Indomethacin inhibits lordosis induced by ring a-reduced progestins: Possible role of 3α-oxoreduction in progestin-facilitated lordosis

Hormones and Behavior

Volumn 35, Issue 1, 1999, Pages 1-8

  Beyer, C ^a   Gonzalez Flores O ^a   Ramirez Orduna J M ^a   Gonzalez Mariscal G ^a  

^a CENTRO TLAXCALA DE BIOLOGÍA DE LA CONDUCTA   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

ELTANOLONE; ESTROGEN; GESTAGEN; GONADORELIN; INDOMETACIN; MEGESTROL ACETATE; MELATONIN; PROGESTERONE DERIVATIVE; PROGESTERONE RECEPTOR; PROSTAGLANDIN SYNTHASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CONFORMATION; DRUG MECHANISM; DRUG RECEPTOR BINDING; ESTRUS CYCLE; FEMALE; INTRAVENOUS DRUG ADMINISTRATION; LOCOMOTION; LORDOSIS; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; RAT;

EID: 0344389011     PISSN: 0018506X     EISSN: None     Source Type: Journal    
DOI: 10.1006/hbeh.1998.1457     Document Type: Article

References (55)

1. Agmo A., Soria P., Paredes R. GABAergic drugs and lordosis behavior in the female rat. Horm. Behav. 23:1989;368-380.
2. Akarasereenont P., Mitchell J. A., Thiemermann C., Vane J. R. Relative potency of nonsteroid anti-inflammatory drugs as inhibitors of cyclooxygenase-1 or cyclooxygenase 2. Br. J. Pharmacol. 112:1994;183P.
3. Beyer C., González-Mariscal G., Eguíbar J. R., Gómora P. Lordosis facilitation in estrogen primed rats by intrabrain injection of pregnanes. Pharmacol. Biochem. Behav. 31:1989;919-926.
4. Beyer C., González-Mariscal G. Effect of progesterone and natural progestins in brain. Reproduction, Growth and Development. 1991;Raven Press, New York. p. 199-208.
5. Beyer C., González-Flores O., González-Mariscal G. Ring A reduced progestins potently stimulate estrous behavior in rats: Paradoxical effect through the progesterone receptor. Physiol. Behav. 58:1995;985-993.
6. Blaustein J. D., Feder H. H. Cytoplasmic progestin receptors in guinea pig brain: Characteristics and relationship to the induction of sexual behavior. Brain Res. 169:1979;481-497.
7. Blaustein J. D., Wade G. Progestin binding by brain and pituitary cell nuclei and female rat sexual behavior. Brain Res. 140:1978;360-367.
8. Campbell J. S., Karavolas H. J. Characterization of the purified pituitary cytosolic NADPH: 5α-Dihydroprogesterone 3α-hydroxysteroid oxidoreductase. J. Steroid Biochem. Mol. Biol. 37:1990;535-543.
9. Czaja J. A., Goldfoot D. A., Karavolas H. J. Comparative facilitation and inhibition of lordosis in guinea pigs with progesterone, 5α-pregnane-3,20-dione, or 3α-hydroxy-5α-pregnan-20-one. Horm. Behav. 5:1974;261-274.
10. Etgen A. M. Progestin receptors and the activation of female reproductive behavior: A critical review. Horm. Behav. 18:1984;411-430.
11. Flower R. J., Vane J. R. Inhibition of prostaglandin synthesis. Gen. Pharmacol. 23:1974;1439-1450.
12. Flower R. J., Moncada S., Vane J. R. Analgesic-antipyretics and anti-inflammatory agents: Drugs employed in the treatment of gout. Gilman A. Goodman, Goodman L. S., Gilman A. The Pharmacological Basis of Therapeutics. 1980;682-728 MacMillan, New York.
13. Frölich J. C. A classification of NSAIDs according to the relative inhibition of cyclooxygenase isoenzymes. Trends Pharmacol. Sci. 18:1997;30-34.
14. Frye C. A., DeBold J. F. Muscimol facilitates sexual receptivity in hamster when infused into the ventral tegmentum. Pharmacol. Biochem. Behav. 42:1992;879-887.
15. Frye C. A., Mermelstein P. G., DeBold J. F. Evidence for a non-genomic action of progestins on sexual receptivity in hamster ventral tegmental area but not hypothalamus. Brain Res. 578:1992;87-93.
16. Frye C. A., De Bold J. F. 3α-OH-DHP and 5α-THDOC implants to the ventral tegmental area facilitate sexual receptivity in hamsters after progesterone priming to the ventral medial hypothalamus. Brain Res. 612:1993;130-137.
17. Frye C. A., Mermelstein P. G., De Bold J. F. Bicuculline infused into the hamster ventral tegmentum inhibits, while sodium valproate facilitates, sexual receptivity. Pharmacol. Biochem. Behav. 46:1993;1-8.
18. Frye C. A., Leadbetter A. 5α-reduced progesterone metabolites are essential in hamster VTA for sexual receptivity. Life Sci. 54:1994;653-659.
19. González-Flores O., Sánchez N., González-Mariscal G., Beyer C. Ring A reductions of progestins are not essential for estrous behavior facilitation in estrogen primed rats. Pharmacol. Biochem. Behav. 60:1998;223-227.
20. González-Mariscal G., González-Flores O., Beyer C. Intrahypothalamic injection of RU 486 antagonizes the lordosis induced by ring A reduced progestins. Physiol. Behav. 46:1989;435-438.
21. Hall N. R., Luttge W. G. Effects of the prostaglandin synthesis inhibitor, indomethacin, on estrogen- and estrogen plus progesterone-induced sexual receptivity in ovariectomized rats. Pharmacol. Biochem. Behav. 8:1978;597-602.
22. Hardy D. F., De Bold J. F. Effects of coital stimulation upon behavior of the female rat. J. Comp. Physiol. Psychol. 78:1972;400-408.
23. Harrison N. L., Simmonds M. A. Modulation of the GABA receptor complex by a steroid anaesthetic. Brain Res. 323:1984;287-292.
24. Harrison N. L., Majewska M. D., Harrington J. W., Barker J. L. Structure-activity relationships for steroid interaction with the GABA-A receptor complex. J. Pharmacol. Exp. Ther. 24:1987;346-353.
25. Karavolas H. J., Bertics P. J., Hodges D., Rudie N. Progesterone-processing by neuroendocrine structures. Celotti F., Naftolin F., Martini L. Metabolism of Hormonal Steroids in the Neuroendocrine Structures. 1984;149-170 Raven Press, New York.
26. Kontula K., Janne O., Vihko R., De Jager E., De Visser J., Zeelen F. Progesterone binding proteins: In vitro binding and biological activity of different steroidal ligands. Acta Endocrinol. 78:1975;574-592.
27. Ku E. C., Wasvary J. S., Court R. H., Wasvary J. M. Properties of bovine brain prostaglandin synthase and its susceptivility to inhibition by nonsteroidal antiinflammatory agents. Fed. Proc. 33:1974;590.
28. López-Colomé A. M., McCarthy M. M., Beyer C. Enhancement of 3H-muscimol binding to brain synaptic membranes by progesterone and related pregnanes. Eur. J. Pharmacol. 176:1990;297-304.
29. Majewska M. D., Harrison N. L., Schwartz R. D., Barker J. L., Paul S. M. Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science. 232:1986;1004-1007.
30. McCarthy M. M., Malik K. F., Feder H. H. Increased GABAergic transmission in medial hypothalamus facilitates lordosis but has the opposite effect in preoptic area. Brain Res. 507:1990;40-44.
31. McCarthy M. M., Masters D. V., Fiber J. M., López-Colomé A. M., Beyer C., Komisaruk B. R., Feder H. H. GABAergic control of receptivity in the female rat. Neuroendocrinology. 53:1991a;473-479.
32. McCarthy M. M., Pfaff D. W., Schwartz-Giblin S. Midbrain central gray GABA-A receptor activation enhances, and block reduces, sexual behavior in the female rat. Exp. Brain Res. 86:1991b;108-116.
33. Meade E. A., Smith W. L., DeWitt D. L. Differential inhibition of prostaglandin endoperoxidase synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs. J. Biol. Chem. 268:1993;6610-6614.
34. Moguilevsky H., Raynaud J. P. The relevance of hypothalamic and hypophyseal progestin receptor regulation in the induction and inhibition of sexual behavior in the female rat. Endocrinology. 105:1979;516-522.
35. Ojeda S. R., Harms P. G., McCann S. M. Effect of inhibitors of prostaglandin synthesis on gonadotropin release in the rat. Endocrinology. 97:1975;843-854.
36. Okada H., Higashi Y., Nishimura T., Ahara M. Metabolism of 6-dehydro-6-chloro-17α-acetoxyprogesterone in rabbit. Folia Endocr. Jpn. 44:1968;1103-1106.
37. Okada H., Higashi Y., Yamamoto H., Sumi M., Ahara M. Metabolism of 6-dehydro-progesterone in rabbit. Folia Endocr. Jpn. 44:1968;885-888.
38. Penning T. M., Talalay P. Inhibition of a major NAD(P)-linked oxidoreductase from rat liver cytosol by steroidal and nonsteroidal anti-inflammatory agents and by prostaglandins. Proc. Nat. Acad. Sci. USA. 80:1983;4504-4508.
39. Penning T. M., Sharp R. B., Krieger N. R. Purification and propreties of 3α-hydroxysteroid dehydrogenase from rat brain cytosol: Inhibition by nonsteroidal anti-inflammatory drugs and progestins. J. Biol. Chem. 260:1985;15266-15272.
40. Penning T. M., Pawlowski J. E., Schlegel B. P., Jez J. M., Lin H. K., Hoog S. S., Bennett M. J., Lewis M. Mammalian 3α-hydroxysteroid dehydrogenases. Steroids. 61:1996;508-523.
41. Purdy R. H., Morrow A. L., Blinn J. R., Paul S. M. Synthesis, metabolism, and pharmacological activity of 3α-hydroxy steroids which potentiate GABA-receptor-mediated chloride ion uptake in rat cerebral cortical synaptoneurosomes. J. Med. Chem. 33:1990;1572-1581.
42. Raynaud J. R., Ojasoo T., Pottier J., Salmon J. Chemical substitution of steroid hormones: Effect on receptor binding and pharmacokinetics. Litwack G. Biochemical Actions of Hormones. 1982;305-342 Academic Press, New York.
43. Rodríguez-Sierra J. F., Komisaruk B. R. Effects of prostaglandin E2 and indomethacin on sexual behavior in female rat. Horm. Behav. 4:1979;281-289.
44. Rupprecht R., Reul J. M. H. M., Trapp T., Van Steensel B., Wetzel C., Damm K., Zieglgänsberger W., Holsboer F. Progesterone receptor-mediated effects of neuroactive steroids. Neuron. 11:1993;523-530.
45. Rupprecht R., Berning B., Hauser C. A. E., Holsboer F., Reul J. M. H. M. Steroid receptor-mediated effects of neuroactive steroids: Characterization of structure-activity relationship. Eur. J. Pharmacol. 303:1996;227-234.
46. Siegel S., Castellan N. Jr. Nonparametric Statistics for the Behavioral Sciences. 1988;McGrawHill, New York.
47. Siegel S., Castellan N. Jr. Nonparametric Statistics for the Behavioral Sciences. 1988;McGraw Hill, New York.
48. Smith H. E., Smith R. G., Toft D. O., Neegard J. R., Burrows E. P., O'Malley B. W. Binding of steroids to progesterone receptor proteins in chick oviduct and human uterus. J. Biol. Chem. 249:1974;5924-5932.
49. Smithgall T. E., Penning T. M. Indomethacin-sensitive 3α-hydroxysteroid dehydrogenase in rat tissues. Biochem. Pharmacol. 34:1985;831-835.
50. Thijssen J. H. H. The metabolism of orally active synthetic progestational compunds. Peters A., Tausk M. Pharmacology of the Endocrine System and Related Drugs: Progesterone, Progestational Drugs and Antifertility Agents. 1972;217-244 Pergamon Press, Oxford.
51. Vathy I. U., Etgen A. M., Barfield R. J. Action of progestins on estrous behavior in female rats. Physiol. Behav. 40:1987;591-595.
52. Verma U., Laumas K. R. Screening of anti-progestins using in vitro human uterine progesterone receptor assay system. J. Steroid Biochem. 14:1981;733-740.
53. Vukoson M. B., Greiner J. W., Kramer R. E., Colby H. D. Effect of indomethacin administration on hepatic steroid and drug metabolism in male and female rats. Biochem. Pharmacol. 27:1978;1977-1979.
54. Xie W., Chipman J. J., Robertson D. L., Erikson R. L., Simmons D. L. Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing. Proc. Nat. Acad. Sci. USA. 88:1991;2692-2696.
55. Yamagata K., Andreasson K. I., Kaufmann W. E., Barnes C. A., Worley P. F. Expression of a mitogen-inducible cyclooxygenase in brain neurons: Regulation by synaptic activity and glucocorticoids. Neuron. 11:1993;371-386.