Synergistic efficacy of sorafenib and genistein in growth inhibition by down regulating angiogenic and survival factors and increasing apoptosis through upregulation of p53 and p21 in malignant neuroblastoma cells having N-Myc amplification or non-amplification

Investigational New Drugs

Volumn 28, Issue 6, 2010, Pages 812-824

  Roy Choudhury, Subhasree ^a   Karmakar, Surajit ^a   Banik, Naren L ^b   Ray, Swapan K ^a  

^a UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Apoptosis; Caspase; Genistein; Neuroblastoma; Sorafenib

Indexed keywords

CALPAIN; CASPASE 3; CASPASE 8; CELL DNA; CYTOCHROME C; FIBROBLAST GROWTH FACTOR 2; GENISTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITOR OF APOPTOSIS PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN; MYC PROTEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BID; PROTEIN KINASE B; PROTEIN MCL 1; PROTEIN P21; PROTEIN P53; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; SORAFENIB; TELOMERASE REVERSE TRANSCRIPTASE; VASCULOTROPIN;

APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CELL STRAIN; CELL STRAIN SH SY5Y; CELL STRAIN SK N DZ; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; DNA CONTENT; DOWN REGULATION; DRUG EFFICACY; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME RELEASE; GENE AMPLIFICATION; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; UPREGULATION;

ANGIOGENESIS INDUCING AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BENZENESULFONATES; CASPASE 3; CELL CYCLE; CELL PROLIFERATION; CELL SHAPE; CELL SURVIVAL; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DOWN-REGULATION; DRUG SYNERGISM; FLOW CYTOMETRY; GENE AMPLIFICATION; GENISTEIN; HUMANS; MITOCHONDRIA; NEUROBLASTOMA; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTO-ONCOGENE PROTEINS C-MYC; PYRIDINES; SIGNAL TRANSDUCTION; TELOMERASE; TREATMENT OUTCOME; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 78549267195     PISSN: 01676997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10637-009-9324-7     Document Type: Article

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