Mutant mice provide new insight into the role of (mis-)glycation in IgA nephropathy and other glomerular diseases

Nephrology Dialysis Transplantation

Volumn 22, Issue 6, 2007, Pages 1518-1520

  Floege, Jürgen ^a   Eitner, Frank ^a   Barratt, Jonathan ^b   Smith, Alice C ^b   Feehally, John ^b  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^b LEICESTER GENERAL HOSPITAL   (United Kingdom)

Author keywords

Aminopeptidase N; Glomerular; Glomerulonephritis; Glycosylation; IgA; Podocalyxin

Indexed keywords

GALACTOSYLTRANSFERASE; IMMUNOGLOBULIN A;

ANAPHYLACTOID PURPURA; DISEASE COURSE; DISEASE PREDISPOSITION; ENZYME ACTIVITY; ENZYME LOCALIZATION; GENE DELETION; GENETIC CODE; GLOMERULOPATHY; GLYCATION; HUMAN; IMMUNOGLOBULIN A NEPHROPATHY; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOGLOBULIN STRUCTURE; IMMUNOPATHOGENESIS; NONHUMAN; NOTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; PROTEINURIA;

ANIMALS; CARBOHYDRATE METABOLISM; DISEASE MODELS, ANIMAL; GALACTOSYLTRANSFERASES; GLOMERULONEPHRITIS, IGA; GLYCOSYLATION; HUMANS; MICE; POINT MUTATION;

EID: 34447532356     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfm003     Document Type: Note

References (12)

1. Alexander WS, Viney EM, Zhang JG et al. Thrombocytopenia and kidney disease in mice with a mutation in the C1galT1 gene. Proc Natl Acad Sci USA 2006; 103: 16442-16447
2. Allen AC, Bailey EM, Barratt J et al. Analysis of IgA1 O-glycans in IgA nephropathy by fluorophore-assisted carbohydrate electrophoresis. J Am Soc Nephrol 1999; 10: 1763-1771
3. Allen AC, Bailey EM, Brenchley PE et al. Mesangial IgA1 in IgA nephropathy exhibits aberrant O-glycosylation: Observations in three patients. Kidney Int 2001; 60: 969-973
4. Hiki Y, Odani H, Takahashi M et al. Mass spectrometry proves under-O-glycosylation of glomerular IgA1 in IgA nephropathy. Kidney Int 2001; 59: 1077-1085
5. Allen AC, Topham PS, Harper SJ et al. Leucocyte Β 1,3 galactosyltransferase activity in IgA nephropathy. Nephrol Dial Transplant 1997; 12: 701-706
6. Ju T, Brewer K, D'Souza A et al. Cloning and expression of human core 1 β1,3-galactosyltransferase. J Biol Chem 2002; 277: 178-186
7. Allen AC, Harper SJ, Feehally J. Galactosylation of N- and O- linked carbohydrate moieties of IgA1 and IgG in IgA nephropathy. Clin Exp Immunol 1995; 100: 470-474
8. Smith AC, de Wolff JF, Molyneux K et al. O-glycosylation of serum IgD in IgA nephropathy. J Am Soc Nephrol 2006; 17: 1192-1199
9. Nishie T, Miyaishi O, Naruse C et al. Analysis of human IgA nephropathy-like disease in galactosyltransferase KO mice (abstract). Nephrology Suppl 2004; 2: A48
10. Feehally J, Molyneux K, Smith AC, Barratt J. Cell Surface β 1,4-galactosyltransferase acts as a novel IgA receptor in human mesangial cells. J Am Soc Nephrol 2006; SA-PO785
11. Mcntzel S, Assmann KJ, Dijkman HB et al. inhibition of aminopeptidase A activity causes an acute albuminuria in mice: An angiotensin II-mediated effect? Nephrol Dial Transplant 1996; 11: 2163-2169
12. Gelberg H, Healy L, Whiteley H et al. In vivo enzymatic removal of α 2 →6-linked sialic acid from the glomerular filtration barrier results in podocyte charge alteration and glomerular injury. Lab Invest 1996; 74: 907-920