Protective roles of matrix metalloproteinases: From mouse models to human cancer

Cell Cycle

Volumn 8, Issue 22, 2009, Pages 3657-3662

  López Otín, Carlos ^a   Palavalli, Lavanya H ^b   Samuels, Yardena ^b  

^a DEPARTAMENTO DE BIOQUÍMICA Y BIOLOGÍA MOLECULAR   (Spain)

^b NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

Author keywords

Matrix metalloproteinases; MMP 8; Mouse model; Somatic mutation; Tumor suppressor gene

Indexed keywords

ADAM PROTEIN; ADAMTS15 PROTEIN; GELATINASE A; INTERSTITIAL COLLAGENASE; MACROPHAGE ELASTASE; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE 19; MATRIX METALLOPROTEINASE 26; MATRIX METALLOPROTEINASE INHIBITOR; NEUTROPHIL COLLAGENASE; STROMELYSIN; STROMELYSIN 3; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; BREAST CARCINOMA; CANCER GROWTH; CARCINOGENESIS; DISEASE ASSOCIATION; DNA SEQUENCE; DRUG TARGETING; GENE OVEREXPRESSION; GENE SEQUENCE; GENETIC ANALYSIS; HETEROZYGOSITY LOSS; HIGH THROUGHPUT SCREENING; HISTOPATHOLOGY; HOST; HUMAN; MOLECULAR BIOLOGY; MOUSE; MULTIGENE FAMILY; NEOPLASM; NONHUMAN; PROTEIN EXPRESSION; REVIEW; SOMATIC MUTATION; TUMOR SUPPRESSOR GENE; WILD TYPE;

EID: 70449971114     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.8.22.9956     Document Type: Review

References (38)

1. Lopez-Otin C, Bond JS. Proteases: multifunctional enzymes in life and disease. J Biol Chem 2008; 283:30433-30437
2. Quesada V, Ordonez GR, Sanchez LM, Puente XS, Lopez-Otin C. The Degradome database: mammalian proteases and diseases of proteolysis. Nucleic Acids Res 2009; 37:239-243
3. Fanjul-Fernandez M, Folgueras AR, Cabrera S, Lopez-Otin C. Matrix metalloproteinases: evolution, gene regulation and functional analysis in mouse models. Biochimica et Biophysica Acta 2009; In Press.
4. Liotta LA, Tryggvason K, Garbisa S, Hart I, Foltz CM, Shafie S. Metastatic potential correlates with enzymatic degradation of basement membrane collagen. Nature 1980; 284:67-68 (Pubitemid 10098769)
5. Egeblad M, Werb Z. New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer 2002; 2:161-174 (Pubitemid 37328786)
6. Coussens LM, Fingleton B, Matrisian LM. Matrix metalloproteinase inhibitors and cancer: trials and tribulations. Science 2002; 295:2387-2392 (Pubitemid 34270240)
7. Overall CM, Lopez-Otin C. Strategies for MMP inhibition in cancer: innovations for the post-trial era. Nat Rev Cancer 2002; 2:657-672 (Pubitemid 37328917)
8. Balbin M, Fueyo A, Tester AM, Pendas AM, Pitiot AS, Astudillo A, et al. Loss of collagenase-2 confers increased skin tumor susceptibility to male mice. Nat Genet 2003; 35:252-257 (Pubitemid 37363179)
9. Gutierrez-Fernandez A, Inada M, Balbin M, Fueyo A, Pitiot AS, Astudillo A, et al. Increased inflammation delays wound healing in mice deficient in collagenase-2 (MMP-8). Faseb J 2007; 21:2580-2591 (Pubitemid 47230686)
10. Montel V, Kleeman J, Agarwal D, Spinella D, Kawai K, Tarin D. Altered metastatic behavior of human breast cancer cells after experimental manipulation of matrix metalloproteinase 8 gene expression. Cancer Res 2004; 64:1687-1694 (Pubitemid 38428690)
11. Gutierrez-Fernandez A, Fueyo A, Folgueras AR, Garabaya C, Pennington CJ, Pilgrim S, et al. Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion. Cancer Res 2008; 68:2755-2763 (Pubitemid 351556273)
12. Korpi JT, Kervinen V, Maklin H, Vaananen A, Lahtinen M, Laara E, et al. Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer. Br J Cancer 2008; 98:766-775 (Pubitemid 351272624)
13. Decock J, Long JR, Laxton RC, Shu XO, Hodgkinson C, Hendrickx W, et al. Association of matrix metalloproteinase- 8 gene variation with breast cancer prognosis. Cancer Res 2007; 67:10214-10221 (Pubitemid 350070794)
14. Acuff HB, Sinnamon M, Fingleton B, Boone B, Levy SE, Chen X, et al. Analysis of host- and tumor-derived proteinases using a custom dual species microarray reveals a protective role for stromal matrix metalloproteinase-12 in non-small cell lung cancer. Cancer Res 2006; 66:7968-7975 (Pubitemid 44299160)
15. Savinov AY, Remacle AG, Golubkov VS, Krajewska M, Kennedy S, Duffy MJ, et al. Matrix metalloproteinase 26 proteolysis of the NH2-terminal domain of the estrogen receptor beta correlates with the survival of breast cancer patients. Cancer Res 2006; 66:2716-2724
16. Houghton AM, Grisolano JL, Baumann ML, Kobayashi DK, Hautamaki RD, Nehring LC, et al. Macrophage elastase (matrix metalloproteinase-12) suppresses growth of lung metastases. Cancer Res 2006; 66:6149-6155
17. Lopez-Otin C, Matrisian LM. Emerging roles of proteases in tumor suppression. Nat Rev Cancer 2007; 7:800-808 (Pubitemid 47463671)
18. Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, et al. The consensus coding sequences of human breast and colorectal cancers. Science 2006; 314:268-274 (Pubitemid 44571966)
19. Wood LD, Parsons DW, Jones S, Lin J, Sjoblom T, Leary RJ, et al. The Genomic Landscapes of Human Breast and Colorectal Cancers. Science 2007.
20. Parsons DW, Jones S, Zhang X, Lin JC, Leary RJ, Angenendt P, et al. An integrated genomic analysis of human glioblastoma multiforme. Science 2008; 321:1807-1812
21. Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Angenendt P, et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 2008; 321:1801-1806
22. Gururajan R, Lahti JM, Grenet J, Easton J, Gruber I, Ambros PF, et al. Duplication of a genomic region containing the Cdc2L1-2 and MMP21-22 genes on human chromosome 1p36.3 and their linkage to D1Z2. Genome Res 1998; 8:929-939 (Pubitemid 28495445)
23. Llano E, Pendas AM, Freije JP, Nakano A, Knauper V, Murphy G, et al. Identification and characterization of human MT5-MMP, a new membrane-bound activator of progelatinase a overexpressed in brain tumors. Cancer Res 1999; 59:2570-2576 (Pubitemid 29269100)
24. Palavalli LH, Prickett TD, Wunderlich JR, Wei X, Burrell AS, Porter-Gill P, et al. Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma. Nat Genet 2009; 41:518-520
25. Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, et al. Patterns of somatic mutation in human cancer genomes. Nature 2007; 446:153-158 (Pubitemid 46398669)
26. Brinckerhoff CE, Matrisian LM. Matrix metalloproteinases: a tail of a frog that became a prince. Nat Rev Mol Cell Biol 2002; 3:207-214 (Pubitemid 37237143)
27. Knauper V, Lopez-Otin C, Smith B, Knight G, Murphy G. Biochemical characterization of human collagenase-3. J Biol Chem 1996; 271:1544-1550
28. Porter S, Clark IM, Kevorkian L, Edwards DR. The ADAMTS metalloproteinases. Biochem J 2005; 386:15-27.
29. Viloria CG, Obaya AJ, Moncada-Pazos A, Llamazares M, Astudillo A, Capella G, et al. Genetic inactivation of ADAMTS15 metalloprotease in human colorectal cancer. Cancer Res 2009; 69:4926-4934
30. Lind GE, Kleivi K, Meling GI, Teixeira MR, Thiis- Evensen E, Rognum TO, et al. ADAMTS1, CRABP1 and NR3C1 identified as epigenetically deregulated genes in colorectal tumorigenesis. Cell Oncol 2006; 28:259-272
31. Lo PH, Leung AC, Kwok CY, Cheung WS, Ko JM, Yang LC, et al. Identification of a tumor suppressive critical region mapping to 3p14.2 in esophageal squamous cell carcinoma and studies of a candidate tumor suppressor gene, ADAMTS9. Oncogene 2007; 26:148-157
32. Jin H, Wang X, Ying J, Wong AH, Li H, Lee KY, et al. Epigenetic identification of ADAMTS18 as a novel 16q23.1 tumor suppressor frequently silenced in esophageal, nasopharyngeal and multiple other carcinomas. Oncogene 2007; 26:7490-7498 (Pubitemid 350158717)
33. Moncada-Pazos A, Obaya AJ, Fraga MF, Viloria CG, Capella G, Gausachs M, et al. The ADAMTS12 metalloprotease gene is epigenetically silenced in tumor cells and transcriptionally activated in the stroma during progression of colon cancer. J Cell Sci 2009; 122:2906-2913
34. Druker BJ. Translation of the Philadelphia chromosome into therapy for CML. Blood 2008; 112:4808-4817
35. Sleijfer S, Wiemer E, Verweij J. Drug Insight: gastrointestinal stromal tumors (GIST) - the solid tumor model for cancer-specific treatment. Nat Clin Pract Oncol 2008; 5:102-111
36. Freije JM, Balbin M, Pendas AM, Sanchez LM, Puente XS, Lopez-Otin C. Matrix metalloproteinases and tumor progression. Adv Exp Med Biol 2003; 532:91-107.
37. Overall CM, Kleifeld O. Tumor microenvironment - opinion: validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy. Nat Rev Cancer 2006; 6:227-239
38. Lopez-Otin C, Overall CM. Protease degradomics: a new challenge for proteomics. Nat Rev Mol Cell Biol 2002; 3:509-519 (Pubitemid 34733432)