Determination of the active metabolite of sibutramine by liquid chromatography-electrospray ionization tandem mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 785, Issue 2, 2003, Pages 197-203

  Chen, Jun ^a   Lu, Wei ^a   Zhang, Qizhi ^a   Jiang, Xinguo ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

N Di desmethylsibutramine; Sibutramine

Indexed keywords

EVAPORATION; LIQUID CHROMATOGRAPHY; METABOLITES; ORGANIC ACIDS; PLASMA DIAGNOSTICS; SEPARATION; SODIUM COMPOUNDS;

HUMAN PLASMAS;

AMINES;

1 AMINO 1 [1 (4 CHLOROPHENYL)CYCLOBUTYL] 3 METHYLBUTANE; ACETONITRILE; PROPRANOLOL; SIBUTRAMINE; SODIUM HYDROXIDE; TERT BUTYL METHYL ETHER; TRIFLUOROACETIC ACID;

ACCURACY; ARTICLE; ASSAY; BODY FLUID; CLINICAL STUDY; DRUG DETERMINATION; EVAPORATION; EXTRACTION; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MASS SPECTROMETRY; NORMAL HUMAN; PLASMA; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; STANDARD;

APPETITE DEPRESSANTS; AREA UNDER CURVE; BIOTRANSFORMATION; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLOBUTANES; HUMANS; INDICATORS AND REAGENTS; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SOLUTIONS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 0037420198     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1570-0232(02)00818-8     Document Type: Article

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