Probing antibody internal dynamics with fluorescence anisotropy and molecular dynamics simulations

mAbs

Volumn 5, Issue 2, 2013, Pages 306-322

  Kortkhonjia, Ekaterine ^a   Brandman, Relly ^b,e   Zhou, Joe Zhongxiang ^b   Voelz, Vincent A ^c,f   Chorny, Ilya ^b   Kabakoff, Bruce ^a   Patapoff, Thomas W ^a   Dill, Ken A ^d   Swartz, Trevor E ^a  

^a GENENTECH INC   (United States)

^b Simprota Corporation   (United States)

^c STANFORD UNIVERSITY   (United States)

^d STONY BROOK UNIVERSITY   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f Temple University   (United States)

Author keywords

Fluorescence anisotropy; Molecular dynamics simulations; Monoclonal antibodies; Solution dynamics; Therapeutic antibodies

Indexed keywords

ANTIBODY; CHLORIDE ION; IMMUNOGLOBULIN G ANTIBODY; MALEIMIDE; PYRENE; RITUXIMAB; TRASTUZUMAB;

ANISOTROPY; ANTIGEN BINDING; ARTICLE; CONJUGATION; CRYSTAL STRUCTURE; DECOMPOSITION; DEPOLARIZATION; DISULFIDE BOND; ELECTRON MICROSCOPY; ENTROPY; GLYCOSYLATION; HEAVY CHAIN; HINGE REGION; HUMAN; HYDRODYNAMICS; INFORMATION SCIENCE; LIGHT CHAIN; MACROMOLECULE; MOLECULAR DYNAMICS; PH; PRINCIPAL COMPONENT ANALYSIS; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

FLUORESCENCE ANISOTROPY; MOLECULAR DYNAMICS SIMULATIONS; MONOCLONAL ANTIBODIES; SOLUTION DYNAMICS; THERAPEUTIC ANTIBODIES;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, MONOCLONAL, HUMANIZED; FLUORESCENCE POLARIZATION; HUMANS; IMMUNOGLOBULIN G; MARKOV CHAINS; MICE; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; PROTEIN CONFORMATION;

EID: 84876534299     PISSN: 19420862     EISSN: 19420870     Source Type: Journal    
DOI: 10.4161/mabs.23651     Document Type: Article

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