Protopanaxatriol ginsenoside Rh1 inhibits the expression of matrix metalloproteinases and the in vitro invasion/migration of human astroglioma cells

Neurochemistry International

Volumn 63, Issue 2, 2013, Pages 80-86

  Jung, Ji Sun ^a   Ahn, Jung Hyuck ^a   Le, Thi Kim ^b   Kim, Dong Hyun ^b   Kim, Hee Sun ^a  

^a Ewha Womans University School of Medicine   (South Korea)

^b Kyung Hee University   (South Korea)

Author keywords

Gene regulation; Ginsenoside Rh1; Invasion; Malignant glioma; Migration; MMP

Indexed keywords

GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERSTITIAL COLLAGENASE; MATRIGEL; MATRIX METALLOPROTEINASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTOPANAXATRIOL GINSENOSIDE RH1; SAPONIN DERIVATIVE; STROMELYSIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; ASTROCYTOMA CELL; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GLIOMA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR CELL LINE; WESTERN BLOTTING; WOUND HEALING; ZYMOGRAPHY;

EID: 84878382574     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2013.05.002     Document Type: Article

References (31)

1. Bignami, A., Hosley, M., Dahl, D., 1993. Hyaluronic acid and hyaluronic acid-binding proteins in brain extracellular matrix. Anat. Embryol. 188, 419-433. (Pubitemid 24000108)
2. Cheng, Y., Shen, L.H., Zhang, J.T., 2005. Anti-amnestic and anti-aging effects of ginsenoside Rg1 and Rb1 and its mechanism of action. Acta Pharmacol. Sin. 26, 143-149. (Pubitemid 40203956)
3. Choi, I.H., 2012. Effects of Panax ginseng in neurodegenerative diseases. J. Ginseng Res. 36, 342-353.
4. Devy, L., Huang, L., Naa, L., Yanamandra, N., Pieters, H., Frans, N., Chang, E., Tao, Q., Vanhove, M., Lejeune, A., van Gool, R., Sexton, D.J., Kuang, G., Rank, D., Hogan, S., Pazmany, C., Ma, Y.L., Schoonbroodt, S., Nixon, A.E., Ladner, R.C., Hoet, R., Henderikx, P., Tenhoor, C., Rabbani, S.A., Valentino, M.L., Wood, C.R., Dransfield, D.T., 2009. Selective inhibition of matrix metalloproteinase-14 blocks tumor growth, invasion, and angiogenesis. Cancer Res. 69, 1517-1526.
5. Hagemann, C., Anacker, J., Ernestus, R.I., Vince, G.H., 2012. A complete compilation of matrix metalloproteinase expression in human malignant gliomas. World J. Clin. Oncol. 3, 67-79.
6. Hua, H., Li, M., Yin, Y., Jiang, Y., 2011. Matrix metalloproteinases in tumorigenesis: an evolving paradigm. Cell. Mol. Life Sci. 68, 3853-3868.
7. Jung, S.H., Woo, M.S., Kim, S.Y., Kim, W.K., Hyun, J.W., Kim, E.J., Kim, D.H., Kim, H.S., 2006. Ginseng saponin metabolite suppresses phorbol ester-induced matrix metalloproteinase-9 expression through inhibition of activator protein-1 and mitogen-activated protein kinase signaling pathways in human astroglioma cells. Int. J. Cancer 118, 490-497.
8. Jung, J.S., Shin, J.A., Park, E.M., Lee, J.E., Kang, Y.S., Min, S.W., Kim, D.H., Hyun, J.W., Shin, C.Y., Kim, H.S., 2010a. Anti-inflammatory mechanism of ginsenoside Rh1 in lipopolysaccharide-stimulated microglia: critical role of the protein kinase A pathway and hemeoxygenase-1 expression. J. Neurochem. 115, 1668-1680.
9. Jung, J.S., Kim, D.H., Kim, H.S., 2010b. Ginsenoside Rh1 suppresses inducible nitric oxide synthase gene expression in IFN-c-stimulated microglia via modulation of JAK/STAT and ERK signaling pathways. Biochem. Biophys. Res. Commun. 397, 323-328.
10. Jung, J.S., Jung, K., Kim, D.H., Kim, H.S., 2012. Selective inhibition of MMP-9 gene expression by mangiferin in PMA-stimulated human astroglioma cells: involvement of PI3K/Akt and MAPK signaling pathways. Pharmacol. Res. 66, 95-103.
11. Kim, Y.S., Joh, T.H., 2012. Matrix metalloproteinases, new insights into the understanding of neurodegenerative diseases. Biomol. Ther. 20, 133-143.
12. Kim, S.Y., Jung, S.H., Kim, H.S., 2005. Curcumin is a potent broad spectrum inhibitor of matrix metalloproteinase gene expression in human astroglioma cells. Biochem. Biophys. Res. Commun. 337, 510-516.
13. Kim, Y.S., Kim, J.J., Cho, K.H., Jung, W.S., Moon, S.K., Park, E.K., Kim, D.H., 2008. Biotransformation of ginsenoside Rb1, crocin, amygdalin, geniposide, puerarin, ginsenoside Re, hesperidin, poncirin, glycyrrhizin, and baicalin by human fecal micorflora and its relation to cytotoxicity against tumor cells. J. Microbiol. Biotechnol. 18, 1109-1114.
14. Lee, N.H., Son, C.G., 2011. Systemic review of randomized controlled trials evaluating the efficacy and safety of ginseng. J. Acupunct. Meridian Stud. 4, 85-97.
15. Lee, E.J., Kim, S.Y., Hyun, J.W., Min, S.W., Kim, D.H., Kim, H.S., 2010. Glycitein inhibits glioma cell invasion through down-regulation of MMP-3 and MMP-9 gene expression. Chem. Biol. Interact. 185, 18-24.
16. Mercapide, J., Lopez, D.C.R., Castresana, J.S., Klein-Szanto, A.J., 2003. Stromelysin-1/matrix metalloproteinase-3 (MMP-3) expression accounts for invasive properties of human astrocytoma cell lines. Int. J. Cancer 106, 676-682. (Pubitemid 36993390)
17. Munaut, C., Noel, A., Hougrand, O., Foidart, J.M., Boniver, J., Deprez, M., 2003. Vascular endothelial growth factor expression correlates with matrix metalloproteinases MT1-MMP, MMP-2 and MMP-9 in human glioblastomas. Int. J. Cancer 106, 848-855. (Pubitemid 37071662)
18. Nabeshima, K., Inoue, T., Shimao, Y., Sameshima, T., 2002. Matrix metalloproteinases in tumor invasion: role for cell migration. Pathol. Int. 52, 255-264. (Pubitemid 34587810)
19. Onishi, M., Icikawa, T., Kurozumi, K., Date, I., 2011. Angiogeneis and invasion in glioma. Brain Tumor Pathol. 28, 13-24.
20. Park, E.K., Choo, M.K., Han, M.J., Kim, D.H., 2004. Ginsenoside Rh1 possess antiallergic and anti-inflammatory activities. Int. Arch. Allergy Immunol. 133, 113-120. (Pubitemid 38314642)
21. Rao, J.S., 2003. Molecular mechanisms of glioma invasiveness: the role of proteases. Nat. Rev. Cancer 3, 489-501. (Pubitemid 37328837)
22. Salhia, B., Tran, N.L., Symons, M., Winkles, J.A., Rutka, J.T., Berens, M.E., 2006. Molecular pathways triggering glioma cell invasion. Expert. Rev. Mol. Diagn. 6, 613-626. (Pubitemid 44179946)
23. Sawaya, R., Go, Y., Kyritisis, A.P., Uhm, J., Venkaiah, B., Mohanam, S., Gokaslan, Z.L., Rao, J.S., 1998. Elevated levels of Mr 92,000 type IV collagenase during tumor growth in vivo. Biochem. Biophys. Res. Commun. 251, 632-636. (Pubitemid 28505074)
24. Shin, Y.W., Bae, E.A., Kim, S.S., Lee, Y.C., Lee, B.Y., Kim, D.H., 2006. The effects of ginsenoside Re and its metabolite, ginsenoside Rh1, on 12-Otetradecanoylphorbol 13-acetate- and oxazolone-induced mouse dermatitis models. Planta Med. 72, 376-378.
25. Wang, Y., Liu, T.H., Wang, W., Wang, B.X., 2001. Research on the transformation of ginsenoside Rg1 by intestinal flora. China J. Chin. Mater. Med. 26, 188-190.
26. Wang, Y., Chen, J., Chu, S., Wang, S., Wang, X., Chen, N., Zhang, J., 2009. Improvement of memory in mice and increase of hippocampal excitability in rats by ginsenoside Rg1's metabolites ginsenoside Rh1 and protopanaxatriol. J. Pharmacol. Sci. 109, 504-510.
27. Wild-Bode, C., Weller, M., Wick, W., 2001. Molecular determinants of glioma cell migration and invasion. J. Neurosurg. 94, 978-984. (Pubitemid 32799599)
28. Woo, M.S., Jung, S.H., Kim, S.Y., Hyun, J.W., Ko, K.H., Kim, W.K., Kim, H.S., 2005. Curcumin suppresses phorbol ester-induced matrix metalloproteinase-9 expression by inhibiting the PKC to MAPK signaling pathways in human astroglioma cells. Biochem. Biophys. Res. Commun. 335, 1017-1025.
29. Yoon, J.H., Choi, Y.J., Lee, S.C., 2012. Ginsenoside Rh1 suppresses matrix metalloproteinase-1 expression through inhibition of activator protein-1 and mitogen-activated protein kinase signaling pathway in human hepatocellular carcinoma cells. Eur. J. Pharmacol. 679, 24-33.
30. Zhao, Y., Xiao, A., diPierro, C.G., Carpenter, J.E., Abdel-Fattah, R., Redpath, G.T., Lopes, M.B., Hussaini, I.M., 2010. An extensive invasive intracranial human glioblastoma xenograft model: role of high level matrix metalloproteinase 9. Am. J. Pathol. 176, 3032-3049.
31. Zhu, D., Wu, L., Li, C.R., 2009. Ginsenoside Rg1 protects rat cardiomyocyte from hypoxia/reoxygenation oxidative injury via antioxidant and intracellular calcium homeostasis. J. Cell. Biochem. 108, 117-124.