextran induces mesangioproliferative nephritis in rats independent of glomerular IgA deposition. Nephrol Dial Transplant 1997;12:1856-1862.
66. Pasi A, Dendorfer U, Holthfer H, Nelson PJ, Tazzari S, Armelloni S, Fornasieri A, DAmico G, Schlndorff D: Characterization of nephropathy induced by immunization with high molecular weight dextran. Nephrol Dial Transplant 1997;12:1849-1855.
67. Macpherson AJ, Lamarre A, McCoy K, Harriman GR, Odermatt B, Dougan G, Hengartner H, Zinkernagel RM: IgA production without mu or delta chain expression in developing B cells. Nat Immunol 2001;2:625-631.
68. Kavukçu S, Soylu A, Sarioǧlu S, Türkmen M, Küpelioǧlu A, Pekçetin C, Güre A: IgA nephropathy in mice following repeated administration of conjugated Haemophilus influenza type B vaccine (PRP- T). Tokai J Exp Clin Med 1997;22:167-174.
69. Kamiyama S: Experimental glomerulonephritis induced by Coxsackie B4 virus in mice- glomerular changes associated with intermittent viral inoculations (in Japanese). Nippon Jinzo Gakkai Shi 1990;32:939-948.
70. Yoshida K, Suzuki J, Suzuki S, Kume K, Mutoh S, Kato K, Suzuki H: Experimental IgA nephropathy induced by coxsackie B4 virus in mice. Am J Nephrol 1997;17:81-88.
71. Isome M, Yoshida K, Suzuki S, Kume K, Suzuki J, Kato K, Suzuki H: Experimental glomerulonephritis following successive inoculation of five different serotypes of group B coxsackieviruses in mice. Nephron 1997;77:93-99.
72. Kawasaki Y, Mitsuaki H, Isome M, Nozawa R, Suzuki H: Renal effects of Coxsackie B4 virus in hyper- IgA mice. J Am Soc Nephrol 2006;17:2760-2769.
73. Marquina R, Díez MA, López- Hoyos M, Buelta L, Kuroki A, Kikuchi S, Villegas J, Pih lgren M, Siegrist CA, Arias M, Izui S, Merino J, Merino R: Inhibition of B cell death causes the development of an IgA nephropathy in (New Zealand white x C57BL/6) F(1)- bcl- 2 transgenic mice. J Immunol 2004;172:7177-7185.
74. Marín MJ, García I, Peña M, Bolívar A, Zubiaga A, Lóez- Hoyos M: E2F1- /- C57BL/6 mice overexpressing a human Bcl- 2 transgene in B cells develop a mild autoimmune syndrome. Ann NY Acad Sci 2005;1051:156-165.
75. McCarthy DD, Chiu S, Gao Y, Summers- deLuca LE, Gommerman JL: BAFF induces a hyper- IgA syndrome in the intestinal lamina propria concomitant with IgA deposition in the kidney independent of LIGHT. Cell Immunol 2006;241:85-94.
76. Kamata T, Muso E, Yashiro M, Kawamura T, Oyama A, Matsushima H, Takeuchi E, Yoshida H, Sasayama S: Up- regulation of glomerular extracellular matrix and transforming growth factor- beta expression in RF/J mice. Kidney Int 1999;55:864-876.
77. Ellison CA, Gibson IW, Hayglass KT, Gartner JG: Effect of palifermin in a murine model of graft- versus- host disease (GVHD) associated with Th2 cytokine production, autoantibody production, and glomerulonephritis. J Clin Immunol 2006;26:485-494.
78. Curcio C, Pannellini T, Lanzardo S, Forni G, Musiani P, Antón IM: WIP null mice display a progressive immunological disorder that resembles Wiskott- Aldrich syndrome. J Pathol 2007;211:67-75.
79. Nishizumi H, Taniuchi I, Yamanashi Y, Kitamura D, Ilic D, Mori S, Watanabe T, Yamamoto T: Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn- deficient mice. Immunity 1995;3:549-560.
80. Nogaki F, Muso E, Kobayashi I, Kusano H, Shirakawa K, Kamata T, Oyama A, Ono T, Miyawaki S, Yoshida H, Sasayama S: Interleukin 12 induces crescentic glomerular lesions in a high IgA strain of ddY mice, independently of changes in IgA deposition. Nephrol Dial Transplant 2000;15:1146-1154.
81. Warner RL, Brooks K, Pestka JJ: In vitro effects of vomitoxin (deoxynivalenol) on T- cell interleukin production and IgA secretion. Food ChemToxicol 1994;32:617-625.
82. Senpuku H, Asano T, Matin K, Salam MA, Tsuha Y, Horibata S, Shimazu Y, Soeno Y, Aoba T, Sata T, Hanada N, Honda M: Effects of human interleukin- 18 and interleukin- 12 treatment on human lymphocyte engraftment in NOD- scid mouse. Immunology 2002;107:232-242.
83. Imasawa T, Nagasawa R, Utsunomiya Y, Kawamura T, Zhong Y, Makita N, Muso E, Miyawaki S, Maruyama N, Hosoya T, Sakai O, Ohno T: Bone marrow transplantation attenuates murine IgA nephropathy: role of a stem cell disorder. Kidney Int 1999;56:1809-1817.
84. Suzuki H, Suzuki Y, Aizawa M, Yamanaka T, Kihara M, Pang H, Horikoshi S, Tomino Y: Th1 polarization in murine IgA nephropathy directed by bone marrow- derived cells. Kidney Int 2007;72:319-327.
85. Shimizu Y, Sakurai H, Hirayama K, Seki M, Yoh K, Yamagata K, Koyama A: Staphylococcal cell membrane antigen, a possible antigen in postmethicillin resistant Staphylococcus aureus (MRSA) infection nephritis and IgA nephropathy, exhibits high immunogenic activity that is enhanced by superantigen. J Nephrol 2005;18:249-256.
86. Nagasawa R, Mitarai T, Utsunomiya Y, Yoshida H, Kitamura M, Yamura W, Maruyama N, Isoda K, Sakai O: Neonatal thymectomy diminishes renal IgA deposition in IgA nephropathy- prone ddY mice. Nephron 1994;66:326-332.
87. Bagheri N, Pepple DA, Hassan MO, Harding CV, Emancipator SN: Development of immune- complex glomerulonephritis in athymic mice: T cells are not required for the genesis of glomerular injury. Lab Invest 2005; 85:354-363.
88. Haseyama T, Fujita T, Hirasawa F, Tsukada M, Wakui H, Komatsuda A, Ohtani H, Miura AB, Imai H, Koizumi A: Complications of IgA nephropathy in a non- insulin- dependent diabetes model, the Akita mouse. Tohoku J Exp Med 2002;198:233-244.
89. Miller LL, Izzo MJ, Wemett D, Panner BJ, Schenk EA: Increased plasma IgA, sIgA, and C3- and IgA- containing immune complexes with renal glomerular deposits in diabetic rats. Diabetes 1988;37:185-193.
90. Kennel- De March A, Prin- Mathieu C, Kohler CH, Kolopp- Sarda MN, Faure GC, Béné MV: Back- pack mice as a model of renal mesangial IgA dimmers deposition. Int J Immunopathol Pharmacol 2005;18:701-708.
91. Ramaiah SK, Seguin MA, Carwile HF, Raskin RE: Biclonal gammopathy associated with immunoglobulin A in a dog with multiple myeloma. Vet Clin Pathol 2002;31:83-89.
92. Suzuki Y, Tomino Y: Potential immunopathogenic role of the mucosa- bone marrow axis in IgA nephropathy: insights from animal models. Semin Nephrol 2008;28:66-77.
93. Agodoa LY, Gauthier VJ, Mannik M: Precipitating antigen- antibody systems are required for the formation of subepithelial electron- dense immune deposits in rat glomeruli. J Exp Med 1983;158:1259-1271.
94. Mannik M, Agodoa LY, David KA. Rearrangement of immune complexes in glomeruli leads to persistence and development of electrondense deposits. J Exp Med. 1983 May 1;157(5):1516-28.
95. Agodoa LY, Gauthier VJ, Mannik M: Antibody localization in the glomerular basement membrane may precede in situ immune deposit formation in rat glomeruli. J Immunol 1985;134:880-884.
96. Rifai A, Mannik M. Clearance kinetics and fate of mouse IgA immune complexes prepared with monomeric or dimeric IgA. J Immunol. 1983 Apr;130(4):1826-32.
97. Rifai A, Millard K: Glomerular deposition of immune complexes prepared with monomeric or polymeric IgA. Clin Exp Immunol 1985;60:363-368. (Pubitemid 15099885)
98. Rifai A: Characteristics of nephritogenic IgA immune complexes. Am J Kidney Dis 1988; 12:402-405.
99. Chen A, Sheu LF, Ding SL, Lee WH: Monomeric immunoglobulin A protects glomerulus against polymeric immunoglobulin A immune complex in experimental immunoglobulin A nephropathy. Lab Invest 1996;74:737-746.
100. Chen A, Wong SS, Rifai A: Glomerular immune deposits in experimental IgA nephropathy. A continuum of circulating and in situ formed immune complexes. Am J Pathol 1988;130:216-222.
101. Chen A, Sheu LF, Shaio MF, Huang TH, Ding SL, Lee WH: Anti- idiotype antibody directly interferes with glomerular IgA immune complex deposition. Nephron 1998;78:464-473.
102. Rifai A, Chen A, Imai H: Complement activation in experimental IgA nephropathy: an antigen- mediated process. Kidney Int 1987; 32:838-844.
103. Montinaro V, Esparza AR, Cavallo T, Rifai A: Antigen as mediator of glomerular injury in experimental IgA nephropathy. Lab Invest 1991;64:508-519.
104. Hiki Y, Kokubo T, Iwase H, Masaki Y, Sano T, Tanaka A, Toma K, Hotta K, Kobayashi Y: Underglycosylation of IgA1 hinge plays a certain role for its glomerular deposition in IgA nephropathy. J Am Soc Nephrol 1999;10: 760-769.
105. Sano T, Hiki Y, Kokubo T, Iwase H, Shigematsu H, Kobayashi Y: Enzymatically deglycosylated human IgA1 molecules accumulate and induce inflammatory cell reaction in rat glomeruli. Nephrol Dial Transplant 2002;17:50-56.
106. Davin JC, Dechenne C, Lombet J, Rentier B, Foidart JB, Mahieu PR: Acute experimental glomerulonephritis induced by the glomerular deposition of circulating polymeric IgA- concanavalin A complexes. Virchows Arch A Pathol Anat Histopathol 1989;415:7-20. (Pubitemid 19158858)
107. Amore A, Emancipator SN, Roccatello D, Gianoglio B, Peruzzi L, Porcellini MG, Piccoli G, Coppo R: Functional consequences of the binding of gliadin to cultured rat mesangial cells: bridging immunoglobulin A to cells and modulation of eicosanoid synthesis and altered cytokine production. Am J Kidney Dis 1994;23:290-301.
108. Emancipator SN, Rao CS, Amore A, Coppo R, Nedrud JG: Macromolecular properties that promote mesangial binding and mesangiopathic nephritis. J Am Soc Nephrol 1992;2(Suppl 10):S149-S158.
109. Stad RK, Bruijn JA, van Gijlswijk- Janssen DJ, van Es LA, Daha MR: An acute model for IgA- mediated glomerular inflammation in rats induced by monoclonal polymeric rat IgA antibodies. Clin Exp Immunol 1993; 92:514-521.
110. van Dixhoorn MG, Gorter A, Sato T, van der Wal AM, van Eendenburg JD, Rozing J, Daha MR, de Heer E: Induction of microhematuria by an IgA isotype switch variant of a monoclonal anti- Thy- 1.1 antibody in the rat. Kidney Int 1996;50:1612-1623.
111. Van Dixhoorn MG, Sato T, Muizert Y, Van Gijlswijk- Janssen DJ, de Heer E, Daha MR: Combined administration of IgA and IgG anti- Thy- 1 antibodies enhances renal inflammation in rats. Kidney Int 1999;55:2299-2309.
112. van Dixhoorn MG, Sato T, Muizert Y, van Gijlswijk- Janssen DJ, De Heer E, Daha MR: Combined glomerular deposition of polymeric rat IgA and IgG aggravates renal inflammation. Kidney Int 2000;58:90-99.
113. Zheng F, Kundu GC, Zhang Z, Ward J, DeMayo F, Mukherjee AB: Uteroglobin is essential in preventing immunoglobulin A nephropathy in mice. Nat Med 1999;5:1018-1025.
114. Zhang Z, Kundu GC, Zheng F, Yuan CJ, Lee E, Westphal H, Ward J, DeMayo F, Mukherjee AB: Insight into the physiological function(s) of uteroglobin by gene- knockout and antisense- transgenic approaches. Ann NY Acad Sci 2000;923:210-233.
115. Kim YS, Kang D, Kwon DY, Park WY, Kim H, Lee DS, Lim CS, Han JS, Kim S, Lee JS: Uteroglobin gene polymorphisms affect the progression of immunoglobulin A nephropathy by modulating the level of uteroglobin expression. Pharmacogenetics 2001;11:299-305.
116. Coppo R, Chiesa M, Cirina P, Peruzzi L, Amore A, European IgACE Study Group: In human IgA nephropathy uteroglobin does not play the role inferred from transgenic mice. Am J Kidney Dis 2002;40:495-503.
117. Amore A, Roccatello D, Picciotto G, Emancipator SN, Ropolo R, Cacace G, Suriani A, Gianoglio B, Sena LM, Cirina P, Mazzucco G, Alfieri V, Piccoli G, Coppo R, De Filippi PG: Processing of IgA aggregates in a rat model of chronic liver disease. Clin Immunol Immunopathol 1997;84:107-114.
118. Waxman FJ, Hebert LA, Cosio FG, Smead WL, VanAman ME, Taguiam JM, Birmingham DJ: Differential binding of immunoglobulin A and immunoglobulin G1 immune complexes to primate erythrocytes in vivo. Immunoglobulin A immune complexes bind less well to erythrocytes and are preferentially deposited in glomeruli. J Clin Invest 1986;77:82-89.
119. Hosokawa S, Tagaya O, Mikami T, Nozaki Y, Kawaguchi A, Yamatsu K, Shamoto M: A new rat mutant with chronic conjugated hyperbilirubinemia and renal glomerular lesions. Lab Anim Sci 1992;42:27-34.
120. Smith SM, Tsukamoto H: Time dependency of IgA nephropathy induction in alcohol ingestion. Alcohol Clin Exp Res 1992;16: 471-473.
121. Amore A, Coppo R, Roccatello D, Piccoli G, Mazzucco G, Gomez- Chiarri M, Lamm ME, Emancipator SN: Experimental IgA nephropathy secondary to hepatocellular injury induced by dietary deficiencies and heavy alcohol intake. Lab Invest 1994;70:68-77.
122. Stad RK, Bogers WM, Muizert Y, van Es LA, Daha MR: Deposition of IgA is associated with macrophage influx in the kidney of rats. Scand J Immunol 1991;34:81-89.
123. Smith SM, Yu GS, Tsukamoto H: IgA nephropathy in alcohol abuse. An animal model. Lab Invest 1990;62:179-184.
124. Finbloom DS, Magilavy DB, Harford JB, Rifai A, Plotz PH: Influence of antigen on immune complex behavior in mice. J Clin Invest 1981;68:214-224.
125. Rifai A, Finbloom DS, Magilavy DB, Plotz PH: Modulation of the circulation and hepatic uptake of immune complexes by carbohydrate recognition systems. J Immunol 1982;128:2269-2275.
126. Rifai A, Fadden K, Morrison SL, Chintalacharuvu KR: The N- glycans determine the differential blood clearance and hepatic uptake of human immunoglobulin (Ig) A1 and IgA2 isotypes. J Exp Med 2000;191:2171-2182.
127. Launay P, Grossetête B, Arcos- Fajardo M, Gaudin E, Torres SP, Beaudoin L, Patey- Mariaud de Serre N, Lehuen A, Monteiro RC: Fcalpha receptor (CD89) mediates the development of immunoglobulin A (IgA) nephropathy (Bergers disease). Evidence for pathogenic soluble receptor- Iga complexes in patients and CD89 transgenic mice. J Exp Med 2000;191:1999- 2009. Erratum in: J Exp Med 2000;192:following 309.
128. Robinson JK, Blanchard TG, Levine AD, Emancipator SN, Lamm ME: A mucosal IgA- mediated excretory immune system in vivo. J Immunol 2001;166:3688-3692.
129. Yanagihara T, Kumagai Y, Norose Y, Moro I, Nanno M, Murakami M, Takahashi H: Age- dependent decrease of polymeric Ig receptor expression and IgA elevation in ddY mice: a possible cause of IgA nephropathy. Lab Invest 2004;84:63-70.
130. van der Boog PJ, van Kooten C, van Zandbergen G, Klar- Mohamad N, Oortwijn B, Bos NA, van Remoortere A, Hokke CH, de Fijter JW, Daha MR: Injection of recombinant FcalphaRI/ CD89 in mice does not induce mesangial IgA deposition. Nephrol Dial Transplant 2004;19:2729-2736.
131. Stad RK, van Gijlswijk- Janssen DJ, van Es LA, Daha MR: Complement depletion abolishes IgA- mediated glomerular inflammation in rats. Exp Nephrol 1994;2:182-189.
132. Fornasieri A, DAmico G: Experimental IgA mesangial nephropathy: the role of antigen and antibody. Contrib Nephrol 1995;111: 149-154.
133. Broestl JA, Emancipator SN: Rat mesangial cell lysis in vitro is induced by cationic polypeptides. Am J Pathol 1993;142:529-539.
134. Imai H, Yasuda T, Wakui H, Miura AB: Streptococcal pneumonia polysaccharide increases IgA- class antibody activity under the immunological memory of a protein antigen: two signals on experimental IgA nephropathy. Nippon Jinzo Gakkai Shi 1995; 37:323-329.
135. Montinaro V, Hevey K, Aventaggiato L, Fadden K, Esparza A, Chen A, Finbloom DS, Rifai A: Extrarenal cytokines modulate the glomerular response to IgA immune complexes. Kidney Int 1992;42:341-353.
136. Kobayashi N, Bagheri N, Nedrud JG, Strieter RM, Tomino Y, Lamm ME, Emancipator SN: Differential effects of Sendai virus infection on mediator synthesis by mesangial cells from two mouse strains. Kidney Int 2003;64: 1675-1684.
137. Suzuki H, Suzuki Y, Narita I, Aizawa M, Kihara M, Yamanaka T, Kanou T, Tsukaguchi H, Novak J, Horikoshi S, Tomino Y: Toll- like receptor 9 affects severity of IgA nephropathy. J Am Soc Nephrol 2008;19:2384-2395.
138. Chen A, Ding SL, Sheu LF, Song YB, Shieh SD, Shaio MF, Chou WY, Ho YS: Experimental IgA nephropathy. Enhanced deposition of glomerular IgA immune complex in proteinuric states. Lab Invest 1994;70: 639-647.
139. Shi Y, Pestka JJ: Attenuation of mycotoxin- induced IgA nephropathy by eicosapentaenoic acid in the mouse: dose response and relation to IL- 6 expression. J Nutr Biochem 2006;17:697-706.
140. Jia Q, Zhou HR, Bennink M, Pestka JJ: Docosahexaenoic acid attenuates mycotoxin- induced immunoglobulin a nephropathy, interleukin- 6 transcription, and mitogen- activated protein kinase phosphorylation in mice. J Nutr 2004;134:3343-3349.
141. Ohashi N, Katsurada A, Miyata K, Satou R, Saito T, Urushihara M, Kobori H: Role of activated intrarenal reactive oxygen species and reninangiotensin system in IgA nephropathy model mice. Clin Exp Pharmacol Physiol 2009;36:750-755.
142. Shi Y, Pestka JJ: Mechanisms for suppression of interleukin- 6 expression in peritoneal macrophages from docosahexaenoic acid- fed mice. J Nutr Biochem 2009;20:358-368.
143. Jia Q, Pestka JJ: Role of cyclooxygenase- 2 in deoxynivalenol- induced immunoglobulin a nephropathy. Food Chem Toxicol 2005;43: 721-728.
144. Gesualdo L, Pinzani M, Floriano JJ, Hassan MO, Nagy NU, Schena FP, Emancipator SN, Abboud HE: Platelet- derived growth factor expression in mesangial proliferative glomerulonephritis. Lab Invest 1991;65:160-167.
145. Katsuma S, Shiojima S, Hirasawa A, Suzuki Y, Takagaki K, Murai M, Kaminishi Y, Hada Y, Koba M, Muso E, Miyawaki S, Ohgi T, Yano J, Tsujimoto G: Genomic analysis of a mouse model of immunoglobulin A nephro pathy reveals an enhanced PDGF- EDG5 cascade. Pharmacogenomics J 2001;1:211-217.
146. Hattori T, Sadakane C, Koseki J, Kase Y, Takeda S: Saireito probably prevents mesangial cell proliferation in HIGA mice via PDGF- BB tyrosine kinase inhibition. Clin Exp Nephrol 2007;11:275-282.
147. Suematsu S, Matsuda T, Aozasa K, Akira S, Nakano N, Ohno S, Miyazaki J, Yamamura K, Hirano T, Kishimoto T: IgG1 plasmacytosis in interleukin 6 transgenic mice. Proc Natl Acad Sci USA 1989;86:7547-7551.
148. Katsume A, Saito H, Yamada Y, Yorozu K, Ueda O, Akamatsu K, Nishimoto N, Kishimoto T, Yoshizaki K, Ohsugi Y: Anti- interleukin 6 (IL- 6) receptor antibody suppresses Castlemans disease like symptoms emerged in IL- 6 transgenic mice. Cytokine 2002;20:304-311.
149. Shima Y, Iwano M, Yoshizaki K, Tanaka T, Kawase I, Nishimoto N: All- trans- retinoic acid inhibits the development of mesangial proliferative glomerulonephritis in interleukin- 6 transgenic mice. Nephron Exp Nephrol 2005;100:e54- 62.
150. Horii Y, Iwano M, Hirata E, Shiiki M, Fujii Y, Dohi K, Ishikawa H: Role of interleukin- 6 in the progression of mesangial proliferative glomerulonephritis. Kidney Int Suppl 1993; 39:S71-S75.
151. Ruef C, Budde K, Lacy J, Northemann W, Baumann M, Sterzel RB, Coleman DL: Interleukin 6 is an autocrine growth factor for mesangial cells. Kidney Int 1990;38:249-257.
152. Pestka JJ, Zhou HR: Interleukin- 6- deficient mice refractory to IgA dysregulation but not anorexia induction by vomitoxin (deoxyniva lenol) ingestion. Food Chem Toxicol 2000; 38:565-575.
153. Floege J, Eitner F, Barratt J, Smith AC, Feehally J: Mutant mice provide new insight into the role of (mis- )glycation in IgA nephropathy and other glomerular diseases. Nephrol Dial Transplant 2007;22:1518-1520.
154. Tsushima Y, Tomino Y, Shimizu M, Ohmuro H, Takeuchi K, Kuramoto T, Shirato I, Koide H: IgA deposits might not influence the production of extracellular matrix in glomeruli of ddY mice, a spontaneous animal model for IgA nephropathy. Nephron 1994;66:81-86.
155. Leung JC, Chan LY, Tsang AW, Liu EW, Lam MF, Tang SC, Lai KN: Antimacrophage migration inhibitory factor reduces transforming growth factor-
156. Pestka JJ, Zhou HR: Effects of tumor necrosis factor type 1 and 2 receptor deficiencies on anorexia, growth and IgA dysregulation in mice exposed to the trichothecene vomitoxin. Food Chem Toxicol 2002;40:1623-1631.
157. Bussolati B, Peri G, Salvidio G, Verzola D, Mantovani A, Camussi G: The long pentraxin PTX3 is synthesized in IgA glomerulonephritis and activates mesangial cells. J Immunol 2003;170:1466-1472.
158. Zhang JJ, Xu LX, Zhang Y, Zhao MH: Binding capacity of in vitro deglycosylated IgA1 to human mesangial cells. Clin Immunol 2006;119:103-109.
159. Borda JT, Pauley DR, MacKey JJ, Alvarez X, Simon MA, Klumpp SA: Immunoglobulin- A nephropathy with crescentic glomerulonephritis in a pigtailed macaque (Macaca nemestrina). Vet Pathol 2004;41:44-49.
160. Stephens EB, Tian C, Li Z, Narayan O, Gattone VH 2nd: Rhesus macaques infected with macrophage- tropic simian immunodeficiency virus (SIVmacR71/17E) exhibit extensive focal segmental and global glomerulosclerosis. J Virol 1998;72:8820-8832.
161. Yoshie T: Study on the swine glomerulopathy resembling human IgA nephropathy (in Japanese). Nippon Jinzo Gakkai Shi 1991;33: 179-189.
162. Hedman R, Thuvander A, Gadhasson I, Reverter M, Pettersson H: Influence of dietary nivalenol exposure on gross pathology and selected immunological parameters in young pigs. Nat Toxins 1997;5:238-246.
163. Koeman JP, Biewenga WJ, Gruys E: Proteinuria in the dog: a pathomorphological study of 51 proteinuric dogs. Res Vet Sci: 1987;43:367-378.
164. Center SA, Smith CA, Wilkinson E, Erb HN, Lewis RM: Clinicopathologic, renal immunofluorescent, and light microscopic features of glomerulonephritis in the dog: 41 cases (1975- 1985). J Am Vet Med Assoc 1987;190: 81-90.
165. Miyauchi Y, Nakayama H, Uchida K, Uetsuka K, Hasegawa A, Goto N: Glomerulopathy with IgA deposition in the dog. J Vet Med Sci 1992;54:969-975.
166. Harris CH, Krawiec DR, Gelberg HB, Shapiro SZ: Canine IgA glomerulonephropathy. Vet Immunol Immunopathol 1993;36:1-16.
167. Nieto CG, Navarrete I, Habela MA, Serrano F, Redondo E: Pathological changes in kidneys of dogs with natural Leishmania infection. Vet Parasitol 1992;45:33-47.
168. Zaragoza C, Barrera R, Centeno F, Tapia JA, Mañe MC: Canine pyometra: a study of the urinary proteins by SDS- PAGE and Western blot. Theriogenology 2004;61:1259-1272.
169. Tisdall PL, Rothwell TL, Hunt GB, Malik R: Glomerulopathy in dogs with congenital portosystemic shunts. Aust Vet J 1996;73:52-54.
170. Dambach DM, Smith CA, Lewis RM, Van Winkle TJ: Morphologic, immunohistochemical, and ultrastructural characterization of a distinctive renal lesion in dogs putatively associated with Borrelia burgdorferi infection: 49 cases (1987- 1992). Vet Pathol 1997;34:85-96.
171. Elsinghorst TA: First cases of animal diseases published since 2000. 1. Dogs. Vet Q 2003;25: 112-123.
172. Aresu L, Pregel P, Bollo E, Palmerini D, Sereno A, Valenza F: Immunofluorescence staining for the detection of immunoglobulins and complement (C3) in dogs with renal disease. Vet Rec 2008;163:679-682.
173. Stinson MW, Nisengard RJ, Neiders ME, Albini B: Serology and tissue lesions in rabbits immunized with Streptococcus mutans. J Immunol 1983;131:3021-3027.
174. Albini B, Nisengard RJ, Glurich I, Neiders ME, Stinson MW: Streptococcus mutans- induced nephritis in rabbits. Am J Pathol 1985;118:408-418.
175. Galan JE, Timoney JF: Immune complexes in purpura hemorrhagica of the horse contain IgA and M antigen of Streptococcus equi. J Immunol 1985;135:3134-3137.
176. Sartori A, Roque- Barreira MC, Coe J, Campos- Neto A: Immune complex glomerulonephritis in experimental kala- azar. II: detection and characterization of parasite antigens and antibodies eluted from kidneys of Leishmania donovani- infected hamsters. Clin Exp Immunol 1992;87:386-392.
177. Portis JL, Coe JE: Deposition of IgA in renal glomeruli of mink affected with Aleutian disease. Am J Pathol 1979;96:227-236.
178. Yoshida F, Matsuo S, Fujishima H, Kim HK, Tomita T: Renal lesions of the FGS strain of mice: a spontaneous animal model of progressive glomerulosclerosis. Nephron 1994;66:317-325.
179. Lamm ME, Emancipator SN, Robinson JK, Yamashita M, Fujioka H, Qiu J, Plaut AG: Microbial IgA protease removes IgA immune complexes from mouse glomeruli in vivo: potential therapy for IgA nephropathy. Am J Pathol 2008;172:31-36.