Suppression of non-small cell lung cancer proliferation and tumorigenicity by DENND2D

Lung Cancer

Volumn 79, Issue 2, 2013, Pages 104-110

  Ling, Bing ^a   Zheng, Hongwei ^a   Fu, Guobin ^a   Yuan, Jingsong ^a   Shi, Taiping ^b   Chen, Shiping ^c   Liu, Yu ^a   Liu, Yan ^a   Cao, Yan ^a   Zheng, Shan ^a   Guo, Suping ^a   Han, Naijun ^a   Gao, Yanning ^a   Cheng, Shujun ^a   Zhang, Kaitai ^a  

^a CANCER HOSPITAL   (China)

^b CHINESE NATIONAL HUMAN GENOME CENTER AT SHANGHAI   (China)

^c PEKING UNION MEDICAL COLLEGE   (China)

Author keywords

Apoptosis; DENND2D; Gene expression; Non small cell lung cancer; Proliferation; Tumorigenicity

Indexed keywords

DENN MADD DOMAIN CONTAINING 2D; MESSENGER RNA; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRONCHUS MUCOSA; CANCER CELL CULTURE; CANCER INHIBITION; CANCER SURVIVAL; CANCER TISSUE; CARCINOGENICITY; CELL EXPANSION; CELL IMMORTALIZATION; CELL LEVEL; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; EPITHELIUM CELL; FEMALE; GENE DOSAGE; GENE EXPRESSION; GENE REGULATORY NETWORK; GENETIC DAMAGE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; LUNG NON SMALL CELL CANCER; LUNG SQUAMOUS CELL CARCINOMA; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRECANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR SUPPRESSOR GENE;

ADENOCARCINOMA; ADULT; AGED; ANALYSIS OF VARIANCE; ANIMALS; APOPTOSIS; CARCINOMA, NON-SMALL-CELL LUNG; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; DOWN-REGULATION; FEMALE; GENE DOSAGE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIVER; LUNG NEOPLASMS; MALE; MICE; MICE, INBRED BALB C; MIDDLE AGED; PRECANCEROUS CONDITIONS; RNA, MESSENGER; TRANSFECTION; TUMOR SUPPRESSOR PROTEINS;

EID: 84872159251     PISSN: 01695002     EISSN: 18728332     Source Type: Journal    
DOI: 10.1016/j.lungcan.2012.10.012     Document Type: Article

References (26)

1. Sun W., Zhang K., Zhang X., Lei W., Xiao T., Ma J., et al. Identification of differentially expressed genes in human lung squamous cell carcinoma using suppression subtractive hybridization. Cancer Lett 2004, 212:83-93.
2. Yoshimura S., Gerondopoulos A., Linford A., Rigden D.J., Barr F.A. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. J Cell Biol 2010, 191:367-381.
3. Bloethner S., Mould A., Stark M., Hayward N.K. Identification of ARHGEF17, DENND2D, FGFR3, and RB1 mutations in melanoma by inhibition of nonsense-mediated mRNA decay. Genes Chromosomes Cancer 2008, 47:1076-1085.
4. Lim K.M., Yeo W.S., Chow V.T. Antisense abrogation of DENN expression induces apoptosis of leukemia cells in vitro, causes tumor regression in vivo and alters the transcription of genes involved in apoptosis and the cell cycle. Int J Cancer 2004, 109:24-37.
5. Del Villar K., Miller C.A. Down-regulation of DENN/MADD, a TNF receptor binding protein, correlates with neuronal cell death in Alzheimer's disease brain and hippocampal neurons. Proc Natl Acad Sci USA 2004, 101:4210-4215.
6. Miyoshi J., Takai Y. Dual role of DENN/MADD (Rab3GEP) in neurotransmission and neuroprotection. Trends Mol Med 2004, 10:476-480.
7. Behnia R., Munro S. Organelle identity and the signposts for membrane traffic. Nature 2005, 438:597-604.
8. Zerial M., McBride H. Rab proteins as membrane organizers. Nat Rev Mol Cell Biol 2001, 2:107-117.
9. Schwartz S.L., Cao C., Pylypenko O., Rak A., Wandinger-Ness A. Rab GTPases at a glance. J Cell Sci 2007, 120:3905-3910.
10. Lombardi D., Soldati T., Riederer M.A., Goda Y., Zerial M., Pfeffer S.R. Rab9 functions in transport between late endosomes and the trans Golgi network. EMBO J 1993, 12:677-682.
11. Riederer M.A., Soldati T., Shapiro A.D., Lin J., Pfeffer S.R. Lysosome biogenesis requires Rab9 function and receptor recycling from endosomes to the trans-Golgi network. J Cell Biol 1994, 125:573-582.
12. O'Briant K.C., Bepler G. Delineation of the centromeric and telomeric chromosome segment 11p15.5 lung cancer suppressor regions LOH11A and LOH11B. Genes Chromosomes Cancer 1997, 18:111-114.
13. Schwendel A., Langreck H., Reichel M., Schrock E., Ried T., Dietel M., et al. Primary small-cell lung carcinomas and their metastases are characterized by a recurrent pattern of genetic alterations. Int J Cancer 1997, 74:86-93.
14. Virmani A.K., Fong K.M., Kodagoda D., McIntire D., Hung J., Tonk V., et al. Allelotyping demonstrates common and distinct patterns of chromosomal loss in human lung cancer types. Genes Chromosomes Cancer 1998, 21:308-319.
15. D'Amico D., Carbone D.P., Johnson B.E., Meltzer S.J., Minna J.D. Polymorphic sites within the MCC and APC loci reveal very frequent loss of heterozygosity in human small cell lung cancer. Cancer Res 1992, 52:1996-1999.
16. Levin N.A., Brzoska P., Gupta N., Minna J.D., Gray J.W., Christman M.F. Identification of frequent novel genetic alterations in small cell lung carcinoma. Cancer Res 1994, 54:5086-5091.
17. Petersen I., Bujard M., Petersen S., Wolf G., Goeze A., Schwendel A., et al. Patterns of chromosomal imbalances in adenocarcinoma and squamous cell carcinoma of the lung. Cancer Res 1997, 57:2331-2335.
18. Burkhardt M., Mayordomo E., Winzer K.J., Fritzsche F., Gansukh T., Pahl S., et al. Cytoplasmic overexpression of ALCAM is prognostic of disease progression in breast cancer. J Clin Pathol 2006, 59:403-409.
19. An Q., Pacyna-Gengelbach M., Schluns K., Deutschmann N., Guo S., Gao Y., et al. Identification of differentially expressed genes in immortalized human bronchial epithelial cell line as a model for in vitro study of lung carcinogenesis. Int J Cancer 2003, 103:194-204.
20. Lu Y.J., Guo S.P., Tong T., Xu L.H., Dong X.Y., Hana N.J., et al. Establishment and characterization of a SV40T-transformed human bronchial epithelial cell line. Lung Cancer 1998, 19:15-24.
21. Xiao T., Ying W., Li L., Hu Z., Ma Y., Jiao L., et al. An approach to studying lung cancer-related proteins in human blood. Mol Cell Proteomics 2005, 4:1480-1486.
22. Su Z., Shi Y., Friedman R., Qiao L., McKinstry R., Hinman D., et al. PEA3 sites within the progression elevated gene-3 (PEG-3) promoter and mitogen-activated protein kinase contribute to differential PEG-3 expression in Ha-ras and v-raf oncogene transformed rat embryo cells. Nucleic Acids Res 2001, 29:1661-1671.
23. Yuan J., Ma J., Zheng H., Shi T., Sun W., Zhang Q., et al. Overexpression of OLC1, cigarette smoke, and human lung tumorigenesis. J Natl Cancer Inst 2008, 100:1592-1605.
24. Meuwissen R., Berns A. Mouse models for human lung cancer. Genes Dev 2005, 19:643-664.
25. Dong X.Y., Lu Y.J., Tong T., Wang Y.J., Guo S.P., Bai J.F., et al. Molecular cytogenetic alterations in the early stage at human bronchial epithelial cell carcinogenesis. J Cell Biochem Suppl 1997, 28-29:74-80.
26. Petersen S., Aninat-Meyer M., Schluns K., Gellert K., Dietel M., Petersen I. Chromosomal alterations in the clonal evolution to the metastatic stage of squamous cell carcinomas of the lung. Br J Cancer 2000, 82:65-73.