Simultaneous determination of anti-diabetes/anti-obesity drugs by LC/PDA, and targeted analysis of sibutramine analog in dietary supplements by LC/MS/MS

Biomedical Chromatography

Volumn 23, Issue 12, 2009, Pages 1259-1265

  Kim, So Hyun ^a   Lee, Jeongmi ^b   Yoon, Taehyung ^c   Choi, Jangduck ^c   Choi, Dongmi ^c   Kim, Deukjoon ^a   Kwon, Sung Won ^a  

^a Seoul National University   (South Korea)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c Korea Food and Drug Administration   (South Korea)

Author keywords

Adulterant; Liquid chromatography; Mass spectrometry; Photo diode array

Indexed keywords

CRIME; DIETARY SUPPLEMENTS; FOOD ADDITIVES; LIQUID CHROMATOGRAPHY; NUTRITION; VITAMINS;

ADULTERANT; ANTIDIABETIC DRUG; DIODE ARRAYS; ILLEGAL ADULTERANTS; LC-MS-MS; OBESITY DRUGS; PHENFORMIN; PHOTO DIODE ARRAY; PHOTO DIODES; SIMULTANEOUS DETERMINATIONS;

MASS SPECTROMETRY;

ANTIDIABETIC AGENT; ANTIOBESITY AGENT; DRUG METABOLITE; EPHEDRINE; FENFLURAMINE; FLUOXETINE; GLIBENCLAMIDE; GLICLAZIDE; GLIMEPIRIDE; GLIPIZIDE; LIOTHYRONINE; N NORSIBUTRAMINE; PHENFORMIN; ROSIGLITAZONE; SIBUTRAMINE; THYROXINE; UNCLASSIFIED DRUG;

ACCURACY; ANALYTIC METHOD; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG CONTAMINATION; DRUG DETERMINATION; DRUG STRUCTURE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHOTODIODE ARRAY; QUANTITATIVE ANALYSIS; REPRODUCIBILITY; SCREENING TEST; VALIDATION PROCESS;

EID: 71649100874     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1248     Document Type: Article

References (14)

1. Binkley K and Knowles SR. Sibutramine and panic attacks. The American Journal of Psychiatry 2002; 159: 1793-1794.
2. Bogusz MJ, Hassan H, Al-Enazi E, Ibrahim Z and Al-Tufail M. Application of LC-ESI-MS-MS for detection of synthetic adulterants in herbal remedies. Journal of Pharmaceutical and Biomedical Analysis 2006; 41: 554-564.
3. Cianchino V, Acosta G, Ortega C, Martínez LD and Gomez MR. Analysis of potential adulteration in herbal medicines and dietary supplements for the weight control by capillary electrophoresis. Food Chemistry 2008; 108: 1075-1081.
4. Hind ID, Mangham JE, Ghani SP, Haddock RE, Garratt CJ and Jones RW. Sibutramine pharmacokinetics in young and elderly healthy subjects. European Journal of Clinical Pharmacology 1999; 54: 847-849. (Pubitemid 29051330)
5. Julia J, Maren H-C and Wolfgang W. Anorectic sibutramine detected in a Chinese herbal drug for weight loss. Forensic Science International 2006; 161(2-3): 221-222.
6. Lai K-C, Liu Y-C, Tseng M-C, Lin Y-L and Lin J-H. Isolation and identification of a sibutramine analogue in a healthy food for weight loss. Journal of Food and Drug Analysis 2007; 15: 20-24.
7. Luscombe GP, Hopcroft RH, Thomas PC and Buckett WR. The contribution of metabolites to the rapid and potent down-regulation of rat cortical beta-adrenoceptors by the putative antidepressant sibutramine hydrochloride. Neuropharmacology 1989; 28: 129-134.
8. Marchei E, Pellegrini M, Pacifici R, Zuccaro P and Pichini S. A rapid and simple procedure for the determination of ephedrine alkaloids in dietary supplements by gas chromatography-mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 2006; 41: 1633-1641. (Pubitemid 44247465)
9. McNeely W and Goa KL. Sibutramine. A review of its contribution to the management of obesity. Drugs 1998; 56: 1093-1124. (Pubitemid 29010230)
10. Phinney KW, Ihara T and Sander LC. Determination of ephedrine alkaloid stereoisomers in dietary supplements by capillary electrophoresis. Journal of Chromatography A 2005; 1077: 90-97. (Pubitemid 40755110)
11. Taflinski T and Chojnacka J. Sibutramine-associated psychotic episode. The American Journal of Psychiatry 2000; 157: 2057-2058.
12. Thevis M, Sigmund G, Schiffer AK and Schanzer W. Determination of N-desmethyl- and N-bisdesmethyl metabolites of sibutramine in doping control analysis using liquid chromatography-tandem mass spectrometry. European Journal of Mass Spectrometry 2006; 12: 129-136. (Pubitemid 43988659)
13. Wang J, Chen B and Yao S. Analysis of six synthetic adulterants in herbal weight-reducing dietary supplements by LC electrospray ionization-MS. Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment 2008; 25: 822-830.
14. Woolard J, Bennett T, Dunn WR, Heal DJ, Aspley S and Gardiner SM. Acute cardiovascular effects of sibutramine in conscious rats. Journal of Pharmacology and Experimental Therapeutics 2004; 308: 1102-1110. (Pubitemid 38263987)