Characterization of metabolites of sibutramine in primary cultures of rat hepatocytes by liquid chromatography-ion trap mass spectrometry

Analytical and Bioanalytical Chemistry

Volumn 393, Issue 4, 2009, Pages 1327-1336

  Hakala, Kati S ^a   Link, Marek ^b   Szotakova, Barbora ^c   Skalova, Lenka ^c   Kostiainen, Risto ^a   Ketola, Raimo A ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF DEFENCE   (Czech Republic)

^c Charles University in Prague Faculty of Pharmacy   (Czech Republic)

Author keywords

Enantiomers; Liquid chromatography ion trap mass spectrometry; Metabolism; Product ion spectra; Rat hepatocytes; Sibutramine hydrochloride

Indexed keywords

ACID MOIETIES; CHIRAL CENTERS; DEMETHYLATION; ENANTIOSELECTIVE FORMATIONS; GLUCURONIDATION; GLUCURONIDE; HYDROXYL-DERIVATIVES; LIQUID CHROMATOGRAPHY-ION TRAP MASS SPECTROMETRY; OBESITY DRUGS; PRIMARY CULTURES; PRODUCT ION SPECTRA; RAT HEPATOCYTES; SIBUTRAMINE HYDROCHLORIDE; STRUCTURAL CHARACTERIZATIONS;

BIOCHEMISTRY; BIOMOLECULES; BODY FLUIDS; CHEMICAL REACTIONS; CHIRALITY; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; ENANTIOMERS; ENANTIOSELECTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; HYDROXYLATION; ION CHROMATOGRAPHY; IONS; ISOMERS; MASS SPECTROMETERS; MASS SPECTROMETRY; METABOLISM; METABOLITES; SPECTROMETERS; SPECTROMETRY; SPECTRUM ANALYSIS;

LIQUID CHROMATOGRAPHY;

ANOREXIGENIC AGENT; CYCLOBUTANE DERIVATIVE; SIBUTRAMINE;

ANIMAL; ARTICLE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER CELL; MALE; METABOLISM; METHODOLOGY; MOLECULAR WEIGHT; RAT; STANDARD; TANDEM MASS SPECTROMETRY; WISTAR RAT;

ANIMALS; APPETITE DEPRESSANTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLOBUTANES; HEPATOCYTES; MALE; MOLECULAR WEIGHT; RATS; RATS, WISTAR; REFERENCE STANDARDS; TANDEM MASS SPECTROMETRY;

RATTUS;

EID: 59849091731     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-008-2540-8     Document Type: Article

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