The non-benzodiazepine anxiolytic drug etifoxine causes a rapid, receptor-independent stimulation of neurosteroid biosynthesis

PLoS ONE

Volumn 10, Issue 3, 2015, Pages

  Luc Do Rego, Jean ^a,b   Vaudry, David ^a,b   Vaudry, Hubert ^a,b  

^a UNIVERSITY OF ROUEN   (France)

^b UNIVERSITÉ DE ROUEN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

17 HYDROXYPREGNENOLONE; 20ALPHA DIHYDROPROGESTERONE; ANXIOLYTIC AGENT; BICUCULLINE; ETIFOXINE; FLUMAZENIL; MEMBRANE RECEPTOR; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; NEUROPEPTIDE; NEUROSTEROID; PRASTERONE; PROGESTERONE; TETRAHYDROPROGESTERONE; TRIAKONTATETRANEUROPEPTIDE; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; BENZODIAZEPINE RECEPTOR AFFECTING AGENT; DRUG MIXTURE; ELTANOLONE; ISOQUINOLINE DERIVATIVE; OXAZINE DERIVATIVE; PEPTIDE FRAGMENT;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; EXPLANT; HYPOTHALAMUS; MALE; NONHUMAN; PELOPHYLAX ESCULENTUS; SIGNAL TRANSDUCTION; STEROIDOGENESIS; TISSUE HOMOGENATE; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CHEMISTRY; DRUG EFFECTS; DRUG MIXTURE; GENE EXPRESSION; GENETICS; METABOLISM; TISSUE CULTURE TECHNIQUE;

ANURA;

17-ALPHA-HYDROXYPREGNENOLONE; 20-ALPHA-DIHYDROPROGESTERONE; ANIMALS; ANTI-ANXIETY AGENTS; BICUCULLINE; COMPLEX MIXTURES; DEHYDROEPIANDROSTERONE; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUMAZENIL; GABA MODULATORS; GABA-A RECEPTOR ANTAGONISTS; GENE EXPRESSION; HYPOTHALAMUS; ISOQUINOLINES; MALE; NEUROPEPTIDES; OXAZINES; PEPTIDE FRAGMENTS; PREGNANOLONE; PROGESTERONE; RANA ESCULENTA; RECEPTORS, GABA-A; TISSUE CULTURE TECHNIQUES;

EID: 84925400748     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0120473     Document Type: Article

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