An overview of the fission yeast septation initiation network (SIN)

Biochemical Society Transactions

Volumn 36, Issue 3, 2008, Pages 411-415

  Krapp, Andrea ^a   Simanis, Viesturs ^a  

^a SWISS INST FOR EXP CANCER RESEARCH   (Switzerland)

Author keywords

Cell cycle; Cytokinesis; Fission yeast; Kinase; Septation initiation network (SIN)

Indexed keywords

MUTANT PROTEIN; PHOSPHOPROTEIN PHOSPHATASE 2A; PHOSPHOPROTEIN PHOSPHATASE CDC14; PROTEIN KINASE; PROTEIN SUBUNIT; RING FINGER PROTEIN; SCAFFOLD PROTEIN;

AMINO TERMINAL SEQUENCE; ANAPHASE; CARBOXY TERMINAL SEQUENCE; CELL ACTIVITY; CELL CYCLE; CELL CYCLE S PHASE; CELL DIVISION; CELL FUNCTION; CELL GROWTH; CELL SEPARATION; CONFERENCE PAPER; CYTOKINESIS; ENZYME ACTIVITY; ENZYME BINDING; ENZYME LOCALIZATION; ENZYME REGULATION; EPISTASIS; EUKARYOTE; FISSION YEAST; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; FUNGUS GROWTH; GENE FUNCTION; INTERPHASE; MEIOSIS; MITOSIS; MITOSIS INHIBITION; MITOSIS SPINDLE; MOLECULAR DYNAMICS; NONHUMAN; NUCLEAR DIVISION; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TARGETING; REGULATORY MECHANISM; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES POMBE; SEPTATION INITIATION NETWORK; SIGNAL TRANSDUCTION; SPINDLE POLE BODY; YEAST; YEAST CELL;

CELL DIVISION; MEIOSIS; PROTEIN TRANSPORT; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS;

SCHIZOSACCHAROMYCES POMBE; SCHIZOSACCHAROMYCETACEAE;

EID: 45249094564     PISSN: 03005127     EISSN: None     Source Type: Journal    
DOI: 10.1042/BST0360411     Document Type: Conference Paper

References (75)

1. Daga, R.R. and Chang, F. (2005) Dynamic positioning of the fission yeast cell division plane. Proc. Natl. Acad. Sci. U.S.A. 102, 8228-8232
2. Chang, F., Woollard, A. and Nurse, P. (1996) Isolation and characterization of fission yeast mutants defective in the assembly and placement of the contractile actin ring. J. Cell Sci. 109, 131-142
3. Sohrmann, M., Fankhauser, C., Brodbeck, C. and Simanis, V. (1996) The dmf1/mid1 gene is essential for correct positioning of the division septum in fission yeast. Genes Dev. 10, 2707-2719
4. Wu, J.Q., Kuhn, J.R., Kovar, D.R. and Pollard, T.D. (2003) Spatial and temporal pathway for assembly and constriction of the contractile ring in fission yeast cytokinesis. Dev. Cell 5, 723-734
5. Mitchison, J.M. and Nurse, P. (1985) Growth in cell length in the fission yeast Schizosaccharomyces pombe. J. Cell Sci. 75, 357-376
6. Krapp, A., Gulli, M.P. and Simanis, V. (2004) SIN and the art of splitting the fission yeast cell. Curr. Biol. 14, R722-R730
7. Simanis, V. (2003) Events at the end of mitosis in the budding and fission yeasts. J. Cell Sci. 116, 4263-4275
8. Wolfe, B.A. and Gould, K.L. (2005) Split decisions: coordinating cytokinesis in yeast. Trends Cell Biol. 15, 10-18
9. Schmidt, S., Sohrmann, M., Hofmann, K., Woollard, A. and Simanis, V. (1997) The Spg1p GTPase is an essential, dosage-dependent inducer of septum formation in Schizosaccharomyces pombe. Genes Dev. 11, 1519-1534
10. Fankhauser, C., Marks, J., Reymond, A. and Simanis, V. (1993) The S. pombe cdc16 gene is required both for maintenance of p34cdc2 kinase activity and regulation of septum formation: a link between mitosis and cytokinesis? EMBO J. 12, 2697-2704
11. Minet, M., Nurse, P., Thuriaux, P. and Mitchison, J.M. (1979) Uncontrolled septation in a cell division cycle mutant of the fission yeast Schizosaccharomyces pombe. J. Bacteriol. 137, 440-446
12. Song, K., Mach, K.E., Chen, C.Y., Reynolds, T. and Albright, C.F. (1996) A novel suppressor of ras1 in fission yeast, byr4, is a dosage-dependent inhibitor of cytokinesis. J. Cell Biol. 133, 1307-1319
13. Furge, K.A., Wong, K., Armstrong, J., Balasubramanian, M. and Albright, C.F. (1998) Byr4 and Cdc16 form a two-component GTPase-activating protein for the Spg1 GTPase that controls septation in fission yeast. Curr. Biol. 8, 947-954
14. Furge, K.A., Cheng, Q.C., Jwa, M., Shin, S., Song, K. and Albright, C.F. (1999) Regions of Byr4, a regulator of septation in fission yeast, that bind Spg1 or Cdc16 and form a two-component GTPase-activating protein with Cdc16. J. Biol. Chem. 274, 11339-11343
15. Mehta, S. and Gould, K.L. (2006) Identification of functional domains within the septation initiation network kinase, Cdc7. J. Biol. Chem. 281, 9935-9941
16. Sohrmann, M., Schmidt, S., Hagan, I. and Simanis, V. (1998) Asymmetric segregation on spindle poles of the Schizosaccharomyces pombe septum-inducing protein kinase Cdc7p. Genes Dev. 12, 84-94
17. Guertin, D.A., Chang, L., Irshad, F., Gould, K.L. and McCollum, D. (2000) The role of the sid1p kinase and cdc14p in regulating the onset of cytokinesis in fission yeast. EMBO J. 19, 1803-1815
18. Sparks, C.A., Morphew, M. and McCollum, D. (1999) Sid2p, a spindle pole body kinase that regulates the onset of cytokinesis. J. Cell Biol. 146, 777-790
19. Fankhauser, C. and Simanis, V. (1993) The Schizosaccharomyces pombe cdc14 gene is required for septum formation and can also inhibit nuclear division. Mol. Biol. Cell 4, 531-539
20. Hou, M.C., Salek, J. and McCollum, D. (2000) Mob1p interacts with the Sid2p kinase and is required for cytokinesis in fission yeast. Curr. Biol. 10, 619-622
21. Salimova, E., Sohrmann, M., Fournier, N. and Simanis, V. (2000) The S. pombe orthologue of the S. cerevisiae mob1 gene is essential and functions in signalling the onset of septum formation. J. Cell Sci. 113, 1695-1704
22. Guertin, D.A. and McCollum, D. (2001) Interaction between the noncatalytic region of Sid1p kinase and Cdc14p is required for full catalytic activity and localization of Sid1p. J. Biol. Chem. 276, 28185-28189
23. Hou, M.C., Guertin, D.A. and McCollum, D. (2004) Initiation of cytokinesis is controlled through multiple modes of regulation of the Sid2p-Mob1p kinase complex. Mol. Cell. Biol. 24, 3262-3276
24. Krapp, A., Schmidt, S., Cano, E. and Simanis, V. (2001) S. pombe cdc11p, together with sid4p, provides an anchor for septation initiation network proteins on the spindle pole body. Curr. Biol. 11, 1559-1568
25. Tomlin, G.C., Morrell, J.L. and Gould, K.L. (2002) The spindle pole body protein cdc11p links sid4p to the fission yeast septation initiation network. Mol. Biol. Cell 13, 1203-1214
26. Rosenberg, J.A., Tomlin, G.C., McDonald, W.H., Snydsman, B.E., Muller, E.G., Yates, 3rd, J.R. and Gould, K.L. (2006) Ppc89 links multiple proteins, including the septation initiation network, to the core of the fission yeast spindle-pole body. Mol. Biol. Cell 17, 3793-3805
27. Morrell, J.L., Tomlin, G.C., Rajagopalan, S., Venkatram, S., Feoktistova, A.S., Tasto, J.J., Mehta, S., Jennings, J.L., Link, A., Balasubramanian, M.K. and Gould, K.L. (2004) Sid4p-Cdc11p assembles the septation initiation network and its regulators at the S. pombe SPB. Curr. Biol. 14, 579-584
28. Krapp, A., Cano, E. and Simanis, V. (2004) Analysis of the S. pombe signalling scaffold protein Cdc11p reveals an essential role for the N-terminal domain in SIN signalling. FEBS Lett. 565, 176-180
29. Nurse, P., Thuriaux, P. and Nasmyth, K. (1976) Genetic control of the cell division cycle in the fission yeast Schizosaccharomyces pombe. Mol. Gen. Genet. 146, 167-178
30. Jin, Q.W., Zhou, M., Bimbo, A., Balasubramanian, M.K. and McCollum, D. (2006) A role for the septation initiation network in septum assembly revealed by genetic analysis of sid2-s250 suppressors. Genetics 172, 2101-2112
31. Ohkura, H., Hagan, I.M. and Glover, D.M. (1995) The conserved Schizosaccharomyces pombe kinase plo1, required to form a bipolar spindle, the actin ring, and septum, can drive septum formation in G1 and G2 cells. Genes Dev. 9, 1059-1073
32. Tanaka, K., Petersen, J., MacIver, F., Mulvihill, D.P., Glover, D.M. and Hagan, I.M. (2001) The role of Plo1 kinase in mitotic commitment and septation in Schizosaccharomyces pombe. EMBO J. 20, 1259-1270
33. Fankhauser, C. and Simanis, V. (1994) The cdc7 protein kinase is a dosage dependent regulator of septum formation in fission yeast. EMBO J. 13, 3011-3019
34. Chang, L. and Gould, K.L. (2000) Sid4p is required to localize components of the septation initiation pathway to the spindle pole body in fission yeast. Proc. Natl. Acad. Sci. U.S.A. 97, 5249-5254
35. Cerutti, L. and Simanis, V. (1999) Asymmetry of the spindle pole bodies and spg1p GAP segregation during mitosis in fission yeast. J. Cell Sci. 112, 2313-2321
36. Li, C., Furge, K.A., Cheng, Q.C. and Albright, C.F. (2000) Byr4 localizes to spindle-pole bodies in a cell cycle-regulated manner to control Cdc7 localization and septation in fission yeast. J. Biol. Chem. 275, 14381-14387
37. Grallert, A., Krapp, A., Bagley, S., Simanis, V. and Hagan, I.M. (2004) Recruitment of NIMA kinase shows that maturation of the S. pombe spindle-pole body occurs over consecutive cell cycles and reveals a role for NIMA in modulating SIN activity. Genes Dev. 18, 1007-1021
38. Magidson, V., Chang, F. and Khodjakov, A. (2006) Regulation of cytokinesis by spindle-pole bodies. Nat. Cell Biol. 8, 891-893
39. Mulvihill, D.P., Petersen, J., Ohkura, H., Glover, D.M. and Hagan, I.M. (1999) Plo1 kinase recruitment to the spindle pole body and its role in cell division in Schizosaccharomyces pombe. Mol. Biol. Cell 10, 2771-2785
40. Jimenez, J. and Oballe, J. (1994) Ethanol-hypersensitive and ethanol-dependent cdc- mutants in Schizosaccharomyces pombe. Mol. Gen. Genet. 245, 86-95
41. Daga, R.R., Lahoz, A., Munoz, M.J., Moreno, S. and Jimenez, J. (2005) Etd1p is a novel protein that links the SIN cascade with cytokinesis. EMBO J. 24, 2436-2446
42. Murone, M. and Simanis, V. (1996) The fission yeast dma1 gene is a component of the spindle assembly checkpoint, required to prevent septum formation and premature exit from mitosis if spindle function is compromised. EMBO J. 15, 6605-6616
43. Guertin, D.A., Venkatram, S., Gould, K.L. and McCollum, D. (2002) Dma1 prevents mitotic exit and cytokinesis by inhibiting the septation initiation network (SIN). Dev. Cell 3, 779-790
44. Le Goff, X., Buvelot, S., Salimova, E., Guerry, F., Schmidt, S., Cueille, N., Cano, E. and Simanis, V. (2001) The protein phosphatase 2A B′-regulatory subunit par1p is implicated in regulation of the S. pombe septation initiation network. FEBS Lett. 508, 136-142
45. +: two Schizosaccharomyces pombe genes encoding B′ subunits of protein phosphatase 2A. Genetics 154, 1025-1038
46. Jiang, W. and Hallberg, R.L. (2001) Correct regulation of the septation initiation network in Schizosaccharomyces pombe requires the activities of par1 and par2. Genetics 158, 1413-1429
47. Krapp, A., Cano, E. and Simanis, V. (2003) Mitotic hyperphosphorylation of the fission yeast SIN scaffold protein cdc11p is regulated by the protein kinase cdc7p. Curr. Biol. 13, 168-172
48. Nurse, P. (1990) Universal control mechanism regulating onset of M-phase. Nature 344, 503-508
49. Karagiannis, J., Oulton, R. and Young, P.G. (2002) The Scw1 RNA-binding domain protein regulates septation and cell-wall structure in fission yeast. Genetics 162, 45-58
50. Jin, Q.W. and McCollum, D. (2003) Scw1p antagonizes the septation initiation network to regulate septum formation and cell separation in the fission yeast Schizosaccharomyces pombe. Eukaryotic Cell 2, 510-520
51. Beltraminelli, N., Murone, M. and Simanis, V. (1999) The S. pombe zfs1 gene is required to prevent septation if mitotic progression is inhibited. J. Cell Sci. 112, 3103-3114
52. Cuthbertson, B.J., Liao, Y., Birnbaumer, L. and Blackshear, P.J. (2007) Characterization of zfs1 as an mRNA binding and destabilizing protein in Schizosaccharomyces pombe. J. Biol. Chem. 283, 2586-2594
53. Trautmann, S., Wolfe, B.A., Jorgensen, P., Tyers, M., Gould, K.L. and McCollum, D. (2001) Fission yeast Clp1p phosphatase regulates G2/M transition and coordination of cytokinesis with cell cycle progression. Curr. Biol. 11, 931-940
54. Cueille, N., Salimova, E., Esteban, V., Blanco, M., Moreno, S., Bueno, A. and Simanis, V. (2001) Flp1, a fission yeast orthologue of the S. cerevisiae CDC14 gene, is not required for cyclin degradation or rum1p stabilisation at the end of mitosis. J. Cell Sci., 114, 2649-2664
55. Jin, Q.W., Ray, S., Choi, S.H. and McCollum, D. (2007) The nucleolar Net1/Cfi1-related protein Dnt1 antagonizes the septation initiation network in fission yeast. Mol. Biol. Cell 18, 2924-2934
56. Liu, J., Wang, H. and Balasubramanian, M.K. (2000) A checkpoint that monitors cytokinesis in Schizosaccharomyces pombe. J. Cell Sci. 113, 1223-1230
57. Le Goff, X., Woollard, A. and Simanis, V. (1999) Analysis of the cps1 gene provides evidence for a septation checkpoint in Schizosaccharomyces pombe. Mol. Gen. Genet. 262, 163-172
58. Liu, J., Wang, H., McCollum, D. and Balasubramanian, M.K. (1999) Drc1p/Cps1p, a 1,3-β-glucan synthase subunit, is essential for division septum assembly in Schizosaccharomyces pombe. Genetics 153, 1193-1203
59. Mishra, M., Karagiannis, J., Sevugan, M., Singh, P. and Balasubramanian, M.K. (2005) The 14-3-3 protein rad24p modulates function of the cdc14p family phosphatase clp1p/flp1p in fission yeast. Curr. Biol. 15, 1376-1383
60. Karagiannis, J., Bimbo, A., Rajagopalan, S., Liu, J. and Balasubramanian, M.K. (2005) The nuclear kinase Lsk1p positively regulates the septation initiation network and promotes the successful completion of cytokinesis in response to perturbation of the actomyosin ring in Schizosaccharomyces pombe. Mol. Biol. Cell 16, 358-371
61. Mishra, M., Karagiannis, J., Trautmann, S., Wang, H., McCollum, D. and Balasubramanian, M.K. (2004) The Clp1p/Flp1p phosphatase ensures completion of cytokinesis in response to minor perturbation of the cell division machinery in Schizosaccharomyces pombe. J. Cell Sci. 117, 3897-3910
62. Trautmann, S. and McCollum, D. (2005) Distinct nuclear and cytoplasmic functions of the S. pombe Cdc14-like phosphatase Clp1p/Flp1p and a role for nuclear shuttling in its regulation. Curr. Biol. 15, 1384-1389
63. Vogel, S.K., Raabe, I., Dereli, A., Maghelli, N. and Tolic-Norrelykke, I. (2007) Interphase microtubules determine the initial alignment of the mitotic spindle. Curr. Biol. 17, 438-444
64. Krapp, A., Collin, P., Cokoja, A., Dischinger, S., Cano, E. and Simanis, V. (2006) The Schizosaccharomyces pombe septation initiation network (SIN) is required for spore formation in meiosis. J. Cell Sci. 119, 2882-2891
65. Mah, A.S., Jang, J. and Deshaies, R.J. (2001) Protein kinase Cdc15 activates the Dbf2-Mob1 kinase complex. Proc. Natl. Acad. Sci. U.S.A. 98, 7325-7330
66. Bardin, A.J. and Amon, A. (2001) MEN and SIN: what's the difference? Nat. Rev. Mol. Cell Biol. 2, 815-826
67. Bement, W.M. (2007) Cytokinetic pyrotechnics. Dev. Cell 12, 663-664
68. Hergovich, A., Cornils, H. and Hemmings, B.A. (2008) Mammalian NDR protein kinases: from regulation to a role in centrosome duplication. Biochim. Biophys. Acta 1784, 3-15
69. Hergovich, A., Stegert, M.R., Schmitz, D. and Hemmings, B.A. (2006) NDR kinases regulate essential cell processes from yeast to humans. Nat. Rev. Mol. Cell Biol. 7, 253-264
70. Hammarton, T.C., Lillico, S.G., Welburn, S.C. and Mottram, J.C. (2005) Trypanosoma brucei MOB1 is required for accurate and efficient cytokinesis but not for exit from mitosis. Mol. Microbiol. 56, 104-116
71. Citterio, S., Piatti, S., Albertini, E., Aina, R., Varotto, S. and Barcaccia, G. (2006) Alfalfa Mob1-like proteins are involved in cell proliferation and are localized in the cell division plane during cytokinesis. Exp. Cell Res. 312, 1050-1064
72. Yabuta, N., Okada, N., Ito, A., Hosomi, T., Nishihara, S., Sasayama, Y., Fujimori, A., Okuzaki, D., Zhao, H., Ikawa, M. et al. (2007) Lats2 is an essential mitotic regulator required for the coordination of cell division. J. Biol. Chem. 282, 19259-19271
73. Gromley, A., Yeaman, C., Rosa, J., Redick, S., Chen, C.T., Mirabelle, S., Guha, M., Sillibourne, J. and Doxsey, S.J. (2005) Centriolin anchoring of exocyst and SNARE complexes at the midbody is required for secretory-vesicle- mediated abscission. Cell 123, 75-87
74. Gromley, A., Jurczyk, A., Sillibourne, J., Halilovic, E., Mogensen, M., Groisman, I., Blomberg, M. and Doxsey, S. (2003) A novel human protein of the maternal centriole is required for the final stages of cytokinesis and entry into S phase. J. Cell Biol. 161, 535-545
75. Bedhomme, M., Jouannic, S., Champion, A., Simanis, V. and Henry, Y. (2008) Plants, MEN and SIN. Plant Physiol. Biochem. 46, 1-10