Determination of synthetic drugs used to adulterate botanical dietary supplements using QTRAP LC-MS/MS

Food Additives and Contaminants - Part A

Volumn 26, Issue 5, 2009, Pages 595-603

  Chen, Y ^a   Zhao, L ^b   Lu, F ^a   Yu, Y ^c   Chai, Y ^a   Wu, Y ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b Shandong Provincial Institute for Drug Control   (China)

^c Applied Biosystems   (China)

Author keywords

Adulteration; Botanical dietary supplements; Liquid chromatography tandem mass spectrometry (LC MS MS); QTRAP; Synthetic drugs

Indexed keywords

ALPRAZOLAM; ANTIDIABETIC AGENT; CAPTOPRIL; ENALAPRILAT; ESTAZOLAM; FENFLURAMINE; GEMFIBROZIL; GLIBENCLAMIDE; GLIDLAZIDE; GLIPIZIDE; INDAPAMIDE; LISINOPRIL; METFORMIN; METHYLDOPA; METHYLTESTOSTERONE; MEVINOLIN; NICARDIPINE; PHENOLPHTHALEIN; RESERPINE; SIBUTRAMINE; SILDENAFIL; SIMVASTATIN; TADALAFIL; TRIAZOLAM; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG DETERMINATION; FOOD CONTAMINATION; HIGH THROUGHPUT SCREENING; ION TRAP MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; RELIABILITY; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 70749118402     PISSN: 19440049     EISSN: 14645122     Source Type: Journal    
DOI: 10.1080/02652030802641880     Document Type: Article

References (22)

1. Anon. 2005. FDA Consumer Magazine, 39(1). Available from: http://www.fda.gov/fdac/departs/2005/105_upd.html
2. Bogusz MJ, Hassan H, Al-Enazi E, Ibrahim Z, Al-Tufail M. 2006. Application of LC-ESI-MS-MS for detection of synthetic adulterants in herbal remedies. J Pharm Biomed Anal. 41:554-564.
3. Breemen RBV, Fong HH, Farnsworth NR. 2008. Ensuring the safety of botanical dietary supplements. Am J Clin Nutr. 87(Suppl.):509S-513S.
4. Chan TY, Critchley JA. 1996. Usage and adverse effects of Chinese herbal medicines. Hum Exp Toxicol. 15:5-12.
5. Ernst E. 2002. Adulteration of Chinese herbal medicines with synthetic drugs: asystematic review. J Int Med. 252:107-113.
6. Ernst E, Pittler MH. 2002. Herbal medicine. Complem Alt Med. 86:149-161.
7. Huang WF, Wen KC, Hsiao ML. 1997. Adulteration by synthetic therapeutic substances of traditional Chinese medicines in Taiwan. J Clin Pharmacol. 37:344-350.
8. Jansen R, Lachatre G, Marquet P. 2005. LC-MS/MS systematic toxicological analysis: comparison of MS/MS spectra obtained with different instruments and settings. Clin Biochem. 38:362-372.
9. Liang QL, Qu J, Luo GA, Wang YM. 2006. Rapid and reliable determination of illegal adulterant in herbal medicines and dietary supplements by LC/MS/MS. J Pharm Biomed Anal. 40:305-311.
10. Lu F, Li S, Le J, Chen GL, Cao Y, Qi YP, Chai YF, Wu YT. 2007. A new method for testing synthetic drugs adulterated in herbal medicines based on infrared spectroscopy. Anal Chim Acta. 589:200-207.
11. Mohameda R, Hammela YA, LeBreton M-H, Tabet J-H, Jullien L, Guy PA. 2007. Evaluation of atmospheric pressure ionization interfaces for quantitative measurement of sulfonamides in honey using isotope dilution liquid chromatography coupled with tandem mass spectrometry techniques. J Chromatogr A. 1160:194-205.
12. Mueller CA, Weinmann W, Dresen S, Schreiber A, Gergov M. 2005. Development of a multi-target screening analysis for 301 drugs using a QTrap liquid chromato-graphy/tandem mass spectrometry system and automated library searching. Mass Spectrom. 29:1332-1338.
13. Rader JI, Delmonte P, Trucksess MW. 2007. Recent studies on selected botanical dietary supplement ingredients. Anal Bioanal Chem. 389:27-35.
14. Scholz K, Dekant W, Volkel W, Pahler A. 2005. Rapid detection and identification of N-acetyl-L-cysteine thioethers using constant neutral loss and theoretical multiple reaction monitoring combined with enhanced product-ion scans on a linear ion trap mass spectrometer. J Am Soc Mass Spectrom. 16:1976-1984.
15. Shin MH, Hong MK, Kim WS, Lee YJ, Jeoung YC. 2003. Identification of a new analogue of sildenafil added illegally to a functional food marketed for penile erectile dysfunction. Food Add Contam. 20:793-796.
16. Stanley SMR, Foo HC. 2006. Screening for basic drugs in equine urine using direct-injection differential-gradient LC-LC coupled to hybrid tandem MS/MS. J Chromatogr B. 836:1-14.
17. Stanley SMR, Wee WK, Lim BH, Foo HC. 2007. Directinjection screening for acidic drugs in plasma and neutral drugs in equine urine by differential-gradient LC-LC coupled MS/MS. J Chromatogr B. 848:292-302.
18. Wang J, Chen B, Yao S. 2008. Analysis of six synthetic adulterants in herbal weight-reducing dietary supplements by LC electrospray ionization-MS. Food Add Contam. 25(7):822-830.
19. World Health Organization (WHO). 1998. Guidelines for the appropriate use of herbal medicines. WHO Regional Publications. Manila (Philippines): WHO Regional Office for the Western Pacific.
20. World Health Organization (WHO). 2004. Guidelines on safety monitoring of herbal medicines in pharmacovigilance systems. Geneva (Switzerland): WHO.
21. Zheng J, Ma L, Xin B, Olah T, Humphreys WG, Zhu MS. 2007. Screening and identification of GSH-trapped reactive metabolites using hybrid triple quadruple linear ion trap mass spectrometry. Chem Res Toxicol. 20:757-766.
22. Zou P, Hou PL, Low MY, Koh HL. 2006. Structural elucidation of a tadalafil analogue found as an adulterant of a herbal product. Food Add Contam. 23(5):446-451.