Simultaneous determination of sibutramine and N-Di-desmethylsibutramine in dietary supplements for weight control by HPLC-ESI-MS

Journal of Chromatographic Science

Volumn 46, Issue 8, 2008, Pages 707-711

  Huang, Ziqiang ^a,b,c   Xiao, Song ^b   Luo, Dan ^b   Chen, Bo ^b   Yao, Shouzhuo ^a,b  

^a HUNAN UNIVERSITY   (China)

^b HUNAN NORMAL UNIVERSITY   (China)

^c Hunan Entry Exit Inspection and Quarantine Bureau   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOBUTANE DERIVATIVE; SIBUTRAMINE;

ARTICLE; DIET SUPPLEMENTATION; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METHODOLOGY; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; ULTRAVIOLET SPECTROPHOTOMETRY; VALIDATION STUDY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLOBUTANES; DIETARY SUPPLEMENTS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 51849147646     PISSN: 00219665     EISSN: None     Source Type: Journal    
DOI: 10.1093/chromsci/46.8.707     Document Type: Article

References (12)

1. M. LeBlanc and L. Thibault. Effect of sibutramine on macronutrient selection in male and female rats. Physiol. Behav. 80: 243-252 (2003).
2. S.D. Glick, R.E. Haskew, I.M. Maisonneuve, J.N. Carlson, and T.P. Jerussi. Enantioselective behavioral effects of sibutramine metabolites. Eur. J. Pharmacol. 397: 93-102 (2000).
3. I.P. Connoley, Y.L. Liu, I. Frost, I.P. Reckless, D.J. Heal, and M.J. Stock. Thermogenic effects of sibutramine and its metabolites. Brit. J. Pharmacol. 126: 1487 (1999).
4. C.A. Luque and J.A. Rey. The discovery and status of sibutramine as an anti-obesity drug. Eur. J. Pharmacol. 440: 119-128 (2002).
5. I.D. Hind, J.E. Mangham, S.P. Ghani, R.E. Haddock, C.J. Garratt, and R.W. Jones. Sibutramine pharmacokinetics in young and elderly healthy subjects. Eur. J. Clin. Pharmacol. 54: 847-9 (1999).
6. K.M. Walsh, E. Leen, and M.E.J. Lean. The effect of sibutramine on resting energy expenditure and adrenaline-induced thermogenesis in obese females. Int. J. Obes. 23: 1009-1015 (1999).
7. T. Radhakrishna, C.L. Narayana, D.S. Rao, K. Vyas, and G.O. Reddy. LC method for the determination of assay and purity of sibutramine hydrochloride and its enantiomers by chiral chromatography. J. Pharm. Biomed. Anal. 22: 627-639 (2000).
8. J. Chen, W. Lu, Q. Zhang, and X. Jiang. Determination of the active metabolite of sibutramine by liquid chromatography-electrospray ionization tandem mass spectrometry. J. Chromatogr. B 785: 197-203 (2003).
9. L. Ding, X. Hao, X. Huang, and S. Zhang. Simultaneous determination of sibutramine and its N-desmethyl metabolites in human plasma by liquid chromatography-electrospray ionization-mass spectrometry method and clinical applications. Anal. Chim. Acta 492: 241-248 (2003).
10. P. Zou, S.S. Oh, K.H. Kiang, M.Y. Low, and B.C. Bloodworth. Detection of sibutramine, its two metabolites and one analogue in an herbal product for weight loss by liquid chromatography triple quadrupole mass spectrometry and time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom. 21: 614-618 (2007).
11. J. Jung, M. Hermanns-Clausen, and W. Weinmann. Anorectic sibutramine detected in a Chinese herbal drug for weight loss. Forensic Sci. Int. 161: 221-222 (2006).
12. US. Department of Health and Human Services, Food and Drug Administration. Guidance for Industry: Bioanalytical Method Validation, 1st ed. Food and Drug Administration, 2001, pp. 4-6.