Increased cortical synaptic activation of TrkB and downstream signaling markers in a mouse model of Down Syndrome

Neurobiology of Disease

Volumn 77, Issue , 2015, Pages 173-190

  Nosheny, R L ^a,b   Belichenko, P V ^a   Busse, B L ^b   Weissmiller, A M ^a   Dang, V ^c   Das, D ^c   Fahimi, A ^c   Salehi, A ^c   Smith, S J ^b   Mobley, W C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b STANFORD UNIVERSITY   (United States)

^c VA PALO ALTO HEALTH CARE SYSTEM   (United States)

Author keywords

BDNF; Cerebral cortex; Down syndrome; Signaling endosomes; Synapses; TrkB; Ts65Dn mice

Indexed keywords

ALPHA TUBULIN; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; GEPHYRIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; POSTSYNAPTIC DENSITY PROTEIN 95; PROTEIN KINASE B; RAB PROTEIN; SYNAPSIN I; VESICULAR ACETYLCHOLINE TRANSPORTER; VESICULAR GLUTAMATE TRANSPORTER 1; VESICULAR GLUTAMATE TRANSPORTER 2; VESICULAR INHIBITORY AMINO ACID TRANSPORTER; BRAIN DERIVED NEUROTROPHIC FACTOR; GREEN FLUORESCENT PROTEIN; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARRAY TOMOGRAPHY; ARTICLE; BIOCHEMISTRY; BRAIN CORTEX; BRAIN SYNAPTOSOME; CELL COMPARTMENTALIZATION; CELLULAR DISTRIBUTION; CHOLINERGIC SYNAPSE; CONTROLLED STUDY; DOWN SYNDROME; ENDOSOME; FEMALE; GABAERGIC SYNAPSE; GLUTAMATERGIC SYNAPSE; INFANT; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEOMICS; SIGNAL TRANSDUCTION; SOMATOSENSORY CORTEX; SYNAPSE; SYNAPTIC INHIBITION; TOMOGRAPHY; ANIMAL; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; PATHOLOGY; PHYSIOLOGY; SYNAPTOSOME; TRANSGENIC MOUSE;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CEREBRAL CORTEX; DISEASE MODELS, ANIMAL; DOWN SYNDROME; GENE EXPRESSION REGULATION; GREEN FLUORESCENT PROTEINS; HUMANS; MALE; MICE; MICE, TRANSGENIC; RECEPTOR, TRKB; RNA, MESSENGER; SIGNAL TRANSDUCTION; SYNAPTOSOMES;

EID: 84925397494     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2015.02.022     Document Type: Article

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