The endozepine triakontatetraneuropeptide diazepam-binding inhibitor [17-50] stimulates neurosteroid biosynthesis in the frog hypothalamus

Neuroscience

Volumn 83, Issue 2, 1998, Pages 555-570

  Do Rego, J L ^a   Mensah Nyagan, A G ^a   Feuilloley, M ^a   Ferrara, P ^b   Pelletier, G ^c   Vaudry, H ^a  

^a UNIVERSITÉ DE ROUEN   (France)

^b SANOFI   (France)

^c LAVAL UNIVERSITY   (Canada)

Author keywords

3 hydroxysteroid dehydrogenase 5 4 isomerase; Diazepam binding inhibitor; Neurosteroid biosynthesis; Peripheral type benzodiazepine receptors

Indexed keywords

17 HYDROXYPREGNENOLONE; 3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; 4' CHLORODIAZEPAM; ANDROSTANOLONE; BENZODIAZEPINE RECEPTOR; BENZODIAZEPINE RECEPTOR BLOCKING AGENT; DIAZEPAM BINDING INHIBITOR; FLUMAZENIL; HYDROXYPROGESTERONE; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; PREGNENOLONE; TRIAKONTATETRANEUROPEPTIDE [17-50]; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; DRUG RECEPTOR BINDING; FROG; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; MALE; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RECEPTOR UPREGULATION; STEROIDOGENESIS;

3-HYDROXYSTEROID DEHYDROGENASES; ANIMALS; BENZODIAZEPINONES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CONVULSANTS; FLUORESCENT ANTIBODY TECHNIQUE, DIRECT; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; MALE; NEUROPEPTIDES; PEPTIDE FRAGMENTS; PERIPHERAL NERVES; RANA RIDIBUNDA; RECEPTORS, GABA-A; STEROIDS; STIMULATION, CHEMICAL;

EID: 0031906748     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(97)00362-X     Document Type: Article

References (21)

1. Akwa Y., Young J., Kabbadj K., Sancho M. J., Zucman D., Vourc'h C., Jung-Testas I., Hu Z. Y., Le Goascogne C., Jo D. H., Corpéchot C., Simon P., Baulieu E. E. and Robel P. (1991) Neurosteroids: biosynthesis, metabolism and function of pregnenolone and dehydroepiandrosterone in the brain. J. Steroid Biochem. molec. Biol. 40, 71-81.
2. Alho H., Varga V. and Krueger K. E. (1994) Expression of mitochondrial benzodiazepine receptor and its putative endogenous ligand diazepam binding inhibitor in cultured primary astrocytes and C-6 cells: relation to cell growth. Cell. Growth Diff. 5, 1005-1014.
3. A receptor complex β2/3 subunits in the brain of the frog Rana pipiens. Neurosci. Lett. 225, 65-68.
4. Amsterdam A. and Suh S. B. (1991) An inducible functional peripheral benzodiazepine receptor in mitochondria of steroidogenic granulosa cells. Endocrinology 129, 503-510.
5. Anholt R. R. H., Pedersen P. L., De Souza E. B. and Snyder S. H. (1986) The peripheral-type benzodiazepine receptor. Localization to the mitochondrial outer membrane. J. biol. Chem. 261, 576-583.
6. Bauer H. C. and Bauer H. (1989) Micromethod for the determination of 3β-HSD activity in cultured cells. J. Steroid Biochem. 33, 643-646.
7. Benavides J. J., Guilloux F., Allan D. E., Uzan A., Mizoule J., Renault C., Dubroeucq C., Guérémy C. and Le Fur G. (1984) Opposite effects of an agonist, Ro5-4864, and an antagonist, PK11195, of the peripheral-type benzodiazepine binding sites on audiogenic seizures in DBA/2J mice. Life Sci. 34, 2613-2620.
8. Berkovich A., McPhie P., Campagnone M., Guidotti A. and Costa E. (1990) A natural processing product of rat diazepam binding inhibitor, triakontatetraneuropeptide (diazepam binding inhibitor 17-50) contains an α-helix which allows discrimination between benzodiazepine binding site subtypes. Molec. Pharmac. 37, 164-172.
9. Brogden R. N. and Goa K. L. (1991) Flumazenil: a reappraisal of its pharmacological properties and therapeutic efficacy as a benzodiazepine antagonist. Drugs 42, 1061-1089.
10. Brown A. S., Hall P. F., Shoyab M. and Papadopoulos V. (1992) Endozepine/diazepam binding inhibitor in adrenocortical and Leydig cell lines: absence of hormonal regulation. Molec. cell. Endocr. 83, 1-9.
11. Chen Z. W., Agerberth B., Gell K., Andersson M., Mutt V., Östenson C. G., Efendic S., Barros-Söderling J., Persson B. and Jörnvall H. (1988) Isolation and characterization of porcine diazepam-binding inhibitor, a polypeptide not only of cerebral occurrence but also common in intestinal tissues and with effects on regulation of insulin release. Eur. J. Biochem. 174, 239-245.
12. Costa E., Auta J., Guidotti A., Korneyev A. and Romeo E. (1994) The pharmacology of neurosteroidogenesis. J. Steroid Biochem. molec. Biol. 49, 385-389.
13. Drugan R. C. (1996) Peripheral benzodiazepine receptors: molecular pharmacology to possible physiological significance in stress-induced hypertension. Clin. Neuropharmac. 19, 475-496.
14. Dupont E., Simard J., Luu-The V., Labrie F. and Pelletier G. (1994) Localization of 3β-hydroxysteroid dehydrogenase in rat brain as studied by in situ hybridization. Molec. cell. Neurosci. 5, 119-123.
15. Ferrero P., Santi M. R., Conti-Tronconi B., Costa E. and Guidotti A. (1986) Study of an octadecaneuropeptide derived from diazepam binding inhibitor (DBI): biological activity and presence in rat brain. Proc. natn. Acad. Sci. U.S.A. 83, 827-831.
16. Franzoni M. F. and Morino P. (1989) The distribution of GABA-like immunoreactive neurons in the brain of the newt, Triturus cristatus carnifex, and the green frog, Rana esculenta. Cell Tiss. Res. 255, 155-166.
17. Gamier M., Boujrad N., Oke B. O., Brown S., Riond J., Ferrara P., Shoyab M., Suarez-Quian A. and Papadopoulos V. (1993) Diazepam binding inhibitor is a paracrine/autocrine regulator of Leydig cell proliferation and steroidogenesis: action via peripheral-type benzodiazepine receptor and independent mechanisms. Endocrinology 132, 444-458.
18. Gray P. W., Glaister D., Seeburg P. H., Guidotti A. and Costa E. (1986) Cloning and expression of cDNA for human diazepam binding inhibitor, a natural ligand of an allosteric regulatory site of the γ-aminobutyric acid type A receptor. Proc. natn. Acad. Sci. U.S.A. 83, 7547-7551.
19. 4-isomerase (3β-HSD), is expressed in rat brain. Molec. Brain Res. 30, 287-300.
20. Guidotti A., Forchetti C. M., Corda M. G., Konkel D., Bennet C. D. and Costa E. (1983) Isolation, characterization, and purification to homogeneity of an endogenous polypeptide with agonistic action on benzodiazepine receptors. Proc. natn. Acad. Sci. U.S.A. 83, 3531-3533.
21. Hassl A. and Aspöck H. (1988) Purification of egg yolk immunoglobulins: a two steps procedure using hydrophobic interaction chromatography and gel filtration. J. immun. Meth. 110, 225-228.