An increase in basal BDNF provokes hyperactivation of the Akt-Mammalian target of rapamycin pathway and deregulation of local dendritic translation in a mouse model of down's syndrome

Journal of Neuroscience

Volumn 31, Issue 26, 2011, Pages 9445-9455

  Troca Marín, José Antonio ^a   Alves Sampaio, Alexandra ^a   Montesinos, María Luz ^a  

^a UNIVERSITY OF SEVILLE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; BRAIN DERIVED NEUROTROPHIC FACTOR; DIZOCILPINE; MAMMALIAN TARGET OF RAPAMYCIN; MEMANTINE; PROTEIN KINASE B; RAPAMYCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; BRAIN LEVEL; BRAIN REGION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DENDRITE; DOWN SYNDROME; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FEMALE; HIPPOCAMPUS; MALE; MOUSE; NERVE CELL PLASTICITY; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; RNA TRANSLATION; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION; TISSUE DISTRIBUTION;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELLS, CULTURED; DENDRITES; DISEASE MODELS, ANIMAL; DOWN SYNDROME; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MICE; MICE, TRANSGENIC; NEURONS; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; SIROLIMUS; STATISTICS, NONPARAMETRIC; TOR SERINE-THREONINE KINASES;

EID: 79959986145     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0011-11.2011     Document Type: Article

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