The N-glycans determine the differential blood clearance and hepatic uptake of human immunoglobulin (Ig)A1 and IgA2 isotypes

Journal of Experimental Medicine

Volumn 191, Issue 12, 2000, Pages 2171-2181

  Rifai, Abdalla ^a   Fadden, Kim ^a   Morrison, Sherie L ^b   Chintalacharuvu, Koteswara R ^b  

^a BROWN UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Asialoglycoprotein; Blood clearance; Glycosylation; IgA; Liver

Indexed keywords

GLYCAN DERIVATIVE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN A1; IMMUNOGLOBULIN A2; IODINE 125;

ANIMAL CELL; ANTIBODY PRODUCTION; ARTICLE; FEMALE; GLYCOSYLATION; ISOTOPE LABELING; LIVER METABOLISM; MOLECULAR SIZE; MOUSE; NONHUMAN; PLASMA CLEARANCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN METABOLISM; TISSUE DISTRIBUTION;

ANIMALS; ANTIBODIES; ASIALOGLYCOPROTEIN RECEPTOR; GLYCOPROTEINS; GLYCOSYLATION; HUMANS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN ALLOTYPES; IMMUNOGLOBULIN ISOTYPES; LIVER; METABOLIC CLEARANCE RATE; MICE; MICE, MUTANT STRAINS; MOLECULAR WEIGHT; RECEPTORS, CELL SURFACE; RECOMBINANT PROTEINS;

EID: 0034686416     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.191.12.2171     Document Type: Article

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