Fyn requires hnRNPA2B1 and Sam68 to synergistically regulate apoptosis in pancreatic cancer

Carcinogenesis

Volumn 32, Issue 10, 2011, Pages 1419-1426

  Cheny, Zhi Yu ^a   Cai, Lei ^a   Zhu, Jin ^a   Chen, Min ^a   Chen, Jian ^a   Li, Zhi Hua ^a   Liu, Xiang De ^a   Wang, Shu Guang ^a   Bie, Ping ^a   Jiang, Peng ^a   Dong, Jia Hong ^a   Li, Xiao Wu ^a  

^a SOUTHWEST HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A2B1; PROTEIN KINASE FYN; PROTEIN SAM68; RNA; UNCLASSIFIED DRUG;

ADENOVIRUS; APOPTOSIS; ARTICLE; CANCER CELL; CARCINOGENESIS; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER METASTASIS; MALE; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TWO DIMENSIONAL DIFFERENCE GEL ELECTROPHORESIS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; APOPTOSIS; BCL-X PROTEIN; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; DNA-BINDING PROTEINS; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEIN GROUP A-B; HUMANS; IMMUNOENZYME TECHNIQUES; IMMUNOPRECIPITATION; PANCREATIC NEOPLASMS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-FYN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA SPLICING; RNA, MESSENGER; RNA, SMALL INTERFERING; RNA-BINDING PROTEINS;

EID: 80053157711     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgr088     Document Type: Article

References (24)

1. Lowenfels,A.B. et al. (1993) Pancreatitis and the risk of pancreatic cancer. International Pancreatitis Study Group. N. Engl. J. Med., 328, 1433-1437.
2. Summy,J.M. et al. (2003) Src family kinases in tumor progression and metastasis. Cancer Metastasis Rev., 22, 337-358.
3. Ito,H. et al. (2003) Inhibition of tyrosine kinase Src suppresses pancreatic cancer invasiveness. Surgery, 134, 221-226.
4. Bjorge,J.D. et al. (2000) Selected glimpses into the activation and function of Src kinase. Oncogene, 19, 5620-5635.
5. Li,X. et al. (2001) Integrin alphavbeta3 mediates K1735 murine melanoma cell motility in vivo and in vitro. J. Cell Sci., 114, 2665-2672.
6. Martin,G.S. (2001) The hunting of the Src. Nat. Rev. Mol. Cell Biol., 2, 467-475.
7. Johnson,D. et al. (2000) Regulation of both apoptosis and cell survival by the v-Src oncoprotein. Cell Death Differ., 7, 685-696.
8. Stein,P.L. et al. (1992) pp.59fyn mutant mice display differential signaling in thymocytes and peripheral T cells. Cell, 70, 741-750.
9. Umemori,H. et al. (1994) Initial events of myelination involve Fyn tyrosine kinase signalling. Nature, 367, 572-576.
10. Li,X. et al. (2003) Alphavbeta6-Fyn signaling promotes oral cancer progression. J. Biol. Chem., 278, 41646-41653.
11. Chen,Z.Y. et al. (2010) Roles of Fyn in pancreatic cancer metastasis. J. Gastroenterol. Hepatol., 25, 293-301.
12. Boise,L.H. et al. (1993) bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell, 74, 597-608.
13. Olopade,O.I. et al. (1997) Overexpression of BCL-x protein in primary breast cancer is associated with high tumor grade and nodal metastases. Cancer J. Sci. Am., 3, 230-237.
14. Paronetto,M.P. et al. (2007) The RNA-binding protein Sam68 modulates the alternative splicing of Bcl-x. J. Cell Biol., 176, 929-939.
15. Cote,J. et al. (2003) Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1. Mol. Biol. Cell., 14, 274-287.
16. Lukong,K.E. et al. (2005) Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression. J. Biol. Chem., 280, 38639-38647.
17. Matter,N. et al. (2002) Signal-dependent regulation of splicing via phosphorylation of Sam68. Nature, 420, 691-695.
18. He,Y. et al. (2005) Roles of heterogeneous nuclear ribonucleoproteins A and B in cell proliferation. J. Cell Sci., 118, 3173-3183.
19. Yan-Sanders,Y. et al. (2002) Increased expression of heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP) in pancreatic tissue from smokers and pancreatic tumor cells. Cancer Lett., 183, 215-220.
20. Tockman,M.S. et al. (1997) Prospective detection of preclinical lung cancer: results from two studies of heterogeneous nuclear ribonucleoprotein A2/B1 overexpression. Clin. Cancer Res., 3, 2237-2246.
21. Paronetto,M.P. et al. (2006) The nuclear RNA-binding protein Sam68 translocates to the cytoplasm and associates with the polysomes in mouse spermatocytes. Mol. Biol. Cell., 17, 14-24.
22. Irby,R.B. et al. (2000) Role of Src expression and activation in human cancer. Oncogene, 19, 5636-5642.
23. Stamm,S. (2002) Signals and their transduction pathways regulating alternative splicing: a new dimension of the human genome. Hum. Mol. Genet., 11, 2409-2416.
24. Eperon,I.C. et al. (2000) Selection of alternative 5' splice sites: role of U1 snRNP and models for the antagonistic effects of SF2/ASF and hnRNP A1. Mol. Cell. Biol., 20, 8303-8318.