MafA is critical for maintenance of the mature beta cell phenotype in mice

Diabetologia

Volumn 58, Issue 3, 2015, Pages 566-574

  Nishimura, Wataru ^a,b   Takahashi, Satoru ^c   Yasuda, Kazuki ^a  

^a NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^b JICHI MEDICAL UNIVERSITY   (Japan)

^c UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Beta cells; Cell plasticity; Dedifferentiation; Lineage tracing; MafA

Indexed keywords

DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; GLUCAGON; GLUCOSE; INSULIN; MESSENGER RNA; MONOCARBOXYLATE TRANSPORTER 1; MYCL PROTEIN; NEUROGENIC DIFFERENTIATION FACTOR; NEUROGENIN 3; PROTEIN; STREPTOZOCIN; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR MAFA; TRANSCRIPTION FACTOR MAFB; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR NKX6.1; TRANSCRIPTION FACTOR PAX4; TRANSCRIPTION FACTOR PAX6; TRANSCRIPTION FACTOR PDX 1; TRANSCRIPTION FACTOR SOX2; TRANSCRIPTION FACTOR SOX9; UNCLASSIFIED DRUG; MAFA PROTEIN, MOUSE; TRANSCRIPTION FACTOR MAF;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DEDIFFERENTIATION; CELL FATE; CELL LINEAGE; CELL MATURATION; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; DIABETES MELLITUS; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INSULIN RELEASE; MOUSE; NONHUMAN; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PHENOTYPE; PHENOTYPIC PLASTICITY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; UPREGULATION; ANIMAL; GENETICS; KNOCKOUT MOUSE; METABOLISM; PANCREAS ISLET; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; GLUCAGON-SECRETING CELLS; IMMUNOHISTOCHEMISTRY; ISLETS OF LANGERHANS; MAF TRANSCRIPTION FACTORS; MAF TRANSCRIPTION FACTORS, LARGE; MAFB TRANSCRIPTION FACTOR; MICE; MICE, KNOCKOUT; MICROSCOPY, ELECTRON, TRANSMISSION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84925496747     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-014-3464-9     Document Type: Article

References (40)

1. Takahashi K, Yamanaka S (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126:663–676
2. Jopling C, Boue S, Izpisua Belmonte JC (2011) Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration. Nat Rev Mol Cell Biol 12:79–89
3. Thorel F, Népote V, Avril I et al (2010) Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss. Nature 464:1149–1154
4. Dhawan S, Georgia S, Tschen SI, Fan G, Bhushan A (2011) Pancreatic beta cell identity is maintained by DNA methylation-mediated repression of Arx. Dev Cell 20:419–429
5. Papizan JB, Singer RA, Tschen SI et al (2011) Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming. Genes Dev 25:2291–2305
6. Elghazi L, Weiss AJ, Barker DJ et al (2009) Regulation of pancreas plasticity and malignant transformation by Akt signaling. Gastroenterology 136:1091–1103
7. Landsman L, Parent A, Hebrok M (2011) Elevated hedgehog/Gli signaling causes beta-cell dedifferentiation in mice. Proc Natl Acad Sci U S A 108:17010–17015
8. Talchai C, Xuan S, Lin HV, Sussel L, Accili D (2012) Pancreatic beta cell dedifferentiation as a mechanism of diabetic beta cell failure. Cell 150:1223–1234
9. Collombat P, Xu X, Ravassard P et al (2009) The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells. Cell 138:449–462
10. Collombat P, Hecksher-Sørensen J, Krull J et al (2007) Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression. J Clin Invest 117:961–970
11. Zhou Q, Brown J, Kanarek A, Rajagopal J, Melton DA (2008) In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature 455:627–632
12. Jonas JC, Sharma A, Hasenkamp W et al (1999) Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes. J Biol Chem 274:14112–14121
13. Wang Z, York NW, Nichols CG, Remedi MS (2014) Pancreatic β cell dedifferentiation in diabetes and redifferentiation following insulin therapy. Cell Metab 19:872–882
14. Gao T, McKenna B, Li C et al (2014) Pdx1 maintains β cell identity and function by repressing an α cell program. Cell Metab 19:259–271
15. Taylor BL, Liu FF, Sander M (2013) Nkx6.1 is essential for maintaining the functional state of pancreatic beta cells. Cell Rep 4:1262–1275
16. Puri S, Akiyama H, Hebrok M (2013) VHL-mediated disruption of Sox9 activity compromises β-cell identity and results in diabetes mellitus. Genes Dev 27:2563–2575
17. Tata PR, Mou H, Pardo-Saganta A et al (2013) Dedifferentiation of committed epithelial cells into stem cells in vivo. Nature 503:218–223
18. Nutt SL, Heavey B, Rolink AG, Busslinger M (1999) Commitment to the B-lymphoid lineage depends on the transcription factor Pax5. Nature 401:556–562
19. Gurdon JB, Elsdale TR, Fischberg M (1958) Sexually mature individuals of Xenopus laevis from the transplantation of single somatic nuclei. Nature 182:64–65
20. Olbrot M, Rud J, Moss LG, Sharma A (2002) Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA. Proc Natl Acad Sci U S A 99:6737–6742
21. Nishimura W, Kondo T, Salameh T et al (2006) A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells. Dev Biol 293:526–539
22. Artner I, Hang Y, Mazur M et al (2010) MafA and MafB regulate genes critical to beta-cells in a unique temporal manner. Diabetes 59:2530–2539
23. Nishimura W, Bonner-Weir S, Sharma A (2009) Expression of MafA in pancreatic progenitors is detrimental for pancreatic development. Dev Biol 333:108–120
24. Kaneto H, Matsuoka TA, Nakatani Y et al (2005) A crucial role of MafA as a novel therapeutic target for diabetes. J Biol Chem 280:15047–15052
25. Butler AE, Robertson RP, Hernandez R, Matveyenko AV, Gurlo T, Butler PC (2012) Beta cell nuclear musculoaponeurotic fibrosarcoma oncogene family A (MafA) is deficient in type 2 diabetes. Diabetologia 55:2985–2988
26. Guo S, Dai C, Guo M et al (2013) Inactivation of specific beta cell transcription factors in type 2 diabetes. J Clin Invest 123:3305–3316
27. Zhang C, Moriguchi T, Kajihara M et al (2005) MafA is a key regulator of glucose-stimulated insulin secretion. Mol Cell Biol 25:4969–4976
28. Moriguchi T, Hamada M, Morito N et al (2006) MafB is essential for renal development and F4/80 expression in macrophages. Mol Cell Biol 26:5715–5727
29. Nishimura W, Eto K, Miki A et al (2013) Quantitative assessment of Pdx1 promoter activity in vivo using a secreted luciferase reporter system. Endocrinology 154:4388–4395
30. Shirato Y, Tamura M, Yoneda M, Nemoto S (2006) Centrosome destined to decay in starfish oocytes. Development 133:343–350
31. Hang Y, Yamamoto T, Benninger RK et al (2014) The MafA transcription factor becomes essential to islet β-cells soon after birth. Diabetes 63:1994–2005
32. Eto K, Nishimura W, Oishi H et al (2014) MafA is required for postnatal proliferation of pancreatic β-cells. PLoS One 9:e104184
33. Laybutt DR, Hawkins YC, Lock J et al (2007) Influence of diabetes on the loss of beta cell differentiation after islet transplantation in rats. Diabetologia 50:2117–2125
34. Pullen TJ, Rutter GA (2013) When less is more: the forbidden fruits of gene repression in the adult β-cell. Diabetes Obes Metab 15:503–512
35. Thorrez L, Laudadio I, van Deun K et al (2011) Tissue-specific disallowance of housekeeping genes: the other face of cell differentiation. Genome Res 21:95–105
36. Neri F, Krepelova A, Incarnato D et al (2013) Dnmt3L antagonizes DNA methylation at bivalent promoters and favors DNA methylation at gene bodies in ESCs. Cell 26:121–134
37. Harmon JS, Stein R, Robertson RP (2005) Oxidative stress-mediated, post-translational loss of MafA protein as a contributing mechanism to loss of insulin gene expression in glucotoxic beta cells. J Biol Chem 280:11107–11113
38. Matsuoka TA, Kaneto H, Miyatsuka T et al (2010) Regulation of MafA expression in pancreatic beta-cells in db/db mice with diabetes. Diabetes 59:1709–1720
39. Vicente-Dueñas C, Romero-Camarero I, González-Herrero I et al (2012) A novel molecular mechanism involved in multiple myeloma development revealed by targeting MafB to haematopoietic progenitors. EMBO J 31:3704–3717
40. Bramswig NC, Everett LJ, Schug J et al (2013) Epigenomic plasticity enables human pancreatic alpha to beta cell reprogramming. J Clin Invest 123:1275–1284