Loss of expression of a new member of the DNAJ protein family confers resistance to chemotherapeutic agents used in the treatment of ovarian cancer

Cancer Research

Volumn 61, Issue 10, 2001, Pages 4258-4265

  Shridhar, V ^a   Bible, K C ^a   Staub, J ^a   Avula, R ^a   Lee, Y K ^a   Kalli, K ^a   Huang, H ^a   Hartmann, L C ^a   Kaufmann, S H ^a   Smith, D I ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CISPLATIN; HEAT SHOCK PROTEIN; PACLITAXEL; TOPOTECAN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CHEMOTHERAPY; CELL VIABILITY; EPITHELIUM CELL; GENE DELETION; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; METHYLATION; OVARY CANCER; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FOLDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AMINO ACID SEQUENCE; AZACITIDINE; BASE SEQUENCE; CHROMOSOME MAPPING; CISPLATIN; CLONING, MOLECULAR; DNA, NEOPLASM; DOWN-REGULATION; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HEAT-SHOCK PROTEINS; HSP40 HEAT-SHOCK PROTEINS; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LOSS OF HETEROZYGOSITY; MOLECULAR SEQUENCE DATA; OVARIAN NEOPLASMS; OXIMES; PACLITAXEL; PIPERAZINES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY, AMINO ACID; TOPOTECAN; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0035872480     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. NMR structure of the J-domain and the Gly/Phe-rich region of the Escherichia coli DnaJ chaperone
2. The J-domain family and the recruitment of chaperone power
3. Role of the J-domain in the cooperation of Hsp40 with Hsp70
4. Interaction of the Hsp70 molecular chaperone, DnaK, with its cochaperone DnaJ
5. Control of folding and membrane translocation by binding of the chaperone DnaJ to nascent polypeptides
6. The conserved G/F motif of the DnaJ chaperone is necessary for the activation of the substrate binding properties of the DnaK chaperone
7. The DnaJ domain of polyomavirus large T antigen is required to regulate Rb family tumor suppressor function
8. DnaJ/hsp40 chaperone domain of SV40 large T antigen promotes efficient viral DNA replication
9. The J domain of simian virus 40 large T antigen is required to functionally inactivate RB family proteins
10. Molecular chaperone function of the SV40 large T antigen
11. A novel human DnaJ protein, hTid-1, a homolog of the Drosophila tumor suppressor protein Tid56, can interact with the human papillomavirus type 16 E7 oncoprotein
12. The molecular chaperone Ydjl is required for the p34CDC28-dependent phosphorylation of the cyclin Cln3 that signals its degradation
13. Hormone-dependent transactivation by the human androgen receptor is regulated by a DnaJ protein
14. Biological characterization of human epithelial ovarian carcinoma cells in primary culture: The insulin-like growth factor system
15. Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction
16. Characterization of an ovarian carcinoma cell line resistant to cisplatin and flavopiridol
17. Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands
18. Flavopiridol (NSC 649890, L86-8275): A cytotoxic flavone that induces death in noncycling A549 human lung carcinoma cells
19. Cytotoxic synergy between flavopiridol (NSC 649890, L86-8275) and various antineoplastic agents: The importance of sequence of administration
20. Effect of P-glycoprotein expression on the accumulation and cytotoxicity of topotecan (SK&F 104864), a new camptothecin analogue
21. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
22. An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs
23. A physical map of 30,000 human genes
24. Induction by 5-aza-2′-deoxycytidine, an inhibitor of DNA methylation, of Le(y) antigen, apoptosis, and differentiation in human lung cancer cells
25. The DNA methyltransferase inhibitor 5-aza-cytidine specifically alters the expression of helix-loop-helix proteins ld1, ld2, and ld3 during neuronal differentiation
26. Cancer Statistics 1999
27. Prognostic factors in ovarian cancer
28. Exploratory Phase III study of paclitaxel and cisplatin versus paclitaxel and carboplatin in advanced ovarian cancer
29. High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis
30. Glutathione and drug resistance
31. Cellular pharmacology of cisplatin: Perspectives on mechanisms of acquired resistance
32. Cisplatin sensitivity of ovarian cancer in the histoculture drug response assay correlates to clinical response to combination chemotherapy with cisplatin, doxorubicin, and cyclophosphamide
33. Mechanisms of drug resistance to the platinum complex ZD0473 in ovarian cancer cell lines
34. TP53 mutation in ovarian carcinoma
35. Molecular analysis of the retinoblastoma gene in primary ovarian cancer cells
36. NOEY2 (ARHI), an imprinted putative tumor suppressor gene in ovarian and breast carcinomas
37. The DnaJ60 gene of Drosophila melanogaster encodes a new member of the DnaJ family of proteins
38. MSJ-1, a new member of the DNAJ family of proteins, is a male germ cell specific gene product
39. P-Glycoprotein-mediated multidrug resistance: Experimental and clinical strategies for its reversal