Steroid synthesis and metabolism in the nervous system: Trophic and protective effects

Journal of Neurocytology

Volumn 29, Issue 5-6, 2000, Pages 307-326

  Schumacher, Michael ^a   Akwa, Yvette ^a   Guennoun, Rachida ^a   Robert, Françoise ^a   Labombarda, Florencia ^b   Désarnaud, Franck ^a   Robel, Paul ^a   De Nicola, Alejandro F ^b   Baulieu, Etienne Emile ^a,b  

^a INSERM   (France)

^b INST DE BIOL Y MED EXPERIMENTAL   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; N METHYL DEXTRO ASPARTIC ACID; NEUROTRANSMITTER RECEPTOR; NITRIC OXIDE SYNTHASE; PRASTERONE; PREGNENOLONE; PREGNENOLONE SULFATE; PROGESTERONE; SIGMA 1 OPIATE RECEPTOR; STEROID; SULFATE;

AMNESIA; ANTICONVULSANT ACTIVITY; ARTICLE; BRAIN INJURY; CELL INTERACTION; ENZYME INDUCTION; GENE EXPRESSION; GLIA CELL; LIPID PEROXIDATION; MYELIN SHEATH; NERVE CELL PLASTICITY; NERVE REGENERATION; NERVOUS SYSTEM; NEUROMODULATION; NEUROPROTECTION; NONHUMAN; PERIPHERAL NERVE; PRIORITY JOURNAL; REGULATORY MECHANISM; SCHWANN CELL; SEDATION; SIGNAL TRANSDUCTION; SPINAL CORD INJURY; STEROID METABOLISM; STEROIDOGENESIS; TRANQUILIZING ACTIVITY;

ANIMALS; BRAIN INJURIES; NERVOUS SYSTEM; SPINAL CORD INJURIES; STEROIDS;

EID: 0034477199     PISSN: 03004864     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007152904926     Document Type: Article

References (180)

1. The mouse 3β-hydroxysteroid dehydrogenase multigene family includes two functionally distinct groups of proteins
2. Astrocytes and neurosteroids: Metabolism of pregnenolone and dehydroepiandrosterone. Regulation by cell density
3. The amygdala mediates the anxiolytic-like effect of the neurosteroid allopregnanolone in rat
4. Dopaminergic regulation of progesterone receptors: Brain D5 dopamine receptors mediate induction of lordosis by D1-like agonists in rats
5. Progesterone facilitates the acquisition of avoidance learning and protects against subcortical neuronal death following prefrontal cortex ablation in the rat
6. New insights into the regulation and function of brain estrogen synthase (aromatase)
7. Steroidal modulation of sigma receptor function
8. Neurosteroids: A new function in the brain
9. Non-genomic mechanisms of action of steroid hormones
10. Effects of intravenous progesterone infusions on the epileptic discharge frequency in women with partial epilepsy
11. Immunocytochemical localization and biological activity of hydroxysteroid sulfotransferase in the frog brain
12. Protection against oxidative stress-induced neuronal cell death - A novel role for RU486
13. Effect of benzodiazepines and neurosteroids on ammonia-induced swelling in cultured astrocytes
14. A receptor
15. A synaptic model of memory: Long-term potentiation in the hippocampus
16. Dehydroepiandrosterone and its sulfated derivative reduce neuronal death and enhance astrocytic differentiation in brain ceil cultures
17. Ethanol-like discriminative stimulus effects of endogenous neuroactive steroids: Effect of ethanol training dose and dosing procedure
18. Emerging diversities in the mechanism of action of steroid hormones
19. A receptors
20. Dehydroepiandrosterone protects hippocampal neurons against neurotoxin-induced cell death: Mechanism of action
21. Detection of P450c17 independent pathways for dehydroepiandrosterone (DHEA) biosynthesis in brain glial tumor cells
22. The 5α-reductase in the brain: Molecular aspects and relation to brain function
23. Glucocorticoids and progestins signal the initiation and enhance the rate of myelin formation
24. Cytokine-stimulated astrocytes damage human neurons via nitric oxide mechanism
25. Nitric oxide: Foe or friend to the injured brain?
26. Dehydroepiandrosterone: A potential signalling molecule for neocortical organization during development
27. Expression of steroid sulfatase during embryogenesis
28. Steroidogenic enzyme P450c17 is expressed in the embryonic central nervous system
29. Characterization and measurement of dehydroepiandrosterone sulfate in the rat brain
30. In vitro studies on the role of the peripheral-type benzodiazepine receptor in steroidogenesis
31. Antagonism by intracerebellar Ro15-4513 of acute ethanol-induced motor incoordination in mice
32. The neurosteroid pregnenolone sulfate increases cortical acetylcholine release: A microdialysis study in freely moving rats
33. Brain corticosteroid receptor balance in health and disease
34. Steroid Hormones and Neuronal Regeneration
35. Regulation of gene expression by corticoid hormones in the brain and spinal cord
36. Neuroactive steroids regulate astroglia morphology in hippocampal cultures from adult rats
37. A receptors to neuroactiye steroids in rats during ethanol withdrawal
38. Progesterone stimulates the activity of the promoters of peripheral myelin protein-22 and P0 genes in Schwann cells
39. Expression of the inducible form of nitric oxide synthase by reactive astrocytes after transient global ischemia
40. The steroid thyroid hormone receptor superfamily
41. Peripheral nerve regeneration
42. The spectrum of age-associated brain abnormalities: Their measurement and histopathological correlates
43. Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it
44. Pregnenolone sulfate enhances post-training memory processes when injected in very low doses into limbic system structures: The amygdala is by far the most sensitive
45. Seizure activity is increased in endocrine states characterized by decline in endogenous levels of the neurosteroid 3 alpha, 5 alpha-THP
46. Cyclic withdrawal from endogenous and exogenous progesterone increases kainic acid and perforant pathway induced seizures
47. Pharmacology of traumatic brain injury: Experimental models and clinical implications
48. SCC (CYP XIA1), and 3βhydroxysteroid dehydrogenase in the rat brain
49. Cloning and characterization of PRAX-1. A new protein that specifically interacts with the peripheral benzodiazepine receptor
50. Hippocampal neurodegeneration in aging
51. Dehydroepiandrosterone, pregnenolone and sex steroids down-regulate reactive astroglia in the male rat brain after a penetrating brain injury
52. Estradiol upregulates Bcl-2 expression in adult brain neurons
53. Role of astroglia in estrogen regulation of synaptic plasticity and brain repair
54. Increased expression of peripheral benzodiazepine receptors in the facial nucleus following motor neuron axotomy
55. The proximal region of the MBP gene promoter is sufficient to induce oligodendroglial-specific expression in transgenic mice
56. Ethanol-like discriminative stimulus effects of the neurosteroid 3 alpha-hydroxy-5 alpha-pregnan-20-one in female Macaca fascicularis monkeys
57. Control of transcription activation by steroid hormone receptors
58. γ-Aminobutyric acid type A/benzodiazepine receptors regulate rat retina neurosteroidogenesis
59. A key enzyme in the biosynthesis of neurosteroids, 3β-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase (3β-HSD), is expressed in rat brain
60. Neurosteroids: Expression of functional 3β-hydroxysteroid dehydrogenase by rat sensory neurons and Schwann cells
61. Key role for pregnenolone in combination therapy promotes recovery after spinal cord injury
62. Learning to modulate transmitter release: Themes and variations on synaptic plasticity
63. Psychoneuroendocrine aspects of temporolimbic epilepsy. Part I. Brain, reproductive steroids, and emotions
64. The effects of pregnenolone on acquisition and retention of a food search task
65. Agedependent, steroid-specific effects of oestrogen on long-term potentiation in rat hippocampal slices
66. Progesterone is neuroprotective after transient middle cerebral artery occlusion in male rats
67. C receptors: Relatively simple transmitter-gated ion channels?
68. Demonstration of progesterone receptors in rat Schwann cells
69. The neurosteroid progesterone increases the expression of myelin proteins (MBP and CNPase) in rat oligodendrocytes in primary culture
70. Biosynthesis of pregnenolone and progesterone in primary cultures of rat glial cells
71. Estrogen-inducible progesterone receptor in primary cultures of rat glial cells
72. Gene expression of progesterone receptor isoforms in the rat brain
73. Progesterone synthesis and myelin formation by Schwann cells
74. Age- and region-specific expressions of the messenger RNAs encoding for steroidogenic enzymes P450scc, P450c17 and 3β-HSD in the postnatal rat brain
75. Finasteride, a 5α-reductase inhibitor, blocks the anticonvulsant activity of progesterone in mice
76. Stimulation of brain pregnenolone synthesis by mitochondrial diazepam binding inhibitor receptor ligands in vivo
77. Nonneuronal localization for steroid converting enzyme: 3αHydroxysteroid oxidoreductase in olfactory tubercle of rat brain
78. The peripheral benzodiazepine receptor is a sensitive indicator of domoic acid neurotoxicity
79. Regional and temporal expression of the peripheral benzodiazepine receptor in MPTP neurotoxicity
80. Immunocytochemical evidence for a progesterone receptor in neurons and glial cells of the rat spinal cord
81. Progesterone-induced changes of NADPH-diaphorase and glial fibrillary acidic protein in astrocytes from normal and injured rat spinal cord
82. Enhanced expression of the peripheral benzodiazepine receptor (PBR) and its endogenous ligand octadecaneuropeptide (ODN) in the regenerating adult rat sciatic nerve
83. Regulation of the expression of peripheral benzodiazepine receptors and their endogenous ligands during rat sciatic nerve degeneration and regeneration: A role for PBR in neurosteroidogenesis
84. Prolonged intracerebroventricular infusion of neurosteroids affects cognitive performances in the mouse
85. A receptor
86. Neurosteroid progesterone is up-regulated in the brain of Jimpy and Shiverer mice
87. Neurosteroids: Cytochrome P450scc in rat brain
88. The cholesterol side-chain cleavage complex in human brain white matter
89. The molecular genetics of myelination: An update
90. Reversal of scopolamine induced amnesia in rats by the steroid sulfatase inhibitor estrone-3-O-sulfamate
91. Progestin receptors in rat brain: Distribution and properties of cytoplasmic progestin-binding sites
92. A receptor. Mechanism of action and physiological significance
93. Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor
94. The neurosteroid pregnenolone sulfate blocks NMDA antagonist - Induced deficits in a passive avoidance memory task
95. σ1 (sigma 1) receptor agonists and neurosteroids attenuate B25-B35-amyloid peptide-induced amnesia in mice through a common mechanism
96. Infusion of neurosteroids into the nucleus basalis magnocellularis affects cognitive processes in the rat
97. Neurosteroids: Behavioral studies
98. The brain is an important target of adrenal steroid actions. A comparison of synthetic and natural steroids
99. Gonadal hormone regulation of synaptic plasticity in the brain: What is the mechanism?
100. Estrogen actions in the central nervous system
101. Topographic analysis of the innervation of the rat neocortex and hippocampus by the basal forebrain cholinergic system
102. The 5alpha-reductase in the central nervous system: Expression and modes of control
103. Age-induced decrease of glycoprotein P0 and myelin basic protein gene expression in the rat sciatic nerve. Repair by steroid derivatives
104. Progesterone derivatives are able to influence peripheral myelin protein 22 and P0 gene expression: Possible mechanisms of action
105. P0 promoter directs expression of reporter and toxin genes to Schwann cells of transgenic mice
106. The neurosteroid pregnenolone sulfate reduces learning deficits induced by scopolamine and has promnestic effects in mice performing an appetitive learning task
107. Molecular pathology and mechanism of action of the steroidogenic acute regulatory protein, StAR
108. Progesterone withdrawal I: Pro-Convulsant effects
109. Epilepsy in women: The science of why it is special
110. Differential modulation of the γ-aminobutyric acid type C receptor by neuroactive steroids
111. Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5
112. Pregnenolone binds to microtubule-associated protein 2 and stimulates microtubule assembly
113. Benzodiazepine receptors: Localization in the rat amygdala
114. Temporal expression pattern of peripheral myelin protein 22 during in vivo and in vitro myelination
115. Steroid hormones protect spinal cord neurons from glutamate toxicity
116. The neurosteroid pregnenolone sulfate infused into the nucleus basalis increases both acetylcholine release in the frontal cortex or amygdala and spatial memory
117. Targeted disruption of the peripheral-type benzodiazepine receptor gene inhibits steroidogenesis in the R2C Leydig tumor cell line
118. Peripheral-type benzodiazepine/diazepam binding inhibitor receptor - Biological role in steroidogenic cell function
119. Regulation of C6 glioma cell steroidogenesis by adenosine 3′,5′-cyclic monophosphate
120. Sulfated and unsulfated steroids modulate gamma-aminobutyric acidA receptor function through distinct sites
121. Neuroactive steroids
122. Role of adrenal steroid mineralocorticoid and glucocorticoid receptors in long-term potentiation in the CA1 field of hippocampal slices
123. Age-related changes in oligodendrocytes in monkey cerebral cortex
124. Modulation of steroidal levels by adrenalectomy/castration and inhibition of neurosteroid synthesis enzymes affect sigma1 receptor-mediated behaviour in mice
125. New insights into activation of the steroid hormone receptor superfamily
126. Potentiation of GABAergic neurotransmission by steroids
127. Hydroxysteroid sulfotransferase activity in the rat brain and liver as a function of age and sex
128. Preserved neuron number in the hippocampus of aged rats with spatial learning deficits
129. Proconvulsant effects of neurosteroids pregnenolone sulfate and dehydroepiandrosterone sulfate in mice
130. Enhanced plasma DHEAS, brain acetylcholine and memory mediated by steroid sulfatase inhibition
131. Neurosteroids: From definition and biochemistry to physiopathologic function
132. Synthesis of progesterone in Schwann cells: Regulation by neurons
133. Behaviorally selective effects of neuroactive steroids on plus-maze anxiety in mice
134. Effects of antidepressant treatment on neuroactive steroids in major depression
135. Gender influences outcome of brain injury - Progesterone plays a protective role
136. Progesterone facilitates cognitive recovery and reduces secondary neuronal loss caused by cortical contusion injury in male rats
137. Progesterone protects against lipid peroxidation following traumatic brain injury in rats
138. Progesterone rapidly decreases brain edema: Treatment delayed up to 24 hours is still effective
139. Neuroactive steroids: Mechanisms of action and neuropsychopharmacological perspectives
140. Progesterone receptor-mediated effects of neuroactive steroids
141. A receptors in the amygdala
142. Rapid membrane effects of steroid hormones: An emerging concept in neuroendocrinology
143. A receptors
144. Progesterone administration attenuates excitatory amino acid responses of cerebellar Purkinje cells
145. Identification of a putative estrogen response element in the gene encoding brain-derived neurotrophic factor
146. Progesterone and recovery after traumatic brain injury
147. A receptors
148. A Star search: Implications in controlling steroidogenesis
149. Specific pattern of nitric oxide synthase expression in glial cells after hippocampal injury
150. Concentrations of 3 alpha-reduced neuroactive steroids and their precursors in plasma of patients with major depression and after clinical recovery
151. Messenger RNAs encoding steroidogenic enzymes are expressed in rodent brain
152. Biology and genetics of hereditary motor and sensory neuropathies
153. Regulation of tissue-specific expression of alternative peripheral myelin protein-22 (PMP22) gene transcripts by two promoters
154. A selective imidazobenzodiazepine antagonist of ethanol in the rat
155. Pregnenolone, pregnenolone sulfate, and cytochrome P450 side-chain cleavage enzyme in the amphibian brain and their seasonal changes
156. Progesterone is neuroprotective after acute experimental spinal cord trauma in rats
157. Krox-20 controls myelination in the peripheral nervous system
158. Novel mechanisms of estrogen action in the developing brain: The role of steroid/neurotrophin interactions
159. Novel mechanisms of estrogen action in the brain: New players in an old story
160. Steroid hormone receptors: Interaction with deoxyribonucleic acid and transcription factors
161. Avian neurosteroids. I. Pregnenolone biosynthesis in the quail brain
162. The modulation by neurosteroids of the scopolamine-induced learning impairment in mice involves an interaction with σ1 (sigma1) receptors
163. Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine
164. Soids: Deficient cognitive performance in aged rats depends on low pregnenolone sulfate levels in the hippocampus
165. Neuroactive steroid 3α-hydroxy-5α-pregnane-20-one modulates electrophysiological and behavioral actions of ethanol
166. PK11195 binding to the peripheral benzodiazepine receptor as a marker of microglia activation in multiple sclerosis and experimental autoimmune encephalomyelitis
167. The regional brain distribution of the neurosteroids pregnenolone and pregnenolone sulfate following intravenous infusion
168. Pregnenolone sulfate exacerbates NMDA-induced death of hippocampal neurons
169. Nongenomic actions of steroid hormones
170. Stereological methods for estimating the total number of neurons and synapses: Issues of precision and bias
171. Is hippocampal cell death a myth?
172. For the cortex, neuron loss may be less than thought
173. Comparative behavioral characterization of the neuroactive steroids 3 alpha-OH,5 alpha-pregnan-20-one and 3 alpha-OH,5 beta-pregnan-20-one in rodents
174. Expression of nitric oxide synthase in injured CNS neurons as shown by NADP-diaphorase histochemistry
175. Dose-response study of dehydroepiandrosterone sulfate on dentate gyrus long-term potentiation
176. Neurosteroids: Pharmacological effects of a 3α-hydroxysteroid dehydrogenase inhibitor
177. Survival of motoneurons following axotomy is enhanced by lactation or by progesterone treatment
178. Neurosteroidogenesis in astrocytes, oligodendrocytes, and neurons of cerebral cortex of rat brain
179. Dehydroepiandrosterone (DHEA): Biosynthesis and metabolism in the brain