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Volumn 51, Issue 11, 2012, Pages 895-906

PTBP1-dependent regulation of USP5 alternative RNA splicing plays a role in glioblastoma tumorigenesis

Author keywords

Exon array; GBM; Isopeptidase T; USP5

Indexed keywords

POLYPYRIMIDINE TRACT BINDING PROTEIN 1; RNA BINDING PROTEIN; UBIQUITIN; UBIQUITIN SPECIFIC PEPTIDASE 5; UNCLASSIFIED DRUG;

EID: 84867900618     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.20859     Document Type: Article
Times cited : (72)

References (47)
  • 1
    • 84872662082 scopus 로고    scopus 로고
    • CBTRUS. Volume 2009.: Central Brain Tumor Registry of the United States
    • CBTRUS. Volume 2009. http://www.cbtrus.org/: Central Brain Tumor Registry of the United States; 2009.
    • (2009)
  • 2
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • Cancer Genome Atlas Research N.
    • Cancer Genome Atlas Research N. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 2008; 455: 1061-1068.
    • (2008) Nature , vol.455 , pp. 1061-1068
  • 4
    • 56749098074 scopus 로고    scopus 로고
    • Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing
    • Pan Q, Shai O, Lee LJ, Frey BJ, Blencowe BJ. Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing. Nat Genet 2008; 40: 1413-1415.
    • (2008) Nat Genet , vol.40 , pp. 1413-1415
    • Pan, Q.1    Shai, O.2    Lee, L.J.3    Frey, B.J.4    Blencowe, B.J.5
  • 5
    • 56549101959 scopus 로고    scopus 로고
    • Alternative isoform regulation in human tissue transcriptomes
    • Wang ET, Sandberg R, Luo S, et al. Alternative isoform regulation in human tissue transcriptomes. Nature 2008; 456: 470-476.
    • (2008) Nature , vol.456 , pp. 470-476
    • Wang, E.T.1    Sandberg, R.2    Luo, S.3
  • 6
    • 33746927884 scopus 로고    scopus 로고
    • The connection between splicing and cancer
    • Srebrow A, Kornblihtt AR. The connection between splicing and cancer. J Cell Sci 2006; 119: 2635-2641.
    • (2006) J Cell Sci , vol.119 , pp. 2635-2641
    • Srebrow, A.1    Kornblihtt, A.R.2
  • 8
    • 44649126097 scopus 로고    scopus 로고
    • Global analysis of aberrant pre-mRNA splicing in glioblastoma using exon expression arrays
    • Cheung H, Baggerly K, Tsavachidis S, et al. Global analysis of aberrant pre-mRNA splicing in glioblastoma using exon expression arrays. BMC Genomics 2008; 9: 216.
    • (2008) BMC Genomics , vol.9 , pp. 216
    • Cheung, H.1    Baggerly, K.2    Tsavachidis, S.3
  • 9
    • 73149083495 scopus 로고    scopus 로고
    • Inhibition of Y-box binding protein-1 slows the growth of glioblastoma multiforme and sensitizes to temozolomide independent O6-methylguanine-DNA methyltransferase
    • Gao Y, Fotovati A, Lee C, et al. Inhibition of Y-box binding protein-1 slows the growth of glioblastoma multiforme and sensitizes to temozolomide independent O6-methylguanine-DNA methyltransferase. Mol Cancer Ther 2009; 8: 3276-3284.
    • (2009) Mol Cancer Ther , vol.8 , pp. 3276-3284
    • Gao, Y.1    Fotovati, A.2    Lee, C.3
  • 10
    • 55549143293 scopus 로고    scopus 로고
    • The emerging role of splicing factors in cancer
    • Grosso AR, Martins S, Carmo-Fonseca M. The emerging role of splicing factors in cancer. EMBO Rep 2008; 9: 1087-1093.
    • (2008) EMBO Rep , vol.9 , pp. 1087-1093
    • Grosso, A.R.1    Martins, S.2    Carmo-Fonseca, M.3
  • 11
    • 7444220147 scopus 로고    scopus 로고
    • Aberrant and alternative splicing in cancer
    • Venables JP. Aberrant and alternative splicing in cancer. Cancer Res 2004; 64: 7647-7654.
    • (2004) Cancer Res , vol.64 , pp. 7647-7654
    • Venables, J.P.1
  • 12
    • 21244439380 scopus 로고    scopus 로고
    • Regulation of apoptosis by alternative pre-mRNA splicing
    • Schwerk C, Schulze-Osthoff K. Regulation of apoptosis by alternative pre-mRNA splicing. Mol Cell 2005; 19: 1-13.
    • (2005) Mol Cell , vol.19 , pp. 1-13
    • Schwerk, C.1    Schulze-Osthoff, K.2
  • 13
    • 78751647679 scopus 로고    scopus 로고
    • Knockdown of splicing factor SRp20 causes apoptosis in ovarian cancer cells and its expression is associated with malignancy of epithelial ovarian cancer
    • He X, Arslan AD, Pool MD, et al. Knockdown of splicing factor SRp20 causes apoptosis in ovarian cancer cells and its expression is associated with malignancy of epithelial ovarian cancer. Oncogene 2010; 30: 356-365.
    • (2010) Oncogene , vol.30 , pp. 356-365
    • He, X.1    Arslan, A.D.2    Pool, M.D.3
  • 14
    • 34547489950 scopus 로고    scopus 로고
    • Knockdown of polypyrimidine tract-binding protein suppresses ovarian tumor cell growth and invasiveness in vitro
    • He X, Pool M, Darcy KM, et al. Knockdown of polypyrimidine tract-binding protein suppresses ovarian tumor cell growth and invasiveness in vitro. Oncogene 2007; 26: 4961-4968.
    • (2007) Oncogene , vol.26 , pp. 4961-4968
    • He, X.1    Pool, M.2    Darcy, K.M.3
  • 16
    • 77956923246 scopus 로고    scopus 로고
    • Deficiency of splicing factor 1 suppresses the occurrence of testicular germ cell tumors
    • Zhu R, Heaney J, Nadeau JH, Ali S, Matin A. Deficiency of splicing factor 1 suppresses the occurrence of testicular germ cell tumors. Cancer Res 2010; 70: 7264-7272.
    • (2010) Cancer Res , vol.70 , pp. 7264-7272
    • Zhu, R.1    Heaney, J.2    Nadeau, J.H.3    Ali, S.4    Matin, A.5
  • 17
    • 50649091392 scopus 로고    scopus 로고
    • Polypyrimidine tract-binding protein (PTB) differentially affects malignancy in a cell line-dependent manner
    • Wang C, Norton JT, Ghosh S, et al. Polypyrimidine tract-binding protein (PTB) differentially affects malignancy in a cell line-dependent manner. J Biol Chem 2008; 283: 20277-20287.
    • (2008) J Biol Chem , vol.283 , pp. 20277-20287
    • Wang, C.1    Norton, J.T.2    Ghosh, S.3
  • 18
    • 33746322370 scopus 로고    scopus 로고
    • Polypyrimidine tract binding protein and Notch1 are independently re-expressed in glioma
    • Cheung HC, Corley LJ, Fuller GN, McCutcheon IE, Cote GJ. Polypyrimidine tract binding protein and Notch1 are independently re-expressed in glioma. Mod Pathol 2006; 19: 1034-1041.
    • (2006) Mod Pathol , vol.19 , pp. 1034-1041
    • Cheung, H.C.1    Corley, L.J.2    Fuller, G.N.3    McCutcheon, I.E.4    Cote, G.J.5
  • 19
    • 67749110060 scopus 로고    scopus 로고
    • Splicing factors PTBP1 and PTBP2 promote proliferation and migration of glioma cell lines
    • Cheung HC, Hai T, Zhu W, et al. Splicing factors PTBP1 and PTBP2 promote proliferation and migration of glioma cell lines. Brain 2009; 132: 2277-2288.
    • (2009) Brain , vol.132 , pp. 2277-2288
    • Cheung, H.C.1    Hai, T.2    Zhu, W.3
  • 20
    • 76649102764 scopus 로고    scopus 로고
    • The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism
    • Clower CV, Chatterjee D, Wang Z, Cantley LC, Vander Heiden MG, Krainer AR. The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism. Proc Natl Acad Sci USA 2010; 107: 1894-1899.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 1894-1899
    • Clower, C.V.1    Chatterjee, D.2    Wang, Z.3    Cantley, L.C.4    Vander Heiden, M.G.5    Krainer, A.R.6
  • 21
    • 75149150660 scopus 로고    scopus 로고
    • HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer
    • David CJ, Chen M, Assanah M, Canoll P, Manley JL. HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer. Nature 2010; 463: 364-368.
    • (2010) Nature , vol.463 , pp. 364-368
    • David, C.J.1    Chen, M.2    Assanah, M.3    Canoll, P.4    Manley, J.L.5
  • 22
    • 0033990048 scopus 로고    scopus 로고
    • Primer3 on the WWW for general users and for biologist programmers
    • Rozen S, Skaletsky H. Primer3 on the WWW for general users and for biologist programmers. Methods Mol Biol 2000; 132: 365-386.
    • (2000) Methods Mol Biol , vol.132 , pp. 365-386
    • Rozen, S.1    Skaletsky, H.2
  • 23
    • 0034163539 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor-1 alpha-exon exclusion and polypyrimidine tract-binding protein in glioblastoma multiforme tumors
    • Jin W, McCutcheon IE, Fuller GN, Huang ES, Cote GJ. Fibroblast growth factor receptor-1 alpha-exon exclusion and polypyrimidine tract-binding protein in glioblastoma multiforme tumors. Cancer Res 2000; 60: 1221-1224.
    • (2000) Cancer Res , vol.60 , pp. 1221-1224
    • Jin, W.1    McCutcheon, I.E.2    Fuller, G.N.3    Huang, E.S.4    Cote, G.J.5
  • 24
    • 0032938851 scopus 로고    scopus 로고
    • Polypyrimidine tract-binding protein positively regulates inclusion of an alternative 3'-terminal exon
    • Lou H, Helfman DM, Gagel RF, Berget SM. Polypyrimidine tract-binding protein positively regulates inclusion of an alternative 3'-terminal exon. Mol Cell Biol 1999; 19: 78-85.
    • (1999) Mol Cell Biol , vol.19 , pp. 78-85
    • Lou, H.1    Helfman, D.M.2    Gagel, R.F.3    Berget, S.M.4
  • 25
    • 19544363571 scopus 로고    scopus 로고
    • Correction of aberrant FGFR1 alternative RNA splicing through targeting of intronic regulatory elements
    • Bruno IG, Jin W, Cote GJ. Correction of aberrant FGFR1 alternative RNA splicing through targeting of intronic regulatory elements. Hum Mol Genet 2004; 13: 2409-2420.
    • (2004) Hum Mol Genet , vol.13 , pp. 2409-2420
    • Bruno, I.G.1    Jin, W.2    Cote, G.J.3
  • 26
    • 73249131626 scopus 로고    scopus 로고
    • Next-generation SELEX identifies sequence and structural determinants of splicing factor binding in human pre-mRNA sequence
    • Reid DC, Chang BL, Gunderson SI, Alpert L, Thompson WA, Fairbrother WG. Next-generation SELEX identifies sequence and structural determinants of splicing factor binding in human pre-mRNA sequence. RNA 2009; 15: 2385-2397.
    • (2009) RNA , vol.15 , pp. 2385-2397
    • Reid, D.C.1    Chang, B.L.2    Gunderson, S.I.3    Alpert, L.4    Thompson, W.A.5    Fairbrother, W.G.6
  • 27
    • 0024842159 scopus 로고
    • Identification and purification of a 62,000-dalton protein that binds specifically to the polypyrimidine tract of introns
    • García-Blanco MA, Jamison SF, Sharp PA. Identification and purification of a 62, 000-dalton protein that binds specifically to the polypyrimidine tract of introns. Genes Dev 1989; 3: 1874-1886.
    • (1989) Genes Dev , vol.3 , pp. 1874-1886
    • García-Blanco, M.A.1    Jamison, S.F.2    Sharp, P.A.3
  • 28
    • 34547205013 scopus 로고    scopus 로고
    • Crossregulation and functional redundancy between the splicing regulator PTB and its paralogs nPTB and ROD1
    • Spellman R, Llorian M, Smith CWJ. Crossregulation and functional redundancy between the splicing regulator PTB and its paralogs nPTB and ROD1. Mol Cell 2007; 27: 420-434.
    • (2007) Mol Cell , vol.27 , pp. 420-434
    • Spellman, R.1    Llorian, M.2    Smith, C.W.J.3
  • 29
    • 0035038207 scopus 로고    scopus 로고
    • Polypyrimidine tract binding protein antagonizes exon definition
    • Wagner EJ, Garcia-Blanco MA. Polypyrimidine tract binding protein antagonizes exon definition. Mol Cell Biol 2001; 21: 3281-3288.
    • (2001) Mol Cell Biol , vol.21 , pp. 3281-3288
    • Wagner, E.J.1    Garcia-Blanco, M.A.2
  • 30
    • 0032055106 scopus 로고    scopus 로고
    • Determination of functional domains in polypyrimidine-tract binding protein
    • Oh YL, Hahm B, Kim YK, et al. Determination of functional domains in polypyrimidine-tract binding protein. Biochem J 1998; 331: 169-175.
    • (1998) Biochem J , vol.331 , pp. 169-175
    • Oh, Y.L.1    Hahm, B.2    Kim, Y.K.3
  • 31
    • 49349112872 scopus 로고    scopus 로고
    • Polypyrimidine-tract binding protein: A multifunctional RNA-binding protein
    • Sawicka K, Bushell M, Spriggs KA, Willis AE. Polypyrimidine-tract binding protein: A multifunctional RNA-binding protein. Biochem Soc Trans 2008; 36: 641-647.
    • (2008) Biochem Soc Trans , vol.36 , pp. 641-647
    • Sawicka, K.1    Bushell, M.2    Spriggs, K.A.3    Willis, A.E.4
  • 32
    • 77956342570 scopus 로고    scopus 로고
    • Position-dependent alternative splicing activity revealed by global profiling of alternative splicing events regulated by PTB
    • Llorian M, Schwartz S, Clark TA, et al. Position-dependent alternative splicing activity revealed by global profiling of alternative splicing events regulated by PTB. Nat Struct Mol Biol 2010; 17: 1114-1123.
    • (2010) Nat Struct Mol Biol , vol.17 , pp. 1114-1123
    • Llorian, M.1    Schwartz, S.2    Clark, T.A.3
  • 33
    • 34347384211 scopus 로고    scopus 로고
    • A post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons
    • Boutz PL, Stoilov P, Li Q, et al. A post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons. Genes Dev 2007; 21: 1636-1652.
    • (2007) Genes Dev , vol.21 , pp. 1636-1652
    • Boutz, P.L.1    Stoilov, P.2    Li, Q.3
  • 34
    • 48149096726 scopus 로고    scopus 로고
    • MADS: A new and improved method for analysis of differential alternative splicing by exon-tiling microarrays
    • Xing Y, Stoilov P, Kapur K, et al. MADS: A new and improved method for analysis of differential alternative splicing by exon-tiling microarrays. RNA 2008; 14: 1470-1479.
    • (2008) RNA , vol.14 , pp. 1470-1479
    • Xing, Y.1    Stoilov, P.2    Kapur, K.3
  • 35
    • 34547212309 scopus 로고    scopus 로고
    • The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing
    • Makeyev EV, Zhang J, Carrasco MA, Maniatis T. The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing. Mol Cell 2007; 27: 435-448.
    • (2007) Mol Cell , vol.27 , pp. 435-448
    • Makeyev, E.V.1    Zhang, J.2    Carrasco, M.A.3    Maniatis, T.4
  • 36
    • 34250795169 scopus 로고    scopus 로고
    • Identification of differentially regulated splice variants and novel exons in glial brain tumors using exon expression arrays
    • French PJ, Peeters J, Horsman S, et al. Identification of differentially regulated splice variants and novel exons in glial brain tumors using exon expression arrays. Cancer Res 2007; 67: 5635-5642.
    • (2007) Cancer Res , vol.67 , pp. 5635-5642
    • French, P.J.1    Peeters, J.2    Horsman, S.3
  • 38
    • 0029943614 scopus 로고    scopus 로고
    • A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13
    • Ansari-Lari MA, Muzny DM, Lu J, et al. A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13. Genome Res 1996; 6: 314-326.
    • (1996) Genome Res , vol.6 , pp. 314-326
    • Ansari-Lari, M.A.1    Muzny, D.M.2    Lu, J.3
  • 39
    • 12344250822 scopus 로고    scopus 로고
    • Function of alternative splicing
    • Stamm S, Ben-Ari S, Rafalska I, et al. Function of alternative splicing. Gene 2005; 344: 1-20.
    • (2005) Gene , vol.344 , pp. 1-20
    • Stamm, S.1    Ben-Ari, S.2    Rafalska, I.3
  • 40
    • 72149117411 scopus 로고    scopus 로고
    • Genome-wide analysis of PTB-RNA interactions reveals a strategy used by the general splicing repressor to modulate exon inclusion or skipping
    • Xue Y, Zhou Y, Wu T, et al. Genome-wide analysis of PTB-RNA interactions reveals a strategy used by the general splicing repressor to modulate exon inclusion or skipping. Mol Cell 2009; 36: 996-1006.
    • (2009) Mol Cell , vol.36 , pp. 996-1006
    • Xue, Y.1    Zhou, Y.2    Wu, T.3
  • 41
    • 33646765735 scopus 로고    scopus 로고
    • Gene expression profiling reveals the profound upregulation of hypoxia-responsive genes in primary human astrocytes
    • Mense SM, Sengupta A, Zhou M, et al. Gene expression profiling reveals the profound upregulation of hypoxia-responsive genes in primary human astrocytes. Physiol Genomics 2006; 25: 435-449.
    • (2006) Physiol Genomics , vol.25 , pp. 435-449
    • Mense, S.M.1    Sengupta, A.2    Zhou, M.3
  • 43
    • 0942266266 scopus 로고    scopus 로고
    • Expression of the splicing regulator polypyrimidine tract-binding protein in normal and neoplastic brain
    • McCutcheon IE Hentschel SJ Fuller GN Jin W Cote GJ Expression of the splicing regulator polypyrimidine tract-binding protein in normal and neoplastic brain Neuro Oncol 2004; 6: 9-14.
    • (2004) Neuro Oncol , vol.6 , pp. 9-14
    • McCutcheon, I.E.1    Hentschel, S.J.2    Fuller, G.N.3    Jin, W.4    Cote, G.J.5
  • 44
    • 50349102579 scopus 로고    scopus 로고
    • Recognition of polyubiquitin isoforms by the multiple ubiquitin binding modules of isopeptidase T
    • Reyes-Turcu FE, Shanks JR, Komander D, Wilkinson KD. Recognition of polyubiquitin isoforms by the multiple ubiquitin binding modules of isopeptidase T. J Biol Chem 2008; 283: 19581-19592.
    • (2008) J Biol Chem , vol.283 , pp. 19581-19592
    • Reyes-Turcu, F.E.1    Shanks, J.R.2    Komander, D.3    Wilkinson, K.D.4
  • 45
    • 84867897514 scopus 로고    scopus 로고
    • Sciences EL. Isopeptidase T [UBP5] long form (human, recombinant) product data sheet. Volume 2010;.
    • Sciences EL. Isopeptidase T [UBP5] long form (human, recombinant) product data sheet. Volume 2010; 2009.
    • (2009)
  • 46
    • 78549247880 scopus 로고    scopus 로고
    • Deubiquitinase inhibition by small-molecule WP1130 triggers aggresome formation and tumor cell apoptosis
    • Kapuria V, Peterson LF, Fang D, Bornmann WG, Talpaz M, Donato NJ. Deubiquitinase inhibition by small-molecule WP1130 triggers aggresome formation and tumor cell apoptosis. Cancer Res 2010; 70: 9265-9276.
    • (2010) Cancer Res , vol.70 , pp. 9265-9276
    • Kapuria, V.1    Peterson, L.F.2    Fang, D.3    Bornmann, W.G.4    Talpaz, M.5    Donato, N.J.6
  • 47
    • 64149087218 scopus 로고    scopus 로고
    • Suppression of the deubiquitinating enzyme USP5 causes the accumulation of unanchored polyubiquitin and the activation of p53
    • Dayal S, Sparks A, Jacob J, Allende-Vega N, Lane DP, Saville MK. Suppression of the deubiquitinating enzyme USP5 causes the accumulation of unanchored polyubiquitin and the activation of p53. J Biol Chem 2009; 284: 5030-5041.
    • (2009) J Biol Chem , vol.284 , pp. 5030-5041
    • Dayal, S.1    Sparks, A.2    Jacob, J.3    Allende-Vega, N.4    Lane, D.P.5    Saville, M.K.6


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