Quantification of sibutramine and its two metabolites in human plasma by LC-ESI-MS/MS and its application in a bioequivalence study

Journal of Pharmaceutical Analysis

Volumn 2, Issue 4, 2012, Pages 249-257

  Ponnuru, Venkata Suresh ^a,c   Challa, B R ^b   Nadendla, Ramarao ^a  

^a CHALAPATHI INSTITUTE OF PHARMACEUTICAL SCIENCES   (India)

^b Nirmala College of Pharmacy   (India)

^c KRISHNA UNIVERSITY   (India)

Author keywords

Bioequivalence; Human plasma; LC ESI MS MS; Pharmacokinetic study; Sibutramine

Indexed keywords

ACETONITRILE; AMMONIUM FORMATE; DRUG METABOLITE; N DES METHYL SIBUTRAMINE; N DI DESMETHYL SIBUTRAMINE; SIBUTRAMINE; UNCLASSIFIED DRUG;

ARTICLE; BIOEQUIVALENCE; DRUG DETERMINATION; DRUG STABILITY; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; LIMIT OF DETECTION; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; PLASMA CONCENTRATION-TIME CURVE; PROCESS DEVELOPMENT; SENSITIVITY AND SPECIFICITY; SEPARATION TECHNIQUE; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

EID: 84925835379     PISSN: 20951779     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpha.2012.02.010     Document Type: Article

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