Identifying static and kinetic lipid phenotypes by high resolution UPLC-MS: Unraveling diet-induced changes in lipid homeostasis by coupling metabolomics and fluxomics

Journal of Proteome Research

Volumn 10, Issue 9, 2011, Pages 4281-4290

  Castro Perez, Jose M ^a,b   Roddy, Thomas P ^a   Shah, Vinit ^a   McLaren, David G ^a   Wang, Sheng Ping ^a   Jensen, Kristian ^a   Vreeken, Rob J ^b   Hankemeier, Thomas ^b   Johns, Douglas G ^a   Previs, Stephen F ^a   Hubbard, Brian K ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

atherosclerosis; denovo lipogenesis; Deuterium oxide; dyslipidemia; isotopomer; mass spectrometry; metabolomics; multivariate statistical analysis

Indexed keywords

DEUTERIUM OXIDE; LIPID; TRIACYLGLYCEROL;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ARTICLE; BIOMICS; CARBOHYDRATE INTAKE; FLUXOMICS; HOMEOSTASIS; ISOTOPE LABELING; KINETICS; LIPID BLOOD LEVEL; LIPOGENESIS; LOW FAT DIET; MALE; MASS SPECTROMETRY; METABOLOMICS; MOUSE; NONHUMAN; PHENOTYPE; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; UPREGULATION;

ANIMALS; ATHEROSCLEROSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEUTERIUM EXCHANGE MEASUREMENT; DIET; DIETARY CARBOHYDRATES; DIETARY FATS; DYSLIPIDEMIAS; LIPID METABOLISM; LIPIDS; LIVER; MASS SPECTROMETRY; METABOLOMICS; MICE; MICE, INBRED C57BL; PHENOTYPE; PRINCIPAL COMPONENT ANALYSIS;

ANIMALIA; MUS;

EID: 80052483304     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr200480g     Document Type: Article

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