Development and validation of high performance liquid chromatography method for analysis of sibutramine hydrochloride and its impurity

Pakistan Journal of Pharmaceutical Sciences

Volumn 21, Issue 2, 2008, Pages 121-124

  Chandorkar, J G ^a   Kotwal, V B ^a   Dhande, N S ^a   Pachpor, M P ^a   Pande, V V ^a  

^a Aarti Drugs Ltd   (India)

Author keywords

Impurity* 5 (2R) 2 aminopropyl 2 methoxybenzene sulphonamide; Sibutramine hydrochloride

Indexed keywords

ACETONITRILE; SIBUTRAMINE; SODIUM DIHYDROGEN PHOSPHATE; ANTIDEPRESSANT AGENT; CYCLOBUTANE DERIVATIVE; DRUG;

ANALYTIC METHOD; ANALYTICAL EQUIPMENT; ARTICLE; DRUG FORMULATION; DRUG PURITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; OBESITY; QUALITY CONTROL; REPRODUCIBILITY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; VALIDATION STUDY; CHEMISTRY; ISOLATION AND PURIFICATION; METHODOLOGY; SENSITIVITY AND SPECIFICITY;

ANTIDEPRESSIVE AGENTS; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLOBUTANES; PHARMACEUTICAL PREPARATIONS; QUALITY CONTROL; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 44449144079     PISSN: 1011601X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (4)

1. Li Ding, Xinyu Hao, Xin Huang and Shengqiang Zhang (2004). Reversed-phase HPLC determination of sibutramine hydrochloride in the presence of its oxidatively-induced degradation products. Department of Pharmaceutical Analysis, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, CHINE.
2. Radhakrishna T, Narayana CL and Rao DS et al. (2000). LC method for the determination of assay and purity of sibutramine hydrochloride and its enantiomers by chiral chromatography[J]. J. Pharm. Biomed. Anal., 22(4): 627-639. (Pubitemid 30145567)
3. Sabina Strano-Rossi, Cristiana Colamonici and Francesco Botrè, (2006). Detection of Sibutramine administration: a gas chromatography/mass spectrometry study of the main urinary metabolites. Rapid Communications in Mass Spectrometry, 21(2): 79-88.
4. Valarmathi R, Karpagam Kumara, Sundari S and Revathi (2004). Spectrophotometric determination of sibutramine hydrochloride using folin - ciocalteu reagent. The Indian Pharmacist (Indian Pharm.), 3(25): 71-72.